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Updated November 2019
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Protein Info
Short Name:
PIWIL2
Full Name:
Piwi-like protein 2
Alias:
Cancer/testis antigen 80
Type:
Mass (Da):
109849
Number AA:
973
UniProt ID:
Q8TC59
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
P
F
R
P
S
F
R
G
Q
S
P
I
Site 2
S12
R
P
S
F
R
G
Q
S
P
I
H
P
S
Q
C
Site 3
S17
G
Q
S
P
I
H
P
S
Q
C
Q
A
V
R
M
Site 4
S32
P
G
C
W
P
Q
A
S
K
P
L
D
P
A
L
Site 5
S58
F
G
K
P
E
E
P
S
T
Q
R
G
P
A
Q
Site 6
T59
G
K
P
E
E
P
S
T
Q
R
G
P
A
Q
R
Site 7
S68
R
G
P
A
Q
R
E
S
V
G
L
V
S
M
F
Site 8
T82
F
R
G
L
G
I
E
T
V
S
K
T
P
L
K
Site 9
S84
G
L
G
I
E
T
V
S
K
T
P
L
K
R
E
Site 10
T86
G
I
E
T
V
S
K
T
P
L
K
R
E
M
L
Site 11
S95
L
K
R
E
M
L
P
S
G
R
G
I
L
G
R
Site 12
S105
G
I
L
G
R
G
L
S
A
N
L
V
R
K
D
Site 13
S117
R
K
D
R
E
E
L
S
P
T
F
W
D
P
K
Site 14
T119
D
R
E
E
L
S
P
T
F
W
D
P
K
V
L
Site 15
S131
K
V
L
A
A
G
D
S
K
M
A
E
T
S
V
Site 16
S137
D
S
K
M
A
E
T
S
V
G
W
S
R
T
L
Site 17
S141
A
E
T
S
V
G
W
S
R
T
L
G
R
G
S
Site 18
T143
T
S
V
G
W
S
R
T
L
G
R
G
S
S
D
Site 19
S148
S
R
T
L
G
R
G
S
S
D
A
S
L
L
P
Site 20
S149
R
T
L
G
R
G
S
S
D
A
S
L
L
P
L
Site 21
S152
G
R
G
S
S
D
A
S
L
L
P
L
G
R
A
Site 22
T173
E
V
D
K
P
P
C
T
F
S
T
P
S
R
G
Site 23
S175
D
K
P
P
C
T
F
S
T
P
S
R
G
P
P
Site 24
T176
K
P
P
C
T
F
S
T
P
S
R
G
P
P
Q
Site 25
S178
P
C
T
F
S
T
P
S
R
G
P
P
Q
L
S
Site 26
S185
S
R
G
P
P
Q
L
S
S
P
P
A
L
P
Q
Site 27
S186
R
G
P
P
Q
L
S
S
P
P
A
L
P
Q
S
Site 28
S193
S
P
P
A
L
P
Q
S
P
L
H
S
P
D
R
Site 29
S197
L
P
Q
S
P
L
H
S
P
D
R
P
L
V
L
Site 30
T205
P
D
R
P
L
V
L
T
V
E
H
K
E
K
E
Site 31
T222
V
K
Q
G
S
K
G
T
P
Q
S
L
G
L
N
Site 32
S225
G
S
K
G
T
P
Q
S
L
G
L
N
L
V
K
Site 33
Y241
Q
C
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
Site 34
Y243
H
N
E
A
V
Y
Q
Y
H
V
T
F
S
P
N
Site 35
T246
A
V
Y
Q
Y
H
V
T
F
S
P
N
V
E
C
Site 36
S293
Q
Q
V
L
E
L
K
S
Q
R
K
T
D
S
A
Site 37
T297
E
L
K
S
Q
R
K
T
D
S
A
E
I
S
I
Site 38
S299
K
S
Q
R
K
T
D
S
A
E
I
S
I
K
I
Site 39
S303
K
T
D
S
A
E
I
S
I
K
I
Q
M
T
K
Site 40
Y344
K
L
V
G
R
N
F
Y
D
P
T
S
A
M
V
Site 41
Y363
R
L
Q
I
W
P
G
Y
A
A
S
I
R
R
T
Site 42
S366
I
W
P
G
Y
A
A
S
I
R
R
T
D
G
G
Site 43
Y398
L
D
V
M
H
A
I
Y
Q
Q
N
K
E
H
F
Site 44
T410
E
H
F
Q
D
E
C
T
K
L
L
V
G
N
I
Site 45
Y422
G
N
I
V
I
T
R
Y
N
N
R
T
Y
R
I
Site 46
T426
I
T
R
Y
N
N
R
T
Y
R
I
D
D
V
D
Site 47
Y427
T
R
Y
N
N
R
T
Y
R
I
D
D
V
D
W
Site 48
T437
D
D
V
D
W
N
K
T
P
K
D
S
F
T
M
Site 49
S441
W
N
K
T
P
K
D
S
F
T
M
S
D
G
K
Site 50
T443
K
T
P
K
D
S
F
T
M
S
D
G
K
E
I
Site 51
S445
P
K
D
S
F
T
M
S
D
G
K
E
I
T
F
Site 52
T451
M
S
D
G
K
E
I
T
F
L
E
Y
Y
S
K
Site 53
Y455
K
E
I
T
F
L
E
Y
Y
S
K
N
Y
G
I
Site 54
Y456
E
I
T
F
L
E
Y
Y
S
K
N
Y
G
I
T
Site 55
S477
P
L
L
I
H
R
P
S
E
R
Q
D
N
H
G
Site 56
S524
L
A
Q
Q
I
N
L
S
P
K
Q
H
H
S
A
Site 57
S579
R
I
N
L
K
N
T
S
F
I
T
S
Q
E
L
Site 58
S583
K
N
T
S
F
I
T
S
Q
E
L
N
W
V
K
Site 59
S597
K
E
V
T
R
D
P
S
I
L
T
I
P
M
H
Site 60
T651
L
K
D
D
R
I
E
T
Y
V
R
T
I
Q
S
Site 61
Y652
K
D
D
R
I
E
T
Y
V
R
T
I
Q
S
T
Site 62
T659
Y
V
R
T
I
Q
S
T
L
G
A
E
G
K
I
Site 63
Y681
M
G
P
R
D
D
L
Y
G
A
I
K
K
L
C
Site 64
S712
G
Q
P
T
R
L
R
S
V
A
Q
K
I
L
L
Site 65
Y747
M
V
I
G
M
D
V
Y
H
D
P
S
R
G
M
Site 66
S751
M
D
V
Y
H
D
P
S
R
G
M
R
S
V
V
Site 67
S756
D
P
S
R
G
M
R
S
V
V
G
F
V
A
S
Site 68
Y772
N
L
T
L
T
K
W
Y
S
R
V
V
F
Q
M
Site 69
Y800
V
G
S
L
K
K
F
Y
E
V
N
H
C
L
P
Site 70
T824
V
S
D
G
Q
L
K
T
V
A
N
Y
E
I
P
Site 71
Y828
Q
L
K
T
V
A
N
Y
E
I
P
Q
L
Q
K
Site 72
Y861
K
K
I
S
T
N
L
Y
L
A
A
P
Q
N
F
Site 73
T872
P
Q
N
F
V
T
P
T
P
G
T
V
V
D
H
Site 74
S916
V
L
N
T
A
N
L
S
P
D
H
M
Q
R
L
Site 75
T924
P
D
H
M
Q
R
L
T
F
K
L
C
H
M
Y
Site 76
S954
A
H
K
L
A
F
L
S
G
H
I
L
H
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation