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Updated November 2019
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Protein Info
Short Name:
MDM1
Full Name:
Nuclear protein MDM1
Alias:
Type:
Mass (Da):
80735
Number AA:
714
UniProt ID:
Q8TC05
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
V
R
F
K
G
L
S
E
Y
Q
R
N
F
L
Site 2
Y11
R
F
K
G
L
S
E
Y
Q
R
N
F
L
W
K
Site 3
Y21
N
F
L
W
K
K
S
Y
L
S
E
S
C
N
S
Site 4
S23
L
W
K
K
S
Y
L
S
E
S
C
N
S
S
V
Site 5
S25
K
K
S
Y
L
S
E
S
C
N
S
S
V
G
R
Site 6
S29
L
S
E
S
C
N
S
S
V
G
R
K
Y
P
W
Site 7
Y34
N
S
S
V
G
R
K
Y
P
W
A
G
L
R
S
Site 8
T47
R
S
D
Q
L
G
I
T
K
E
P
S
F
I
S
Site 9
S51
L
G
I
T
K
E
P
S
F
I
S
K
R
R
V
Site 10
S54
T
K
E
P
S
F
I
S
K
R
R
V
P
Y
H
Site 11
Y60
I
S
K
R
R
V
P
Y
H
D
P
Q
I
S
K
Site 12
S68
H
D
P
Q
I
S
K
S
L
E
W
N
G
A
I
Site 13
S83
S
E
S
N
V
V
A
S
P
E
P
E
A
P
E
Site 14
T91
P
E
P
E
A
P
E
T
P
K
S
Q
E
A
E
Site 15
S94
E
A
P
E
T
P
K
S
Q
E
A
E
Q
K
D
Site 16
T103
E
A
E
Q
K
D
V
T
Q
E
R
V
H
S
L
Site 17
S109
V
T
Q
E
R
V
H
S
L
E
A
S
R
V
P
Site 18
S113
R
V
H
S
L
E
A
S
R
V
P
K
R
T
R
Site 19
T119
A
S
R
V
P
K
R
T
R
S
H
S
A
D
S
Site 20
S121
R
V
P
K
R
T
R
S
H
S
A
D
S
R
A
Site 21
S123
P
K
R
T
R
S
H
S
A
D
S
R
A
E
G
Site 22
S126
T
R
S
H
S
A
D
S
R
A
E
G
A
S
D
Site 23
S132
D
S
R
A
E
G
A
S
D
V
E
N
N
E
G
Site 24
T144
N
E
G
V
T
N
H
T
P
V
N
E
N
V
E
Site 25
S155
E
N
V
E
L
E
H
S
T
K
V
L
S
E
N
Site 26
T178
L
R
K
K
A
G
L
T
V
V
P
S
Y
N
A
Site 27
Y183
G
L
T
V
V
P
S
Y
N
A
L
R
N
S
E
Site 28
S189
S
Y
N
A
L
R
N
S
E
Y
Q
R
Q
F
V
Site 29
Y191
N
A
L
R
N
S
E
Y
Q
R
Q
F
V
W
K
Site 30
S227
V
P
P
F
K
G
N
S
V
I
H
E
T
E
Y
Site 31
Y234
S
V
I
H
E
T
E
Y
K
R
N
F
K
G
L
Site 32
S242
K
R
N
F
K
G
L
S
P
V
K
E
P
K
L
Site 33
T261
R
E
N
R
N
L
E
T
V
S
P
E
R
K
S
Site 34
S263
N
R
N
L
E
T
V
S
P
E
R
K
S
N
K
Site 35
S268
T
V
S
P
E
R
K
S
N
K
I
D
D
R
L
Site 36
T294
H
Q
P
K
R
K
L
T
P
W
K
H
Q
R
L
Site 37
S306
Q
R
L
G
K
V
N
S
E
Y
R
A
K
F
L
Site 38
Y308
L
G
K
V
N
S
E
Y
R
A
K
F
L
S
P
Site 39
S314
E
Y
R
A
K
F
L
S
P
A
Q
Y
L
Y
K
Site 40
Y318
K
F
L
S
P
A
Q
Y
L
Y
K
A
G
A
W
Site 41
Y320
L
S
P
A
Q
Y
L
Y
K
A
G
A
W
T
H
Site 42
S356
R
V
Q
G
T
H
F
S
R
D
H
L
N
Q
I
Site 43
S374
S
N
C
C
W
D
V
S
S
T
T
S
S
E
G
Site 44
S375
N
C
C
W
D
V
S
S
T
T
S
S
E
G
T
Site 45
S378
W
D
V
S
S
T
T
S
S
E
G
T
V
S
S
Site 46
S379
D
V
S
S
T
T
S
S
E
G
T
V
S
S
N
Site 47
T382
S
T
T
S
S
E
G
T
V
S
S
N
I
R
A
Site 48
S385
S
S
E
G
T
V
S
S
N
I
R
A
L
D
L
Site 49
T397
L
D
L
A
G
D
P
T
S
H
K
T
L
Q
K
Site 50
S398
D
L
A
G
D
P
T
S
H
K
T
L
Q
K
C
Site 51
T401
G
D
P
T
S
H
K
T
L
Q
K
C
P
S
T
Site 52
S407
K
T
L
Q
K
C
P
S
T
E
P
E
E
K
G
Site 53
T446
R
R
R
L
A
W
D
T
E
N
T
S
E
D
V
Site 54
T474
E
E
E
G
D
R
K
T
G
K
Q
A
F
M
G
Site 55
S492
K
L
D
V
R
E
K
S
K
A
D
K
M
K
E
Site 56
S501
A
D
K
M
K
E
G
S
D
S
S
V
S
S
E
Site 57
S503
K
M
K
E
G
S
D
S
S
V
S
S
E
K
G
Site 58
S504
M
K
E
G
S
D
S
S
V
S
S
E
K
G
G
Site 59
S506
E
G
S
D
S
S
V
S
S
E
K
G
G
R
L
Site 60
S507
G
S
D
S
S
V
S
S
E
K
G
G
R
L
P
Site 61
T515
E
K
G
G
R
L
P
T
P
K
L
R
E
L
G
Site 62
T532
Q
R
T
H
H
D
L
T
T
P
A
V
G
G
A
Site 63
T533
R
T
H
H
D
L
T
T
P
A
V
G
G
A
V
Site 64
S545
G
A
V
L
V
S
P
S
K
M
K
P
P
A
P
Site 65
T559
P
E
Q
R
K
R
M
T
S
Q
D
C
L
E
T
Site 66
S560
E
Q
R
K
R
M
T
S
Q
D
C
L
E
T
S
Site 67
S567
S
Q
D
C
L
E
T
S
K
N
D
F
T
K
K
Site 68
T572
E
T
S
K
N
D
F
T
K
K
E
S
R
A
V
Site 69
S576
N
D
F
T
K
K
E
S
R
A
V
S
L
L
T
Site 70
S580
K
K
E
S
R
A
V
S
L
L
T
S
P
A
A
Site 71
S584
R
A
V
S
L
L
T
S
P
A
A
G
I
K
T
Site 72
T591
S
P
A
A
G
I
K
T
V
D
P
L
P
L
R
Site 73
S601
P
L
P
L
R
E
D
S
E
D
N
I
H
K
F
Site 74
S616
A
E
A
T
L
P
V
S
K
I
P
K
Y
P
T
Site 75
Y621
P
V
S
K
I
P
K
Y
P
T
N
P
P
G
Q
Site 76
T623
S
K
I
P
K
Y
P
T
N
P
P
G
Q
L
P
Site 77
S631
N
P
P
G
Q
L
P
S
P
P
H
V
P
S
Y
Site 78
S637
P
S
P
P
H
V
P
S
Y
W
H
P
S
R
R
Site 79
Y638
S
P
P
H
V
P
S
Y
W
H
P
S
R
R
I
Site 80
S642
V
P
S
Y
W
H
P
S
R
R
I
Q
G
S
L
Site 81
S648
P
S
R
R
I
Q
G
S
L
R
D
P
E
F
Q
Site 82
S683
D
E
D
E
D
R
L
S
E
I
S
A
R
S
A
Site 83
S686
E
D
R
L
S
E
I
S
A
R
S
A
A
S
S
Site 84
S689
L
S
E
I
S
A
R
S
A
A
S
S
L
R
A
Site 85
S692
I
S
A
R
S
A
A
S
S
L
R
A
F
Q
T
Site 86
S693
S
A
R
S
A
A
S
S
L
R
A
F
Q
T
L
Site 87
T699
S
S
L
R
A
F
Q
T
L
A
R
A
K
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation