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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDR66
Full Name:
WD repeat-containing protein 66
Alias:
Type:
Mass (Da):
130645
Number AA:
1154
UniProt ID:
Q8TBY9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
A
E
A
P
R
E
A
T
G
E
N
G
E
T
E
Site 2
T18
A
T
G
E
N
G
E
T
E
M
K
E
E
E
E
Site 3
Y30
E
E
E
P
N
P
N
Y
K
E
V
E
D
P
Q
Site 4
T44
Q
Q
E
S
K
D
D
T
I
A
W
R
E
S
Q
Site 5
S50
D
T
I
A
W
R
E
S
Q
E
E
E
R
K
T
Site 6
T57
S
Q
E
E
E
R
K
T
G
E
E
E
G
E
E
Site 7
S95
E
V
Q
E
K
E
A
S
G
I
Q
E
E
T
T
Site 8
T102
S
G
I
Q
E
E
T
T
V
E
P
Q
E
V
T
Site 9
S111
E
P
Q
E
V
T
A
S
M
I
R
L
E
T
Q
Site 10
T117
A
S
M
I
R
L
E
T
Q
I
T
D
S
Q
S
Site 11
T120
I
R
L
E
T
Q
I
T
D
S
Q
S
I
T
S
Site 12
S122
L
E
T
Q
I
T
D
S
Q
S
I
T
S
G
I
Site 13
S124
T
Q
I
T
D
S
Q
S
I
T
S
G
I
F
P
Site 14
T126
I
T
D
S
Q
S
I
T
S
G
I
F
P
K
T
Site 15
T133
T
S
G
I
F
P
K
T
Q
R
G
S
K
S
K
Site 16
S137
F
P
K
T
Q
R
G
S
K
S
K
L
S
L
Q
Site 17
S139
K
T
Q
R
G
S
K
S
K
L
S
L
Q
L
E
Site 18
S142
R
G
S
K
S
K
L
S
L
Q
L
E
D
A
E
Site 19
T150
L
Q
L
E
D
A
E
T
D
E
L
L
R
D
L
Site 20
S158
D
E
L
L
R
D
L
S
T
Q
I
E
F
L
D
Site 21
S170
F
L
D
L
D
Q
I
S
P
E
E
Q
Q
I
S
Site 22
S177
S
P
E
E
Q
Q
I
S
S
P
E
R
Q
P
S
Site 23
S178
P
E
E
Q
Q
I
S
S
P
E
R
Q
P
S
G
Site 24
S184
S
S
P
E
R
Q
P
S
G
E
L
E
E
K
T
Site 25
T191
S
G
E
L
E
E
K
T
D
R
M
P
Q
D
E
Site 26
S220
E
G
Q
E
R
R
V
S
D
I
Q
S
K
A
G
Site 27
S224
R
R
V
S
D
I
Q
S
K
A
G
I
S
R
E
Site 28
S229
I
Q
S
K
A
G
I
S
R
E
S
L
V
S
S
Site 29
S232
K
A
G
I
S
R
E
S
L
V
S
S
T
T
E
Site 30
S235
I
S
R
E
S
L
V
S
S
T
T
E
D
I
L
Site 31
S236
S
R
E
S
L
V
S
S
T
T
E
D
I
L
F
Site 32
S248
I
L
F
Q
K
D
K
S
T
P
V
Y
P
L
T
Site 33
T249
L
F
Q
K
D
K
S
T
P
V
Y
P
L
T
M
Site 34
Y252
K
D
K
S
T
P
V
Y
P
L
T
M
T
W
S
Site 35
Y269
W
N
S
S
L
P
V
Y
Y
I
R
E
E
R
Q
Site 36
Y270
N
S
S
L
P
V
Y
Y
I
R
E
E
R
Q
R
Site 37
Y298
N
V
F
R
N
N
Q
Y
H
L
Q
G
H
A
N
Site 38
T321
E
D
R
R
W
I
A
T
A
D
K
G
P
D
C
Site 39
S347
P
V
H
T
I
F
D
S
C
P
E
G
N
G
I
Site 40
Y365
A
M
T
H
D
A
K
Y
L
A
T
I
S
D
A
Site 41
S370
A
K
Y
L
A
T
I
S
D
A
E
V
Q
K
V
Site 42
Y404
T
E
Y
G
V
Q
N
Y
V
T
F
N
P
T
N
Site 43
S419
N
K
E
L
V
S
N
S
K
T
R
A
I
Y
Y
Site 44
T421
E
L
V
S
N
S
K
T
R
A
I
Y
Y
A
W
Site 45
Y425
N
S
K
T
R
A
I
Y
Y
A
W
Y
E
E
R
Site 46
Y426
S
K
T
R
A
I
Y
Y
A
W
Y
E
E
R
D
Site 47
Y429
R
A
I
Y
Y
A
W
Y
E
E
R
D
T
L
A
Site 48
T434
A
W
Y
E
E
R
D
T
L
A
H
S
A
P
L
Site 49
S438
E
R
D
T
L
A
H
S
A
P
L
L
T
E
K
Site 50
T446
A
P
L
L
T
E
K
T
F
N
K
L
V
G
K
Site 51
S455
N
K
L
V
G
K
F
S
Q
S
I
F
H
L
N
Site 52
S485
W
D
I
H
R
P
P
S
S
A
S
T
F
L
G
Site 53
S486
D
I
H
R
P
P
S
S
A
S
T
F
L
G
F
Site 54
S488
H
R
P
P
S
S
A
S
T
F
L
G
F
P
Y
Site 55
T489
R
P
P
S
S
A
S
T
F
L
G
F
P
Y
I
Site 56
S555
A
I
R
T
L
S
F
S
K
T
P
A
T
P
P
Site 57
T557
R
T
L
S
F
S
K
T
P
A
T
P
P
T
E
Site 58
T560
S
F
S
K
T
P
A
T
P
P
T
E
K
S
N
Site 59
T563
K
T
P
A
T
P
P
T
E
K
S
N
Y
P
P
Site 60
S566
A
T
P
P
T
E
K
S
N
Y
P
P
D
C
T
Site 61
Y568
P
P
T
E
K
S
N
Y
P
P
D
C
T
L
K
Site 62
T573
S
N
Y
P
P
D
C
T
L
K
G
D
L
F
V
Site 63
Y640
G
M
I
K
V
W
N
Y
E
N
K
Q
Y
L
F
Site 64
Y645
W
N
Y
E
N
K
Q
Y
L
F
S
R
V
F
E
Site 65
S659
E
K
G
F
G
V
Q
S
L
T
Y
N
P
E
G
Site 66
T661
G
F
G
V
Q
S
L
T
Y
N
P
E
G
A
L
Site 67
S685
V
Y
I
L
D
A
M
S
L
E
N
E
S
P
E
Site 68
S690
A
M
S
L
E
N
E
S
P
E
P
F
K
Y
S
Site 69
Y696
E
S
P
E
P
F
K
Y
S
R
T
S
V
T
H
Site 70
S697
S
P
E
P
F
K
Y
S
R
T
S
V
T
H
I
Site 71
S700
P
F
K
Y
S
R
T
S
V
T
H
I
S
F
S
Site 72
T702
K
Y
S
R
T
S
V
T
H
I
S
F
S
H
D
Site 73
S705
R
T
S
V
T
H
I
S
F
S
H
D
S
Q
Y
Site 74
Y712
S
F
S
H
D
S
Q
Y
M
A
T
A
D
R
S
Site 75
T715
H
D
S
Q
Y
M
A
T
A
D
R
S
F
T
V
Site 76
Y738
N
G
Q
R
V
W
E
Y
L
A
R
L
R
S
H
Site 77
S744
E
Y
L
A
R
L
R
S
H
R
K
S
I
R
S
Site 78
S748
R
L
R
S
H
R
K
S
I
R
S
L
L
F
G
Site 79
S751
S
H
R
K
S
I
R
S
L
L
F
G
V
Y
L
Site 80
Y757
R
S
L
L
F
G
V
Y
L
D
S
N
E
P
R
Site 81
S767
S
N
E
P
R
L
L
S
L
G
T
D
R
L
L
Site 82
Y777
T
D
R
L
L
I
E
Y
D
L
L
R
S
Y
K
Site 83
S782
I
E
Y
D
L
L
R
S
Y
K
D
H
L
E
V
Site 84
Y783
E
Y
D
L
L
R
S
Y
K
D
H
L
E
V
L
Site 85
Y807
Y
P
T
C
M
V
W
Y
P
P
L
T
R
E
L
Site 86
T838
T
T
K
M
C
R
K
T
L
L
G
P
A
Y
G
Site 87
Y844
K
T
L
L
G
P
A
Y
G
S
P
I
E
Q
T
Site 88
S846
L
L
G
P
A
Y
G
S
P
I
E
Q
T
Q
V
Site 89
T889
V
D
G
N
P
H
K
T
S
A
I
V
C
H
P
Site 90
S920
T
A
G
G
H
D
R
S
V
V
Q
W
K
I
T
Site 91
Y946
G
E
D
L
T
P
F
Y
G
L
L
S
G
G
R
Site 92
S950
T
P
F
Y
G
L
L
S
G
G
R
E
G
K
F
Site 93
Y958
G
G
R
E
G
K
F
Y
R
E
L
E
D
Y
F
Site 94
Y964
F
Y
R
E
L
E
D
Y
F
Y
Y
S
Q
L
R
Site 95
Y966
R
E
L
E
D
Y
F
Y
Y
S
Q
L
R
S
Q
Site 96
Y967
E
L
E
D
Y
F
Y
Y
S
Q
L
R
S
Q
G
Site 97
S968
L
E
D
Y
F
Y
Y
S
Q
L
R
S
Q
G
I
Site 98
S972
F
Y
Y
S
Q
L
R
S
Q
G
I
D
T
M
E
Site 99
S984
T
M
E
T
R
K
V
S
E
H
I
C
L
S
E
Site 100
Y1002
V
M
R
A
I
G
F
Y
P
S
E
E
K
I
D
Site 101
S1004
R
A
I
G
F
Y
P
S
E
E
K
I
D
D
I
Site 102
Y1020
N
E
I
K
F
G
E
Y
V
D
T
G
K
L
I
Site 103
T1023
K
F
G
E
Y
V
D
T
G
K
L
I
D
K
I
Site 104
Y1039
L
P
D
F
L
K
V
Y
L
N
H
K
P
P
F
Site 105
S1051
P
P
F
G
N
T
M
S
G
I
H
K
S
F
E
Site 106
S1056
T
M
S
G
I
H
K
S
F
E
V
L
G
Y
T
Site 107
Y1062
K
S
F
E
V
L
G
Y
T
N
S
K
G
K
K
Site 108
S1065
E
V
L
G
Y
T
N
S
K
G
K
K
A
I
R
Site 109
S1109
L
N
P
E
G
W
K
S
E
P
A
T
C
S
V
Site 110
T1113
G
W
K
S
E
P
A
T
C
S
V
K
G
S
E
Site 111
S1115
K
S
E
P
A
T
C
S
V
K
G
S
E
I
C
Site 112
S1119
A
T
C
S
V
K
G
S
E
I
C
L
E
E
E
Site 113
T1132
E
E
L
P
D
E
I
T
A
E
I
F
A
T
E
Site 114
T1144
A
T
E
I
L
G
L
T
I
S
E
D
S
G
Q
Site 115
S1146
E
I
L
G
L
T
I
S
E
D
S
G
Q
D
G
Site 116
S1149
G
L
T
I
S
E
D
S
G
Q
D
G
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation