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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHDC4
Full Name:
Kelch domain-containing protein 4
Alias:
DKFZp434G0522; Kelch domain containing 4; KLDC4
Type:
Unknown function
Mass (Da):
57892
Number AA:
520
UniProt ID:
Q8TBB5
International Prot ID:
IPI00152182
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
K
G
R
G
A
E
K
T
A
A
K
M
E
K
K
Site 2
S26
A
K
M
E
K
K
V
S
K
R
S
R
K
E
E
Site 3
T51
Q
T
L
D
A
K
R
T
Q
T
V
E
L
P
C
Site 4
T53
L
D
A
K
R
T
Q
T
V
E
L
P
C
P
P
Site 5
S62
E
L
P
C
P
P
P
S
P
R
L
N
A
S
L
Site 6
S68
P
S
P
R
L
N
A
S
L
S
V
H
P
E
K
Site 7
S70
P
R
L
N
A
S
L
S
V
H
P
E
K
D
E
Site 8
Y94
N
G
Q
K
T
F
L
Y
N
E
L
Y
V
Y
N
Site 9
Y98
T
F
L
Y
N
E
L
Y
V
Y
N
T
R
K
D
Site 10
Y100
L
Y
N
E
L
Y
V
Y
N
T
R
K
D
T
W
Site 11
T106
V
Y
N
T
R
K
D
T
W
T
K
V
D
I
P
Site 12
T108
N
T
R
K
D
T
W
T
K
V
D
I
P
S
P
Site 13
S114
W
T
K
V
D
I
P
S
P
P
P
R
R
C
A
Site 14
S143
V
F
G
G
E
F
A
S
P
N
G
E
Q
F
Y
Site 15
Y150
S
P
N
G
E
Q
F
Y
H
Y
K
D
L
W
V
Site 16
Y152
N
G
E
Q
F
Y
H
Y
K
D
L
W
V
L
H
Site 17
S170
K
T
W
E
Q
V
K
S
T
G
G
P
S
G
R
Site 18
S175
V
K
S
T
G
G
P
S
G
R
S
G
H
R
M
Site 19
S178
T
G
G
P
S
G
R
S
G
H
R
M
V
A
W
Site 20
Y202
F
H
E
S
T
R
D
Y
I
Y
Y
N
D
V
Y
Site 21
Y204
E
S
T
R
D
Y
I
Y
Y
N
D
V
Y
A
F
Site 22
Y205
S
T
R
D
Y
I
Y
Y
N
D
V
Y
A
F
N
Site 23
Y209
Y
I
Y
Y
N
D
V
Y
A
F
N
L
D
T
F
Site 24
T217
A
F
N
L
D
T
F
T
W
S
K
L
S
P
S
Site 25
S219
N
L
D
T
F
T
W
S
K
L
S
P
S
G
T
Site 26
S222
T
F
T
W
S
K
L
S
P
S
G
T
G
P
T
Site 27
S224
T
W
S
K
L
S
P
S
G
T
G
P
T
P
R
Site 28
T226
S
K
L
S
P
S
G
T
G
P
T
P
R
S
G
Site 29
T229
S
P
S
G
T
G
P
T
P
R
S
G
C
Q
M
Site 30
S232
G
T
G
P
T
P
R
S
G
C
Q
M
S
V
T
Site 31
S237
P
R
S
G
C
Q
M
S
V
T
P
Q
G
G
I
Site 32
Y247
P
Q
G
G
I
V
V
Y
G
G
Y
S
K
Q
R
Site 33
S266
V
D
K
G
T
R
H
S
D
M
F
L
L
K
P
Site 34
T294
N
P
S
G
V
K
P
T
P
R
S
G
F
S
V
Site 35
S297
G
V
K
P
T
P
R
S
G
F
S
V
A
M
A
Site 36
S300
P
T
P
R
S
G
F
S
V
A
M
A
P
N
H
Site 37
S323
C
D
E
E
E
E
E
S
L
S
G
E
F
F
N
Site 38
S325
E
E
E
E
E
S
L
S
G
E
F
F
N
D
L
Site 39
Y333
G
E
F
F
N
D
L
Y
F
Y
D
A
T
R
N
Site 40
Y335
F
F
N
D
L
Y
F
Y
D
A
T
R
N
R
W
Site 41
S352
G
Q
L
K
G
P
K
S
E
K
K
K
R
R
R
Site 42
T403
V
T
I
K
Q
V
L
T
A
P
G
S
A
G
Q
Site 43
S407
Q
V
L
T
A
P
G
S
A
G
Q
P
R
S
E
Site 44
S413
G
S
A
G
Q
P
R
S
E
D
E
D
S
L
E
Site 45
S418
P
R
S
E
D
E
D
S
L
E
E
A
G
S
P
Site 46
S424
D
S
L
E
E
A
G
S
P
A
P
G
P
C
P
Site 47
S433
A
P
G
P
C
P
R
S
N
A
M
L
A
V
K
Site 48
T459
E
A
G
D
R
Q
V
T
L
S
D
L
H
C
L
Site 49
S461
G
D
R
Q
V
T
L
S
D
L
H
C
L
D
L
Site 50
T484
L
V
E
M
D
P
E
T
Q
E
W
L
E
E
T
Site 51
S493
E
W
L
E
E
T
D
S
E
E
D
S
E
E
V
Site 52
S497
E
T
D
S
E
E
D
S
E
E
V
E
G
A
E
Site 53
S512
G
G
V
D
D
E
D
S
G
E
E
S
G
A
E
Site 54
S516
D
E
D
S
G
E
E
S
G
A
E
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation