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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMGCLL1
Full Name:
Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
Alias:
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1
Type:
Mass (Da):
39514
Number AA:
370
UniProt ID:
Q8TB92
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
S
A
V
K
H
C
L
S
Y
Q
Q
L
L
R
E
Site 2
S69
A
C
I
H
W
E
T
S
Q
L
S
G
L
P
E
Site 3
S124
E
V
T
S
F
V
S
S
R
W
V
P
Q
M
A
Site 4
T134
V
P
Q
M
A
D
H
T
E
V
M
K
G
I
H
Site 5
Y143
V
M
K
G
I
H
Q
Y
P
G
V
R
Y
P
V
Site 6
Y148
H
Q
Y
P
G
V
R
Y
P
V
L
T
P
N
L
Site 7
T152
G
V
R
Y
P
V
L
T
P
N
L
Q
G
F
H
Site 8
S176
I
S
V
F
G
A
A
S
E
S
F
S
K
K
N
Site 9
S178
V
F
G
A
A
S
E
S
F
S
K
K
N
I
N
Site 10
S180
G
A
A
S
E
S
F
S
K
K
N
I
N
C
S
Site 11
S187
S
K
K
N
I
N
C
S
I
E
E
S
M
G
K
Site 12
S191
I
N
C
S
I
E
E
S
M
G
K
F
E
E
V
Site 13
S201
K
F
E
E
V
V
K
S
A
R
H
M
N
I
P
Site 14
Y221
S
C
A
L
G
C
P
Y
E
G
S
I
T
P
Q
Site 15
S224
L
G
C
P
Y
E
G
S
I
T
P
Q
K
V
T
Site 16
T226
C
P
Y
E
G
S
I
T
P
Q
K
V
T
E
V
Site 17
S234
P
Q
K
V
T
E
V
S
K
R
L
Y
G
M
G
Site 18
Y238
T
E
V
S
K
R
L
Y
G
M
G
C
Y
E
I
Site 19
Y243
R
L
Y
G
M
G
C
Y
E
I
S
L
G
D
T
Site 20
T255
G
D
T
I
G
V
G
T
P
G
S
M
K
R
M
Site 21
S258
I
G
V
G
T
P
G
S
M
K
R
M
L
E
S
Site 22
Y313
S
G
L
G
G
C
P
Y
A
K
G
A
S
G
N
Site 23
Y342
L
N
T
G
V
N
L
Y
K
V
M
E
A
G
D
Site 24
S361
A
V
N
K
T
T
N
S
K
V
A
Q
A
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation