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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC8
Full Name:
Tetratricopeptide repeat protein 8
Alias:
Bardet-Biedl syndrome 8 protein
Type:
Mass (Da):
60392
Number AA:
531
UniProt ID:
Q8TAM2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
P
L
L
L
A
W
S
Y
F
R
R
R
K
F
Site 2
Y14
P
L
L
L
A
W
S
Y
F
R
R
R
K
F
Q
Site 3
Y36
Q
M
L
E
K
S
P
Y
D
Q
A
A
W
I
L
Site 4
T82
A
Q
V
P
R
P
G
T
S
L
K
L
P
G
T
Site 5
T89
T
S
L
K
L
P
G
T
N
Q
T
G
G
P
S
Site 6
T92
K
L
P
G
T
N
Q
T
G
G
P
S
Q
A
V
Site 7
S96
T
N
Q
T
G
G
P
S
Q
A
V
R
P
I
T
Site 8
T103
S
Q
A
V
R
P
I
T
Q
A
G
R
P
I
T
Site 9
T110
T
Q
A
G
R
P
I
T
G
F
L
R
P
S
T
Site 10
S116
I
T
G
F
L
R
P
S
T
Q
S
G
R
P
G
Site 11
T117
T
G
F
L
R
P
S
T
Q
S
G
R
P
G
T
Site 12
S119
F
L
R
P
S
T
Q
S
G
R
P
G
T
M
E
Site 13
T124
T
Q
S
G
R
P
G
T
M
E
Q
A
I
R
T
Site 14
T131
T
M
E
Q
A
I
R
T
P
R
T
A
Y
T
A
Site 15
T134
Q
A
I
R
T
P
R
T
A
Y
T
A
R
P
I
Site 16
Y136
I
R
T
P
R
T
A
Y
T
A
R
P
I
T
S
Site 17
T137
R
T
P
R
T
A
Y
T
A
R
P
I
T
S
S
Site 18
T142
A
Y
T
A
R
P
I
T
S
S
S
G
R
F
V
Site 19
S144
T
A
R
P
I
T
S
S
S
G
R
F
V
R
L
Site 20
S145
A
R
P
I
T
S
S
S
G
R
F
V
R
L
G
Site 21
S155
F
V
R
L
G
T
A
S
M
L
T
S
P
D
G
Site 22
S159
G
T
A
S
M
L
T
S
P
D
G
P
F
I
N
Site 23
S168
D
G
P
F
I
N
L
S
R
L
N
L
T
K
Y
Site 24
Y175
S
R
L
N
L
T
K
Y
S
Q
K
P
K
L
A
Site 25
S176
R
L
N
L
T
K
Y
S
Q
K
P
K
L
A
K
Site 26
Y188
L
A
K
A
L
F
E
Y
I
F
H
H
E
N
D
Site 27
T198
H
H
E
N
D
V
K
T
I
H
L
E
D
V
V
Site 28
S232
A
L
D
L
A
A
L
S
T
E
H
S
Q
Y
K
Site 29
Y251
K
V
Q
I
G
K
C
Y
Y
R
L
G
M
Y
R
Site 30
S266
E
A
E
K
Q
F
K
S
A
L
K
Q
Q
E
M
Site 31
T276
K
Q
Q
E
M
V
D
T
F
L
Y
L
A
K
V
Site 32
Y318
L
C
G
I
A
R
I
Y
E
E
M
N
N
M
S
Site 33
Y330
N
M
S
S
A
A
E
Y
Y
K
E
V
L
K
Q
Site 34
T340
E
V
L
K
Q
D
N
T
H
V
E
A
I
A
C
Site 35
Y354
C
I
G
S
N
H
F
Y
S
D
Q
P
E
I
A
Site 36
S355
I
G
S
N
H
F
Y
S
D
Q
P
E
I
A
L
Site 37
Y365
P
E
I
A
L
R
F
Y
R
R
L
L
Q
M
G
Site 38
Y374
R
L
L
Q
M
G
I
Y
N
G
Q
L
F
N
N
Site 39
T395
Y
A
Q
Q
Y
D
M
T
L
T
S
F
E
R
A
Site 40
S398
Q
Y
D
M
T
L
T
S
F
E
R
A
L
S
L
Site 41
S404
T
S
F
E
R
A
L
S
L
A
E
N
E
E
E
Site 42
T472
Q
A
R
A
L
L
Q
T
A
S
S
L
A
P
H
Site 43
Y481
S
S
L
A
P
H
M
Y
E
P
H
F
N
F
A
Site 44
T489
E
P
H
F
N
F
A
T
I
S
D
K
I
G
D
Site 45
S500
K
I
G
D
L
Q
R
S
Y
V
A
A
Q
K
S
Site 46
Y501
I
G
D
L
Q
R
S
Y
V
A
A
Q
K
S
E
Site 47
S507
S
Y
V
A
A
Q
K
S
E
A
A
F
P
D
H
Site 48
T517
A
F
P
D
H
V
D
T
Q
H
L
I
K
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation