KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIF18A
Full Name:
Kinesin-like protein KIF18A
Alias:
DKFZP434G2226; KI18A; Kinesin family member 18A; Marrow stromal KIF18A; MS(marrow stromal)-KIF18A
Type:
Motor protein; Microtubule binding protein
Mass (Da):
102281
Number AA:
898
UniProt ID:
Q8NI77
International Prot ID:
IPI00171768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005901
GO:0005813
GO:0005828
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0051010
PhosphoSite+
KinaseNET
Biological Process:
GO:0007019
GO:0007018
GO:0007080
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
D
P
K
Q
E
E
V
S
F
F
H
G
K
K
T
Site 2
T59
S
F
F
H
G
K
K
T
T
N
Q
N
V
I
K
Site 3
T83
F
D
A
V
F
D
E
T
S
T
Q
S
E
V
F
Site 4
T93
Q
S
E
V
F
E
H
T
T
K
P
I
L
R
S
Site 5
S100
T
T
K
P
I
L
R
S
F
L
N
G
Y
N
C
Site 6
T122
T
G
A
G
K
T
H
T
M
L
G
S
A
D
E
Site 7
S126
K
T
H
T
M
L
G
S
A
D
E
P
G
V
M
Site 8
S154
I
K
E
E
K
I
C
S
T
A
V
S
Y
L
E
Site 9
S158
K
I
C
S
T
A
V
S
Y
L
E
V
Y
N
E
Site 10
T183
P
L
A
V
R
E
D
T
Q
K
G
V
V
V
H
Site 11
T193
G
V
V
V
H
G
L
T
L
H
Q
P
K
S
S
Site 12
S199
L
T
L
H
Q
P
K
S
S
E
E
I
L
H
L
Site 13
T219
K
N
R
T
Q
H
P
T
D
M
N
A
T
S
S
Site 14
T224
H
P
T
D
M
N
A
T
S
S
R
S
H
A
V
Site 15
S225
P
T
D
M
N
A
T
S
S
R
S
H
A
V
F
Site 16
S226
T
D
M
N
A
T
S
S
R
S
H
A
V
F
Q
Site 17
Y235
S
H
A
V
F
Q
I
Y
L
R
Q
Q
D
K
T
Site 18
T242
Y
L
R
Q
Q
D
K
T
A
S
I
N
Q
N
V
Site 19
S244
R
Q
Q
D
K
T
A
S
I
N
Q
N
V
R
I
Site 20
S262
S
L
I
D
L
A
G
S
E
R
A
S
T
S
G
Site 21
S266
L
A
G
S
E
R
A
S
T
S
G
A
K
G
T
Site 22
T267
A
G
S
E
R
A
S
T
S
G
A
K
G
T
R
Site 23
S268
G
S
E
R
A
S
T
S
G
A
K
G
T
R
F
Site 24
T279
G
T
R
F
V
E
G
T
N
I
N
R
S
L
L
Site 25
S284
E
G
T
N
I
N
R
S
L
L
A
L
G
N
V
Site 26
S298
V
I
N
A
L
A
D
S
K
R
K
N
Q
H
I
Site 27
Y307
R
K
N
Q
H
I
P
Y
R
N
S
K
L
T
R
Site 28
S310
Q
H
I
P
Y
R
N
S
K
L
T
R
L
L
K
Site 29
T313
P
Y
R
N
S
K
L
T
R
L
L
K
D
S
L
Site 30
S319
L
T
R
L
L
K
D
S
L
G
G
N
C
Q
T
Site 31
Y339
V
S
P
S
S
V
F
Y
D
D
T
Y
N
T
L
Site 32
T342
S
S
V
F
Y
D
D
T
Y
N
T
L
K
Y
A
Site 33
Y343
S
V
F
Y
D
D
T
Y
N
T
L
K
Y
A
N
Site 34
Y348
D
T
Y
N
T
L
K
Y
A
N
R
A
K
D
I
Site 35
S357
N
R
A
K
D
I
K
S
S
L
K
S
N
V
L
Site 36
S358
R
A
K
D
I
K
S
S
L
K
S
N
V
L
N
Site 37
S361
D
I
K
S
S
L
K
S
N
V
L
N
V
N
N
Site 38
Y373
V
N
N
H
I
T
Q
Y
V
K
I
C
N
E
Q
Site 39
S412
D
Q
A
K
L
M
I
S
N
P
Q
E
K
E
I
Site 40
Y440
R
E
E
I
R
Q
E
Y
L
K
L
E
M
L
L
Site 41
S469
K
Q
I
E
M
M
C
S
E
D
K
V
E
K
A
Site 42
T489
H
R
L
A
M
L
K
T
R
R
S
Y
L
E
K
Site 43
S492
A
M
L
K
T
R
R
S
Y
L
E
K
R
R
E
Site 44
Y493
M
L
K
T
R
R
S
Y
L
E
K
R
R
E
E
Site 45
S523
E
K
E
M
G
L
L
S
Q
N
G
H
I
P
K
Site 46
T569
Q
E
Q
Q
H
R
Q
T
E
A
V
L
N
A
L
Site 47
Y584
L
P
T
L
R
K
Q
Y
C
T
L
K
E
A
G
Site 48
T586
T
L
R
K
Q
Y
C
T
L
K
E
A
G
L
S
Site 49
S593
T
L
K
E
A
G
L
S
N
A
A
F
E
S
D
Site 50
S599
L
S
N
A
A
F
E
S
D
F
K
E
I
E
H
Site 51
S674
T
R
R
K
L
M
P
S
P
L
K
G
Q
H
T
Site 52
T681
S
P
L
K
G
Q
H
T
L
K
S
P
P
S
Q
Site 53
S684
K
G
Q
H
T
L
K
S
P
P
S
Q
S
V
Q
Site 54
S687
H
T
L
K
S
P
P
S
Q
S
V
Q
L
N
D
Site 55
S689
L
K
S
P
P
S
Q
S
V
Q
L
N
D
S
L
Site 56
S695
Q
S
V
Q
L
N
D
S
L
S
K
E
L
Q
P
Site 57
S697
V
Q
L
N
D
S
L
S
K
E
L
Q
P
I
V
Site 58
T706
E
L
Q
P
I
V
Y
T
P
E
D
C
R
K
A
Site 59
T719
K
A
F
Q
N
P
S
T
V
T
L
M
K
P
S
Site 60
T730
M
K
P
S
S
F
T
T
S
F
Q
A
I
S
S
Site 61
S731
K
P
S
S
F
T
T
S
F
Q
A
I
S
S
N
Site 62
S737
T
S
F
Q
A
I
S
S
N
I
N
S
D
N
C
Site 63
S741
A
I
S
S
N
I
N
S
D
N
C
L
K
M
L
Site 64
S768
C
G
Q
E
D
L
D
S
T
F
T
I
C
E
D
Site 65
T769
G
Q
E
D
L
D
S
T
F
T
I
C
E
D
I
Site 66
S778
T
I
C
E
D
I
K
S
S
K
C
K
L
P
E
Site 67
S779
I
C
E
D
I
K
S
S
K
C
K
L
P
E
Q
Site 68
S788
C
K
L
P
E
Q
E
S
L
P
N
D
N
K
D
Site 69
S804
L
Q
R
L
D
P
S
S
F
S
T
K
H
S
M
Site 70
S806
R
L
D
P
S
S
F
S
T
K
H
S
M
P
V
Site 71
T807
L
D
P
S
S
F
S
T
K
H
S
M
P
V
P
Site 72
S810
S
S
F
S
T
K
H
S
M
P
V
P
S
M
V
Site 73
S815
K
H
S
M
P
V
P
S
M
V
P
S
Y
M
A
Site 74
T834
A
K
R
K
R
K
L
T
S
S
T
S
N
S
S
Site 75
S835
K
R
K
R
K
L
T
S
S
T
S
N
S
S
L
Site 76
S836
R
K
R
K
L
T
S
S
T
S
N
S
S
L
T
Site 77
T837
K
R
K
L
T
S
S
T
S
N
S
S
L
T
A
Site 78
S838
R
K
L
T
S
S
T
S
N
S
S
L
T
A
D
Site 79
S840
L
T
S
S
T
S
N
S
S
L
T
A
D
V
N
Site 80
S841
T
S
S
T
S
N
S
S
L
T
A
D
V
N
S
Site 81
T843
S
T
S
N
S
S
L
T
A
D
V
N
S
G
F
Site 82
S848
S
L
T
A
D
V
N
S
G
F
A
K
R
V
R
Site 83
S859
K
R
V
R
Q
D
N
S
S
E
K
H
L
Q
E
Site 84
S860
R
V
R
Q
D
N
S
S
E
K
H
L
Q
E
N
Site 85
T870
H
L
Q
E
N
K
P
T
M
E
H
K
R
N
I
Site 86
S893
R
K
F
G
R
N
I
S
K
G
N
L
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation