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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCOA7
Full Name:
Nuclear receptor coactivator 7
Alias:
140 kDa estrogen receptor-associated protein; DJ187J11.3; ERAP140; ESNA1; Estrogen nuclear receptor coactivator 1; Estrogen receptor associated protein 140 kDa
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
106162
Number AA:
942
UniProt ID:
Q8NI08
International Prot ID:
IPI00453458
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
K
K
E
R
K
Q
S
Y
F
A
R
L
K
K
Site 2
Y14
K
K
E
R
K
Q
S
Y
F
A
R
L
K
K
K
Site 3
T40
A
V
A
T
R
T
H
T
G
K
E
D
N
N
T
Site 4
T47
T
G
K
E
D
N
N
T
V
V
L
E
P
D
K
Site 5
T65
A
V
E
E
E
Y
M
T
D
E
K
K
K
R
K
Site 6
S73
D
E
K
K
K
R
K
S
N
Q
L
K
E
I
R
Site 7
T82
Q
L
K
E
I
R
R
T
E
L
K
R
Y
Y
S
Site 8
Y87
R
R
T
E
L
K
R
Y
Y
S
I
D
D
N
Q
Site 9
Y88
R
T
E
L
K
R
Y
Y
S
I
D
D
N
Q
N
Site 10
S89
T
E
L
K
R
Y
Y
S
I
D
D
N
Q
N
K
Site 11
T134
I
A
L
K
F
N
I
T
P
N
K
L
V
E
L
Site 12
S162
L
F
V
P
D
A
N
S
P
S
S
T
L
R
L
Site 13
S164
V
P
D
A
N
S
P
S
S
T
L
R
L
S
S
Site 14
S165
P
D
A
N
S
P
S
S
T
L
R
L
S
S
S
Site 15
T166
D
A
N
S
P
S
S
T
L
R
L
S
S
S
S
Site 16
S170
P
S
S
T
L
R
L
S
S
S
S
P
G
A
T
Site 17
S171
S
S
T
L
R
L
S
S
S
S
P
G
A
T
V
Site 18
S172
S
T
L
R
L
S
S
S
S
P
G
A
T
V
S
Site 19
S173
T
L
R
L
S
S
S
S
P
G
A
T
V
S
P
Site 20
T177
S
S
S
S
P
G
A
T
V
S
P
S
S
S
D
Site 21
S179
S
S
P
G
A
T
V
S
P
S
S
S
D
A
E
Site 22
S181
P
G
A
T
V
S
P
S
S
S
D
A
E
Y
D
Site 23
S182
G
A
T
V
S
P
S
S
S
D
A
E
Y
D
K
Site 24
S183
A
T
V
S
P
S
S
S
D
A
E
Y
D
K
L
Site 25
Y187
P
S
S
S
D
A
E
Y
D
K
L
P
D
A
D
Site 26
S208
K
P
I
E
R
V
L
S
S
T
S
E
E
D
E
Site 27
S209
P
I
E
R
V
L
S
S
T
S
E
E
D
E
P
Site 28
T210
I
E
R
V
L
S
S
T
S
E
E
D
E
P
G
Site 29
S211
E
R
V
L
S
S
T
S
E
E
D
E
P
G
V
Site 30
Y228
F
L
K
M
N
C
R
Y
F
T
D
G
K
G
V
Site 31
T230
K
M
N
C
R
Y
F
T
D
G
K
G
V
V
G
Site 32
S254
I
M
F
D
P
H
K
S
D
P
L
V
I
E
N
Site 33
S295
K
I
K
D
A
L
P
S
D
L
P
Q
D
L
C
Site 34
Y305
P
Q
D
L
C
P
L
Y
R
P
G
E
W
E
D
Site 35
S315
G
E
W
E
D
L
A
S
E
K
D
I
N
P
F
Site 36
S323
E
K
D
I
N
P
F
S
K
F
K
S
I
N
K
Site 37
S327
N
P
F
S
K
F
K
S
I
N
K
E
K
R
Q
Site 38
T342
Q
N
G
E
K
I
M
T
S
D
S
R
P
I
V
Site 39
S343
N
G
E
K
I
M
T
S
D
S
R
P
I
V
P
Site 40
S345
E
K
I
M
T
S
D
S
R
P
I
V
P
L
E
Site 41
S354
P
I
V
P
L
E
K
S
T
G
H
T
P
T
K
Site 42
T358
L
E
K
S
T
G
H
T
P
T
K
P
S
G
S
Site 43
T360
K
S
T
G
H
T
P
T
K
P
S
G
S
S
V
Site 44
S363
G
H
T
P
T
K
P
S
G
S
S
V
S
E
K
Site 45
S365
T
P
T
K
P
S
G
S
S
V
S
E
K
L
K
Site 46
S366
P
T
K
P
S
G
S
S
V
S
E
K
L
K
K
Site 47
S376
E
K
L
K
K
L
D
S
S
R
E
T
S
H
G
Site 48
S377
K
L
K
K
L
D
S
S
R
E
T
S
H
G
S
Site 49
T380
K
L
D
S
S
R
E
T
S
H
G
S
P
T
V
Site 50
S381
L
D
S
S
R
E
T
S
H
G
S
P
T
V
T
Site 51
S384
S
R
E
T
S
H
G
S
P
T
V
T
K
L
S
Site 52
T386
E
T
S
H
G
S
P
T
V
T
K
L
S
K
E
Site 53
T388
S
H
G
S
P
T
V
T
K
L
S
K
E
P
S
Site 54
S391
S
P
T
V
T
K
L
S
K
E
P
S
D
T
S
Site 55
S395
T
K
L
S
K
E
P
S
D
T
S
S
A
F
E
Site 56
T397
L
S
K
E
P
S
D
T
S
S
A
F
E
S
T
Site 57
S398
S
K
E
P
S
D
T
S
S
A
F
E
S
T
A
Site 58
S399
K
E
P
S
D
T
S
S
A
F
E
S
T
A
K
Site 59
S403
D
T
S
S
A
F
E
S
T
A
K
E
N
F
L
Site 60
S423
F
V
D
L
E
E
L
S
S
Q
T
G
G
G
M
Site 61
S424
V
D
L
E
E
L
S
S
Q
T
G
G
G
M
H
Site 62
T435
G
G
M
H
K
K
D
T
L
K
E
C
L
S
L
Site 63
S441
D
T
L
K
E
C
L
S
L
D
P
E
E
R
K
Site 64
S452
E
E
R
K
K
A
E
S
Q
I
N
N
S
A
V
Site 65
T486
K
G
A
L
D
L
E
T
C
E
K
Q
D
I
M
Site 66
S500
M
P
E
V
D
K
Q
S
G
S
P
E
S
R
V
Site 67
S502
E
V
D
K
Q
S
G
S
P
E
S
R
V
E
N
Site 68
S505
K
Q
S
G
S
P
E
S
R
V
E
N
T
L
N
Site 69
T510
P
E
S
R
V
E
N
T
L
N
I
H
E
D
L
Site 70
Y525
D
K
V
K
L
I
E
Y
Y
L
T
K
N
K
E
Site 71
Y526
K
V
K
L
I
E
Y
Y
L
T
K
N
K
E
G
Site 72
T528
K
L
I
E
Y
Y
L
T
K
N
K
E
G
P
Q
Site 73
S546
N
L
Q
K
T
E
L
S
D
G
K
S
I
E
P
Site 74
S550
T
E
L
S
D
G
K
S
I
E
P
G
G
I
D
Site 75
T559
E
P
G
G
I
D
I
T
L
S
S
S
L
S
Q
Site 76
S562
G
I
D
I
T
L
S
S
S
L
S
Q
A
G
D
Site 77
S563
I
D
I
T
L
S
S
S
L
S
Q
A
G
D
P
Site 78
T572
S
Q
A
G
D
P
I
T
E
G
N
K
E
P
D
Site 79
T581
G
N
K
E
P
D
K
T
W
V
K
K
G
E
P
Site 80
S596
L
P
V
K
L
N
S
S
T
E
A
N
V
I
K
Site 81
S608
V
I
K
E
A
L
D
S
S
L
E
S
T
L
D
Site 82
S609
I
K
E
A
L
D
S
S
L
E
S
T
L
D
N
Site 83
S612
A
L
D
S
S
L
E
S
T
L
D
N
S
C
Q
Site 84
T613
L
D
S
S
L
E
S
T
L
D
N
S
C
Q
G
Site 85
S627
G
A
Q
M
D
N
K
S
E
V
Q
L
W
L
L
Site 86
S647
P
I
E
D
I
L
P
S
K
E
E
K
S
K
T
Site 87
S652
L
P
S
K
E
E
K
S
K
T
P
P
M
F
L
Site 88
T654
S
K
E
E
K
S
K
T
P
P
M
F
L
C
I
Site 89
S670
V
G
K
P
M
R
K
S
F
A
T
H
T
A
A
Site 90
T673
P
M
R
K
S
F
A
T
H
T
A
A
M
V
Q
Site 91
Y691
K
R
R
K
Q
P
E
Y
W
F
A
V
P
R
E
Site 92
Y704
R
E
R
V
D
H
L
Y
T
F
F
V
Q
W
S
Site 93
Y715
V
Q
W
S
P
D
V
Y
G
K
D
A
K
E
Q
Site 94
T744
N
F
F
S
E
P
T
T
K
S
W
E
I
I
T
Site 95
S746
F
S
E
P
T
T
K
S
W
E
I
I
T
V
E
Site 96
S760
E
E
A
K
R
R
K
S
T
C
S
Y
Y
E
D
Site 97
T761
E
A
K
R
R
K
S
T
C
S
Y
Y
E
D
E
Site 98
S763
K
R
R
K
S
T
C
S
Y
Y
E
D
E
D
E
Site 99
Y764
R
R
K
S
T
C
S
Y
Y
E
D
E
D
E
E
Site 100
Y765
R
K
S
T
C
S
Y
Y
E
D
E
D
E
E
V
Site 101
S780
L
P
V
L
R
P
H
S
A
L
L
E
N
M
H
Site 102
Y802
L
P
A
R
V
Q
G
Y
P
W
R
L
A
Y
S
Site 103
Y808
G
Y
P
W
R
L
A
Y
S
T
L
E
H
G
T
Site 104
T810
P
W
R
L
A
Y
S
T
L
E
H
G
T
S
L
Site 105
S816
S
T
L
E
H
G
T
S
L
K
T
L
Y
R
K
Site 106
T819
E
H
G
T
S
L
K
T
L
Y
R
K
S
A
S
Site 107
Y821
G
T
S
L
K
T
L
Y
R
K
S
A
S
L
D
Site 108
S824
L
K
T
L
Y
R
K
S
A
S
L
D
S
P
V
Site 109
Y857
P
F
K
F
S
D
H
Y
Y
G
T
G
E
T
F
Site 110
Y858
F
K
F
S
D
H
Y
Y
G
T
G
E
T
F
L
Site 111
Y866
G
T
G
E
T
F
L
Y
T
F
S
P
H
F
K
Site 112
T867
T
G
E
T
F
L
Y
T
F
S
P
H
F
K
V
Site 113
S869
E
T
F
L
Y
T
F
S
P
H
F
K
V
F
K
Site 114
Y883
K
W
S
G
E
N
S
Y
F
I
N
G
D
I
S
Site 115
Y910
L
W
L
D
A
D
L
Y
H
G
R
S
N
S
C
Site 116
S914
A
D
L
Y
H
G
R
S
N
S
C
S
T
F
N
Site 117
S916
L
Y
H
G
R
S
N
S
C
S
T
F
N
N
D
Site 118
S918
H
G
R
S
N
S
C
S
T
F
N
N
D
I
L
Site 119
T919
G
R
S
N
S
C
S
T
F
N
N
D
I
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation