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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPCN2
Full Name:
Two pore calcium channel protein 2
Alias:
Voltage-dependent calcium channel protein TPC2
Type:
Mass (Da):
85243
Number AA:
752
UniProt ID:
Q8NHX9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
G
D
W
P
A
G
L
T
T
Y
R
S
I
Q
V
Site 2
T28
D
W
P
A
G
L
T
T
Y
R
S
I
Q
V
G
Site 3
Y29
W
P
A
G
L
T
T
Y
R
S
I
Q
V
G
P
Site 4
Y74
D
A
S
S
M
W
L
Y
R
R
Y
Y
S
N
V
Site 5
Y78
M
W
L
Y
R
R
Y
Y
S
N
V
C
Q
R
T
Site 6
S107
E
T
P
S
S
L
T
S
T
A
D
V
R
Y
R
Site 7
T108
T
P
S
S
L
T
S
T
A
D
V
R
Y
R
A
Site 8
Y113
T
S
T
A
D
V
R
Y
R
A
A
P
W
E
P
Site 9
S199
P
F
F
L
L
Q
N
S
S
M
M
K
K
T
L
Site 10
S200
F
F
L
L
Q
N
S
S
M
M
K
K
T
L
K
Site 11
T253
G
Q
D
R
E
R
L
T
Y
F
Q
N
L
P
E
Site 12
Y254
Q
D
R
E
R
L
T
Y
F
Q
N
L
P
E
S
Site 13
Y282
P
D
V
M
I
P
A
Y
S
K
N
R
A
Y
A
Site 14
Y318
I
Y
S
Q
F
R
G
Y
L
M
K
S
L
Q
T
Site 15
S322
F
R
G
Y
L
M
K
S
L
Q
T
S
L
F
R
Site 16
S326
L
M
K
S
L
Q
T
S
L
F
R
R
R
L
G
Site 17
S392
S
Y
G
S
V
L
L
S
A
E
E
F
Q
K
L
Site 18
S406
L
F
N
E
L
D
R
S
V
V
K
E
H
P
P
Site 19
Y417
E
H
P
P
R
P
E
Y
Q
S
P
F
L
Q
S
Site 20
S419
P
P
R
P
E
Y
Q
S
P
F
L
Q
S
A
Q
Site 21
Y432
A
Q
F
L
F
G
H
Y
Y
F
D
Y
L
G
N
Site 22
S498
L
G
L
R
G
Y
L
S
Y
P
S
N
V
F
D
Site 23
Y499
G
L
R
G
Y
L
S
Y
P
S
N
V
F
D
G
Site 24
S501
R
G
Y
L
S
Y
P
S
N
V
F
D
G
L
L
Site 25
Y523
E
I
S
T
L
A
V
Y
R
L
P
H
P
G
W
Site 26
T571
L
M
A
V
V
A
S
T
V
L
G
L
V
Q
N
Site 27
S620
S
L
A
P
A
N
G
S
A
P
C
G
S
F
E
Site 28
S625
N
G
S
A
P
C
G
S
F
E
Q
L
E
Y
W
Site 29
Y631
G
S
F
E
Q
L
E
Y
W
A
N
N
F
D
D
Site 30
Y662
W
Q
V
F
L
D
A
Y
R
R
Y
S
G
P
W
Site 31
Y665
F
L
D
A
Y
R
R
Y
S
G
P
W
S
K
I
Site 32
S666
L
D
A
Y
R
R
Y
S
G
P
W
S
K
I
Y
Site 33
S705
L
H
K
W
D
P
R
S
H
L
Q
P
L
A
G
Site 34
T713
H
L
Q
P
L
A
G
T
P
E
A
T
Y
Q
M
Site 35
T721
P
E
A
T
Y
Q
M
T
V
E
L
L
F
R
D
Site 36
T739
E
P
G
E
D
E
L
T
E
R
L
S
Q
H
P
Site 37
S743
D
E
L
T
E
R
L
S
Q
H
P
H
L
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation