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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEDD1
Full Name:
Protein NEDD1
Alias:
Neural precursor cell expressed developmentally down-regulated protein 1
Type:
Cell cycle regulation
Mass (Da):
71966
Number AA:
660
UniProt ID:
Q8NHV4
International Prot ID:
IPI00169345
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Q
E
N
L
R
F
A
S
S
G
D
D
I
K
I
Site 2
S10
E
N
L
R
F
A
S
S
G
D
D
I
K
I
W
Site 3
T32
V
D
K
F
N
P
H
T
S
P
H
G
I
S
S
Site 4
S33
D
K
F
N
P
H
T
S
P
H
G
I
S
S
I
Site 5
S39
T
S
P
H
G
I
S
S
I
C
W
S
S
N
N
Site 6
T51
S
N
N
N
F
L
V
T
A
S
S
S
G
D
K
Site 7
S62
S
G
D
K
I
V
V
S
S
C
K
C
K
P
V
Site 8
T81
L
A
E
G
Q
K
Q
T
C
V
N
L
N
S
T
Site 9
T88
T
C
V
N
L
N
S
T
S
M
Y
L
V
S
G
Site 10
S89
C
V
N
L
N
S
T
S
M
Y
L
V
S
G
G
Site 11
Y91
N
L
N
S
T
S
M
Y
L
V
S
G
G
L
N
Site 12
S94
S
T
S
M
Y
L
V
S
G
G
L
N
N
T
V
Site 13
T100
V
S
G
G
L
N
N
T
V
N
I
W
D
L
K
Site 14
S108
V
N
I
W
D
L
K
S
K
R
V
H
R
S
L
Site 15
S114
K
S
K
R
V
H
R
S
L
K
D
H
K
D
Q
Site 16
Y133
T
Y
N
W
N
D
C
Y
I
A
S
G
S
L
S
Site 17
S153
H
S
V
T
T
N
L
S
S
T
P
F
G
H
G
Site 18
S154
S
V
T
T
N
L
S
S
T
P
F
G
H
G
S
Site 19
T155
V
T
T
N
L
S
S
T
P
F
G
H
G
S
N
Site 20
S161
S
T
P
F
G
H
G
S
N
Q
S
V
R
H
L
Site 21
S164
F
G
H
G
S
N
Q
S
V
R
H
L
K
Y
S
Site 22
Y170
Q
S
V
R
H
L
K
Y
S
L
F
K
K
S
L
Site 23
S171
S
V
R
H
L
K
Y
S
L
F
K
K
S
L
L
Site 24
S176
K
Y
S
L
F
K
K
S
L
L
G
S
V
S
D
Site 25
T188
V
S
D
N
G
I
V
T
L
W
D
V
N
S
Q
Site 26
Y198
D
V
N
S
Q
S
P
Y
H
N
F
D
S
V
H
Site 27
S203
S
P
Y
H
N
F
D
S
V
H
K
A
P
A
S
Site 28
S215
P
A
S
G
I
C
F
S
P
V
N
E
L
L
F
Site 29
Y234
L
D
K
R
I
I
L
Y
D
T
S
S
K
K
L
Site 30
T236
K
R
I
I
L
Y
D
T
S
S
K
K
L
V
K
Site 31
S237
R
I
I
L
Y
D
T
S
S
K
K
L
V
K
T
Site 32
T244
S
S
K
K
L
V
K
T
L
V
A
D
T
P
L
Site 33
T262
D
F
M
P
D
G
A
T
L
A
I
G
S
S
R
Site 34
S267
G
A
T
L
A
I
G
S
S
R
G
K
I
Y
Q
Site 35
Y273
G
S
S
R
G
K
I
Y
Q
Y
D
L
R
M
L
Site 36
Y275
S
R
G
K
I
Y
Q
Y
D
L
R
M
L
K
S
Site 37
S282
Y
D
L
R
M
L
K
S
P
V
K
T
I
S
A
Site 38
T286
M
L
K
S
P
V
K
T
I
S
A
H
K
T
S
Site 39
S288
K
S
P
V
K
T
I
S
A
H
K
T
S
V
Q
Site 40
T306
F
Q
Y
S
T
V
L
T
K
S
S
L
N
K
G
Site 41
S308
Y
S
T
V
L
T
K
S
S
L
N
K
G
C
S
Site 42
S309
S
T
V
L
T
K
S
S
L
N
K
G
C
S
N
Site 43
S315
S
S
L
N
K
G
C
S
N
K
P
T
T
V
N
Site 44
T319
K
G
C
S
N
K
P
T
T
V
N
K
R
S
V
Site 45
T320
G
C
S
N
K
P
T
T
V
N
K
R
S
V
N
Site 46
S325
P
T
T
V
N
K
R
S
V
N
V
N
A
A
S
Site 47
S332
S
V
N
V
N
A
A
S
G
G
V
Q
N
S
G
Site 48
S338
A
S
G
G
V
Q
N
S
G
I
V
R
E
A
P
Site 49
T358
T
V
L
P
Q
P
M
T
S
A
M
G
K
G
T
Site 50
T365
T
S
A
M
G
K
G
T
V
A
V
Q
E
K
A
Site 51
S377
E
K
A
G
L
P
R
S
I
N
T
D
T
L
S
Site 52
T380
G
L
P
R
S
I
N
T
D
T
L
S
K
E
T
Site 53
T382
P
R
S
I
N
T
D
T
L
S
K
E
T
D
S
Site 54
S384
S
I
N
T
D
T
L
S
K
E
T
D
S
G
K
Site 55
T387
T
D
T
L
S
K
E
T
D
S
G
K
N
Q
D
Site 56
S389
T
L
S
K
E
T
D
S
G
K
N
Q
D
F
S
Site 57
S396
S
G
K
N
Q
D
F
S
S
F
D
D
T
G
K
Site 58
S397
G
K
N
Q
D
F
S
S
F
D
D
T
G
K
S
Site 59
T401
D
F
S
S
F
D
D
T
G
K
S
S
L
G
D
Site 60
S404
S
F
D
D
T
G
K
S
S
L
G
D
M
F
S
Site 61
S405
F
D
D
T
G
K
S
S
L
G
D
M
F
S
P
Site 62
S411
S
S
L
G
D
M
F
S
P
I
R
D
D
A
V
Site 63
S423
D
A
V
V
N
K
G
S
D
E
S
I
G
K
G
Site 64
S426
V
N
K
G
S
D
E
S
I
G
K
G
D
G
F
Site 65
S441
D
F
L
P
Q
L
N
S
V
F
P
P
R
K
N
Site 66
T451
P
P
R
K
N
P
V
T
S
S
T
S
V
L
H
Site 67
S452
P
R
K
N
P
V
T
S
S
T
S
V
L
H
S
Site 68
S453
R
K
N
P
V
T
S
S
T
S
V
L
H
S
S
Site 69
S455
N
P
V
T
S
S
T
S
V
L
H
S
S
P
L
Site 70
S460
S
T
S
V
L
H
S
S
P
L
N
V
F
M
G
Site 71
S468
P
L
N
V
F
M
G
S
P
G
K
E
E
N
E
Site 72
T480
E
N
E
N
R
D
L
T
A
E
S
K
K
I
Y
Site 73
Y487
T
A
E
S
K
K
I
Y
M
G
K
Q
E
S
K
Site 74
S493
I
Y
M
G
K
Q
E
S
K
D
S
F
K
Q
L
Site 75
S496
G
K
Q
E
S
K
D
S
F
K
Q
L
A
K
L
Site 76
S510
L
V
T
S
G
A
E
S
G
N
L
N
T
S
P
Site 77
T515
A
E
S
G
N
L
N
T
S
P
S
S
N
Q
T
Site 78
S516
E
S
G
N
L
N
T
S
P
S
S
N
Q
T
R
Site 79
S518
G
N
L
N
T
S
P
S
S
N
Q
T
R
N
S
Site 80
S519
N
L
N
T
S
P
S
S
N
Q
T
R
N
S
E
Site 81
T522
T
S
P
S
S
N
Q
T
R
N
S
E
K
F
E
Site 82
S525
S
S
N
Q
T
R
N
S
E
K
F
E
K
P
E
Site 83
S548
C
E
P
P
I
N
G
S
S
T
P
N
P
K
I
Site 84
S549
E
P
P
I
N
G
S
S
T
P
N
P
K
I
A
Site 85
T550
P
P
I
N
G
S
S
T
P
N
P
K
I
A
S
Site 86
S557
T
P
N
P
K
I
A
S
S
V
T
A
G
V
A
Site 87
S558
P
N
P
K
I
A
S
S
V
T
A
G
V
A
S
Site 88
T560
P
K
I
A
S
S
V
T
A
G
V
A
S
S
L
Site 89
S565
S
V
T
A
G
V
A
S
S
L
S
E
K
I
A
Site 90
S566
V
T
A
G
V
A
S
S
L
S
E
K
I
A
D
Site 91
S568
A
G
V
A
S
S
L
S
E
K
I
A
D
S
I
Site 92
S574
L
S
E
K
I
A
D
S
I
G
N
N
R
Q
N
Site 93
S586
R
Q
N
A
P
L
T
S
I
Q
I
R
F
I
Q
Site 94
S631
M
Q
L
N
E
M
H
S
L
L
E
R
Y
S
V
Site 95
Y636
M
H
S
L
L
E
R
Y
S
V
N
E
G
L
V
Site 96
S637
H
S
L
L
E
R
Y
S
V
N
E
G
L
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation