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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXD1
Full Name:
Exonuclease 3'-5' domain-containing protein 1
Alias:
Exonuclease 3'-5' domain-like-containing protein 1
Type:
Mass (Da):
58305
Number AA:
514
UniProt ID:
Q8NHP7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
E
D
S
E
F
L
A
Y
V
E
L
L
D
E
V
Site 2
S20
L
D
E
V
E
Q
G
S
V
R
A
K
A
S
S
Site 3
S26
G
S
V
R
A
K
A
S
S
V
S
L
H
A
E
Site 4
S27
S
V
R
A
K
A
S
S
V
S
L
H
A
E
R
Site 5
S29
R
A
K
A
S
S
V
S
L
H
A
E
R
T
W
Site 6
S52
L
N
V
C
E
P
A
S
P
A
P
E
A
P
A
Site 7
T60
P
A
P
E
A
P
A
T
S
L
L
N
D
L
K
Site 8
Y68
S
L
L
N
D
L
K
Y
S
P
S
E
E
E
E
Site 9
S69
L
L
N
D
L
K
Y
S
P
S
E
E
E
E
V
Site 10
S71
N
D
L
K
Y
S
P
S
E
E
E
E
V
T
Y
Site 11
T77
P
S
E
E
E
E
V
T
Y
T
V
I
N
Q
F
Site 12
Y78
S
E
E
E
E
V
T
Y
T
V
I
N
Q
F
Q
Site 13
T79
E
E
E
E
V
T
Y
T
V
I
N
Q
F
Q
Q
Site 14
S102
I
K
K
Q
N
V
L
S
V
A
A
E
G
A
N
Site 15
Y218
H
L
Q
V
A
P
K
Y
L
S
F
L
E
K
R
Site 16
S220
Q
V
A
P
K
Y
L
S
F
L
E
K
R
Q
K
Site 17
Y278
L
T
T
L
V
D
G
Y
L
N
T
Y
R
E
G
Site 18
T281
L
V
D
G
Y
L
N
T
Y
R
E
G
S
A
D
Site 19
Y282
V
D
G
Y
L
N
T
Y
R
E
G
S
A
D
R
Site 20
S286
L
N
T
Y
R
E
G
S
A
D
R
L
G
G
T
Site 21
Y322
R
E
K
A
A
R
E
Y
R
V
N
A
Q
G
L
Site 22
S367
F
R
I
D
K
A
P
S
F
T
S
Q
D
F
H
Site 23
S370
D
K
A
P
S
F
T
S
Q
D
F
H
G
D
V
Site 24
S384
V
N
L
L
K
E
E
S
L
N
K
Q
A
T
N
Site 25
T390
E
S
L
N
K
Q
A
T
N
P
Q
H
L
P
P
Site 26
T398
N
P
Q
H
L
P
P
T
E
E
G
E
T
S
E
Site 27
T403
P
P
T
E
E
G
E
T
S
E
D
S
S
N
K
Site 28
S404
P
T
E
E
G
E
T
S
E
D
S
S
N
K
L
Site 29
S407
E
G
E
T
S
E
D
S
S
N
K
L
I
C
T
Site 30
S408
G
E
T
S
E
D
S
S
N
K
L
I
C
T
K
Site 31
T414
S
S
N
K
L
I
C
T
K
S
K
G
S
E
D
Site 32
S416
N
K
L
I
C
T
K
S
K
G
S
E
D
Q
R
Site 33
T425
G
S
E
D
Q
R
I
T
Q
K
E
H
F
M
T
Site 34
T432
T
Q
K
E
H
F
M
T
P
K
H
E
F
Q
A
Site 35
S440
P
K
H
E
F
Q
A
S
L
S
L
K
E
E
T
Site 36
S442
H
E
F
Q
A
S
L
S
L
K
E
E
T
E
Q
Site 37
S467
K
C
T
K
Q
A
V
S
M
S
S
F
P
Q
E
Site 38
S469
T
K
Q
A
V
S
M
S
S
F
P
Q
E
T
R
Site 39
S470
K
Q
A
V
S
M
S
S
F
P
Q
E
T
R
V
Site 40
S478
F
P
Q
E
T
R
V
S
P
S
D
T
F
Y
P
Site 41
S480
Q
E
T
R
V
S
P
S
D
T
F
Y
P
I
R
Site 42
T482
T
R
V
S
P
S
D
T
F
Y
P
I
R
K
A
Site 43
S505
P
A
L
E
K
I
D
S
W
I
S
P
F
L
N
Site 44
S508
E
K
I
D
S
W
I
S
P
F
L
N
L
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation