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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXL10
Full Name:
Lysine-specific demethylase 2B
Alias:
[Histone-H3]-lysine-36 demethylase 1B; CXXC2; FBL10; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; FXLA; JEMMA protein; JHD1B; JHDM1B; Jumonji C domain-containing histone demethylase 1B; Lysine (K)-specific demethylase 2B; PCCX2; Protein containing CXXC domain 2
Type:
EC 1.14.11.27; DNA binding protein; Oxidoreductase; Demethylase
Mass (Da):
152615
Number AA:
1336
UniProt ID:
Q8NHM5
International Prot ID:
IPI00185326
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0051864
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0019941
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
G
P
Q
M
G
G
S
A
E
D
H
P
P
R
Site 2
T28
A
E
K
Q
K
K
K
T
V
I
Y
T
K
C
F
Site 3
S39
T
K
C
F
E
F
E
S
A
T
Q
R
P
I
D
Site 4
T41
C
F
E
F
E
S
A
T
Q
R
P
I
D
R
Q
Site 5
Y50
R
P
I
D
R
Q
R
Y
D
E
N
E
D
L
S
Site 6
S57
Y
D
E
N
E
D
L
S
D
V
E
E
I
V
S
Site 7
S64
S
D
V
E
E
I
V
S
V
R
G
F
S
L
E
Site 8
S69
I
V
S
V
R
G
F
S
L
E
E
K
L
R
S
Site 9
S76
S
L
E
E
K
L
R
S
Q
L
Y
Q
G
D
F
Site 10
Y79
E
K
L
R
S
Q
L
Y
Q
G
D
F
V
H
A
Site 11
Y94
M
E
G
K
D
F
N
Y
E
Y
V
Q
R
E
A
Site 12
Y96
G
K
D
F
N
Y
E
Y
V
Q
R
E
A
L
R
Site 13
T124
K
M
P
D
P
D
F
T
V
R
D
V
K
L
L
Site 14
S134
D
V
K
L
L
V
G
S
R
R
L
V
D
V
M
Site 15
T145
V
D
V
M
D
V
N
T
Q
K
G
T
E
M
S
Site 16
T149
D
V
N
T
Q
K
G
T
E
M
S
M
S
Q
F
Site 17
S152
T
Q
K
G
T
E
M
S
M
S
Q
F
V
R
Y
Site 18
S154
K
G
T
E
M
S
M
S
Q
F
V
R
Y
Y
E
Site 19
Y159
S
M
S
Q
F
V
R
Y
Y
E
T
P
E
A
Q
Site 20
Y160
M
S
Q
F
V
R
Y
Y
E
T
P
E
A
Q
R
Site 21
T162
Q
F
V
R
Y
Y
E
T
P
E
A
Q
R
D
K
Site 22
Y171
E
A
Q
R
D
K
L
Y
N
V
I
S
L
E
F
Site 23
S175
D
K
L
Y
N
V
I
S
L
E
F
S
H
T
K
Site 24
S179
N
V
I
S
L
E
F
S
H
T
K
L
E
H
L
Site 25
T181
I
S
L
E
F
S
H
T
K
L
E
H
L
V
K
Site 26
T191
E
H
L
V
K
R
P
T
V
V
D
L
V
D
W
Site 27
Y223
N
A
I
A
E
M
K
Y
P
K
V
K
K
Y
C
Site 28
Y229
K
Y
P
K
V
K
K
Y
C
L
M
S
V
K
G
Site 29
Y252
F
G
G
T
S
V
W
Y
H
V
F
R
G
G
K
Site 30
S280
L
Y
E
E
W
V
L
S
G
K
Q
S
D
I
F
Site 31
S284
W
V
L
S
G
K
Q
S
D
I
F
L
G
D
R
Site 32
Y304
R
I
E
L
K
Q
G
Y
T
F
F
I
P
S
G
Site 33
Y342
V
P
M
Q
L
R
I
Y
E
I
E
D
R
T
R
Site 34
Y372
Y
V
L
E
R
Y
V
Y
C
V
T
Q
R
S
H
Site 35
Y384
R
S
H
L
T
Q
E
Y
Q
R
E
S
M
L
I
Site 36
S388
T
Q
E
Y
Q
R
E
S
M
L
I
D
A
P
R
Site 37
S398
I
D
A
P
R
K
P
S
I
D
G
F
S
S
D
Site 38
S403
K
P
S
I
D
G
F
S
S
D
S
W
L
E
M
Site 39
S404
P
S
I
D
G
F
S
S
D
S
W
L
E
M
E
Site 40
S406
I
D
G
F
S
S
D
S
W
L
E
M
E
E
E
Site 41
T440
D
R
A
P
K
P
P
T
D
G
S
T
S
P
T
Site 42
S443
P
K
P
P
T
D
G
S
T
S
P
T
S
T
P
Site 43
T444
K
P
P
T
D
G
S
T
S
P
T
S
T
P
S
Site 44
S445
P
P
T
D
G
S
T
S
P
T
S
T
P
S
E
Site 45
T447
T
D
G
S
T
S
P
T
S
T
P
S
E
D
Q
Site 46
S448
D
G
S
T
S
P
T
S
T
P
S
E
D
Q
E
Site 47
T449
G
S
T
S
P
T
S
T
P
S
E
D
Q
E
A
Site 48
S451
T
S
P
T
S
T
P
S
E
D
Q
E
A
L
G
Site 49
T472
A
L
R
F
L
K
R
T
L
S
N
E
S
E
E
Site 50
S474
R
F
L
K
R
T
L
S
N
E
S
E
E
S
V
Site 51
S477
K
R
T
L
S
N
E
S
E
E
S
V
K
S
T
Site 52
S480
L
S
N
E
S
E
E
S
V
K
S
T
T
L
A
Site 53
S483
E
S
E
E
S
V
K
S
T
T
L
A
V
D
Y
Site 54
T484
S
E
E
S
V
K
S
T
T
L
A
V
D
Y
P
Site 55
Y490
S
T
T
L
A
V
D
Y
P
K
T
P
T
G
S
Site 56
T493
L
A
V
D
Y
P
K
T
P
T
G
S
P
A
T
Site 57
T495
V
D
Y
P
K
T
P
T
G
S
P
A
T
E
V
Site 58
S497
Y
P
K
T
P
T
G
S
P
A
T
E
V
S
A
Site 59
T500
T
P
T
G
S
P
A
T
E
V
S
A
K
W
T
Site 60
S503
G
S
P
A
T
E
V
S
A
K
W
T
H
L
T
Site 61
S526
A
L
V
E
K
L
E
S
L
P
E
N
K
K
C
Site 62
S561
E
H
A
D
D
D
P
S
L
A
I
T
G
V
P
Site 63
T576
V
V
T
W
P
K
K
T
P
K
N
R
A
V
G
Site 64
S593
K
G
K
L
G
P
A
S
A
V
K
L
A
A
N
Site 65
T603
K
L
A
A
N
R
T
T
A
G
A
R
R
R
R
Site 66
T611
A
G
A
R
R
R
R
T
R
C
R
K
C
E
A
Site 67
T673
G
E
A
G
K
E
D
T
V
E
E
E
E
G
K
Site 68
Y739
K
R
G
P
G
F
K
Y
A
S
N
L
P
G
S
Site 69
S741
G
P
G
F
K
Y
A
S
N
L
P
G
S
L
L
Site 70
S746
Y
A
S
N
L
P
G
S
L
L
K
E
Q
K
M
Site 71
S768
Q
E
P
A
K
R
R
S
E
C
E
E
A
P
R
Site 72
S778
E
E
A
P
R
R
R
S
D
E
H
S
K
K
V
Site 73
S782
R
R
R
S
D
E
H
S
K
K
V
P
P
D
G
Site 74
S795
D
G
L
L
R
R
K
S
D
D
V
H
L
R
K
Site 75
Y806
H
L
R
K
K
R
K
Y
E
K
P
Q
E
L
S
Site 76
S813
Y
E
K
P
Q
E
L
S
G
R
K
R
A
S
S
Site 77
S819
L
S
G
R
K
R
A
S
S
L
Q
T
S
P
G
Site 78
S820
S
G
R
K
R
A
S
S
L
Q
T
S
P
G
S
Site 79
T823
K
R
A
S
S
L
Q
T
S
P
G
S
S
S
H
Site 80
S824
R
A
S
S
L
Q
T
S
P
G
S
S
S
H
L
Site 81
S827
S
L
Q
T
S
P
G
S
S
S
H
L
S
P
R
Site 82
S828
L
Q
T
S
P
G
S
S
S
H
L
S
P
R
P
Site 83
S829
Q
T
S
P
G
S
S
S
H
L
S
P
R
P
P
Site 84
S832
P
G
S
S
S
H
L
S
P
R
P
P
L
G
S
Site 85
S839
S
P
R
P
P
L
G
S
S
L
S
P
W
W
R
Site 86
S840
P
R
P
P
L
G
S
S
L
S
P
W
W
R
S
Site 87
S842
P
P
L
G
S
S
L
S
P
W
W
R
S
S
L
Site 88
Y851
W
W
R
S
S
L
T
Y
F
Q
Q
Q
L
K
P
Site 89
S871
L
F
R
K
K
R
R
S
W
K
N
A
E
D
R
Site 90
T904
L
P
E
A
P
P
K
T
R
E
S
D
H
S
R
Site 91
S907
A
P
P
K
T
R
E
S
D
H
S
R
S
S
S
Site 92
S910
K
T
R
E
S
D
H
S
R
S
S
S
P
T
A
Site 93
S912
R
E
S
D
H
S
R
S
S
S
P
T
A
G
P
Site 94
S913
E
S
D
H
S
R
S
S
S
P
T
A
G
P
S
Site 95
S914
S
D
H
S
R
S
S
S
P
T
A
G
P
S
T
Site 96
T916
H
S
R
S
S
S
P
T
A
G
P
S
T
E
G
Site 97
S920
S
S
P
T
A
G
P
S
T
E
G
A
E
G
P
Site 98
S947
R
L
P
N
K
E
L
S
R
E
L
S
K
E
L
Site 99
S951
K
E
L
S
R
E
L
S
K
E
L
N
H
E
I
Site 100
T961
L
N
H
E
I
Q
R
T
E
N
S
L
A
N
E
Site 101
S964
E
I
Q
R
T
E
N
S
L
A
N
E
N
Q
Q
Site 102
S975
E
N
Q
Q
P
I
K
S
E
P
E
S
E
G
E
Site 103
S979
P
I
K
S
E
P
E
S
E
G
E
E
P
K
R
Site 104
S998
C
E
R
P
H
R
F
S
K
G
L
N
G
T
P
Site 105
T1004
F
S
K
G
L
N
G
T
P
R
E
L
R
H
Q
Site 106
S1015
L
R
H
Q
L
G
P
S
L
R
S
P
P
R
V
Site 107
S1018
Q
L
G
P
S
L
R
S
P
P
R
V
I
S
R
Site 108
S1024
R
S
P
P
R
V
I
S
R
P
P
P
S
V
S
Site 109
S1029
V
I
S
R
P
P
P
S
V
S
P
P
K
C
I
Site 110
S1031
S
R
P
P
P
S
V
S
P
P
K
C
I
Q
M
Site 111
S1049
V
I
R
P
P
P
I
S
P
P
P
D
S
L
P
Site 112
S1054
P
I
S
P
P
P
D
S
L
P
L
D
D
G
A
Site 113
S1128
I
I
R
R
Q
P
V
S
L
D
L
S
W
T
N
Site 114
S1132
Q
P
V
S
L
D
L
S
W
T
N
I
S
K
K
Site 115
S1196
A
Q
M
R
D
L
L
S
P
P
T
D
N
R
P
Site 116
T1199
R
D
L
L
S
P
P
T
D
N
R
P
G
Q
M
Site 117
S1210
P
G
Q
M
D
N
R
S
K
L
R
N
I
V
E
Site 118
S1246
L
L
S
K
L
H
L
S
Y
C
N
H
V
T
D
Site 119
T1265
L
L
T
A
V
G
T
T
T
R
D
S
L
T
E
Site 120
S1269
V
G
T
T
T
R
D
S
L
T
E
I
N
L
S
Site 121
T1271
T
T
T
R
D
S
L
T
E
I
N
L
S
D
C
Site 122
S1276
S
L
T
E
I
N
L
S
D
C
N
K
V
T
D
Site 123
Y1302
I
C
H
I
D
L
R
Y
C
K
Q
V
T
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation