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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PJA1
Full Name:
E3 ubiquitin-protein ligase Praja-1
Alias:
EC 6.3.2.-; Praja 1; RING finger protein 70
Type:
Ubiquitin conjugating system, Ligase
Mass (Da):
71002
Number AA:
643
UniProt ID:
Q8NG27
International Prot ID:
IPI00251615
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
W
P
N
P
T
G
G
Y
Q
S
N
T
G
R
R
Site 2
S19
N
P
T
G
G
Y
Q
S
N
T
G
R
R
Y
G
Site 3
T21
T
G
G
Y
Q
S
N
T
G
R
R
Y
G
R
R
Site 4
Y25
Q
S
N
T
G
R
R
Y
G
R
R
H
A
Y
V
Site 5
Y31
R
Y
G
R
R
H
A
Y
V
S
F
R
P
P
T
Site 6
S33
G
R
R
H
A
Y
V
S
F
R
P
P
T
S
Q
Site 7
T38
Y
V
S
F
R
P
P
T
S
Q
R
E
R
I
A
Site 8
S39
V
S
F
R
P
P
T
S
Q
R
E
R
I
A
S
Site 9
S46
S
Q
R
E
R
I
A
S
Q
R
K
T
N
S
E
Site 10
T50
R
I
A
S
Q
R
K
T
N
S
E
V
P
M
H
Site 11
S52
A
S
Q
R
K
T
N
S
E
V
P
M
H
R
S
Site 12
S62
P
M
H
R
S
A
P
S
Q
T
T
K
R
S
R
Site 13
T64
H
R
S
A
P
S
Q
T
T
K
R
S
R
S
P
Site 14
T65
R
S
A
P
S
Q
T
T
K
R
S
R
S
P
F
Site 15
S68
P
S
Q
T
T
K
R
S
R
S
P
F
S
T
T
Site 16
S70
Q
T
T
K
R
S
R
S
P
F
S
T
T
R
R
Site 17
S73
K
R
S
R
S
P
F
S
T
T
R
R
S
W
D
Site 18
T74
R
S
R
S
P
F
S
T
T
R
R
S
W
D
D
Site 19
T75
S
R
S
P
F
S
T
T
R
R
S
W
D
D
S
Site 20
S78
P
F
S
T
T
R
R
S
W
D
D
S
E
S
S
Site 21
S82
T
R
R
S
W
D
D
S
E
S
S
G
T
N
L
Site 22
S84
R
S
W
D
D
S
E
S
S
G
T
N
L
N
I
Site 23
Y96
L
N
I
D
N
E
D
Y
S
R
Y
P
P
R
E
Site 24
S97
N
I
D
N
E
D
Y
S
R
Y
P
P
R
E
Y
Site 25
Y99
D
N
E
D
Y
S
R
Y
P
P
R
E
Y
R
A
Site 26
Y104
S
R
Y
P
P
R
E
Y
R
A
S
G
S
R
R
Site 27
S107
P
P
R
E
Y
R
A
S
G
S
R
R
G
M
A
Site 28
S109
R
E
Y
R
A
S
G
S
R
R
G
M
A
Y
G
Site 29
Y115
G
S
R
R
G
M
A
Y
G
H
I
D
S
Y
G
Site 30
S120
M
A
Y
G
H
I
D
S
Y
G
A
D
D
S
E
Site 31
Y121
A
Y
G
H
I
D
S
Y
G
A
D
D
S
E
E
Site 32
S126
D
S
Y
G
A
D
D
S
E
E
E
G
A
G
P
Site 33
T143
R
P
P
V
R
G
K
T
G
K
F
K
D
D
K
Site 34
Y152
K
F
K
D
D
K
L
Y
D
P
E
K
G
A
R
Site 35
S160
D
P
E
K
G
A
R
S
L
A
G
P
P
P
H
Site 36
S169
A
G
P
P
P
H
F
S
S
F
S
R
D
V
R
Site 37
S170
G
P
P
P
H
F
S
S
F
S
R
D
V
R
E
Site 38
S172
P
P
H
F
S
S
F
S
R
D
V
R
E
E
R
Site 39
S193
P
A
A
R
C
S
A
S
R
A
D
F
L
P
Q
Site 40
S201
R
A
D
F
L
P
Q
S
S
V
A
S
Q
S
S
Site 41
S202
A
D
F
L
P
Q
S
S
V
A
S
Q
S
S
S
Site 42
S205
L
P
Q
S
S
V
A
S
Q
S
S
S
E
G
K
Site 43
S208
S
S
V
A
S
Q
S
S
S
E
G
K
L
A
T
Site 44
S209
S
V
A
S
Q
S
S
S
E
G
K
L
A
T
K
Site 45
T215
S
S
E
G
K
L
A
T
K
G
D
S
S
E
R
Site 46
S219
K
L
A
T
K
G
D
S
S
E
R
E
R
R
E
Site 47
S220
L
A
T
K
G
D
S
S
E
R
E
R
R
E
Q
Site 48
S234
Q
N
L
P
A
R
P
S
R
A
P
V
S
I
C
Site 49
S239
R
P
S
R
A
P
V
S
I
C
G
G
G
E
N
Site 50
S248
C
G
G
G
E
N
T
S
K
S
A
E
E
P
V
Site 51
S250
G
G
E
N
T
S
K
S
A
E
E
P
V
V
R
Site 52
S265
P
K
I
R
N
L
A
S
P
N
C
V
K
P
K
Site 53
T277
K
P
K
I
F
F
D
T
D
D
D
D
D
M
P
Site 54
S286
D
D
D
D
M
P
H
S
T
S
R
W
R
D
T
Site 55
T293
S
T
S
R
W
R
D
T
A
N
D
N
E
G
H
Site 56
S312
A
R
R
G
R
G
E
S
S
S
G
Y
P
E
P
Site 57
S313
R
R
G
R
G
E
S
S
S
G
Y
P
E
P
K
Site 58
S314
R
G
R
G
E
S
S
S
G
Y
P
E
P
K
Y
Site 59
Y316
R
G
E
S
S
S
G
Y
P
E
P
K
Y
P
E
Site 60
Y321
S
G
Y
P
E
P
K
Y
P
E
D
K
R
E
A
Site 61
S330
E
D
K
R
E
A
R
S
D
Q
V
K
P
E
K
Site 62
T344
K
V
P
R
R
R
R
T
M
A
D
P
D
F
W
Site 63
Y358
W
T
H
S
D
D
Y
Y
K
Y
C
D
E
D
S
Site 64
Y360
H
S
D
D
Y
Y
K
Y
C
D
E
D
S
D
S
Site 65
S367
Y
C
D
E
D
S
D
S
D
K
E
W
I
A
A
Site 66
Y379
I
A
A
L
R
R
K
Y
R
S
R
E
Q
T
L
Site 67
S381
A
L
R
R
K
Y
R
S
R
E
Q
T
L
S
S
Site 68
T385
K
Y
R
S
R
E
Q
T
L
S
S
S
G
E
S
Site 69
S387
R
S
R
E
Q
T
L
S
S
S
G
E
S
W
E
Site 70
S388
S
R
E
Q
T
L
S
S
S
G
E
S
W
E
T
Site 71
S389
R
E
Q
T
L
S
S
S
G
E
S
W
E
T
L
Site 72
S392
T
L
S
S
S
G
E
S
W
E
T
L
P
G
K
Site 73
T395
S
S
G
E
S
W
E
T
L
P
G
K
E
E
R
Site 74
S410
E
P
P
Q
A
K
V
S
A
S
T
G
T
S
P
Site 75
S412
P
Q
A
K
V
S
A
S
T
G
T
S
P
G
P
Site 76
S416
V
S
A
S
T
G
T
S
P
G
P
G
A
S
A
Site 77
S422
T
S
P
G
P
G
A
S
A
S
A
G
A
G
A
Site 78
S432
A
G
A
G
A
G
A
S
A
G
S
N
G
S
N
Site 79
Y440
A
G
S
N
G
S
N
Y
L
E
E
V
R
E
P
Site 80
S448
L
E
E
V
R
E
P
S
L
Q
E
E
Q
A
S
Site 81
S455
S
L
Q
E
E
Q
A
S
L
E
E
G
E
I
P
Site 82
Y466
G
E
I
P
W
L
Q
Y
H
E
N
D
S
S
S
Site 83
S472
Q
Y
H
E
N
D
S
S
S
E
G
D
N
D
S
Site 84
S473
Y
H
E
N
D
S
S
S
E
G
D
N
D
S
G
Site 85
S479
S
S
E
G
D
N
D
S
G
H
E
L
M
Q
P
Site 86
S502
N
N
L
E
D
D
S
S
V
S
E
D
L
E
V
Site 87
S512
E
D
L
E
V
D
W
S
L
F
D
G
F
A
D
Site 88
Y537
V
D
P
Q
F
L
T
Y
M
A
L
E
E
R
L
Site 89
S570
E
V
A
N
P
P
A
S
K
E
S
I
D
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation