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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXO18
Full Name:
F-box only protein 18
Alias:
FBH1; F-box DNA helicase 1; F-box only 18; F-box protein, helicase, 18; FBX18; FLJ14590
Type:
Helicase; EC 3.6.1.-
Mass (Da):
117668
Number AA:
1043
UniProt ID:
Q8NFZ0
International Prot ID:
IPI00409721
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
F
K
R
K
H
L
T
A
I
D
C
Q
H
L
Site 2
Y42
R
D
P
N
H
G
L
Y
P
K
P
R
T
K
R
Site 3
T47
G
L
Y
P
K
P
R
T
K
R
G
S
R
G
Q
Site 4
S51
K
P
R
T
K
R
G
S
R
G
Q
G
S
Q
R
Site 5
S56
R
G
S
R
G
Q
G
S
Q
R
C
I
P
E
F
Site 6
S78
C
T
N
D
M
A
K
S
N
S
V
G
Q
D
S
Site 7
S80
N
D
M
A
K
S
N
S
V
G
Q
D
S
C
Q
Site 8
S85
S
N
S
V
G
Q
D
S
C
Q
D
S
E
G
D
Site 9
S89
G
Q
D
S
C
Q
D
S
E
G
D
M
I
F
P
Site 10
S108
C
A
L
P
Q
E
G
S
A
G
P
G
S
P
G
Site 11
S113
E
G
S
A
G
P
G
S
P
G
S
A
P
P
S
Site 12
S116
A
G
P
G
S
P
G
S
A
P
P
S
R
K
R
Site 13
S120
S
P
G
S
A
P
P
S
R
K
R
S
W
S
S
Site 14
S124
A
P
P
S
R
K
R
S
W
S
S
E
E
E
S
Site 15
S126
P
S
R
K
R
S
W
S
S
E
E
E
S
N
Q
Site 16
S127
S
R
K
R
S
W
S
S
E
E
E
S
N
Q
A
Site 17
S131
S
W
S
S
E
E
E
S
N
Q
A
T
G
T
S
Site 18
T135
E
E
E
S
N
Q
A
T
G
T
S
R
W
D
G
Site 19
S144
T
S
R
W
D
G
V
S
K
K
A
P
R
H
H
Site 20
S153
K
A
P
R
H
H
L
S
V
P
C
T
R
P
R
Site 21
T157
H
H
L
S
V
P
C
T
R
P
R
E
A
R
Q
Site 22
S169
A
R
Q
E
A
E
D
S
T
S
R
L
S
A
E
Site 23
T170
R
Q
E
A
E
D
S
T
S
R
L
S
A
E
S
Site 24
S171
Q
E
A
E
D
S
T
S
R
L
S
A
E
S
G
Site 25
S174
E
D
S
T
S
R
L
S
A
E
S
G
E
T
D
Site 26
S177
T
S
R
L
S
A
E
S
G
E
T
D
Q
D
A
Site 27
T180
L
S
A
E
S
G
E
T
D
Q
D
A
G
D
V
Site 28
S195
G
P
D
P
I
P
D
S
Y
Y
G
L
L
G
T
Site 29
Y196
P
D
P
I
P
D
S
Y
Y
G
L
L
G
T
L
Site 30
Y197
D
P
I
P
D
S
Y
Y
G
L
L
G
T
L
P
Site 31
Y259
F
I
P
W
K
K
L
Y
H
R
Y
L
M
N
E
Site 32
S278
S
K
V
D
G
I
L
S
N
C
G
I
E
K
E
Site 33
T299
N
L
I
R
Y
T
A
T
T
K
C
S
P
S
V
Site 34
T300
L
I
R
Y
T
A
T
T
K
C
S
P
S
V
D
Site 35
S303
Y
T
A
T
T
K
C
S
P
S
V
D
P
E
R
Site 36
S305
A
T
T
K
C
S
P
S
V
D
P
E
R
V
L
Site 37
S314
D
P
E
R
V
L
W
S
L
R
D
H
P
L
L
Site 38
Y336
R
Q
H
L
P
D
L
Y
A
A
A
G
G
V
N
Site 39
S372
L
F
C
L
R
R
P
S
S
T
V
T
M
P
D
Site 40
S373
F
C
L
R
R
P
S
S
T
V
T
M
P
D
V
Site 41
T374
C
L
R
R
P
S
S
T
V
T
M
P
D
V
T
Site 42
T376
R
R
P
S
S
T
V
T
M
P
D
V
T
E
T
Site 43
Y411
R
I
H
Y
N
I
F
Y
C
L
Y
L
Q
E
N
Site 44
T421
Y
L
Q
E
N
S
C
T
Q
A
T
K
V
K
E
Site 45
S431
T
K
V
K
E
E
P
S
V
W
P
G
K
K
T
Site 46
T438
S
V
W
P
G
K
K
T
I
Q
L
T
H
E
Q
Site 47
T442
G
K
K
T
I
Q
L
T
H
E
Q
Q
L
I
L
Site 48
T472
A
G
T
G
K
T
S
T
L
V
K
Y
A
E
K
Site 49
Y476
K
T
S
T
L
V
K
Y
A
E
K
W
S
Q
S
Site 50
Y487
W
S
Q
S
R
F
L
Y
V
T
F
N
K
S
I
Site 51
T489
Q
S
R
F
L
Y
V
T
F
N
K
S
I
A
K
Site 52
S493
L
Y
V
T
F
N
K
S
I
A
K
Q
A
E
R
Site 53
Y516
K
T
F
H
S
M
A
Y
G
H
I
G
R
K
Y
Site 54
Y523
Y
G
H
I
G
R
K
Y
Q
S
K
K
K
L
N
Site 55
S525
H
I
G
R
K
Y
Q
S
K
K
K
L
N
L
F
Site 56
Y627
H
Q
M
T
H
D
G
Y
L
K
L
W
Q
L
S
Site 57
S634
Y
L
K
L
W
Q
L
S
K
P
S
L
A
S
F
Site 58
Y678
G
D
P
H
Q
Q
I
Y
T
F
R
G
A
V
N
Site 59
T679
D
P
H
Q
Q
I
Y
T
F
R
G
A
V
N
A
Site 60
Y697
V
P
H
T
H
V
F
Y
L
T
Q
S
F
R
F
Site 61
T726
C
K
R
V
R
K
K
T
L
V
G
G
N
H
Q
Site 62
S734
L
V
G
G
N
H
Q
S
G
I
R
G
D
A
K
Site 63
T762
F
D
E
A
V
R
V
T
E
G
E
F
P
S
R
Site 64
Y824
G
F
S
G
F
K
R
Y
V
T
A
A
E
D
K
Site 65
T826
S
G
F
K
R
Y
V
T
A
A
E
D
K
E
L
Site 66
Y867
E
D
L
D
F
A
E
Y
I
L
G
T
V
H
K
Site 67
S909
L
P
H
F
R
V
E
S
F
S
E
D
E
W
N
Site 68
S911
H
F
R
V
E
S
F
S
E
D
E
W
N
L
L
Site 69
Y919
E
D
E
W
N
L
L
Y
V
A
V
T
R
A
K
Site 70
T986
T
M
K
K
L
P
I
T
Y
S
N
R
K
E
N
Site 71
S988
K
K
L
P
I
T
Y
S
N
R
K
E
N
K
G
Site 72
Y997
R
K
E
N
K
G
G
Y
L
C
H
S
C
A
E
Site 73
T1026
Q
V
R
A
M
E
R
T
V
E
N
I
V
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation