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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KBTBD8
Full Name:
Kelch repeat and BTB domain-containing protein 8
Alias:
KBTB8; Kelch repeat and BTB (POZ) domain containing 8; KIAA1842; TAKRP; TA-KRP; T-cell activation Kelch repeat protein
Type:
Unknown function
Mass (Da):
68823
Number AA:
575
UniProt ID:
Q8NFY9
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
S
A
D
L
S
K
S
S
P
T
P
N
Site 2
S10
A
S
A
D
L
S
K
S
S
P
T
P
N
G
I
Site 3
S11
S
A
D
L
S
K
S
S
P
T
P
N
G
I
P
Site 4
T13
D
L
S
K
S
S
P
T
P
N
G
I
P
S
S
Site 5
S19
P
T
P
N
G
I
P
S
S
D
P
A
S
D
A
Site 6
S20
T
P
N
G
I
P
S
S
D
P
A
S
D
A
M
Site 7
S24
I
P
S
S
D
P
A
S
D
A
M
D
P
F
H
Site 8
T41
S
I
L
K
Q
L
K
T
M
Y
D
E
G
Q
L
Site 9
Y43
L
K
Q
L
K
T
M
Y
D
E
G
Q
L
T
D
Site 10
T49
M
Y
D
E
G
Q
L
T
D
I
V
V
E
V
D
Site 11
S77
A
I
S
P
Y
F
R
S
M
F
T
S
G
L
T
Site 12
S81
Y
F
R
S
M
F
T
S
G
L
T
E
S
T
Q
Site 13
Y142
I
Q
D
Q
C
A
K
Y
M
I
S
H
L
D
P
Site 14
Y162
V
F
I
F
A
D
H
Y
G
H
Q
E
L
G
D
Site 15
S171
H
Q
E
L
G
D
R
S
K
E
Y
I
R
K
K
Site 16
Y174
L
G
D
R
S
K
E
Y
I
R
K
K
F
L
C
Site 17
S198
L
T
K
D
Q
L
I
S
I
L
D
S
D
D
L
Site 18
S202
Q
L
I
S
I
L
D
S
D
D
L
N
V
D
R
Site 19
Y214
V
D
R
E
E
H
V
Y
E
S
I
I
R
W
F
Site 20
T248
R
F
P
L
M
E
D
T
F
I
E
K
I
P
P
Site 21
S264
F
A
Q
A
I
A
K
S
C
V
E
K
G
P
S
Site 22
S271
S
C
V
E
K
G
P
S
N
T
N
G
C
T
Q
Site 23
T277
P
S
N
T
N
G
C
T
Q
R
L
G
M
T
A
Site 24
Y338
V
S
P
D
N
D
I
Y
I
A
G
G
Y
R
P
Site 25
Y343
D
I
Y
I
A
G
G
Y
R
P
S
S
S
E
V
Site 26
S346
I
A
G
G
Y
R
P
S
S
S
E
V
S
I
D
Site 27
S347
A
G
G
Y
R
P
S
S
S
E
V
S
I
D
H
Site 28
S348
G
G
Y
R
P
S
S
S
E
V
S
I
D
H
K
Site 29
S351
R
P
S
S
S
E
V
S
I
D
H
K
A
E
N
Site 30
S372
H
S
T
N
R
W
L
S
K
P
S
L
L
R
A
Site 31
S375
N
R
W
L
S
K
P
S
L
L
R
A
R
I
G
Site 32
Y400
Y
A
I
G
G
R
V
Y
E
G
D
G
R
N
S
Site 33
S407
Y
E
G
D
G
R
N
S
L
K
S
V
E
C
Y
Site 34
S410
D
G
R
N
S
L
K
S
V
E
C
Y
D
S
R
Site 35
Y414
S
L
K
S
V
E
C
Y
D
S
R
E
N
C
W
Site 36
Y444
V
E
Y
K
E
K
I
Y
V
L
Q
G
E
F
F
Site 37
Y454
Q
G
E
F
F
L
F
Y
E
P
Q
K
D
Y
W
Site 38
Y460
F
Y
E
P
Q
K
D
Y
W
G
F
L
T
P
M
Site 39
T465
K
D
Y
W
G
F
L
T
P
M
T
V
P
R
I
Site 40
Y485
V
Y
K
D
S
I
Y
Y
I
A
G
T
C
G
N
Site 41
T498
G
N
H
Q
R
M
F
T
V
E
A
Y
D
I
E
Site 42
Y524
C
D
Q
S
I
N
P
Y
L
K
L
V
L
F
Q
Site 43
T544
F
V
R
A
T
Q
V
T
V
E
E
H
V
F
R
Site 44
T552
V
E
E
H
V
F
R
T
S
R
K
N
S
L
Y
Site 45
S553
E
E
H
V
F
R
T
S
R
K
N
S
L
Y
Q
Site 46
S557
F
R
T
S
R
K
N
S
L
Y
Q
Y
D
D
I
Site 47
Y559
T
S
R
K
N
S
L
Y
Q
Y
D
D
I
A
D
Site 48
Y561
R
K
N
S
L
Y
Q
Y
D
D
I
A
D
Q
W
Site 49
Y572
A
D
Q
W
M
K
V
Y
E
T
P
D
R
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation