KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SEMA6D
Full Name:
Semaphorin-6D
Alias:
FLJ11598; KIAA1479; SEM6D; Sema domain, transmembrane domain (TM) and cytoplasmic domain (semaphorin) 6D; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Semaphorin 6D; Semaphorin-6D; Semaphorin-6D: Semaphorin-6D: Semaphorin-6D: Semaphorin-6D: Semaphorin-6D: Semaphorin-6D
Type:
Membrane protein, integral; Cell surface
Mass (Da):
119872
Number AA:
1073
UniProt ID:
Q8NFY4
International Prot ID:
IPI00332846
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y472
L
L
E
E
I
E
A
Y
N
H
A
K
C
S
A
Site 2
S703
K
I
H
K
D
A
E
S
A
Q
S
C
T
D
S
Site 3
S706
K
D
A
E
S
A
Q
S
C
T
D
S
S
G
S
Site 4
T708
A
E
S
A
Q
S
C
T
D
S
S
G
S
F
A
Site 5
S710
S
A
Q
S
C
T
D
S
S
G
S
F
A
K
L
Site 6
S711
A
Q
S
C
T
D
S
S
G
S
F
A
K
L
N
Site 7
S713
S
C
T
D
S
S
G
S
F
A
K
L
N
G
L
Site 8
S723
K
L
N
G
L
F
D
S
P
V
K
E
Y
Q
Q
Site 9
S734
E
Y
Q
Q
N
I
D
S
P
K
L
Y
S
N
L
Site 10
Y738
N
I
D
S
P
K
L
Y
S
N
L
L
T
S
R
Site 11
S739
I
D
S
P
K
L
Y
S
N
L
L
T
S
R
K
Site 12
T743
K
L
Y
S
N
L
L
T
S
R
K
E
L
P
P
Site 13
T754
E
L
P
P
N
G
D
T
K
S
M
V
M
D
H
Site 14
S756
P
P
N
G
D
T
K
S
M
V
M
D
H
R
G
Site 15
T773
P
E
L
A
A
L
P
T
P
E
S
T
P
V
L
Site 16
S776
A
A
L
P
T
P
E
S
T
P
V
L
H
Q
K
Site 17
T777
A
L
P
T
P
E
S
T
P
V
L
H
Q
K
T
Site 18
S790
K
T
L
Q
A
M
K
S
H
S
E
K
A
H
G
Site 19
S792
L
Q
A
M
K
S
H
S
E
K
A
H
G
H
G
Site 20
S801
K
A
H
G
H
G
A
S
R
K
E
T
P
Q
F
Site 21
T805
H
G
A
S
R
K
E
T
P
Q
F
F
P
S
S
Site 22
S811
E
T
P
Q
F
F
P
S
S
P
P
P
H
S
P
Site 23
S812
T
P
Q
F
F
P
S
S
P
P
P
H
S
P
L
Site 24
S817
P
S
S
P
P
P
H
S
P
L
S
H
G
H
I
Site 25
S820
P
P
P
H
S
P
L
S
H
G
H
I
P
S
A
Site 26
Y837
L
P
N
A
T
H
D
Y
N
T
S
F
S
N
S
Site 27
S840
A
T
H
D
Y
N
T
S
F
S
N
S
N
A
H
Site 28
S842
H
D
Y
N
T
S
F
S
N
S
N
A
H
K
A
Site 29
S844
Y
N
T
S
F
S
N
S
N
A
H
K
A
E
K
Site 30
T861
Q
N
I
D
H
P
L
T
K
S
S
S
K
R
D
Site 31
S863
I
D
H
P
L
T
K
S
S
S
K
R
D
H
R
Site 32
S865
H
P
L
T
K
S
S
S
K
R
D
H
R
R
S
Site 33
S872
S
K
R
D
H
R
R
S
V
D
S
R
N
T
L
Site 34
S875
D
H
R
R
S
V
D
S
R
N
T
L
N
D
L
Site 35
T878
R
S
V
D
S
R
N
T
L
N
D
L
L
K
H
Site 36
S891
K
H
L
N
D
P
N
S
N
P
K
A
I
M
G
Site 37
S914
L
M
L
D
P
M
G
S
M
S
E
V
P
P
K
Site 38
S916
L
D
P
M
G
S
M
S
E
V
P
P
K
V
P
Site 39
S928
K
V
P
N
R
E
A
S
L
Y
S
P
P
S
T
Site 40
Y930
P
N
R
E
A
S
L
Y
S
P
P
S
T
L
P
Site 41
S931
N
R
E
A
S
L
Y
S
P
P
S
T
L
P
R
Site 42
S934
A
S
L
Y
S
P
P
S
T
L
P
R
N
S
P
Site 43
T935
S
L
Y
S
P
P
S
T
L
P
R
N
S
P
T
Site 44
S940
P
S
T
L
P
R
N
S
P
T
K
R
V
D
V
Site 45
T949
T
K
R
V
D
V
P
T
T
P
G
V
P
M
T
Site 46
T950
K
R
V
D
V
P
T
T
P
G
V
P
M
T
S
Site 47
S957
T
P
G
V
P
M
T
S
L
E
R
Q
R
G
Y
Site 48
Y964
S
L
E
R
Q
R
G
Y
H
K
N
S
S
Q
R
Site 49
S968
Q
R
G
Y
H
K
N
S
S
Q
R
H
S
I
S
Site 50
S969
R
G
Y
H
K
N
S
S
Q
R
H
S
I
S
A
Site 51
S973
K
N
S
S
Q
R
H
S
I
S
A
M
P
K
N
Site 52
S975
S
S
Q
R
H
S
I
S
A
M
P
K
N
L
N
Site 53
S983
A
M
P
K
N
L
N
S
P
N
G
V
L
L
S
Site 54
S990
S
P
N
G
V
L
L
S
R
Q
P
S
M
N
R
Site 55
S994
V
L
L
S
R
Q
P
S
M
N
R
G
G
Y
M
Site 56
Y1000
P
S
M
N
R
G
G
Y
M
P
T
P
T
G
A
Site 57
T1003
N
R
G
G
Y
M
P
T
P
T
G
A
K
V
D
Site 58
T1005
G
G
Y
M
P
T
P
T
G
A
K
V
D
Y
I
Site 59
Y1011
P
T
G
A
K
V
D
Y
I
Q
G
T
P
V
S
Site 60
T1015
K
V
D
Y
I
Q
G
T
P
V
S
V
H
L
Q
Site 61
S1024
V
S
V
H
L
Q
P
S
L
S
R
Q
S
S
Y
Site 62
S1026
V
H
L
Q
P
S
L
S
R
Q
S
S
Y
T
S
Site 63
S1029
Q
P
S
L
S
R
Q
S
S
Y
T
S
N
G
T
Site 64
S1030
P
S
L
S
R
Q
S
S
Y
T
S
N
G
T
L
Site 65
Y1031
S
L
S
R
Q
S
S
Y
T
S
N
G
T
L
P
Site 66
T1032
L
S
R
Q
S
S
Y
T
S
N
G
T
L
P
R
Site 67
S1033
S
R
Q
S
S
Y
T
S
N
G
T
L
P
R
T
Site 68
T1036
S
S
Y
T
S
N
G
T
L
P
R
T
G
L
K
Site 69
T1040
S
N
G
T
L
P
R
T
G
L
K
R
T
P
S
Site 70
T1045
P
R
T
G
L
K
R
T
P
S
L
K
P
D
V
Site 71
S1047
T
G
L
K
R
T
P
S
L
K
P
D
V
P
P
Site 72
S1057
P
D
V
P
P
K
P
S
F
V
P
Q
T
P
S
Site 73
T1062
K
P
S
F
V
P
Q
T
P
S
V
R
P
L
N
Site 74
S1064
S
F
V
P
Q
T
P
S
V
R
P
L
N
K
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation