KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DMBX1
Full Name:
Diencephalon/mesencephalon homeobox protein 1
Alias:
Diencephalon/mesencephalon homeobox 1; MBX; Orthodenticle 3; OTX3; Paired-like homeobox DMBX1; PAXB
Type:
Transcription protein, repressor. Paired homeobox family.
Mass (Da):
41198
Number AA:
382
UniProt ID:
Q8NFW5
International Prot ID:
IPI00219522
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
GO:0016564
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0048589
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
Q
A
Q
H
A
P
D
Y
R
P
S
V
H
A
L
Site 2
S40
H
A
P
D
Y
R
P
S
V
H
A
L
T
L
A
Site 3
S66
I
L
E
A
R
Y
G
S
Q
H
R
K
Q
R
R
Site 4
S74
Q
H
R
K
Q
R
R
S
R
T
A
F
T
A
Q
Site 5
T76
R
K
Q
R
R
S
R
T
A
F
T
A
Q
Q
L
Site 6
T89
Q
L
E
A
L
E
K
T
F
Q
K
T
H
Y
P
Site 7
Y95
K
T
F
Q
K
T
H
Y
P
D
V
V
M
R
E
Site 8
T108
R
E
R
L
A
M
C
T
N
L
P
E
A
R
V
Site 9
S132
K
F
R
K
K
Q
R
S
L
Q
K
E
Q
L
Q
Site 10
S147
K
Q
K
E
A
E
G
S
H
G
E
G
K
A
E
Site 11
T157
E
G
K
A
E
A
P
T
P
D
T
Q
L
D
T
Site 12
T160
A
E
A
P
T
P
D
T
Q
L
D
T
E
Q
P
Site 13
T164
T
P
D
T
Q
L
D
T
E
Q
P
P
R
L
P
Site 14
S173
Q
P
P
R
L
P
G
S
D
P
P
A
E
L
H
Site 15
S182
P
P
A
E
L
H
L
S
L
S
E
Q
S
A
S
Site 16
S184
A
E
L
H
L
S
L
S
E
Q
S
A
S
E
S
Site 17
S189
S
L
S
E
Q
S
A
S
E
S
A
P
E
D
Q
Site 18
S191
S
E
Q
S
A
S
E
S
A
P
E
D
Q
P
D
Site 19
S215
E
D
P
K
A
E
K
S
P
G
A
D
S
K
G
Site 20
S220
E
K
S
P
G
A
D
S
K
G
L
G
C
K
R
Site 21
S229
G
L
G
C
K
R
G
S
P
K
A
D
S
P
G
Site 22
S234
R
G
S
P
K
A
D
S
P
G
S
L
T
I
T
Site 23
S237
P
K
A
D
S
P
G
S
L
T
I
T
P
V
A
Site 24
S253
G
G
G
L
L
G
P
S
H
S
Y
S
S
S
P
Site 25
S255
G
L
L
G
P
S
H
S
Y
S
S
S
P
L
S
Site 26
S257
L
G
P
S
H
S
Y
S
S
S
P
L
S
L
F
Site 27
S258
G
P
S
H
S
Y
S
S
S
P
L
S
L
F
R
Site 28
S259
P
S
H
S
Y
S
S
S
P
L
S
L
F
R
L
Site 29
S262
S
Y
S
S
S
P
L
S
L
F
R
L
Q
E
Q
Site 30
Y283
A
T
N
N
L
V
H
Y
S
S
F
E
V
G
G
Site 31
S285
N
N
L
V
H
Y
S
S
F
E
V
G
G
P
A
Site 32
S319
L
G
S
L
H
C
Q
S
Y
Y
Q
S
L
S
A
Site 33
Y320
G
S
L
H
C
Q
S
Y
Y
Q
S
L
S
A
A
Site 34
Y321
S
L
H
C
Q
S
Y
Y
Q
S
L
S
A
A
A
Site 35
S323
H
C
Q
S
Y
Y
Q
S
L
S
A
A
A
A
A
Site 36
S325
Q
S
Y
Y
Q
S
L
S
A
A
A
A
A
H
Q
Site 37
S337
A
H
Q
G
V
W
G
S
P
L
L
P
A
P
P
Site 38
S351
P
A
G
L
A
P
A
S
A
T
L
N
S
K
T
Site 39
T353
G
L
A
P
A
S
A
T
L
N
S
K
T
T
S
Site 40
S356
P
A
S
A
T
L
N
S
K
T
T
S
I
E
N
Site 41
T358
S
A
T
L
N
S
K
T
T
S
I
E
N
L
R
Site 42
S360
T
L
N
S
K
T
T
S
I
E
N
L
R
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation