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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IPMK
Full Name:
Inositol polyphosphate multikinase
Alias:
EC 2.7.1.151; IMPK; Inositol polyphosphate multikinase
Type:
Kinase (non-protein); EC 2.7.1.151; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
47222
Number AA:
416
UniProt ID:
Q8NFU5
International Prot ID:
IPI00168907
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008440
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
T
E
P
P
S
P
L
R
V
E
A
P
Site 2
T21
P
G
P
P
E
M
R
T
S
P
A
I
E
S
T
Site 3
S22
G
P
P
E
M
R
T
S
P
A
I
E
S
T
P
Site 4
S27
R
T
S
P
A
I
E
S
T
P
E
G
T
P
Q
Site 5
T28
T
S
P
A
I
E
S
T
P
E
G
T
P
Q
P
Site 6
T32
I
E
S
T
P
E
G
T
P
Q
P
A
G
G
R
Site 7
Y58
H
Q
V
A
G
H
M
Y
G
K
D
K
V
G
I
Site 8
T72
I
L
Q
H
P
D
G
T
V
L
K
Q
L
Q
P
Site 9
Y90
G
P
R
E
L
E
F
Y
N
M
V
Y
A
A
D
Site 10
Y113
L
R
K
Y
L
P
K
Y
Y
G
I
W
S
P
P
Site 11
Y114
R
K
Y
L
P
K
Y
Y
G
I
W
S
P
P
T
Site 12
S118
P
K
Y
Y
G
I
W
S
P
P
T
A
P
N
D
Site 13
T121
Y
G
I
W
S
P
P
T
A
P
N
D
L
Y
L
Site 14
Y127
P
T
A
P
N
D
L
Y
L
K
L
E
D
V
T
Site 15
S151
D
V
K
I
G
Q
K
S
Y
D
P
F
A
S
S
Site 16
Y152
V
K
I
G
Q
K
S
Y
D
P
F
A
S
S
E
Site 17
S166
E
K
I
Q
Q
Q
V
S
K
Y
P
L
M
E
E
Site 18
Y168
I
Q
Q
Q
V
S
K
Y
P
L
M
E
E
I
G
Site 19
S188
M
R
V
Y
H
V
H
S
D
S
Y
E
T
E
N
Site 20
Y191
Y
H
V
H
S
D
S
Y
E
T
E
N
Q
H
Y
Site 21
Y198
Y
E
T
E
N
Q
H
Y
G
R
S
L
T
K
E
Site 22
T203
Q
H
Y
G
R
S
L
T
K
E
T
I
K
D
G
Site 23
Y219
S
R
F
F
H
N
G
Y
C
L
R
K
D
A
V
Site 24
Y257
A
S
S
L
L
F
V
Y
E
G
S
S
Q
P
T
Site 25
S261
L
F
V
Y
E
G
S
S
Q
P
T
T
T
K
L
Site 26
T265
E
G
S
S
Q
P
T
T
T
K
L
N
D
R
T
Site 27
T266
G
S
S
Q
P
T
T
T
K
L
N
D
R
T
L
Site 28
T272
T
T
K
L
N
D
R
T
L
A
E
K
F
L
S
Site 29
S279
T
L
A
E
K
F
L
S
K
G
Q
L
S
D
T
Site 30
S284
F
L
S
K
G
Q
L
S
D
T
E
V
L
E
Y
Site 31
T286
S
K
G
Q
L
S
D
T
E
V
L
E
Y
N
N
Site 32
Y291
S
D
T
E
V
L
E
Y
N
N
N
F
H
V
L
Site 33
S308
T
A
N
G
K
I
E
S
S
V
G
K
S
L
S
Site 34
S309
A
N
G
K
I
E
S
S
V
G
K
S
L
S
K
Site 35
S313
I
E
S
S
V
G
K
S
L
S
K
M
Y
A
R
Site 36
S315
S
S
V
G
K
S
L
S
K
M
Y
A
R
H
R
Site 37
Y318
G
K
S
L
S
K
M
Y
A
R
H
R
K
I
Y
Site 38
Y325
Y
A
R
H
R
K
I
Y
T
K
K
H
H
S
Q
Site 39
S331
I
Y
T
K
K
H
H
S
Q
T
S
L
K
V
E
Site 40
T333
T
K
K
H
H
S
Q
T
S
L
K
V
E
N
L
Site 41
S334
K
K
H
H
S
Q
T
S
L
K
V
E
N
L
E
Site 42
S348
E
Q
D
N
G
W
K
S
M
S
Q
E
H
L
N
Site 43
S350
D
N
G
W
K
S
M
S
Q
E
H
L
N
G
N
Site 44
S360
H
L
N
G
N
V
L
S
Q
L
E
K
V
F
Y
Site 45
Y367
S
Q
L
E
K
V
F
Y
H
L
P
T
G
C
Q
Site 46
Y399
S
N
T
I
D
E
G
Y
V
Y
G
L
K
H
L
Site 47
S412
H
L
I
S
V
L
R
S
I
L
D
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation