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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOCK8
Full Name:
Dedicator of cytokinesis protein 8
Alias:
dedicator of cytokinesis 8; FLJ00026; FLJ00152; FLJ00346; ZIR8
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
238529
Number AA:
2099
UniProt ID:
Q8NF50
International Prot ID:
IPI00797373
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005085
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
L
P
S
A
E
R
R
Site 2
S20
A
L
K
I
N
R
Y
S
S
A
E
I
R
K
Q
Site 3
S21
L
K
I
N
R
Y
S
S
A
E
I
R
K
Q
F
Site 4
T29
A
E
I
R
K
Q
F
T
L
P
P
N
L
G
Q
Site 5
Y37
L
P
P
N
L
G
Q
Y
H
R
Q
S
I
S
T
Site 6
S41
L
G
Q
Y
H
R
Q
S
I
S
T
S
G
F
P
Site 7
S43
Q
Y
H
R
Q
S
I
S
T
S
G
F
P
S
L
Site 8
T44
Y
H
R
Q
S
I
S
T
S
G
F
P
S
L
Q
Site 9
S45
H
R
Q
S
I
S
T
S
G
F
P
S
L
Q
L
Site 10
S49
I
S
T
S
G
F
P
S
L
Q
L
P
Q
F
Y
Site 11
Y56
S
L
Q
L
P
Q
F
Y
D
P
V
E
P
V
D
Site 12
T87
A
Q
E
L
G
D
F
T
D
D
D
L
D
V
V
Site 13
T96
D
D
L
D
V
V
F
T
P
K
E
C
R
T
L
Site 14
T102
F
T
P
K
E
C
R
T
L
Q
P
S
L
P
E
Site 15
S106
E
C
R
T
L
Q
P
S
L
P
E
E
G
V
E
Site 16
S139
V
N
R
K
N
Q
G
S
P
E
I
C
G
F
K
Site 17
T148
E
I
C
G
F
K
K
T
G
S
R
K
D
F
H
Site 18
S150
C
G
F
K
K
T
G
S
R
K
D
F
H
K
T
Site 19
T157
S
R
K
D
F
H
K
T
L
P
K
Q
T
F
E
Site 20
T162
H
K
T
L
P
K
Q
T
F
E
S
E
T
L
E
Site 21
T167
K
Q
T
F
E
S
E
T
L
E
C
S
E
P
A
Site 22
T195
V
S
G
K
G
P
V
T
A
C
D
F
D
L
R
Site 23
S203
A
C
D
F
D
L
R
S
L
Q
P
D
K
R
L
Site 24
S218
E
N
L
L
Q
Q
V
S
A
E
D
F
E
K
Q
Site 25
T232
Q
N
E
E
A
R
R
T
N
R
Q
A
E
L
F
Site 26
Y242
Q
A
E
L
F
A
L
Y
P
S
V
D
E
E
D
Site 27
S244
E
L
F
A
L
Y
P
S
V
D
E
E
D
A
V
Site 28
Y291
L
F
A
S
I
A
L
Y
D
V
K
E
R
K
K
Site 29
T320
K
G
F
L
R
A
H
T
P
S
V
A
A
S
S
Site 30
S322
F
L
R
A
H
T
P
S
V
A
A
S
S
Q
A
Site 31
S326
H
T
P
S
V
A
A
S
S
Q
A
R
S
A
V
Site 32
S335
Q
A
R
S
A
V
F
S
V
T
Y
P
S
S
D
Site 33
T337
R
S
A
V
F
S
V
T
Y
P
S
S
D
I
Y
Site 34
Y344
T
Y
P
S
S
D
I
Y
L
V
V
K
I
E
K
Site 35
Y365
I
G
D
C
A
E
P
Y
T
V
I
K
E
S
D
Site 36
T366
G
D
C
A
E
P
Y
T
V
I
K
E
S
D
G
Site 37
S389
K
L
K
L
Q
A
E
S
F
C
Q
R
L
G
K
Site 38
T416
S
S
F
F
N
V
S
T
L
E
R
E
V
T
D
Site 39
T422
S
T
L
E
R
E
V
T
D
V
D
S
V
V
G
Site 40
S426
R
E
V
T
D
V
D
S
V
V
G
R
S
S
V
Site 41
S432
D
S
V
V
G
R
S
S
V
G
E
R
R
T
L
Site 42
T438
S
S
V
G
E
R
R
T
L
A
Q
S
R
R
L
Site 43
S442
E
R
R
T
L
A
Q
S
R
R
L
S
E
R
A
Site 44
S446
L
A
Q
S
R
R
L
S
E
R
A
L
S
L
E
Site 45
S451
R
L
S
E
R
A
L
S
L
E
E
N
G
V
G
Site 46
T463
G
V
G
S
N
F
K
T
S
T
L
S
V
S
S
Site 47
T465
G
S
N
F
K
T
S
T
L
S
V
S
S
F
F
Site 48
S467
N
F
K
T
S
T
L
S
V
S
S
F
F
K
Q
Site 49
S470
T
S
T
L
S
V
S
S
F
F
K
Q
E
G
D
Site 50
S480
K
Q
E
G
D
R
L
S
D
E
D
L
F
K
F
Site 51
Y491
L
F
K
F
L
A
D
Y
K
R
S
S
S
L
Q
Site 52
S495
L
A
D
Y
K
R
S
S
S
L
Q
R
R
V
K
Site 53
S496
A
D
Y
K
R
S
S
S
L
Q
R
R
V
K
S
Site 54
S503
S
L
Q
R
R
V
K
S
I
P
G
L
L
R
L
Site 55
Y553
E
F
P
T
R
E
V
Y
V
P
H
T
V
Y
R
Site 56
T557
R
E
V
Y
V
P
H
T
V
Y
R
N
L
L
Y
Site 57
Y564
T
V
Y
R
N
L
L
Y
V
Y
P
Q
R
L
N
Site 58
Y566
Y
R
N
L
L
Y
V
Y
P
Q
R
L
N
F
V
Site 59
S578
N
F
V
N
K
L
A
S
A
R
N
I
T
I
K
Site 60
Y615
P
E
F
L
Q
E
V
Y
T
A
V
T
Y
H
N
Site 61
Y620
E
V
Y
T
A
V
T
Y
H
N
K
S
P
D
F
Site 62
S624
A
V
T
Y
H
N
K
S
P
D
F
Y
E
E
V
Site 63
Y628
H
N
K
S
P
D
F
Y
E
E
V
K
I
K
L
Site 64
S661
C
Q
Q
K
Q
G
A
S
V
E
T
L
L
G
Y
Site 65
S683
N
E
R
L
Q
T
G
S
Y
C
L
P
V
A
L
Site 66
Y684
E
R
L
Q
T
G
S
Y
C
L
P
V
A
L
E
Site 67
Y697
L
E
K
L
P
P
N
Y
S
M
H
S
A
E
K
Site 68
S698
E
K
L
P
P
N
Y
S
M
H
S
A
E
K
V
Site 69
S701
P
P
N
Y
S
M
H
S
A
E
K
V
P
L
Q
Site 70
S731
I
E
V
Q
A
V
S
S
V
H
T
Q
D
N
H
Site 71
T734
Q
A
V
S
S
V
H
T
Q
D
N
H
L
E
K
Site 72
T744
N
H
L
E
K
F
F
T
L
C
H
S
L
E
S
Site 73
T754
H
S
L
E
S
Q
V
T
F
P
I
R
V
L
D
Site 74
S765
R
V
L
D
Q
K
I
S
E
M
A
L
E
H
E
Site 75
S817
A
G
Q
T
A
N
F
S
Q
F
A
F
E
S
V
Site 76
S834
I
A
N
S
L
H
N
S
K
D
L
S
K
D
Q
Site 77
S838
L
H
N
S
K
D
L
S
K
D
Q
H
G
R
N
Site 78
S868
V
Q
R
D
V
P
K
S
G
A
P
T
A
L
L
Site 79
T872
V
P
K
S
G
A
P
T
A
L
L
D
P
R
S
Site 80
S879
T
A
L
L
D
P
R
S
Y
H
T
Y
G
R
T
Site 81
Y880
A
L
L
D
P
R
S
Y
H
T
Y
G
R
T
S
Site 82
T882
L
D
P
R
S
Y
H
T
Y
G
R
T
S
A
A
Site 83
Y883
D
P
R
S
Y
H
T
Y
G
R
T
S
A
A
A
Site 84
S887
Y
H
T
Y
G
R
T
S
A
A
A
V
S
S
K
Site 85
S902
L
L
Q
A
R
V
M
S
S
S
N
P
D
L
A
Site 86
S904
Q
A
R
V
M
S
S
S
N
P
D
L
A
G
T
Site 87
S913
P
D
L
A
G
T
H
S
A
A
D
E
E
V
K
Site 88
S933
K
I
A
D
R
N
C
S
R
M
S
Y
Y
C
S
Site 89
S936
D
R
N
C
S
R
M
S
Y
Y
C
S
G
S
S
Site 90
Y937
R
N
C
S
R
M
S
Y
Y
C
S
G
S
S
D
Site 91
Y938
N
C
S
R
M
S
Y
Y
C
S
G
S
S
D
A
Site 92
S940
S
R
M
S
Y
Y
C
S
G
S
S
D
A
P
S
Site 93
S942
M
S
Y
Y
C
S
G
S
S
D
A
P
S
S
P
Site 94
S943
S
Y
Y
C
S
G
S
S
D
A
P
S
S
P
A
Site 95
S947
S
G
S
S
D
A
P
S
S
P
A
A
P
R
P
Site 96
S948
G
S
S
D
A
P
S
S
P
A
A
P
R
P
A
Site 97
S956
P
A
A
P
R
P
A
S
K
K
H
F
H
E
E
Site 98
S993
F
F
E
L
L
V
K
S
M
A
Q
H
V
H
N
Site 99
S1006
H
N
M
D
K
R
D
S
F
R
R
T
R
F
S
Site 100
T1010
K
R
D
S
F
R
R
T
R
F
S
D
R
F
M
Site 101
S1013
S
F
R
R
T
R
F
S
D
R
F
M
D
D
I
Site 102
Y1075
V
F
N
L
I
R
H
Y
C
S
Q
L
S
A
K
Site 103
S1077
N
L
I
R
H
Y
C
S
Q
L
S
A
K
L
S
Site 104
S1080
R
H
Y
C
S
Q
L
S
A
K
L
S
N
L
P
Site 105
S1122
N
A
D
T
A
P
T
S
P
C
P
S
I
S
S
Site 106
S1126
A
P
T
S
P
C
P
S
I
S
S
Q
N
S
S
Site 107
S1128
T
S
P
C
P
S
I
S
S
Q
N
S
S
S
C
Site 108
S1129
S
P
C
P
S
I
S
S
Q
N
S
S
S
C
S
Site 109
S1132
P
S
I
S
S
Q
N
S
S
S
C
S
S
F
Q
Site 110
S1133
S
I
S
S
Q
N
S
S
S
C
S
S
F
Q
D
Site 111
S1134
I
S
S
Q
N
S
S
S
C
S
S
F
Q
D
Q
Site 112
S1136
S
Q
N
S
S
S
C
S
S
F
Q
D
Q
K
I
Site 113
S1137
Q
N
S
S
S
C
S
S
F
Q
D
Q
K
I
A
Site 114
S1145
F
Q
D
Q
K
I
A
S
M
F
D
L
T
S
E
Site 115
T1150
I
A
S
M
F
D
L
T
S
E
Y
R
Q
Q
H
Site 116
S1187
K
V
Q
R
K
A
V
S
A
I
H
S
L
L
S
Site 117
S1194
S
A
I
H
S
L
L
S
S
H
D
L
D
P
R
Site 118
S1195
A
I
H
S
L
L
S
S
H
D
L
D
P
R
C
Site 119
T1233
L
P
Q
L
C
D
F
T
V
A
D
T
R
R
Y
Site 120
T1237
C
D
F
T
V
A
D
T
R
R
Y
R
T
S
G
Site 121
Y1240
T
V
A
D
T
R
R
Y
R
T
S
G
S
D
E
Site 122
T1242
A
D
T
R
R
Y
R
T
S
G
S
D
E
E
Q
Site 123
S1243
D
T
R
R
Y
R
T
S
G
S
D
E
E
Q
E
Site 124
S1245
R
R
Y
R
T
S
G
S
D
E
E
Q
E
G
A
Site 125
T1272
G
N
N
F
N
L
K
T
S
G
I
V
L
S
S
Site 126
S1278
K
T
S
G
I
V
L
S
S
L
P
Y
K
Q
Y
Site 127
S1279
T
S
G
I
V
L
S
S
L
P
Y
K
Q
Y
N
Site 128
S1346
E
Y
K
G
K
Q
S
S
D
K
V
S
T
Q
V
Site 129
S1350
K
Q
S
S
D
K
V
S
T
Q
V
L
Q
K
S
Site 130
S1357
S
T
Q
V
L
Q
K
S
R
D
V
K
A
R
L
Site 131
T1415
A
N
E
K
L
D
K
T
K
A
E
L
D
Q
E
Site 132
T1479
D
Q
S
T
T
Y
L
T
H
C
F
A
T
L
R
Site 133
S1517
Q
V
L
H
H
C
S
S
S
M
D
V
T
R
S
Site 134
S1518
V
L
H
H
C
S
S
S
M
D
V
T
R
S
Q
Site 135
T1522
C
S
S
S
M
D
V
T
R
S
Q
A
C
A
T
Site 136
S1524
S
S
M
D
V
T
R
S
Q
A
C
A
T
L
Y
Site 137
S1573
N
E
E
H
L
R
R
S
L
R
T
I
L
A
Y
Site 138
T1576
H
L
R
R
S
L
R
T
I
L
A
Y
S
E
E
Site 139
Y1580
S
L
R
T
I
L
A
Y
S
E
E
D
T
A
M
Site 140
T1585
L
A
Y
S
E
E
D
T
A
M
Q
M
T
P
F
Site 141
T1590
E
D
T
A
M
Q
M
T
P
F
P
T
Q
V
E
Site 142
Y1608
C
N
L
N
S
I
L
Y
D
T
V
K
M
R
E
Site 143
T1610
L
N
S
I
L
Y
D
T
V
K
M
R
E
F
Q
Site 144
Y1628
E
M
L
M
D
L
M
Y
R
I
A
K
S
Y
Q
Site 145
S1633
L
M
Y
R
I
A
K
S
Y
Q
A
S
P
D
L
Site 146
S1637
I
A
K
S
Y
Q
A
S
P
D
L
R
L
T
W
Site 147
T1643
A
S
P
D
L
R
L
T
W
L
Q
N
M
A
E
Site 148
Y1684
S
M
L
E
D
H
S
Y
L
P
V
G
S
V
S
Site 149
S1689
H
S
Y
L
P
V
G
S
V
S
F
Q
N
I
S
Site 150
S1691
Y
L
P
V
G
S
V
S
F
Q
N
I
S
S
N
Site 151
S1703
S
S
N
V
L
E
E
S
V
V
S
E
D
T
L
Site 152
S1706
V
L
E
E
S
V
V
S
E
D
T
L
S
P
D
Site 153
T1709
E
S
V
V
S
E
D
T
L
S
P
D
E
D
G
Site 154
S1711
V
V
S
E
D
T
L
S
P
D
E
D
G
V
C
Site 155
T1747
S
T
G
G
L
Y
E
T
V
N
E
V
Y
K
L
Site 156
T1769
H
R
E
F
R
K
L
T
L
T
H
S
K
L
Q
Site 157
T1771
E
F
R
K
L
T
L
T
H
S
K
L
Q
R
A
Site 158
S1773
R
K
L
T
L
T
H
S
K
L
Q
R
A
F
D
Site 159
S1781
K
L
Q
R
A
F
D
S
I
V
N
K
D
H
K
Site 160
Y1794
H
K
R
M
F
G
T
Y
F
R
V
G
F
F
G
Site 161
S1802
F
R
V
G
F
F
G
S
K
F
G
D
L
D
E
Site 162
Y1814
L
D
E
Q
E
F
V
Y
K
E
P
A
I
T
K
Site 163
T1820
V
Y
K
E
P
A
I
T
K
L
P
E
I
S
H
Site 164
S1826
I
T
K
L
P
E
I
S
H
R
L
E
A
F
Y
Site 165
Y1833
S
H
R
L
E
A
F
Y
G
Q
C
F
G
A
E
Site 166
T1849
V
E
V
I
K
D
S
T
P
V
D
K
T
K
L
Site 167
T1866
N
K
A
Y
I
Q
I
T
F
V
E
P
Y
F
D
Site 168
Y1871
Q
I
T
F
V
E
P
Y
F
D
E
Y
E
M
K
Site 169
Y1875
V
E
P
Y
F
D
E
Y
E
M
K
D
R
V
T
Site 170
Y1883
E
M
K
D
R
V
T
Y
F
E
K
N
F
N
L
Site 171
Y1895
F
N
L
R
R
F
M
Y
T
T
P
F
T
L
E
Site 172
T1896
N
L
R
R
F
M
Y
T
T
P
F
T
L
E
G
Site 173
T1897
L
R
R
F
M
Y
T
T
P
F
T
L
E
G
R
Site 174
T1900
F
M
Y
T
T
P
F
T
L
E
G
R
P
R
G
Site 175
Y1913
R
G
E
L
H
E
Q
Y
R
R
N
T
V
L
T
Site 176
T1917
H
E
Q
Y
R
R
N
T
V
L
T
T
M
H
A
Site 177
T1920
Y
R
R
N
T
V
L
T
T
M
H
A
F
P
Y
Site 178
S1933
P
Y
I
K
T
R
I
S
V
I
Q
K
E
E
F
Site 179
T1956
I
E
D
M
K
K
K
T
L
Q
L
A
V
A
I
Site 180
T1984
L
Q
G
S
V
G
A
T
V
N
Q
G
P
L
E
Site 181
T2036
E
K
N
K
R
L
I
T
A
D
Q
R
E
Y
Q
Site 182
Y2042
I
T
A
D
Q
R
E
Y
Q
Q
E
L
K
K
N
Site 183
Y2050
Q
Q
E
L
K
K
N
Y
N
K
L
K
E
N
L
Site 184
Y2069
E
R
K
I
P
E
L
Y
K
P
I
F
R
V
E
Site 185
S2077
K
P
I
F
R
V
E
S
Q
K
R
D
S
F
H
Site 186
S2082
V
E
S
Q
K
R
D
S
F
H
R
S
S
F
R
Site 187
S2086
K
R
D
S
F
H
R
S
S
F
R
K
C
E
T
Site 188
S2087
R
D
S
F
H
R
S
S
F
R
K
C
E
T
Q
Site 189
T2093
S
S
F
R
K
C
E
T
Q
L
S
Q
G
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation