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Updated November 2019
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Protein Info
Short Name:
MLL3
Full Name:
Histone-lysine N-methyltransferase MLL3
Alias:
HALR; Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3; KIAA1506; KMT2C; Myeloid/lymphoid or mixed-lineage leukemia 3; Myeloid/lymphoid or mixed-lineage leukemia protein 3 homologue
Type:
Methyltransferase; EC 2.1.1.43
Mass (Da):
541370
Number AA:
4911
UniProt ID:
Q8NEZ4
International Prot ID:
IPI00168806
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
S
E
E
D
K
S
V
E
Q
P
Q
P
P
Site 2
S28
E
P
G
A
P
A
P
S
P
A
A
A
D
K
R
Site 3
S46
R
P
R
K
D
G
A
S
P
F
Q
R
A
R
K
Site 4
S57
R
A
R
K
K
P
R
S
R
G
K
T
A
V
E
Site 5
T61
K
P
R
S
R
G
K
T
A
V
E
D
E
D
S
Site 6
S68
T
A
V
E
D
E
D
S
M
D
G
L
E
T
T
Site 7
T77
D
G
L
E
T
T
E
T
E
T
I
V
E
T
E
Site 8
S89
E
T
E
I
K
E
Q
S
A
E
E
D
A
E
A
Site 9
S101
A
E
A
E
V
D
N
S
K
Q
L
I
P
T
L
Site 10
T107
N
S
K
Q
L
I
P
T
L
Q
R
S
V
S
E
Site 11
S111
L
I
P
T
L
Q
R
S
V
S
E
E
S
A
N
Site 12
S113
P
T
L
Q
R
S
V
S
E
E
S
A
N
S
L
Site 13
S116
Q
R
S
V
S
E
E
S
A
N
S
L
V
S
V
Site 14
S119
V
S
E
E
S
A
N
S
L
V
S
V
G
V
E
Site 15
Y138
E
Q
L
C
A
F
C
Y
C
G
E
K
S
S
L
Site 16
S144
C
Y
C
G
E
K
S
S
L
G
Q
G
D
L
K
Site 17
S177
K
K
D
I
D
D
N
S
N
G
T
Y
E
K
M
Site 18
Y181
D
D
N
S
N
G
T
Y
E
K
M
Q
N
S
A
Site 19
S187
T
Y
E
K
M
Q
N
S
A
P
R
K
Q
R
G
Site 20
S200
R
G
Q
R
K
E
R
S
P
Q
Q
N
I
V
S
Site 21
S207
S
P
Q
Q
N
I
V
S
C
V
S
V
S
T
Q
Site 22
S217
S
V
S
T
Q
T
A
S
D
D
Q
A
G
K
L
Site 23
S281
D
K
A
V
V
S
G
S
T
E
R
C
A
F
C
Site 24
Y306
E
E
K
C
T
Q
M
Y
H
Y
P
C
A
A
G
Site 25
S349
A
N
C
A
V
C
D
S
P
G
D
L
L
D
Q
Site 26
S401
C
K
Q
S
G
E
D
S
K
M
L
V
C
D
T
Site 27
T408
S
K
M
L
V
C
D
T
C
D
K
G
Y
H
T
Site 28
T506
P
T
D
H
E
L
D
T
Q
L
K
E
E
Y
I
Site 29
Y512
D
T
Q
L
K
E
E
Y
I
C
M
Y
C
K
H
Site 30
Y516
K
E
E
Y
I
C
M
Y
C
K
H
L
G
A
E
Site 31
Y542
I
A
E
L
T
T
D
Y
N
N
E
M
E
V
E
Site 32
T572
D
V
N
G
Q
E
S
T
P
G
I
V
P
D
A
Site 33
S590
H
T
E
E
Q
Q
K
S
H
P
S
E
S
L
D
Site 34
S595
Q
K
S
H
P
S
E
S
L
D
T
D
S
L
L
Site 35
T610
I
A
V
S
S
Q
H
T
V
N
T
E
L
E
K
Site 36
S620
T
E
L
E
K
Q
I
S
N
E
V
D
S
E
D
Site 37
S625
Q
I
S
N
E
V
D
S
E
D
L
K
M
S
S
Site 38
S631
D
S
E
D
L
K
M
S
S
E
V
K
H
I
C
Site 39
T675
Q
L
L
E
E
P
E
T
V
V
S
R
E
E
S
Site 40
S678
E
E
P
E
T
V
V
S
R
E
E
S
R
P
P
Site 41
S682
T
V
V
S
R
E
E
S
R
P
P
K
L
V
M
Site 42
S701
L
P
L
E
T
L
V
S
P
H
E
E
S
I
S
Site 43
S708
S
P
H
E
E
S
I
S
L
C
P
E
E
Q
L
Site 44
S730
E
K
E
Q
K
E
N
S
E
L
S
T
G
L
M
Site 45
T734
K
E
N
S
E
L
S
T
G
L
M
D
S
E
M
Site 46
S739
L
S
T
G
L
M
D
S
E
M
T
P
T
I
E
Site 47
T744
M
D
S
E
M
T
P
T
I
E
G
C
V
K
D
Site 48
S753
E
G
C
V
K
D
V
S
Y
Q
G
G
K
S
I
Site 49
Y754
G
C
V
K
D
V
S
Y
Q
G
G
K
S
I
K
Site 50
S759
V
S
Y
Q
G
G
K
S
I
K
L
S
S
E
T
Site 51
S763
G
G
K
S
I
K
L
S
S
E
T
E
S
S
F
Site 52
S764
G
K
S
I
K
L
S
S
E
T
E
S
S
F
S
Site 53
T766
S
I
K
L
S
S
E
T
E
S
S
F
S
S
S
Site 54
S768
K
L
S
S
E
T
E
S
S
F
S
S
S
A
D
Site 55
S769
L
S
S
E
T
E
S
S
F
S
S
S
A
D
I
Site 56
S771
S
E
T
E
S
S
F
S
S
S
A
D
I
S
K
Site 57
S772
E
T
E
S
S
F
S
S
S
A
D
I
S
K
A
Site 58
S773
T
E
S
S
F
S
S
S
A
D
I
S
K
A
D
Site 59
S777
F
S
S
S
A
D
I
S
K
A
D
V
S
S
S
Site 60
S782
D
I
S
K
A
D
V
S
S
S
P
T
P
S
S
Site 61
S783
I
S
K
A
D
V
S
S
S
P
T
P
S
S
D
Site 62
S784
S
K
A
D
V
S
S
S
P
T
P
S
S
D
L
Site 63
T786
A
D
V
S
S
S
P
T
P
S
S
D
L
P
S
Site 64
S788
V
S
S
S
P
T
P
S
S
D
L
P
S
H
D
Site 65
S789
S
S
S
P
T
P
S
S
D
L
P
S
H
D
M
Site 66
S793
T
P
S
S
D
L
P
S
H
D
M
L
H
N
Y
Site 67
Y800
S
H
D
M
L
H
N
Y
P
S
A
L
S
S
S
Site 68
S802
D
M
L
H
N
Y
P
S
A
L
S
S
S
A
G
Site 69
S805
H
N
Y
P
S
A
L
S
S
S
A
G
N
I
M
Site 70
S806
N
Y
P
S
A
L
S
S
S
A
G
N
I
M
P
Site 71
T820
P
T
T
Y
I
S
V
T
P
K
I
G
M
G
K
Site 72
T831
G
M
G
K
P
A
I
T
K
R
K
F
S
P
G
Site 73
S836
A
I
T
K
R
K
F
S
P
G
R
P
R
S
K
Site 74
S842
F
S
P
G
R
P
R
S
K
Q
G
A
W
S
T
Site 75
S848
R
S
K
Q
G
A
W
S
T
H
N
T
V
S
P
Site 76
T849
S
K
Q
G
A
W
S
T
H
N
T
V
S
P
P
Site 77
T852
G
A
W
S
T
H
N
T
V
S
P
P
S
W
S
Site 78
S854
W
S
T
H
N
T
V
S
P
P
S
W
S
P
D
Site 79
S857
H
N
T
V
S
P
P
S
W
S
P
D
I
S
E
Site 80
S859
T
V
S
P
P
S
W
S
P
D
I
S
E
G
R
Site 81
S863
P
S
W
S
P
D
I
S
E
G
R
E
I
F
K
Site 82
S877
K
P
R
Q
L
P
G
S
A
I
W
S
I
K
V
Site 83
S888
S
I
K
V
G
R
G
S
G
F
P
G
K
R
R
Site 84
S902
R
P
R
G
A
G
L
S
G
R
G
G
R
G
R
Site 85
S910
G
R
G
G
R
G
R
S
K
L
K
S
G
I
G
Site 86
T943
E
E
N
S
M
H
N
T
V
V
L
F
S
S
S
Site 87
T954
F
S
S
S
D
K
F
T
L
N
Q
D
M
C
V
Site 88
Y1035
C
D
I
S
Y
H
T
Y
C
L
D
P
P
L
Q
Site 89
T1043
C
L
D
P
P
L
Q
T
V
P
K
G
G
W
K
Site 90
Y1094
C
P
V
C
Y
R
N
Y
R
E
E
D
L
I
L
Site 91
Y1139
D
C
S
M
C
R
P
Y
M
P
A
S
N
V
P
Site 92
S1143
C
R
P
Y
M
P
A
S
N
V
P
S
S
D
C
Site 93
S1147
M
P
A
S
N
V
P
S
S
D
C
C
E
S
S
Site 94
S1148
P
A
S
N
V
P
S
S
D
C
C
E
S
S
L
Site 95
T1171
K
E
L
D
P
P
K
T
Y
T
Q
D
G
V
C
Site 96
Y1172
E
L
D
P
P
K
T
Y
T
Q
D
G
V
C
L
Site 97
T1180
T
Q
D
G
V
C
L
T
E
S
G
M
T
Q
L
Site 98
S1189
S
G
M
T
Q
L
Q
S
L
T
V
T
V
P
R
Site 99
T1191
M
T
Q
L
Q
S
L
T
V
T
V
P
R
R
K
Site 100
T1193
Q
L
Q
S
L
T
V
T
V
P
R
R
K
R
S
Site 101
S1200
T
V
P
R
R
K
R
S
K
P
K
L
K
L
K
Site 102
T1219
N
S
V
A
V
L
Q
T
P
P
D
I
Q
S
E
Site 103
S1225
Q
T
P
P
D
I
Q
S
E
H
S
R
D
G
E
Site 104
S1236
R
D
G
E
M
D
D
S
R
E
G
E
L
M
D
Site 105
S1248
L
M
D
C
D
G
K
S
E
S
S
P
E
R
E
Site 106
S1250
D
C
D
G
K
S
E
S
S
P
E
R
E
A
V
Site 107
S1251
C
D
G
K
S
E
S
S
P
E
R
E
A
V
D
Site 108
T1261
R
E
A
V
D
D
E
T
K
G
V
E
G
T
D
Site 109
Y1278
K
K
R
K
R
K
P
Y
R
P
G
I
G
G
F
Site 110
S1291
G
F
M
V
R
Q
R
S
R
T
G
Q
G
K
T
Site 111
T1293
M
V
R
Q
R
S
R
T
G
Q
G
K
T
K
R
Site 112
T1298
S
R
T
G
Q
G
K
T
K
R
S
V
I
R
K
Site 113
S1301
G
Q
G
K
T
K
R
S
V
I
R
K
D
S
S
Site 114
S1307
R
S
V
I
R
K
D
S
S
G
S
I
S
E
Q
Site 115
S1308
S
V
I
R
K
D
S
S
G
S
I
S
E
Q
L
Site 116
S1310
I
R
K
D
S
S
G
S
I
S
E
Q
L
P
C
Site 117
S1312
K
D
S
S
G
S
I
S
E
Q
L
P
C
R
D
Site 118
S1323
P
C
R
D
D
G
W
S
E
Q
L
P
D
T
L
Site 119
T1329
W
S
E
Q
L
P
D
T
L
V
D
E
S
V
S
Site 120
S1334
P
D
T
L
V
D
E
S
V
S
V
T
E
S
T
Site 121
S1336
T
L
V
D
E
S
V
S
V
T
E
S
T
E
K
Site 122
T1338
V
D
E
S
V
S
V
T
E
S
T
E
K
I
K
Site 123
S1340
E
S
V
S
V
T
E
S
T
E
K
I
K
K
R
Site 124
T1358
R
K
N
K
L
E
E
T
F
P
A
Y
L
Q
E
Site 125
T1375
F
G
K
D
L
L
D
T
S
R
Q
S
K
I
S
Site 126
S1376
G
K
D
L
L
D
T
S
R
Q
S
K
I
S
L
Site 127
S1379
L
L
D
T
S
R
Q
S
K
I
S
L
D
N
L
Site 128
S1382
T
S
R
Q
S
K
I
S
L
D
N
L
S
E
D
Site 129
S1387
K
I
S
L
D
N
L
S
E
D
G
A
Q
L
L
Site 130
Y1395
E
D
G
A
Q
L
L
Y
K
T
N
M
N
T
G
Site 131
S1407
N
T
G
F
L
D
P
S
L
D
P
L
L
S
S
Site 132
S1413
P
S
L
D
P
L
L
S
S
S
S
A
P
T
K
Site 133
S1414
S
L
D
P
L
L
S
S
S
S
A
P
T
K
S
Site 134
S1415
L
D
P
L
L
S
S
S
S
A
P
T
K
S
G
Site 135
S1416
D
P
L
L
S
S
S
S
A
P
T
K
S
G
T
Site 136
T1419
L
S
S
S
S
A
P
T
K
S
G
T
H
G
P
Site 137
S1421
S
S
S
A
P
T
K
S
G
T
H
G
P
A
D
Site 138
S1455
I
S
D
D
L
A
K
S
V
D
H
S
D
I
G
Site 139
S1459
L
A
K
S
V
D
H
S
D
I
G
P
V
T
D
Site 140
T1465
H
S
D
I
G
P
V
T
D
D
P
S
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Y3582
T
I
T
H
G
H
S
Y
P
G
S
T
Q
S
L
Site 445
S3585
H
G
H
S
Y
P
G
S
T
Q
S
L
I
Q
L
Site 446
S3588
S
Y
P
G
S
T
Q
S
L
I
Q
L
Y
S
D
Site 447
Y3593
T
Q
S
L
I
Q
L
Y
S
D
I
I
P
E
E
Site 448
S3594
Q
S
L
I
Q
L
Y
S
D
I
I
P
E
E
K
Site 449
S3618
K
R
D
D
D
A
E
S
T
K
A
P
S
T
P
Site 450
T3619
R
D
D
D
A
E
S
T
K
A
P
S
T
P
H
Site 451
S3623
A
E
S
T
K
A
P
S
T
P
H
S
D
I
T
Site 452
T3624
E
S
T
K
A
P
S
T
P
H
S
D
I
T
A
Site 453
S3627
K
A
P
S
T
P
H
S
D
I
T
A
P
P
T
Site 454
T3630
S
T
P
H
S
D
I
T
A
P
P
T
P
G
I
Site 455
T3634
S
D
I
T
A
P
P
T
P
G
I
S
E
T
T
Site 456
S3638
A
P
P
T
P
G
I
S
E
T
T
S
T
P
A
Site 457
S3642
P
G
I
S
E
T
T
S
T
P
A
V
S
T
P
Site 458
T3643
G
I
S
E
T
T
S
T
P
A
V
S
T
P
S
Site 459
S3647
T
T
S
T
P
A
V
S
T
P
S
E
L
P
Q
Site 460
T3648
T
S
T
P
A
V
S
T
P
S
E
L
P
Q
Q
Site 461
S3650
T
P
A
V
S
T
P
S
E
L
P
Q
Q
A
D
Site 462
S3660
P
Q
Q
A
D
Q
E
S
V
E
P
V
G
P
S
Site 463
T3668
V
E
P
V
G
P
S
T
P
N
M
A
A
G
Q
Site 464
S3687
L
E
N
K
L
P
N
S
D
F
S
Q
A
T
P
Site 465
S3690
K
L
P
N
S
D
F
S
Q
A
T
P
N
Q
Q
Site 466
T3693
N
S
D
F
S
Q
A
T
P
N
Q
Q
T
Y
A
Site 467
S3702
N
Q
Q
T
Y
A
N
S
E
V
D
K
L
S
M
Site 468
S3708
N
S
E
V
D
K
L
S
M
E
T
P
A
K
T
Site 469
T3711
V
D
K
L
S
M
E
T
P
A
K
T
E
E
I
Site 470
T3715
S
M
E
T
P
A
K
T
E
E
I
K
L
E
K
Site 471
T3725
I
K
L
E
K
A
E
T
E
S
C
P
G
Q
E
Site 472
S3742
K
L
E
E
Q
N
G
S
K
V
E
G
N
A
V
Site 473
S3754
N
A
V
A
C
P
V
S
S
A
Q
S
P
P
H
Site 474
S3755
A
V
A
C
P
V
S
S
A
Q
S
P
P
H
S
Site 475
S3758
C
P
V
S
S
A
Q
S
P
P
H
S
A
G
A
Site 476
S3762
S
A
Q
S
P
P
H
S
A
G
A
P
A
A
K
Site 477
S3772
A
P
A
A
K
G
D
S
G
N
E
L
L
K
H
Site 478
S3786
H
L
L
K
N
K
K
S
S
S
L
L
N
Q
K
Site 479
S3788
L
K
N
K
K
S
S
S
L
L
N
Q
K
P
E
Site 480
S3800
K
P
E
G
S
I
C
S
E
D
D
C
T
K
D
Site 481
T3805
I
C
S
E
D
D
C
T
K
D
N
K
L
V
E
Site 482
T3822
N
P
A
E
G
L
Q
T
L
G
A
Q
M
Q
G
Site 483
T3840
C
G
N
Q
L
P
K
T
D
G
G
S
E
T
K
Site 484
S3851
S
E
T
K
K
Q
R
S
K
R
T
Q
R
T
G
Site 485
S3865
G
E
K
A
A
P
R
S
K
K
R
K
K
D
E
Site 486
S3881
E
K
Q
A
M
Y
S
S
T
D
T
F
T
H
L
Site 487
T3884
A
M
Y
S
S
T
D
T
F
T
H
L
K
Q
Q
Site 488
S3895
L
K
Q
Q
N
N
L
S
N
P
P
T
P
P
A
Site 489
T3899
N
N
L
S
N
P
P
T
P
P
A
S
L
P
P
Site 490
S3903
N
P
P
T
P
P
A
S
L
P
P
T
P
P
P
Site 491
T3907
P
P
A
S
L
P
P
T
P
P
P
M
A
C
Q
Site 492
T3939
V
L
V
S
H
E
V
T
K
T
L
G
P
K
P
Site 493
T3941
V
S
H
E
V
T
K
T
L
G
P
K
P
F
Q
Site 494
S3974
K
T
V
D
V
P
A
S
L
P
T
P
P
H
N
Site 495
T3977
D
V
P
A
S
L
P
T
P
P
H
N
N
Q
E
Site 496
T3997
D
H
C
G
D
R
D
T
P
D
S
F
V
P
S
Site 497
S4000
G
D
R
D
T
P
D
S
F
V
P
S
S
S
P
Site 498
S4004
T
P
D
S
F
V
P
S
S
S
P
E
S
V
V
Site 499
S4005
P
D
S
F
V
P
S
S
S
P
E
S
V
V
G
Site 500
Y4018
V
G
V
E
V
S
R
Y
P
D
L
S
L
V
K
Site 501
S4022
V
S
R
Y
P
D
L
S
L
V
K
E
E
P
P
Site 502
S4034
E
P
P
E
P
V
P
S
P
I
I
P
I
L
P
Site 503
S4048
P
S
T
A
G
K
S
S
E
S
R
R
N
D
I
Site 504
S4050
T
A
G
K
S
S
E
S
R
R
N
D
I
K
T
Site 505
T4057
S
R
R
N
D
I
K
T
E
P
G
T
L
Y
F
Site 506
T4061
D
I
K
T
E
P
G
T
L
Y
F
A
S
P
F
Site 507
Y4063
K
T
E
P
G
T
L
Y
F
A
S
P
F
G
P
Site 508
S4066
P
G
T
L
Y
F
A
S
P
F
G
P
S
P
N
Site 509
S4071
F
A
S
P
F
G
P
S
P
N
G
P
R
S
G
Site 510
S4077
P
S
P
N
G
P
R
S
G
L
I
S
V
A
I
Site 511
S4112
L
H
V
R
I
P
N
S
Y
E
V
S
S
A
P
Site 512
Y4113
H
V
R
I
P
N
S
Y
E
V
S
S
A
P
D
Site 513
S4116
I
P
N
S
Y
E
V
S
S
A
P
D
V
P
S
Site 514
S4117
P
N
S
Y
E
V
S
S
A
P
D
V
P
S
M
Site 515
S4123
S
S
A
P
D
V
P
S
M
G
L
V
S
S
H
Site 516
S4129
P
S
M
G
L
V
S
S
H
R
I
N
P
G
L
Site 517
S4151
L
R
G
P
P
P
G
S
A
N
P
P
R
L
V
Site 518
S4159
A
N
P
P
R
L
V
S
S
Y
R
L
K
Q
P
Site 519
S4160
N
P
P
R
L
V
S
S
Y
R
L
K
Q
P
N
Site 520
Y4161
P
P
R
L
V
S
S
Y
R
L
K
Q
P
N
V
Site 521
T4173
P
N
V
P
F
P
P
T
S
N
G
L
S
G
Y
Site 522
S4174
N
V
P
F
P
P
T
S
N
G
L
S
G
Y
K
Site 523
S4178
P
P
T
S
N
G
L
S
G
Y
K
D
S
S
H
Site 524
Y4180
T
S
N
G
L
S
G
Y
K
D
S
S
H
G
I
Site 525
S4183
G
L
S
G
Y
K
D
S
S
H
G
I
A
E
S
Site 526
S4184
L
S
G
Y
K
D
S
S
H
G
I
A
E
S
A
Site 527
S4190
S
S
H
G
I
A
E
S
A
A
L
R
P
Q
W
Site 528
T4218
R
K
S
F
K
D
L
T
L
L
N
K
D
S
R
Site 529
S4224
L
T
L
L
N
K
D
S
R
E
S
T
K
R
V
Site 530
S4227
L
N
K
D
S
R
E
S
T
K
R
V
E
K
D
Site 531
T4228
N
K
D
S
R
E
S
T
K
R
V
E
K
D
I
Site 532
Y4246
S
N
N
C
F
I
L
Y
S
S
T
A
Q
A
K
Site 533
S4255
S
T
A
Q
A
K
N
S
E
N
K
E
S
I
P
Site 534
S4260
K
N
S
E
N
K
E
S
I
P
S
L
P
Q
S
Site 535
S4263
E
N
K
E
S
I
P
S
L
P
Q
S
P
M
R
Site 536
S4267
S
I
P
S
L
P
Q
S
P
M
R
E
T
P
S
Site 537
T4272
P
Q
S
P
M
R
E
T
P
S
K
A
F
H
Q
Site 538
S4274
S
P
M
R
E
T
P
S
K
A
F
H
Q
Y
S
Site 539
Y4280
P
S
K
A
F
H
Q
Y
S
N
N
I
S
T
L
Site 540
S4281
S
K
A
F
H
Q
Y
S
N
N
I
S
T
L
D
Site 541
S4300
P
Q
L
P
E
K
A
S
P
P
A
S
P
P
I
Site 542
S4304
E
K
A
S
P
P
A
S
P
P
I
A
F
P
P
Site 543
T4328
K
P
D
E
L
K
V
T
V
K
L
K
P
R
L
Site 544
T4370
H
I
V
I
P
K
G
T
F
K
P
P
C
E
D
Site 545
T4388
E
F
L
K
K
L
G
T
S
L
K
P
D
P
V
Site 546
T4413
H
E
E
G
D
G
L
T
D
G
P
A
R
L
L
Site 547
T4442
W
S
T
E
V
Y
E
T
Q
A
G
A
L
I
N
Site 548
S4517
G
I
H
E
Q
E
L
S
Y
F
A
V
F
R
R
Site 549
Y4518
I
H
E
Q
E
L
S
Y
F
A
V
F
R
R
V
Site 550
Y4526
F
A
V
F
R
R
V
Y
V
Q
R
D
E
V
R
Site 551
T4547
Q
R
G
E
R
D
H
T
F
R
V
G
S
L
I
Site 552
S4571
Q
Q
M
Q
A
F
H
S
P
K
A
L
F
P
V
Site 553
Y4580
K
A
L
F
P
V
G
Y
E
A
S
R
L
Y
W
Site 554
S4583
F
P
V
G
Y
E
A
S
R
L
Y
W
S
T
R
Site 555
Y4586
G
Y
E
A
S
R
L
Y
W
S
T
R
Y
A
N
Site 556
S4588
E
A
S
R
L
Y
W
S
T
R
Y
A
N
R
R
Site 557
T4589
A
S
R
L
Y
W
S
T
R
Y
A
N
R
R
C
Site 558
Y4591
R
L
Y
W
S
T
R
Y
A
N
R
R
C
R
Y
Site 559
Y4598
Y
A
N
R
R
C
R
Y
L
C
S
I
E
E
K
Site 560
S4601
R
R
C
R
Y
L
C
S
I
E
E
K
D
G
R
Site 561
S4626
G
H
E
D
L
V
L
S
D
I
S
P
K
G
V
Site 562
S4629
D
L
V
L
S
D
I
S
P
K
G
V
W
D
K
Site 563
Y4687
G
V
E
A
C
E
N
Y
T
F
R
Y
G
R
N
Site 564
Y4691
C
E
N
Y
T
F
R
Y
G
R
N
P
L
M
E
Site 565
S4711
N
P
T
G
C
A
R
S
E
P
K
M
S
A
H
Site 566
S4716
A
R
S
E
P
K
M
S
A
H
V
K
R
F
V
Site 567
T4728
R
F
V
L
R
P
H
T
L
N
S
T
S
T
S
Site 568
S4731
L
R
P
H
T
L
N
S
T
S
T
S
K
S
F
Site 569
T4732
R
P
H
T
L
N
S
T
S
T
S
K
S
F
Q
Site 570
S4733
P
H
T
L
N
S
T
S
T
S
K
S
F
Q
S
Site 571
S4735
T
L
N
S
T
S
T
S
K
S
F
Q
S
T
V
Site 572
S4737
N
S
T
S
T
S
K
S
F
Q
S
T
V
T
G
Site 573
T4741
T
S
K
S
F
Q
S
T
V
T
G
E
L
N
A
Site 574
Y4750
T
G
E
L
N
A
P
Y
S
K
Q
F
V
H
S
Site 575
S4751
G
E
L
N
A
P
Y
S
K
Q
F
V
H
S
K
Site 576
S4757
Y
S
K
Q
F
V
H
S
K
S
S
Q
Y
R
K
Site 577
S4759
K
Q
F
V
H
S
K
S
S
Q
Y
R
K
M
K
Site 578
S4760
Q
F
V
H
S
K
S
S
Q
Y
R
K
M
K
T
Site 579
T4767
S
Q
Y
R
K
M
K
T
E
W
K
S
N
V
Y
Site 580
S4771
K
M
K
T
E
W
K
S
N
V
Y
L
A
R
S
Site 581
Y4774
T
E
W
K
S
N
V
Y
L
A
R
S
R
I
Q
Site 582
Y4786
R
I
Q
G
L
G
L
Y
A
A
R
D
I
E
K
Site 583
Y4817
A
N
R
K
E
K
L
Y
E
S
Q
N
R
G
V
Site 584
S4819
R
K
E
K
L
Y
E
S
Q
N
R
G
V
Y
M
Site 585
Y4825
E
S
Q
N
R
G
V
Y
M
F
R
M
D
N
D
Site 586
T4838
N
D
H
V
I
D
A
T
L
T
G
G
P
A
R
Site 587
Y4846
L
T
G
G
P
A
R
Y
I
N
H
S
C
A
P
Site 588
S4871
R
G
H
K
I
I
I
S
S
S
R
R
I
Q
K
Site 589
S4872
G
H
K
I
I
I
S
S
S
R
R
I
Q
K
G
Site 590
S4873
H
K
I
I
I
S
S
S
R
R
I
Q
K
G
E
Site 591
Y4884
Q
K
G
E
E
L
C
Y
D
Y
K
F
D
F
E
Site 592
Y4886
G
E
E
L
C
Y
D
Y
K
F
D
F
E
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation