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Updated November 2019
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Protein Info
Short Name:
NAV1
Full Name:
Neuron navigator 1
Alias:
Pore membrane and/or filament-interacting-like protein 3;Steerin-1;Unc-53 homolog 1
Type:
Mass (Da):
202472
Number AA:
1877
UniProt ID:
Q8NEY1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
V
Q
P
E
V
E
L
S
S
G
G
G
D
E
G
Site 2
S60
G
G
G
M
A
K
A
S
A
A
E
L
K
V
F
Site 3
S69
A
E
L
K
V
F
K
S
G
S
V
D
S
R
V
Site 4
S71
L
K
V
F
K
S
G
S
V
D
S
R
V
P
G
Site 5
S74
F
K
S
G
S
V
D
S
R
V
P
G
G
P
P
Site 6
S83
V
P
G
G
P
P
A
S
N
L
R
K
Q
K
S
Site 7
S90
S
N
L
R
K
Q
K
S
L
T
N
L
S
F
L
Site 8
T92
L
R
K
Q
K
S
L
T
N
L
S
F
L
T
D
Site 9
S95
Q
K
S
L
T
N
L
S
F
L
T
D
S
E
K
Site 10
S100
N
L
S
F
L
T
D
S
E
K
K
L
Q
L
Y
Site 11
Y107
S
E
K
K
L
Q
L
Y
E
P
E
W
S
D
D
Site 12
S112
Q
L
Y
E
P
E
W
S
D
D
M
A
K
A
P
Site 13
S127
K
G
L
G
K
V
G
S
K
G
R
E
A
P
L
Site 14
S136
G
R
E
A
P
L
M
S
K
T
L
S
K
S
E
Site 15
T138
E
A
P
L
M
S
K
T
L
S
K
S
E
H
S
Site 16
S140
P
L
M
S
K
T
L
S
K
S
E
H
S
L
F
Site 17
S142
M
S
K
T
L
S
K
S
E
H
S
L
F
Q
A
Site 18
S152
S
L
F
Q
A
K
G
S
P
A
G
G
A
K
T
Site 19
T159
S
P
A
G
G
A
K
T
P
L
A
P
L
A
P
Site 20
S172
A
P
N
L
G
K
P
S
R
I
P
R
G
P
Y
Site 21
Y179
S
R
I
P
R
G
P
Y
A
E
V
K
P
L
S
Site 22
S186
Y
A
E
V
K
P
L
S
K
A
P
E
A
A
V
Site 23
S194
K
A
P
E
A
A
V
S
E
D
G
K
S
D
D
Site 24
S199
A
V
S
E
D
G
K
S
D
D
E
L
L
S
S
Site 25
S205
K
S
D
D
E
L
L
S
S
K
A
K
A
Q
K
Site 26
S206
S
D
D
E
L
L
S
S
K
A
K
A
Q
K
S
Site 27
S213
S
K
A
K
A
Q
K
S
S
G
P
V
P
S
A
Site 28
S219
K
S
S
G
P
V
P
S
A
K
G
Q
E
E
R
Site 29
S249
D
L
E
Q
L
L
F
S
Q
M
L
D
P
E
S
Site 30
S256
S
Q
M
L
D
P
E
S
Q
R
K
R
T
V
Q
Site 31
T261
P
E
S
Q
R
K
R
T
V
Q
N
V
L
D
L
Site 32
S277
Q
N
L
E
E
T
M
S
S
L
R
G
S
Q
V
Site 33
S278
N
L
E
E
T
M
S
S
L
R
G
S
Q
V
T
Site 34
S282
T
M
S
S
L
R
G
S
Q
V
T
H
S
S
L
Site 35
T285
S
L
R
G
S
Q
V
T
H
S
S
L
E
M
T
Site 36
S287
R
G
S
Q
V
T
H
S
S
L
E
M
T
C
Y
Site 37
S288
G
S
Q
V
T
H
S
S
L
E
M
T
C
Y
D
Site 38
T292
T
H
S
S
L
E
M
T
C
Y
D
S
D
D
A
Site 39
Y294
S
S
L
E
M
T
C
Y
D
S
D
D
A
N
P
Site 40
S296
L
E
M
T
C
Y
D
S
D
D
A
N
P
R
S
Site 41
S303
S
D
D
A
N
P
R
S
V
S
S
L
S
N
R
Site 42
S305
D
A
N
P
R
S
V
S
S
L
S
N
R
S
S
Site 43
S306
A
N
P
R
S
V
S
S
L
S
N
R
S
S
P
Site 44
S308
P
R
S
V
S
S
L
S
N
R
S
S
P
L
S
Site 45
S311
V
S
S
L
S
N
R
S
S
P
L
S
W
R
Y
Site 46
S312
S
S
L
S
N
R
S
S
P
L
S
W
R
Y
G
Site 47
S315
S
N
R
S
S
P
L
S
W
R
Y
G
Q
S
S
Site 48
Y318
S
S
P
L
S
W
R
Y
G
Q
S
S
P
R
L
Site 49
S321
L
S
W
R
Y
G
Q
S
S
P
R
L
Q
A
G
Site 50
S322
S
W
R
Y
G
Q
S
S
P
R
L
Q
A
G
D
Site 51
S332
L
Q
A
G
D
A
P
S
V
G
G
S
C
R
S
Site 52
S336
D
A
P
S
V
G
G
S
C
R
S
E
G
T
P
Site 53
S339
S
V
G
G
S
C
R
S
E
G
T
P
A
W
Y
Site 54
Y346
S
E
G
T
P
A
W
Y
M
H
G
E
R
A
H
Site 55
Y354
M
H
G
E
R
A
H
Y
S
H
T
M
P
M
R
Site 56
T357
E
R
A
H
Y
S
H
T
M
P
M
R
S
P
S
Site 57
S362
S
H
T
M
P
M
R
S
P
S
K
L
S
H
I
Site 58
S364
T
M
P
M
R
S
P
S
K
L
S
H
I
S
R
Site 59
S367
M
R
S
P
S
K
L
S
H
I
S
R
L
E
L
Site 60
S377
S
R
L
E
L
V
E
S
L
D
S
D
E
V
D
Site 61
S380
E
L
V
E
S
L
D
S
D
E
V
D
L
K
S
Site 62
S387
S
D
E
V
D
L
K
S
G
Y
M
S
D
S
D
Site 63
Y389
E
V
D
L
K
S
G
Y
M
S
D
S
D
L
M
Site 64
S391
D
L
K
S
G
Y
M
S
D
S
D
L
M
G
K
Site 65
S393
K
S
G
Y
M
S
D
S
D
L
M
G
K
T
M
Site 66
T407
M
T
E
D
D
D
I
T
T
G
W
D
E
S
S
Site 67
T408
T
E
D
D
D
I
T
T
G
W
D
E
S
S
S
Site 68
S413
I
T
T
G
W
D
E
S
S
S
I
S
S
G
L
Site 69
S414
T
T
G
W
D
E
S
S
S
I
S
S
G
L
S
Site 70
S415
T
G
W
D
E
S
S
S
I
S
S
G
L
S
D
Site 71
S417
W
D
E
S
S
S
I
S
S
G
L
S
D
A
S
Site 72
S418
D
E
S
S
S
I
S
S
G
L
S
D
A
S
D
Site 73
S421
S
S
I
S
S
G
L
S
D
A
S
D
N
L
S
Site 74
S424
S
S
G
L
S
D
A
S
D
N
L
S
S
E
E
Site 75
S428
S
D
A
S
D
N
L
S
S
E
E
F
N
A
S
Site 76
S429
D
A
S
D
N
L
S
S
E
E
F
N
A
S
S
Site 77
S435
S
S
E
E
F
N
A
S
S
S
L
N
S
L
P
Site 78
S436
S
E
E
F
N
A
S
S
S
L
N
S
L
P
S
Site 79
S437
E
E
F
N
A
S
S
S
L
N
S
L
P
S
T
Site 80
S440
N
A
S
S
S
L
N
S
L
P
S
T
P
T
A
Site 81
S443
S
S
L
N
S
L
P
S
T
P
T
A
S
R
R
Site 82
T444
S
L
N
S
L
P
S
T
P
T
A
S
R
R
N
Site 83
T446
N
S
L
P
S
T
P
T
A
S
R
R
N
S
T
Site 84
S448
L
P
S
T
P
T
A
S
R
R
N
S
T
I
V
Site 85
S452
P
T
A
S
R
R
N
S
T
I
V
L
R
T
D
Site 86
T453
T
A
S
R
R
N
S
T
I
V
L
R
T
D
S
Site 87
S460
T
I
V
L
R
T
D
S
E
K
R
S
L
A
E
Site 88
S464
R
T
D
S
E
K
R
S
L
A
E
S
G
L
S
Site 89
S468
E
K
R
S
L
A
E
S
G
L
S
W
F
S
E
Site 90
S471
S
L
A
E
S
G
L
S
W
F
S
E
S
E
E
Site 91
S474
E
S
G
L
S
W
F
S
E
S
E
E
K
A
P
Site 92
S476
G
L
S
W
F
S
E
S
E
E
K
A
P
K
K
Site 93
Y486
K
A
P
K
K
L
E
Y
D
S
G
S
L
K
M
Site 94
S488
P
K
K
L
E
Y
D
S
G
S
L
K
M
E
P
Site 95
S490
K
L
E
Y
D
S
G
S
L
K
M
E
P
G
T
Site 96
T497
S
L
K
M
E
P
G
T
S
K
W
R
R
E
R
Site 97
S498
L
K
M
E
P
G
T
S
K
W
R
R
E
R
P
Site 98
S507
W
R
R
E
R
P
E
S
C
D
D
S
S
K
G
Site 99
S511
R
P
E
S
C
D
D
S
S
K
G
G
E
L
K
Site 100
S512
P
E
S
C
D
D
S
S
K
G
G
E
L
K
K
Site 101
S522
G
E
L
K
K
P
I
S
L
G
H
P
G
S
L
Site 102
S528
I
S
L
G
H
P
G
S
L
K
K
G
K
T
P
Site 103
T534
G
S
L
K
K
G
K
T
P
P
V
A
V
T
S
Site 104
T540
K
T
P
P
V
A
V
T
S
P
I
T
H
T
A
Site 105
S541
T
P
P
V
A
V
T
S
P
I
T
H
T
A
Q
Site 106
T562
G
K
P
E
G
K
A
T
D
K
G
K
L
A
V
Site 107
T572
G
K
L
A
V
K
N
T
G
L
Q
R
S
S
S
Site 108
S577
K
N
T
G
L
Q
R
S
S
S
D
A
G
R
D
Site 109
S578
N
T
G
L
Q
R
S
S
S
D
A
G
R
D
R
Site 110
S579
T
G
L
Q
R
S
S
S
D
A
G
R
D
R
L
Site 111
S587
D
A
G
R
D
R
L
S
D
A
K
K
P
P
S
Site 112
S594
S
D
A
K
K
P
P
S
G
I
A
R
P
S
T
Site 113
S600
P
S
G
I
A
R
P
S
T
S
G
S
F
G
Y
Site 114
T601
S
G
I
A
R
P
S
T
S
G
S
F
G
Y
K
Site 115
S602
G
I
A
R
P
S
T
S
G
S
F
G
Y
K
K
Site 116
S604
A
R
P
S
T
S
G
S
F
G
Y
K
K
P
P
Site 117
Y607
S
T
S
G
S
F
G
Y
K
K
P
P
P
A
T
Site 118
T618
P
P
A
T
G
T
A
T
V
M
Q
T
G
G
S
Site 119
S625
T
V
M
Q
T
G
G
S
A
T
L
S
K
I
Q
Site 120
S629
T
G
G
S
A
T
L
S
K
I
Q
K
S
S
G
Site 121
T647
K
P
V
N
G
R
K
T
S
L
D
V
S
N
S
Site 122
S648
P
V
N
G
R
K
T
S
L
D
V
S
N
S
A
Site 123
S652
R
K
T
S
L
D
V
S
N
S
A
E
P
G
F
Site 124
S654
T
S
L
D
V
S
N
S
A
E
P
G
F
L
A
Site 125
Y670
G
A
R
S
N
I
Q
Y
R
S
L
P
R
P
A
Site 126
S672
R
S
N
I
Q
Y
R
S
L
P
R
P
A
K
S
Site 127
S679
S
L
P
R
P
A
K
S
S
S
M
S
V
T
G
Site 128
S680
L
P
R
P
A
K
S
S
S
M
S
V
T
G
G
Site 129
S681
P
R
P
A
K
S
S
S
M
S
V
T
G
G
R
Site 130
S683
P
A
K
S
S
S
M
S
V
T
G
G
R
G
G
Site 131
T685
K
S
S
S
M
S
V
T
G
G
R
G
G
P
R
Site 132
S695
R
G
G
P
R
P
V
S
S
S
I
D
P
S
L
Site 133
S696
G
G
P
R
P
V
S
S
S
I
D
P
S
L
L
Site 134
S697
G
P
R
P
V
S
S
S
I
D
P
S
L
L
S
Site 135
S701
V
S
S
S
I
D
P
S
L
L
S
T
K
Q
G
Site 136
S704
S
I
D
P
S
L
L
S
T
K
Q
G
G
L
T
Site 137
T705
I
D
P
S
L
L
S
T
K
Q
G
G
L
T
P
Site 138
T711
S
T
K
Q
G
G
L
T
P
S
R
L
K
E
P
Site 139
S713
K
Q
G
G
L
T
P
S
R
L
K
E
P
T
K
Site 140
T719
P
S
R
L
K
E
P
T
K
V
A
S
G
R
T
Site 141
S723
K
E
P
T
K
V
A
S
G
R
T
T
P
A
P
Site 142
T726
T
K
V
A
S
G
R
T
T
P
A
P
V
N
Q
Site 143
T727
K
V
A
S
G
R
T
T
P
A
P
V
N
Q
T
Site 144
T734
T
P
A
P
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Y
I
S
L
L
L
K
H
Site 297
S1557
K
H
R
R
L
V
L
S
G
P
S
G
T
G
K
Site 298
Y1566
P
S
G
T
G
K
T
Y
L
T
N
R
L
A
E
Site 299
T1568
G
T
G
K
T
Y
L
T
N
R
L
A
E
Y
L
Site 300
Y1574
L
T
N
R
L
A
E
Y
L
V
E
R
S
G
R
Site 301
S1579
A
E
Y
L
V
E
R
S
G
R
E
V
T
E
G
Site 302
T1584
E
R
S
G
R
E
V
T
E
G
I
V
S
T
F
Site 303
T1590
V
T
E
G
I
V
S
T
F
N
M
H
Q
Q
S
Site 304
Y1604
S
C
K
D
L
Q
L
Y
L
S
N
L
A
N
Q
Site 305
S1606
K
D
L
Q
L
Y
L
S
N
L
A
N
Q
I
D
Site 306
T1616
A
N
Q
I
D
R
E
T
G
I
G
D
V
P
L
Site 307
S1635
D
D
L
S
E
A
G
S
I
S
E
L
V
N
G
Site 308
Y1648
N
G
A
L
T
C
K
Y
H
K
C
P
Y
I
I
Site 309
T1665
T
N
Q
P
V
K
M
T
P
N
H
G
L
H
L
Site 310
S1673
P
N
H
G
L
H
L
S
F
R
M
L
T
F
S
Site 311
T1678
H
L
S
F
R
M
L
T
F
S
N
N
V
E
P
Site 312
S1680
S
F
R
M
L
T
F
S
N
N
V
E
P
A
N
Site 313
Y1693
A
N
G
F
L
V
R
Y
L
R
R
K
L
V
E
Site 314
S1701
L
R
R
K
L
V
E
S
D
S
D
I
N
A
N
Site 315
S1703
R
K
L
V
E
S
D
S
D
I
N
A
N
K
E
Site 316
T1728
K
L
W
Y
H
L
H
T
F
L
E
K
H
S
T
Site 317
S1734
H
T
F
L
E
K
H
S
T
S
D
F
L
I
G
Site 318
T1735
T
F
L
E
K
H
S
T
S
D
F
L
I
G
P
Site 319
Y1770
W
N
N
S
I
I
P
Y
L
Q
E
G
A
K
D
Site 320
T1798
P
V
E
W
V
R
D
T
L
P
W
P
S
A
Q
Site 321
S1803
R
D
T
L
P
W
P
S
A
Q
Q
D
Q
S
K
Site 322
S1809
P
S
A
Q
Q
D
Q
S
K
L
Y
H
L
P
P
Site 323
Y1812
Q
Q
D
Q
S
K
L
Y
H
L
P
P
P
T
V
Site 324
T1818
L
Y
H
L
P
P
P
T
V
G
P
H
S
I
A
Site 325
S1823
P
P
T
V
G
P
H
S
I
A
S
P
P
E
D
Site 326
S1826
V
G
P
H
S
I
A
S
P
P
E
D
R
T
V
Site 327
T1832
A
S
P
P
E
D
R
T
V
K
D
S
T
P
S
Site 328
S1836
E
D
R
T
V
K
D
S
T
P
S
S
L
D
S
Site 329
T1837
D
R
T
V
K
D
S
T
P
S
S
L
D
S
D
Site 330
S1839
T
V
K
D
S
T
P
S
S
L
D
S
D
P
L
Site 331
S1840
V
K
D
S
T
P
S
S
L
D
S
D
P
L
M
Site 332
S1843
S
T
P
S
S
L
D
S
D
P
L
M
A
M
L
Site 333
Y1859
K
L
Q
E
A
A
N
Y
I
E
S
P
D
R
E
Site 334
S1862
E
A
A
N
Y
I
E
S
P
D
R
E
T
I
L
Site 335
T1867
I
E
S
P
D
R
E
T
I
L
D
P
N
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation