KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EXPH5
Full Name:
Exophilin-5
Alias:
Exophilin 5; KIAA0624; SL2B; SLAC2B; SLAC2-B; SLC2B; Slp homolog lacking C2 domains-b; Synaptotagmin-likeue lacking C2 domains b
Type:
GTPase activating protein, Rab
Mass (Da):
222646
Number AA:
1989
UniProt ID:
Q8NEV8
International Prot ID:
IPI00335771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0017137
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
V
P
P
A
F
D
F
S
F
L
N
D
E
E
A
Site 2
S40
R
A
E
K
D
R
I
S
K
L
Q
K
T
K
R
Site 3
T45
R
I
S
K
L
Q
K
T
K
R
D
I
R
W
L
Site 4
T83
Q
M
L
K
Q
P
L
T
Y
R
L
S
K
E
M
Site 5
S87
Q
P
L
T
Y
R
L
S
K
E
M
A
K
N
D
Site 6
S101
D
P
I
E
L
P
T
S
R
S
K
N
V
T
N
Site 7
S103
I
E
L
P
T
S
R
S
K
N
V
T
N
Q
K
Site 8
T107
T
S
R
S
K
N
V
T
N
Q
K
K
P
T
P
Site 9
T113
V
T
N
Q
K
K
P
T
P
F
S
S
R
M
S
Site 10
S116
Q
K
K
P
T
P
F
S
S
R
M
S
F
R
S
Site 11
S117
K
K
P
T
P
F
S
S
R
M
S
F
R
S
S
Site 12
S120
T
P
F
S
S
R
M
S
F
R
S
S
F
A
S
Site 13
S123
S
S
R
M
S
F
R
S
S
F
A
S
L
F
S
Site 14
S124
S
R
M
S
F
R
S
S
F
A
S
L
F
S
F
Site 15
S127
S
F
R
S
S
F
A
S
L
F
S
F
R
K
S
Site 16
S130
S
S
F
A
S
L
F
S
F
R
K
S
G
K
E
Site 17
S134
S
L
F
S
F
R
K
S
G
K
E
T
S
K
L
Site 18
T138
F
R
K
S
G
K
E
T
S
K
L
P
S
L
G
Site 19
S139
R
K
S
G
K
E
T
S
K
L
P
S
L
G
Q
Site 20
S143
K
E
T
S
K
L
P
S
L
G
Q
K
G
C
D
Site 21
Y169
A
A
V
Q
A
K
I
Y
N
S
P
L
E
N
H
Site 22
S171
V
Q
A
K
I
Y
N
S
P
L
E
N
H
L
V
Site 23
T181
E
N
H
L
V
D
S
T
F
V
P
K
P
A
V
Site 24
S193
P
A
V
M
R
E
E
S
G
M
P
P
P
W
D
Site 25
S202
M
P
P
P
W
D
A
S
L
L
E
N
E
F
F
Site 26
S217
Q
V
L
D
D
L
D
S
K
L
A
Q
E
Q
S
Site 27
S224
S
K
L
A
Q
E
Q
S
A
S
S
V
N
T
R
Site 28
S226
L
A
Q
E
Q
S
A
S
S
V
N
T
R
T
P
Site 29
S227
A
Q
E
Q
S
A
S
S
V
N
T
R
T
P
L
Site 30
T230
Q
S
A
S
S
V
N
T
R
T
P
L
N
Y
G
Site 31
T232
A
S
S
V
N
T
R
T
P
L
N
Y
G
S
R
Site 32
Y236
N
T
R
T
P
L
N
Y
G
S
R
T
Q
F
G
Site 33
S238
R
T
P
L
N
Y
G
S
R
T
Q
F
G
H
F
Site 34
T240
P
L
N
Y
G
S
R
T
Q
F
G
H
F
Y
S
Site 35
Y246
R
T
Q
F
G
H
F
Y
S
S
G
N
R
H
G
Site 36
Y263
T
E
R
H
K
K
H
Y
N
E
T
S
N
M
S
Site 37
S270
Y
N
E
T
S
N
M
S
I
Y
D
I
L
R
P
Site 38
Y272
E
T
S
N
M
S
I
Y
D
I
L
R
P
G
T
Site 39
T279
Y
D
I
L
R
P
G
T
P
R
E
G
F
K
T
Site 40
T286
T
P
R
E
G
F
K
T
F
S
P
R
T
S
T
Site 41
S288
R
E
G
F
K
T
F
S
P
R
T
S
T
I
Y
Site 42
S292
K
T
F
S
P
R
T
S
T
I
Y
D
M
Y
R
Site 43
T293
T
F
S
P
R
T
S
T
I
Y
D
M
Y
R
T
Site 44
Y295
S
P
R
T
S
T
I
Y
D
M
Y
R
T
R
E
Site 45
Y298
T
S
T
I
Y
D
M
Y
R
T
R
E
P
R
V
Site 46
T300
T
I
Y
D
M
Y
R
T
R
E
P
R
V
F
K
Site 47
Y310
P
R
V
F
K
E
D
Y
V
Q
K
N
T
F
G
Site 48
T315
E
D
Y
V
Q
K
N
T
F
G
S
T
S
L
C
Site 49
S318
V
Q
K
N
T
F
G
S
T
S
L
C
F
D
S
Site 50
S320
K
N
T
F
G
S
T
S
L
C
F
D
S
R
Q
Site 51
S325
S
T
S
L
C
F
D
S
R
Q
R
S
A
L
P
Site 52
S329
C
F
D
S
R
Q
R
S
A
L
P
A
T
G
H
Site 53
T338
L
P
A
T
G
H
F
T
A
R
S
L
H
F
P
Site 54
S341
T
G
H
F
T
A
R
S
L
H
F
P
A
T
T
Site 55
T347
R
S
L
H
F
P
A
T
T
Q
S
K
S
G
F
Site 56
T348
S
L
H
F
P
A
T
T
Q
S
K
S
G
F
I
Site 57
S350
H
F
P
A
T
T
Q
S
K
S
G
F
I
P
P
Site 58
S352
P
A
T
T
Q
S
K
S
G
F
I
P
P
R
H
Site 59
S362
I
P
P
R
H
Q
Q
S
P
K
R
T
P
L
S
Site 60
T366
H
Q
Q
S
P
K
R
T
P
L
S
S
I
I
W
Site 61
S369
S
P
K
R
T
P
L
S
S
I
I
W
N
R
S
Site 62
S370
P
K
R
T
P
L
S
S
I
I
W
N
R
S
D
Site 63
S376
S
S
I
I
W
N
R
S
D
S
S
R
D
R
E
Site 64
S378
I
I
W
N
R
S
D
S
S
R
D
R
E
N
Q
Site 65
S379
I
W
N
R
S
D
S
S
R
D
R
E
N
Q
E
Site 66
S393
E
E
F
L
R
A
P
S
P
M
E
I
D
P
A
Site 67
Y403
E
I
D
P
A
D
K
Y
V
Y
P
R
G
F
Q
Site 68
Y405
D
P
A
D
K
Y
V
Y
P
R
G
F
Q
E
N
Site 69
Y415
G
F
Q
E
N
K
R
Y
E
S
Y
H
S
Q
N
Site 70
S420
K
R
Y
E
S
Y
H
S
Q
N
V
Y
Q
R
V
Site 71
Y424
S
Y
H
S
Q
N
V
Y
Q
R
V
S
L
N
A
Site 72
S428
Q
N
V
Y
Q
R
V
S
L
N
A
P
M
E
N
Site 73
S438
A
P
M
E
N
A
M
S
P
D
T
F
E
N
S
Site 74
T441
E
N
A
M
S
P
D
T
F
E
N
S
E
N
M
Site 75
Y451
N
S
E
N
M
P
F
Y
H
Q
S
N
T
F
T
Site 76
T456
P
F
Y
H
Q
S
N
T
F
T
R
S
F
F
S
Site 77
S460
Q
S
N
T
F
T
R
S
F
F
S
N
T
F
G
Site 78
S463
T
F
T
R
S
F
F
S
N
T
F
G
R
S
G
Site 79
T465
T
R
S
F
F
S
N
T
F
G
R
S
G
E
Q
Site 80
S491
E
K
G
H
S
F
W
S
D
F
H
R
S
R
K
Site 81
S496
F
W
S
D
F
H
R
S
R
K
S
F
S
S
S
Site 82
S499
D
F
H
R
S
R
K
S
F
S
S
S
D
R
D
Site 83
S501
H
R
S
R
K
S
F
S
S
S
D
R
D
F
E
Site 84
S502
R
S
R
K
S
F
S
S
S
D
R
D
F
E
M
Site 85
S503
S
R
K
S
F
S
S
S
D
R
D
F
E
M
I
Site 86
S511
D
R
D
F
E
M
I
S
M
E
A
N
S
V
S
Site 87
S518
S
M
E
A
N
S
V
S
A
I
H
G
H
N
V
Site 88
S532
V
S
S
E
H
W
E
S
F
S
S
G
Y
G
T
Site 89
S534
S
E
H
W
E
S
F
S
S
G
Y
G
T
D
V
Site 90
S535
E
H
W
E
S
F
S
S
G
Y
G
T
D
V
S
Site 91
T539
S
F
S
S
G
Y
G
T
D
V
S
R
G
Q
E
Site 92
S542
S
G
Y
G
T
D
V
S
R
G
Q
E
E
P
H
Site 93
T559
Q
F
D
F
Q
R
S
T
L
D
S
M
V
V
S
Site 94
S562
F
Q
R
S
T
L
D
S
M
V
V
S
H
G
N
Site 95
S566
T
L
D
S
M
V
V
S
H
G
N
E
T
Q
L
Site 96
T574
H
G
N
E
T
Q
L
T
P
H
F
G
T
P
N
Site 97
T579
Q
L
T
P
H
F
G
T
P
N
V
C
S
M
T
Site 98
S588
N
V
C
S
M
T
G
S
S
Y
H
V
K
S
S
Site 99
S589
V
C
S
M
T
G
S
S
Y
H
V
K
S
S
E
Site 100
Y590
C
S
M
T
G
S
S
Y
H
V
K
S
S
E
L
Site 101
S594
G
S
S
Y
H
V
K
S
S
E
L
V
S
Q
Q
Site 102
S595
S
S
Y
H
V
K
S
S
E
L
V
S
Q
Q
D
Site 103
S599
V
K
S
S
E
L
V
S
Q
Q
D
S
S
P
V
Site 104
S603
E
L
V
S
Q
Q
D
S
S
P
V
E
V
H
I
Site 105
S604
L
V
S
Q
Q
D
S
S
P
V
E
V
H
I
N
Site 106
S616
H
I
N
K
E
A
S
S
F
G
I
A
Q
T
L
Site 107
S626
I
A
Q
T
L
A
S
S
F
K
T
S
F
S
Q
Site 108
T629
T
L
A
S
S
F
K
T
S
F
S
Q
I
S
D
Site 109
S630
L
A
S
S
F
K
T
S
F
S
Q
I
S
D
D
Site 110
S632
S
S
F
K
T
S
F
S
Q
I
S
D
D
R
R
Site 111
S635
K
T
S
F
S
Q
I
S
D
D
R
R
N
P
Q
Site 112
S643
D
D
R
R
N
P
Q
S
P
N
L
Q
N
P
T
Site 113
S663
I
F
P
N
K
P
A
S
H
P
M
R
S
H
T
Site 114
S668
P
A
S
H
P
M
R
S
H
T
E
V
T
V
T
Site 115
T670
S
H
P
M
R
S
H
T
E
V
T
V
T
N
S
Site 116
T673
M
R
S
H
T
E
V
T
V
T
N
S
N
S
V
Site 117
T675
S
H
T
E
V
T
V
T
N
S
N
S
V
D
S
Site 118
S682
T
N
S
N
S
V
D
S
L
P
L
A
K
S
Q
Site 119
S688
D
S
L
P
L
A
K
S
Q
P
N
I
L
V
T
Site 120
S708
K
D
L
N
E
S
I
S
E
E
D
K
Q
L
S
Site 121
S715
S
E
E
D
K
Q
L
S
K
M
D
Q
T
N
K
Site 122
T720
Q
L
S
K
M
D
Q
T
N
K
A
G
E
I
P
Site 123
S731
G
E
I
P
Q
P
V
S
Q
T
G
I
S
N
S
Site 124
S738
S
Q
T
G
I
S
N
S
L
P
D
F
Q
N
P
Site 125
S747
P
D
F
Q
N
P
L
S
Q
D
S
A
K
S
N
Site 126
S750
Q
N
P
L
S
Q
D
S
A
K
S
N
G
F
G
Site 127
S753
L
S
Q
D
S
A
K
S
N
G
F
G
F
N
A
Site 128
S761
N
G
F
G
F
N
A
S
T
I
I
S
S
K
K
Site 129
T762
G
F
G
F
N
A
S
T
I
I
S
S
K
K
S
Site 130
S765
F
N
A
S
T
I
I
S
S
K
K
S
P
R
V
Site 131
S769
T
I
I
S
S
K
K
S
P
R
V
F
S
R
K
Site 132
S774
K
K
S
P
R
V
F
S
R
K
D
T
S
K
M
Site 133
T778
R
V
F
S
R
K
D
T
S
K
M
Y
I
P
H
Site 134
Y782
R
K
D
T
S
K
M
Y
I
P
H
T
D
K
S
Site 135
T786
S
K
M
Y
I
P
H
T
D
K
S
N
D
I
K
Site 136
T799
I
K
Q
D
K
R
F
T
E
N
R
K
L
G
S
Site 137
S806
T
E
N
R
K
L
G
S
T
A
S
L
P
F
I
Site 138
T807
E
N
R
K
L
G
S
T
A
S
L
P
F
I
Q
Site 139
S809
R
K
L
G
S
T
A
S
L
P
F
I
Q
E
H
Site 140
T818
P
F
I
Q
E
H
R
T
P
P
S
F
P
R
T
Site 141
S821
Q
E
H
R
T
P
P
S
F
P
R
T
D
Q
G
Site 142
T825
T
P
P
S
F
P
R
T
D
Q
G
C
H
Q
E
Site 143
T834
Q
G
C
H
Q
E
L
T
V
N
N
E
D
I
S
Site 144
T845
E
D
I
S
R
I
I
T
N
N
H
W
S
S
A
Site 145
T854
N
H
W
S
S
A
L
T
D
T
Q
N
A
Q
Y
Site 146
T856
W
S
S
A
L
T
D
T
Q
N
A
Q
Y
S
K
Site 147
T867
Q
Y
S
K
C
K
L
T
P
G
H
K
T
S
C
Site 148
T872
K
L
T
P
G
H
K
T
S
C
D
S
L
D
L
Site 149
S873
L
T
P
G
H
K
T
S
C
D
S
L
D
L
S
Site 150
S876
G
H
K
T
S
C
D
S
L
D
L
S
S
A
A
Site 151
S880
S
C
D
S
L
D
L
S
S
A
A
L
P
D
S
Site 152
S881
C
D
S
L
D
L
S
S
A
A
L
P
D
S
S
Site 153
S887
S
S
A
A
L
P
D
S
S
P
S
K
N
S
S
Site 154
S888
S
A
A
L
P
D
S
S
P
S
K
N
S
S
L
Site 155
S890
A
L
P
D
S
S
P
S
K
N
S
S
L
D
A
Site 156
S894
S
S
P
S
K
N
S
S
L
D
A
P
V
V
P
Site 157
T903
D
A
P
V
V
P
S
T
T
V
F
S
R
R
S
Site 158
T904
A
P
V
V
P
S
T
T
V
F
S
R
R
S
P
Site 159
S907
V
P
S
T
T
V
F
S
R
R
S
P
S
D
K
Site 160
S910
T
T
V
F
S
R
R
S
P
S
D
K
D
P
S
Site 161
S912
V
F
S
R
R
S
P
S
D
K
D
P
S
L
G
Site 162
S917
S
P
S
D
K
D
P
S
L
G
E
R
E
E
K
Site 163
S938
Q
K
N
Q
F
I
V
S
H
S
E
N
Q
E
R
Site 164
S940
N
Q
F
I
V
S
H
S
E
N
Q
E
R
N
D
Site 165
S948
E
N
Q
E
R
N
D
S
P
V
P
T
H
D
E
Site 166
T952
R
N
D
S
P
V
P
T
H
D
E
V
V
D
V
Site 167
S963
V
V
D
V
K
C
H
S
H
S
P
F
R
N
E
Site 168
S965
D
V
K
C
H
S
H
S
P
F
R
N
E
R
G
Site 169
S981
G
K
I
R
H
H
I
S
C
I
E
K
L
S
K
Site 170
T989
C
I
E
K
L
S
K
T
E
S
I
S
V
P
T
Site 171
S991
E
K
L
S
K
T
E
S
I
S
V
P
T
S
D
Site 172
S993
L
S
K
T
E
S
I
S
V
P
T
S
D
H
R
Site 173
S997
E
S
I
S
V
P
T
S
D
H
R
S
L
I
E
Site 174
S1001
V
P
T
S
D
H
R
S
L
I
E
A
N
Q
S
Site 175
S1008
S
L
I
E
A
N
Q
S
N
S
K
V
S
E
L
Site 176
S1010
I
E
A
N
Q
S
N
S
K
V
S
E
L
D
T
Site 177
T1017
S
K
V
S
E
L
D
T
I
Y
C
T
L
P
R
Site 178
Y1019
V
S
E
L
D
T
I
Y
C
T
L
P
R
K
S
Site 179
T1021
E
L
D
T
I
Y
C
T
L
P
R
K
S
S
S
Site 180
S1026
Y
C
T
L
P
R
K
S
S
S
F
L
I
H
G
Site 181
S1027
C
T
L
P
R
K
S
S
S
F
L
I
H
G
R
Site 182
S1028
T
L
P
R
K
S
S
S
F
L
I
H
G
R
Q
Site 183
S1044
G
S
K
I
M
A
A
S
L
R
N
G
P
P
P
Site 184
S1071
N
Y
M
L
N
K
F
S
P
S
S
P
E
S
A
Site 185
S1073
M
L
N
K
F
S
P
S
S
P
E
S
A
N
E
Site 186
S1074
L
N
K
F
S
P
S
S
P
E
S
A
N
E
C
Site 187
S1077
F
S
P
S
S
P
E
S
A
N
E
C
S
K
V
Site 188
S1082
P
E
S
A
N
E
C
S
K
V
L
S
D
S
A
Site 189
S1086
N
E
C
S
K
V
L
S
D
S
A
L
E
A
P
Site 190
S1088
C
S
K
V
L
S
D
S
A
L
E
A
P
E
A
Site 191
T1100
P
E
A
T
E
R
M
T
N
V
K
S
S
G
S
Site 192
S1104
E
R
M
T
N
V
K
S
S
G
S
T
S
V
R
Site 193
S1105
R
M
T
N
V
K
S
S
G
S
T
S
V
R
K
Site 194
S1107
T
N
V
K
S
S
G
S
T
S
V
R
K
G
P
Site 195
T1108
N
V
K
S
S
G
S
T
S
V
R
K
G
P
L
Site 196
S1109
V
K
S
S
G
S
T
S
V
R
K
G
P
L
P
Site 197
S1124
F
L
I
N
R
A
M
S
C
P
S
G
E
P
H
Site 198
S1127
N
R
A
M
S
C
P
S
G
E
P
H
A
S
T
Site 199
S1133
P
S
G
E
P
H
A
S
T
G
R
E
G
R
K
Site 200
T1134
S
G
E
P
H
A
S
T
G
R
E
G
R
K
K
Site 201
T1144
E
G
R
K
K
P
L
T
S
G
M
D
A
S
E
Site 202
T1153
G
M
D
A
S
E
L
T
P
R
A
W
E
R
I
Site 203
S1162
R
A
W
E
R
I
I
S
P
V
E
S
D
S
S
Site 204
S1166
R
I
I
S
P
V
E
S
D
S
S
V
R
D
C
Site 205
S1168
I
S
P
V
E
S
D
S
S
V
R
D
C
S
L
Site 206
S1169
S
P
V
E
S
D
S
S
V
R
D
C
S
L
T
Site 207
S1174
D
S
S
V
R
D
C
S
L
T
K
R
Q
H
Q
Site 208
T1176
S
V
R
D
C
S
L
T
K
R
Q
H
Q
K
E
Site 209
Y1188
Q
K
E
N
F
Q
E
Y
T
E
K
E
G
K
M
Site 210
S1198
K
E
G
K
M
A
A
S
R
R
S
V
F
A
L
Site 211
S1201
K
M
A
A
S
R
R
S
V
F
A
L
S
N
E
Site 212
S1206
R
R
S
V
F
A
L
S
N
E
D
P
L
P
F
Site 213
S1215
E
D
P
L
P
F
C
S
D
L
S
G
K
E
R
Site 214
T1225
S
G
K
E
R
G
K
T
L
H
K
V
K
T
T
Site 215
T1231
K
T
L
H
K
V
K
T
T
S
T
F
S
V
S
Site 216
T1234
H
K
V
K
T
T
S
T
F
S
V
S
G
D
E
Site 217
Y1254
L
E
V
V
S
I
Y
Y
T
L
P
R
K
P
S
Site 218
T1255
E
V
V
S
I
Y
Y
T
L
P
R
K
P
S
K
Site 219
S1261
Y
T
L
P
R
K
P
S
K
K
F
C
N
L
L
Site 220
S1281
N
T
N
L
L
I
E
S
P
Q
V
E
T
E
T
Site 221
T1288
S
P
Q
V
E
T
E
T
F
P
N
A
L
E
K
Site 222
S1301
E
K
D
K
Q
N
Y
S
T
R
E
Q
S
G
T
Site 223
S1306
N
Y
S
T
R
E
Q
S
G
T
P
S
C
E
N
Site 224
T1308
S
T
R
E
Q
S
G
T
P
S
C
E
N
L
K
Site 225
S1310
R
E
Q
S
G
T
P
S
C
E
N
L
K
M
S
Site 226
S1317
S
C
E
N
L
K
M
S
V
N
S
D
Q
T
L
Site 227
T1323
M
S
V
N
S
D
Q
T
L
T
T
E
N
M
T
Site 228
S1335
N
M
T
A
F
R
L
S
N
R
G
P
L
A
P
Site 229
S1355
A
S
V
E
A
A
V
S
L
P
E
E
E
S
K
Site 230
S1361
V
S
L
P
E
E
E
S
K
A
R
E
I
F
S
Site 231
S1368
S
K
A
R
E
I
F
S
D
N
L
A
K
T
P
Site 232
T1374
F
S
D
N
L
A
K
T
P
L
G
D
S
E
N
Site 233
S1379
A
K
T
P
L
G
D
S
E
N
K
K
E
R
G
Site 234
T1393
G
K
K
L
Q
S
E
T
L
H
T
S
L
M
L
Site 235
T1396
L
Q
S
E
T
L
H
T
S
L
M
L
Q
R
K
Site 236
S1410
K
N
V
S
E
E
K
S
E
N
C
Q
Q
S
I
Site 237
S1416
K
S
E
N
C
Q
Q
S
I
N
S
S
N
S
G
Site 238
S1419
N
C
Q
Q
S
I
N
S
S
N
S
G
P
S
S
Site 239
S1420
C
Q
Q
S
I
N
S
S
N
S
G
P
S
S
L
Site 240
S1422
Q
S
I
N
S
S
N
S
G
P
S
S
L
P
A
Site 241
S1425
N
S
S
N
S
G
P
S
S
L
P
A
L
S
E
Site 242
S1426
S
S
N
S
G
P
S
S
L
P
A
L
S
E
V
Site 243
S1431
P
S
S
L
P
A
L
S
E
V
N
I
G
N
S
Site 244
S1438
S
E
V
N
I
G
N
S
Q
T
R
R
S
S
W
Site 245
T1440
V
N
I
G
N
S
Q
T
R
R
S
S
W
E
C
Site 246
S1443
G
N
S
Q
T
R
R
S
S
W
E
C
T
G
S
Site 247
S1444
N
S
Q
T
R
R
S
S
W
E
C
T
G
S
G
Site 248
T1448
R
R
S
S
W
E
C
T
G
S
G
R
A
I
P
Site 249
S1450
S
S
W
E
C
T
G
S
G
R
A
I
P
F
T
Site 250
T1457
S
G
R
A
I
P
F
T
G
S
G
K
C
P
Q
Site 251
T1468
K
C
P
Q
K
D
H
T
S
T
A
V
G
D
G
Site 252
S1469
C
P
Q
K
D
H
T
S
T
A
V
G
D
G
S
Site 253
S1476
S
T
A
V
G
D
G
S
S
G
S
Q
P
R
E
Site 254
S1477
T
A
V
G
D
G
S
S
G
S
Q
P
R
E
G
Site 255
S1479
V
G
D
G
S
S
G
S
Q
P
R
E
G
R
G
Site 256
T1490
E
G
R
G
D
I
G
T
N
C
Q
K
M
T
N
Site 257
T1496
G
T
N
C
Q
K
M
T
N
K
T
L
S
H
S
Site 258
T1499
C
Q
K
M
T
N
K
T
L
S
H
S
E
S
Q
Site 259
S1501
K
M
T
N
K
T
L
S
H
S
E
S
Q
V
F
Site 260
S1503
T
N
K
T
L
S
H
S
E
S
Q
V
F
A
L
Site 261
S1505
K
T
L
S
H
S
E
S
Q
V
F
A
L
T
P
Site 262
T1511
E
S
Q
V
F
A
L
T
P
A
L
H
K
L
Q
Site 263
S1525
Q
L
G
E
E
T
Q
S
D
E
P
N
L
E
S
Site 264
S1532
S
D
E
P
N
L
E
S
L
Q
S
E
P
R
E
Site 265
S1535
P
N
L
E
S
L
Q
S
E
P
R
E
L
P
Q
Site 266
S1544
P
R
E
L
P
Q
R
S
Q
E
A
N
M
T
E
Site 267
T1550
R
S
Q
E
A
N
M
T
E
S
R
K
A
E
D
Site 268
S1562
A
E
D
E
M
Q
K
S
A
W
D
Q
P
S
L
Site 269
S1568
K
S
A
W
D
Q
P
S
L
P
E
G
N
K
N
Site 270
T1577
P
E
G
N
K
N
K
T
N
L
D
D
L
V
K
Site 271
S1590
V
K
G
E
N
R
S
S
V
K
H
R
L
A
A
Site 272
S1599
K
H
R
L
A
A
M
S
K
A
S
R
K
F
P
Site 273
S1611
K
F
P
A
K
D
V
S
P
R
R
H
V
A
T
Site 274
T1618
S
P
R
R
H
V
A
T
I
F
P
Q
S
G
S
Site 275
S1623
V
A
T
I
F
P
Q
S
G
S
R
S
G
F
D
Site 276
S1625
T
I
F
P
Q
S
G
S
R
S
G
F
D
H
L
Site 277
S1627
F
P
Q
S
G
S
R
S
G
F
D
H
L
S
L
Site 278
S1633
R
S
G
F
D
H
L
S
L
G
T
V
E
C
N
Site 279
T1647
N
P
L
F
P
E
P
T
P
K
S
A
E
S
I
Site 280
S1650
F
P
E
P
T
P
K
S
A
E
S
I
G
E
S
Site 281
S1653
P
T
P
K
S
A
E
S
I
G
E
S
R
L
S
Site 282
S1657
S
A
E
S
I
G
E
S
R
L
S
E
N
R
K
Site 283
S1660
S
I
G
E
S
R
L
S
E
N
R
K
H
V
K
Site 284
S1669
N
R
K
H
V
K
K
S
E
N
L
L
P
I
T
Site 285
T1676
S
E
N
L
L
P
I
T
V
L
P
N
R
E
P
Site 286
S1684
V
L
P
N
R
E
P
S
T
H
V
S
N
Q
K
Site 287
T1685
L
P
N
R
E
P
S
T
H
V
S
N
Q
K
S
Site 288
S1688
R
E
P
S
T
H
V
S
N
Q
K
S
N
S
I
Site 289
S1692
T
H
V
S
N
Q
K
S
N
S
I
S
Q
R
H
Site 290
S1694
V
S
N
Q
K
S
N
S
I
S
Q
R
H
Q
N
Site 291
S1696
N
Q
K
S
N
S
I
S
Q
R
H
Q
N
E
F
Site 292
S1707
Q
N
E
F
K
N
V
S
E
S
P
S
K
H
E
Site 293
S1709
E
F
K
N
V
S
E
S
P
S
K
H
E
N
S
Site 294
S1711
K
N
V
S
E
S
P
S
K
H
E
N
S
K
D
Site 295
S1716
S
P
S
K
H
E
N
S
K
D
V
T
A
A
Q
Site 296
T1720
H
E
N
S
K
D
V
T
A
A
Q
N
L
V
R
Site 297
S1729
A
Q
N
L
V
R
E
S
G
A
P
S
P
I
T
Site 298
S1733
V
R
E
S
G
A
P
S
P
I
T
F
T
S
L
Site 299
T1736
S
G
A
P
S
P
I
T
F
T
S
L
R
E
A
Site 300
S1739
P
S
P
I
T
F
T
S
L
R
E
A
E
F
S
Site 301
S1746
S
L
R
E
A
E
F
S
D
N
Q
R
R
L
S
Site 302
S1753
S
D
N
Q
R
R
L
S
P
P
F
P
L
E
P
Site 303
S1764
P
L
E
P
A
Q
K
S
R
V
S
S
P
L
A
Site 304
S1767
P
A
Q
K
S
R
V
S
S
P
L
A
S
F
L
Site 305
S1768
A
Q
K
S
R
V
S
S
P
L
A
S
F
L
Q
Site 306
S1772
R
V
S
S
P
L
A
S
F
L
Q
Q
Q
R
S
Site 307
S1779
S
F
L
Q
Q
Q
R
S
A
S
S
L
E
W
E
Site 308
S1781
L
Q
Q
Q
R
S
A
S
S
L
E
W
E
P
E
Site 309
S1782
Q
Q
Q
R
S
A
S
S
L
E
W
E
P
E
P
Site 310
Y1792
W
E
P
E
P
H
L
Y
R
S
K
S
L
K
S
Site 311
S1794
P
E
P
H
L
Y
R
S
K
S
L
K
S
I
N
Site 312
S1796
P
H
L
Y
R
S
K
S
L
K
S
I
N
V
H
Site 313
S1799
Y
R
S
K
S
L
K
S
I
N
V
H
G
D
L
Site 314
S1810
H
G
D
L
L
R
K
S
H
P
P
K
V
R
E
Site 315
S1821
K
V
R
E
R
H
F
S
E
S
T
S
I
D
N
Site 316
S1823
R
E
R
H
F
S
E
S
T
S
I
D
N
A
L
Site 317
S1825
R
H
F
S
E
S
T
S
I
D
N
A
L
S
R
Site 318
T1834
D
N
A
L
S
R
L
T
L
G
N
E
F
S
V
Site 319
S1840
L
T
L
G
N
E
F
S
V
N
N
G
Y
S
R
Site 320
Y1845
E
F
S
V
N
N
G
Y
S
R
R
F
R
S
F
Site 321
S1846
F
S
V
N
N
G
Y
S
R
R
F
R
S
F
S
Site 322
S1851
G
Y
S
R
R
F
R
S
F
S
E
L
P
S
C
Site 323
S1853
S
R
R
F
R
S
F
S
E
L
P
S
C
D
G
Site 324
S1857
R
S
F
S
E
L
P
S
C
D
G
N
E
S
W
Site 325
S1863
P
S
C
D
G
N
E
S
W
A
Y
R
S
G
T
Site 326
Y1866
D
G
N
E
S
W
A
Y
R
S
G
T
K
T
G
Site 327
T1870
S
W
A
Y
R
S
G
T
K
T
G
P
R
S
A
Site 328
T1872
A
Y
R
S
G
T
K
T
G
P
R
S
A
I
S
Site 329
S1876
G
T
K
T
G
P
R
S
A
I
S
I
Y
R
P
Site 330
S1879
T
G
P
R
S
A
I
S
I
Y
R
P
I
D
Y
Site 331
Y1886
S
I
Y
R
P
I
D
Y
G
I
F
G
K
E
Q
Site 332
S1904
F
L
E
N
V
K
R
S
L
T
Q
G
R
L
W
Site 333
T1906
E
N
V
K
R
S
L
T
Q
G
R
L
W
K
P
Site 334
S1914
Q
G
R
L
W
K
P
S
F
L
K
N
P
G
F
Site 335
S1933
L
R
N
P
P
N
P
S
E
S
L
S
S
N
S
Site 336
S1935
N
P
P
N
P
S
E
S
L
S
S
N
S
P
S
Site 337
S1937
P
N
P
S
E
S
L
S
S
N
S
P
S
S
Q
Site 338
S1938
N
P
S
E
S
L
S
S
N
S
P
S
S
Q
V
Site 339
S1940
S
E
S
L
S
S
N
S
P
S
S
Q
V
P
E
Site 340
S1942
S
L
S
S
N
S
P
S
S
Q
V
P
E
D
G
Site 341
S1943
L
S
S
N
S
P
S
S
Q
V
P
E
D
G
L
Site 342
S1951
Q
V
P
E
D
G
L
S
P
S
E
P
L
N
I
Site 343
S1953
P
E
D
G
L
S
P
S
E
P
L
N
I
Y
E
Site 344
Y1959
P
S
E
P
L
N
I
Y
E
D
D
P
V
D
S
Site 345
S1966
Y
E
D
D
P
V
D
S
D
C
D
T
D
T
T
Site 346
T1970
P
V
D
S
D
C
D
T
D
T
T
T
D
D
E
Site 347
T1972
D
S
D
C
D
T
D
T
T
T
D
D
E
Y
Y
Site 348
T1973
S
D
C
D
T
D
T
T
T
D
D
E
Y
Y
L
Site 349
T1974
D
C
D
T
D
T
T
T
D
D
E
Y
Y
L
D
Site 350
Y1978
D
T
T
T
D
D
E
Y
Y
L
D
E
N
D
K
Site 351
Y1979
T
T
T
D
D
E
Y
Y
L
D
E
N
D
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation