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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC50
Full Name:
Leucine-rich repeat-containing protein 50
Alias:
FLJ25330; leucine rich repeat containing 50; leucine-rich repeat-containing 50; LRC50
Type:
Mass (Da):
80040
Number AA:
UniProt ID:
Q8NEP3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035085
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0045502
PhosphoSite+
KinaseNET
Biological Process:
GO:0060271
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
H
P
E
P
S
E
P
A
T
G
G
A
Site 2
T10
P
E
P
S
E
P
A
T
G
G
A
A
E
L
D
Site 3
S33
E
S
A
G
D
H
G
S
A
G
R
G
G
C
K
Site 4
S53
P
K
E
I
C
V
G
S
S
D
T
S
Y
H
S
Site 5
S54
K
E
I
C
V
G
S
S
D
T
S
Y
H
S
Q
Site 6
T56
I
C
V
G
S
S
D
T
S
Y
H
S
Q
Q
K
Site 7
S57
C
V
G
S
S
D
T
S
Y
H
S
Q
Q
K
Q
Site 8
Y58
V
G
S
S
D
T
S
Y
H
S
Q
Q
K
Q
S
Site 9
S60
S
S
D
T
S
Y
H
S
Q
Q
K
Q
S
G
D
Site 10
S65
Y
H
S
Q
Q
K
Q
S
G
D
N
G
S
G
G
Site 11
S70
K
Q
S
G
D
N
G
S
G
G
H
F
A
H
P
Site 12
T89
E
D
R
G
P
R
M
T
K
S
S
L
Q
K
L
Site 13
S91
R
G
P
R
M
T
K
S
S
L
Q
K
L
C
K
Site 14
S92
G
P
R
M
T
K
S
S
L
Q
K
L
C
K
Q
Site 15
Y103
L
C
K
Q
H
K
L
Y
I
T
P
A
L
N
D
Site 16
T105
K
Q
H
K
L
Y
I
T
P
A
L
N
D
T
L
Site 17
Y113
P
A
L
N
D
T
L
Y
L
H
F
K
G
F
D
Site 18
Y128
R
I
E
N
L
E
E
Y
T
G
L
R
C
L
W
Site 19
S181
K
L
D
A
L
N
L
S
N
N
Y
I
K
T
I
Site 20
T187
L
S
N
N
Y
I
K
T
I
E
N
L
S
C
L
Site 21
T209
M
A
H
N
H
L
E
T
V
E
D
I
Q
H
L
Site 22
S228
R
L
C
V
L
D
L
S
H
N
K
L
S
D
P
Site 23
S233
D
L
S
H
N
K
L
S
D
P
E
I
L
S
I
Site 24
S239
L
S
D
P
E
I
L
S
I
L
E
S
M
P
D
Site 25
Y264
V
I
R
Q
I
P
N
Y
R
R
T
V
T
V
R
Site 26
T267
Q
I
P
N
Y
R
R
T
V
T
V
R
L
K
H
Site 27
T269
P
N
Y
R
R
T
V
T
V
R
L
K
H
L
T
Site 28
T276
T
V
R
L
K
H
L
T
Y
L
D
D
R
P
V
Site 29
Y277
V
R
L
K
H
L
T
Y
L
D
D
R
P
V
F
Site 30
Y299
E
A
W
A
R
G
G
Y
A
A
E
K
E
E
R
Site 31
S311
E
E
R
Q
Q
W
E
S
R
E
R
K
K
I
T
Site 32
T318
S
R
E
R
K
K
I
T
D
S
I
E
A
L
A
Site 33
S320
E
R
K
K
I
T
D
S
I
E
A
L
A
M
I
Site 34
S340
E
R
K
R
Q
R
E
S
Q
E
R
G
E
M
T
Site 35
S348
Q
E
R
G
E
M
T
S
S
D
D
G
E
N
V
Site 36
S349
E
R
G
E
M
T
S
S
D
D
G
E
N
V
P
Site 37
S358
D
G
E
N
V
P
A
S
A
E
G
K
E
E
P
Site 38
T371
E
P
P
G
D
R
E
T
R
Q
K
M
E
L
F
Site 39
S382
M
E
L
F
V
K
E
S
F
E
A
K
D
E
L
Site 40
T415
G
G
P
E
P
E
G
T
L
P
A
E
T
L
L
Site 41
T441
G
D
G
E
P
E
G
T
L
P
A
E
A
P
P
Site 42
T467
G
D
Q
E
P
E
G
T
L
P
A
E
T
L
L
Site 43
T493
G
D
R
E
P
E
G
T
L
P
A
E
A
P
P
Site 44
T512
G
A
A
R
E
E
P
T
P
Q
A
V
A
T
E
Site 45
T529
F
V
T
E
L
D
G
T
R
T
E
D
L
E
T
Site 46
T536
T
R
T
E
D
L
E
T
I
R
L
E
T
K
E
Site 47
T541
L
E
T
I
R
L
E
T
K
E
T
F
C
I
D
Site 48
T544
I
R
L
E
T
K
E
T
F
C
I
D
D
L
P
Site 49
T559
D
L
E
D
D
D
E
T
G
K
S
L
E
D
Q
Site 50
S562
D
D
D
E
T
G
K
S
L
E
D
Q
N
M
C
Site 51
S578
P
K
I
E
V
I
S
S
L
S
D
D
S
D
P
Site 52
S580
I
E
V
I
S
S
L
S
D
D
S
D
P
E
L
Site 53
S583
I
S
S
L
S
D
D
S
D
P
E
L
D
Y
T
Site 54
Y589
D
S
D
P
E
L
D
Y
T
S
L
P
V
L
E
Site 55
T590
S
D
P
E
L
D
Y
T
S
L
P
V
L
E
N
Site 56
S591
D
P
E
L
D
Y
T
S
L
P
V
L
E
N
L
Site 57
S604
N
L
P
T
D
T
L
S
N
I
F
A
V
S
K
Site 58
S610
L
S
N
I
F
A
V
S
K
D
T
S
K
A
A
Site 59
S614
F
A
V
S
K
D
T
S
K
A
A
R
V
P
F
Site 60
T640
L
E
I
R
K
Q
D
T
K
S
P
R
P
L
I
Site 61
S642
I
R
K
Q
D
T
K
S
P
R
P
L
I
Q
E
Site 62
S651
R
P
L
I
Q
E
L
S
D
E
D
P
S
G
Q
Site 63
T664
G
Q
L
L
M
P
P
T
C
Q
R
D
A
A
P
Site 64
T673
Q
R
D
A
A
P
L
T
S
S
G
D
R
D
S
Site 65
S675
D
A
A
P
L
T
S
S
G
D
R
D
S
D
F
Site 66
S680
T
S
S
G
D
R
D
S
D
F
L
A
A
S
S
Site 67
S686
D
S
D
F
L
A
A
S
S
P
V
P
T
E
S
Site 68
S687
S
D
F
L
A
A
S
S
P
V
P
T
E
S
A
Site 69
T691
A
A
S
S
P
V
P
T
E
S
A
A
T
P
P
Site 70
S693
S
S
P
V
P
T
E
S
A
A
T
P
P
E
T
Site 71
T696
V
P
T
E
S
A
A
T
P
P
E
T
C
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation