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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZD8
Full Name:
PDZ domain-containing protein 8
Alias:
BA129M16.2; FLJ34427; PDZ domain containing 8; PDZ domain-containing 8; PDZK8; Sarcoma antigen NY-SAR-84/NY-SAR-104
Type:
Unknown function
Mass (Da):
128563
Number AA:
1154
UniProt ID:
Q8NEN9
International Prot ID:
IPI00168698
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
L
A
Q
F
F
L
L
Y
R
R
Q
P
E
P
P
Site 2
Y47
R
A
G
E
G
F
R
Y
I
K
P
V
P
G
L
Site 3
Y59
P
G
L
L
L
R
E
Y
L
Y
G
G
G
R
D
Site 4
Y61
L
L
L
R
E
Y
L
Y
G
G
G
R
D
E
E
Site 5
S70
G
G
R
D
E
E
P
S
G
A
A
P
E
G
G
Site 6
T79
A
A
P
E
G
G
A
T
P
T
A
A
P
E
T
Site 7
T81
P
E
G
G
A
T
P
T
A
A
P
E
T
P
A
Site 8
T86
T
P
T
A
A
P
E
T
P
A
P
P
T
R
E
Site 9
T94
P
A
P
P
T
R
E
T
C
Y
F
L
N
A
T
Site 10
T112
L
F
R
E
L
R
D
T
A
L
T
R
R
W
V
Site 11
T115
E
L
R
D
T
A
L
T
R
R
W
V
T
K
K
Site 12
T120
A
L
T
R
R
W
V
T
K
K
I
K
V
E
F
Site 13
T133
E
F
E
E
L
L
Q
T
K
T
A
G
R
L
L
Site 14
T135
E
E
L
L
Q
T
K
T
A
G
R
L
L
E
G
Site 15
S169
L
V
R
P
V
V
P
S
A
T
G
E
P
D
G
Site 16
T171
R
P
V
V
P
S
A
T
G
E
P
D
G
P
E
Site 17
S257
L
I
D
F
E
V
R
S
Q
F
E
G
R
P
M
Site 18
T284
K
I
I
K
R
K
H
T
L
P
N
Y
K
I
R
Site 19
Y288
R
K
H
T
L
P
N
Y
K
I
R
F
K
P
F
Site 20
Y298
R
F
K
P
F
F
P
Y
Q
T
L
Q
G
F
E
Site 21
S338
S
R
L
L
I
F
G
S
Y
D
R
E
A
N
V
Site 22
Y339
R
L
L
I
F
G
S
Y
D
R
E
A
N
V
H
Site 23
T348
R
E
A
N
V
H
C
T
L
E
L
S
S
S
V
Site 24
S352
V
H
C
T
L
E
L
S
S
S
V
W
E
E
K
Site 25
S354
C
T
L
E
L
S
S
S
V
W
E
E
K
Q
R
Site 26
S363
W
E
E
K
Q
R
S
S
I
K
T
V
E
L
I
Site 27
T366
K
Q
R
S
S
I
K
T
V
E
L
I
K
G
N
Site 28
S386
L
T
L
R
L
V
Q
S
T
D
G
Y
A
G
H
Site 29
T387
T
L
R
L
V
Q
S
T
D
G
Y
A
G
H
V
Site 30
Y444
A
G
D
R
V
L
V
Y
Y
E
R
P
V
G
Q
Site 31
Y445
G
D
R
V
L
V
Y
Y
E
R
P
V
G
Q
S
Site 32
S452
Y
E
R
P
V
G
Q
S
N
Q
G
A
V
L
Q
Site 33
S471
Q
L
E
E
N
F
L
S
S
S
C
Q
S
G
Y
Site 34
S472
L
E
E
N
F
L
S
S
S
C
Q
S
G
Y
E
Site 35
S473
E
E
N
F
L
S
S
S
C
Q
S
G
Y
E
E
Site 36
S476
F
L
S
S
S
C
Q
S
G
Y
E
E
E
A
A
Site 37
Y478
S
S
S
C
Q
S
G
Y
E
E
E
A
A
G
L
Site 38
T486
E
E
E
A
A
G
L
T
V
D
T
E
S
R
E
Site 39
T489
A
A
G
L
T
V
D
T
E
S
R
E
L
D
S
Site 40
S491
G
L
T
V
D
T
E
S
R
E
L
D
S
E
F
Site 41
S496
T
E
S
R
E
L
D
S
E
F
E
D
L
A
S
Site 42
S503
S
E
F
E
D
L
A
S
D
V
R
A
Q
N
E
Site 43
S517
E
F
K
D
E
A
Q
S
L
S
H
S
P
K
R
Site 44
S519
K
D
E
A
Q
S
L
S
H
S
P
K
R
V
P
Site 45
S521
E
A
Q
S
L
S
H
S
P
K
R
V
P
T
T
Site 46
T527
H
S
P
K
R
V
P
T
T
L
S
I
K
P
L
Site 47
T528
S
P
K
R
V
P
T
T
L
S
I
K
P
L
G
Site 48
S538
I
K
P
L
G
A
I
S
P
V
L
N
R
K
L
Site 49
S549
N
R
K
L
A
V
G
S
H
P
L
P
P
K
I
Site 50
S579
I
T
D
P
A
Q
V
S
K
P
T
Q
G
S
A
Site 51
S585
V
S
K
P
T
Q
G
S
A
F
K
P
P
V
P
Site 52
S603
Q
A
K
V
P
L
P
S
A
D
A
P
N
Q
A
Site 53
S631
P
P
P
L
V
D
K
S
A
E
K
Q
A
K
N
Site 54
T662
Q
E
V
A
K
D
V
T
S
E
T
S
C
P
T
Site 55
S663
E
V
A
K
D
V
T
S
E
T
S
C
P
T
K
Site 56
T665
A
K
D
V
T
S
E
T
S
C
P
T
K
D
S
Site 57
T669
T
S
E
T
S
C
P
T
K
D
S
S
D
D
R
Site 58
S673
S
C
P
T
K
D
S
S
D
D
R
Q
T
W
E
Site 59
T678
D
S
S
D
D
R
Q
T
W
E
S
S
E
I
L
Site 60
S681
D
D
R
Q
T
W
E
S
S
E
I
L
Y
R
N
Site 61
Y686
W
E
S
S
E
I
L
Y
R
N
K
L
G
K
W
Site 62
T696
K
L
G
K
W
T
R
T
R
A
S
C
L
F
D
Site 63
S699
K
W
T
R
T
R
A
S
C
L
F
D
I
E
A
Site 64
T749
G
C
L
A
T
S
N
T
E
Y
L
S
K
L
R
Site 65
Y751
L
A
T
S
N
T
E
Y
L
S
K
L
R
L
E
Site 66
S761
K
L
R
L
E
A
P
S
P
K
A
I
V
T
R
Site 67
S775
R
T
A
L
R
N
L
S
M
Q
K
G
F
N
D
Site 68
Y795
D
I
T
I
H
F
K
Y
L
K
E
G
E
S
D
Site 69
S801
K
Y
L
K
E
G
E
S
D
H
H
V
V
T
N
Site 70
S822
P
H
L
V
E
E
V
S
V
L
P
K
E
E
Q
Site 71
T837
F
V
G
Q
M
G
L
T
E
N
K
H
S
F
Q
Site 72
S842
G
L
T
E
N
K
H
S
F
Q
D
T
Q
F
Q
Site 73
T846
N
K
H
S
F
Q
D
T
Q
F
Q
N
P
T
W
Site 74
T852
D
T
Q
F
Q
N
P
T
W
C
D
Y
C
K
K
Site 75
Y856
Q
N
P
T
W
C
D
Y
C
K
K
K
V
W
T
Site 76
S889
E
K
C
L
A
E
T
S
V
C
G
A
T
D
R
Site 77
T894
E
T
S
V
C
G
A
T
D
R
R
I
D
R
T
Site 78
T901
T
D
R
R
I
D
R
T
L
K
N
L
R
L
E
Site 79
T912
L
R
L
E
G
Q
E
T
L
L
G
L
P
P
R
Site 80
S927
V
D
A
E
A
S
K
S
V
N
K
T
T
G
L
Site 81
T931
A
S
K
S
V
N
K
T
T
G
L
T
R
H
I
Site 82
T941
L
T
R
H
I
I
N
T
S
S
R
L
L
N
L
Site 83
S942
T
R
H
I
I
N
T
S
S
R
L
L
N
L
R
Site 84
S952
L
L
N
L
R
Q
V
S
K
T
R
L
S
E
P
Site 85
T954
N
L
R
Q
V
S
K
T
R
L
S
E
P
G
T
Site 86
S957
Q
V
S
K
T
R
L
S
E
P
G
T
D
L
V
Site 87
T961
T
R
L
S
E
P
G
T
D
L
V
E
P
S
P
Site 88
S967
G
T
D
L
V
E
P
S
P
K
H
T
P
N
T
Site 89
T971
V
E
P
S
P
K
H
T
P
N
T
S
D
N
E
Site 90
T974
S
P
K
H
T
P
N
T
S
D
N
E
G
S
D
Site 91
S975
P
K
H
T
P
N
T
S
D
N
E
G
S
D
T
Site 92
T982
S
D
N
E
G
S
D
T
E
V
C
G
P
N
S
Site 93
S989
T
E
V
C
G
P
N
S
P
S
K
R
G
N
S
Site 94
S991
V
C
G
P
N
S
P
S
K
R
G
N
S
T
G
Site 95
S996
S
P
S
K
R
G
N
S
T
G
I
K
L
V
R
Site 96
S1011
K
E
G
G
L
D
D
S
V
F
I
A
V
K
E
Site 97
Y1024
K
E
I
G
R
D
L
Y
R
G
L
P
T
E
E
Site 98
S1056
Q
E
L
E
H
N
N
S
L
V
R
E
E
K
E
Site 99
T1064
L
V
R
E
E
K
E
T
T
D
T
R
K
K
S
Site 100
T1065
V
R
E
E
K
E
T
T
D
T
R
K
K
S
L
Site 101
T1067
E
E
K
E
T
T
D
T
R
K
K
S
L
L
S
Site 102
S1071
T
T
D
T
R
K
K
S
L
L
S
A
A
L
A
Site 103
S1074
T
R
K
K
S
L
L
S
A
A
L
A
K
S
G
Site 104
T1103
A
G
I
E
D
I
E
T
L
E
S
L
S
L
D
Site 105
S1106
E
D
I
E
T
L
E
S
L
S
L
D
Q
H
S
Site 106
S1108
I
E
T
L
E
S
L
S
L
D
Q
H
S
K
K
Site 107
S1113
S
L
S
L
D
Q
H
S
K
K
I
S
K
Y
T
Site 108
S1117
D
Q
H
S
K
K
I
S
K
Y
T
D
D
T
E
Site 109
Y1119
H
S
K
K
I
S
K
Y
T
D
D
T
E
E
D
Site 110
T1120
S
K
K
I
S
K
Y
T
D
D
T
E
E
D
L
Site 111
T1123
I
S
K
Y
T
D
D
T
E
E
D
L
D
N
E
Site 112
S1132
E
D
L
D
N
E
I
S
Q
L
I
D
S
Q
P
Site 113
S1137
E
I
S
Q
L
I
D
S
Q
P
F
S
S
I
S
Site 114
S1141
L
I
D
S
Q
P
F
S
S
I
S
D
D
L
F
Site 115
S1142
I
D
S
Q
P
F
S
S
I
S
D
D
L
F
G
Site 116
S1144
S
Q
P
F
S
S
I
S
D
D
L
F
G
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation