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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Agbl3
Full Name:
Cytosolic carboxypeptidase 3
Alias:
Atp/gtp binding protein-like 3; ATP/GTP-binding protein-like 3; Carboxypeptidase 3, cytosolic; Flj12983; Mgc32955
Type:
EC 3.4.17.-; Protease
Mass (Da):
115993
Number AA:
1001
UniProt ID:
Q8NEM8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004181
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
E
D
S
E
K
E
D
Y
S
D
R
T
I
S
D
Site 2
S11
D
S
E
K
E
D
Y
S
D
R
T
I
S
D
E
Site 3
T14
K
E
D
Y
S
D
R
T
I
S
D
E
D
E
S
Site 4
S16
D
Y
S
D
R
T
I
S
D
E
D
E
S
D
E
Site 5
S21
T
I
S
D
E
D
E
S
D
E
D
M
F
M
K
Site 6
T53
G
D
P
F
F
P
R
T
T
Q
I
L
L
E
Y
Site 7
T54
D
P
F
F
P
R
T
T
Q
I
L
L
E
Y
Q
Site 8
Y76
L
R
E
P
R
D
L
Y
G
V
S
S
S
G
P
Site 9
S79
P
R
D
L
Y
G
V
S
S
S
G
P
L
S
P
Site 10
S80
R
D
L
Y
G
V
S
S
S
G
P
L
S
P
T
Site 11
S81
D
L
Y
G
V
S
S
S
G
P
L
S
P
T
R
Site 12
S85
V
S
S
S
G
P
L
S
P
T
R
W
P
Y
H
Site 13
T87
S
S
G
P
L
S
P
T
R
W
P
Y
H
C
E
Site 14
Y91
L
S
P
T
R
W
P
Y
H
C
E
V
I
D
E
Site 15
T106
K
V
Q
H
I
D
W
T
P
S
C
P
E
P
V
Site 16
Y114
P
S
C
P
E
P
V
Y
I
P
T
G
L
E
T
Site 17
Y125
G
L
E
T
E
P
L
Y
P
D
S
K
E
A
T
Site 18
S128
T
E
P
L
Y
P
D
S
K
E
A
T
V
V
Y
Site 19
T132
Y
P
D
S
K
E
A
T
V
V
Y
L
A
E
D
Site 20
Y135
S
K
E
A
T
V
V
Y
L
A
E
D
A
Y
K
Site 21
Y148
Y
K
E
P
C
F
V
Y
S
R
V
G
G
N
R
Site 22
T156
S
R
V
G
G
N
R
T
P
L
K
Q
P
V
D
Site 23
Y164
P
L
K
Q
P
V
D
Y
R
D
N
T
L
M
F
Site 24
T168
P
V
D
Y
R
D
N
T
L
M
F
E
A
R
F
Site 25
S177
M
F
E
A
R
F
E
S
G
N
L
Q
K
V
V
Site 26
T194
A
E
Y
E
Y
Q
L
T
V
R
P
D
L
F
T
Site 27
T229
R
F
T
I
V
N
F
T
K
P
A
S
L
Y
S
Site 28
S233
V
N
F
T
K
P
A
S
L
Y
S
R
G
M
R
Site 29
Y235
F
T
K
P
A
S
L
Y
S
R
G
M
R
P
L
Site 30
Y244
R
G
M
R
P
L
F
Y
S
E
K
E
A
K
A
Site 31
S245
G
M
R
P
L
F
Y
S
E
K
E
A
K
A
H
Site 32
Y265
R
I
G
D
Q
I
K
Y
Y
R
N
N
P
G
Q
Site 33
Y266
I
G
D
Q
I
K
Y
Y
R
N
N
P
G
Q
D
Site 34
Y277
P
G
Q
D
G
R
H
Y
F
S
L
T
W
T
F
Site 35
Y309
T
Y
T
N
L
Q
E
Y
L
S
G
I
N
N
D
Site 36
S311
T
N
L
Q
E
Y
L
S
G
I
N
N
D
P
V
Site 37
S351
T
P
L
K
N
S
D
S
R
K
R
K
A
V
I
Site 38
T360
K
R
K
A
V
I
L
T
A
R
V
H
P
G
E
Site 39
S386
D
Y
I
L
G
N
S
S
D
A
Q
L
L
R
D
Site 40
S416
I
V
G
N
Y
R
C
S
L
A
G
R
D
L
N
Site 41
Y426
G
R
D
L
N
R
N
Y
T
S
L
L
K
E
S
Site 42
T427
R
D
L
N
R
N
Y
T
S
L
L
K
E
S
F
Site 43
S428
D
L
N
R
N
Y
T
S
L
L
K
E
S
F
P
Site 44
S433
Y
T
S
L
L
K
E
S
F
P
S
V
W
Y
T
Site 45
Y439
E
S
F
P
S
V
W
Y
T
R
N
M
V
H
R
Site 46
T440
S
F
P
S
V
W
Y
T
R
N
M
V
H
R
L
Site 47
Y456
E
K
R
E
V
I
L
Y
C
D
L
H
G
H
S
Site 48
Y471
R
K
E
N
I
F
M
Y
G
C
D
G
S
D
R
Site 49
S479
G
C
D
G
S
D
R
S
K
T
L
Y
L
Q
Q
Site 50
T481
D
G
S
D
R
S
K
T
L
Y
L
Q
Q
R
I
Site 51
Y483
S
D
R
S
K
T
L
Y
L
Q
Q
R
I
F
P
Site 52
S513
C
K
F
N
V
Q
K
S
K
E
G
T
G
R
V
Site 53
T517
V
Q
K
S
K
E
G
T
G
R
V
V
M
W
K
Site 54
T548
T
L
G
N
K
R
G
T
H
F
S
T
K
D
L
Site 55
S551
N
K
R
G
T
H
F
S
T
K
D
L
E
S
M
Site 56
Y560
K
D
L
E
S
M
G
Y
H
F
C
D
S
L
L
Site 57
Y569
F
C
D
S
L
L
D
Y
C
D
P
D
R
T
K
Site 58
Y577
C
D
P
D
R
T
K
Y
Y
R
C
L
K
E
L
Site 59
T592
E
E
M
E
R
H
I
T
L
E
K
V
F
E
D
Site 60
S600
L
E
K
V
F
E
D
S
D
T
P
V
I
D
I
Site 61
T608
D
T
P
V
I
D
I
T
L
D
V
E
S
S
S
Site 62
S613
D
I
T
L
D
V
E
S
S
S
R
G
S
D
S
Site 63
S614
I
T
L
D
V
E
S
S
S
R
G
S
D
S
S
Site 64
S615
T
L
D
V
E
S
S
S
R
G
S
D
S
S
E
Site 65
S618
V
E
S
S
S
R
G
S
D
S
S
E
S
I
D
Site 66
S620
S
S
S
R
G
S
D
S
S
E
S
I
D
S
L
Site 67
S621
S
S
R
G
S
D
S
S
E
S
I
D
S
L
T
Site 68
S623
R
G
S
D
S
S
E
S
I
D
S
L
T
Y
L
Site 69
S626
D
S
S
E
S
I
D
S
L
T
Y
L
L
K
L
Site 70
T628
S
E
S
I
D
S
L
T
Y
L
L
K
L
T
S
Site 71
Y629
E
S
I
D
S
L
T
Y
L
L
K
L
T
S
Q
Site 72
T634
L
T
Y
L
L
K
L
T
S
Q
K
K
H
L
K
Site 73
S635
T
Y
L
L
K
L
T
S
Q
K
K
H
L
K
T
Site 74
S648
K
T
K
K
E
R
N
S
T
I
A
S
H
Q
N
Site 75
T649
T
K
K
E
R
N
S
T
I
A
S
H
Q
N
A
Site 76
S652
E
R
N
S
T
I
A
S
H
Q
N
A
R
G
Q
Site 77
Y662
N
A
R
G
Q
E
V
Y
D
R
G
H
L
L
Q
Site 78
T672
G
H
L
L
Q
R
H
T
Q
S
N
S
D
V
K
Site 79
S676
Q
R
H
T
Q
S
N
S
D
V
K
D
T
R
P
Site 80
T681
S
N
S
D
V
K
D
T
R
P
N
E
P
D
D
Site 81
Y689
R
P
N
E
P
D
D
Y
M
V
D
Y
F
R
R
Site 82
Y693
P
D
D
Y
M
V
D
Y
F
R
R
Q
L
P
N
Site 83
S713
C
K
L
R
L
P
G
S
R
H
S
P
A
S
A
Site 84
S716
R
L
P
G
S
R
H
S
P
A
S
A
S
R
V
Site 85
S719
G
S
R
H
S
P
A
S
A
S
R
V
A
G
T
Site 86
S721
R
H
S
P
A
S
A
S
R
V
A
G
T
T
G
Site 87
T727
A
S
R
V
A
G
T
T
G
T
R
H
H
T
W
Site 88
Y755
P
L
K
G
T
D
L
Y
G
N
C
F
K
V
T
Site 89
T762
Y
G
N
C
F
K
V
T
S
L
Q
S
P
M
G
Site 90
S763
G
N
C
F
K
V
T
S
L
Q
S
P
M
G
K
Site 91
S766
F
K
V
T
S
L
Q
S
P
M
G
K
Q
T
S
Site 92
S773
S
P
M
G
K
Q
T
S
T
W
T
E
K
T
R
Site 93
T783
T
E
K
T
R
I
P
T
E
D
L
H
H
N
L
Site 94
S792
D
L
H
H
N
L
K
S
K
I
K
E
C
I
S
Site 95
S799
S
K
I
K
E
C
I
S
F
Q
S
K
K
T
G
Site 96
Y817
T
D
D
E
K
R
S
Y
K
D
K
G
I
V
Q
Site 97
T867
Q
H
Q
L
N
P
A
T
C
R
N
I
K
K
Y
Site 98
Y874
T
C
R
N
I
K
K
Y
S
T
S
W
T
A
P
Site 99
T879
K
K
Y
S
T
S
W
T
A
P
R
N
H
P
F
Site 100
S902
N
S
S
E
W
V
Q
S
K
P
H
R
S
L
E
Site 101
S907
V
Q
S
K
P
H
R
S
L
E
S
L
S
P
L
Site 102
S910
K
P
H
R
S
L
E
S
L
S
P
L
K
G
P
Site 103
S912
H
R
S
L
E
S
L
S
P
L
K
G
P
K
K
Site 104
S937
N
E
D
I
K
P
L
S
S
K
W
E
T
A
S
Site 105
S938
E
D
I
K
P
L
S
S
K
W
E
T
A
S
S
Site 106
T942
P
L
S
S
K
W
E
T
A
S
S
S
F
G
M
Site 107
S944
S
S
K
W
E
T
A
S
S
S
F
G
M
D
A
Site 108
S945
S
K
W
E
T
A
S
S
S
F
G
M
D
A
N
Site 109
S946
K
W
E
T
A
S
S
S
F
G
M
D
A
N
V
Site 110
S958
A
N
V
L
K
Y
K
S
L
Q
A
E
E
T
N
Site 111
T964
K
S
L
Q
A
E
E
T
N
Q
Q
S
S
K
H
Site 112
Y994
N
D
G
Q
P
T
L
Y
L
K
F
Q
R
E
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation