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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ShcBP1
Full Name:
SHC SH2 domain-binding protein 1
Alias:
FLJ22009; SHC SH2-domain binding protein 1; SHCBP
Type:
Adapter/scaffold protein
Mass (Da):
75660
Number AA:
672
UniProt ID:
Q8NEM2
International Prot ID:
IPI00168691
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
D
G
S
L
T
G
G
G
L
E
Site 2
T7
_
M
A
D
G
S
L
T
G
G
G
L
E
A
A
Site 3
S31
A
V
E
Q
E
L
A
S
L
E
K
G
L
F
Q
Site 4
S42
G
L
F
Q
D
E
D
S
C
S
D
C
S
Y
R
Site 5
S44
F
Q
D
E
D
S
C
S
D
C
S
Y
R
D
K
Site 6
S47
E
D
S
C
S
D
C
S
Y
R
D
K
P
G
S
Site 7
Y48
D
S
C
S
D
C
S
Y
R
D
K
P
G
S
S
Site 8
S54
S
Y
R
D
K
P
G
S
S
L
Q
S
F
M
P
Site 9
S55
Y
R
D
K
P
G
S
S
L
Q
S
F
M
P
E
Site 10
S58
K
P
G
S
S
L
Q
S
F
M
P
E
G
K
T
Site 11
T65
S
F
M
P
E
G
K
T
F
F
P
E
I
F
Q
Site 12
Y79
Q
T
N
Q
L
L
F
Y
E
R
F
R
A
Y
Q
Site 13
Y85
F
Y
E
R
F
R
A
Y
Q
D
Y
I
L
A
D
Site 14
Y88
R
F
R
A
Y
Q
D
Y
I
L
A
D
C
K
A
Site 15
S96
I
L
A
D
C
K
A
S
E
V
Q
E
F
T
A
Site 16
S152
A
E
P
Y
L
C
D
S
Q
V
S
T
F
T
M
Site 17
Y217
D
E
E
E
E
D
E
Y
D
Y
F
V
R
C
V
Site 18
Y219
E
E
E
D
E
Y
D
Y
F
V
R
C
V
E
P
Site 19
Y232
E
P
R
L
R
L
H
Y
D
I
L
E
D
R
V
Site 20
S252
V
D
Y
H
N
L
L
S
Q
C
E
E
S
Y
R
Site 21
S257
L
L
S
Q
C
E
E
S
Y
R
K
F
L
N
L
Site 22
S267
K
F
L
N
L
R
S
S
L
S
N
C
N
S
D
Site 23
S269
L
N
L
R
S
S
L
S
N
C
N
S
D
S
E
Site 24
S273
S
S
L
S
N
C
N
S
D
S
E
Q
E
N
I
Site 25
S275
L
S
N
C
N
S
D
S
E
Q
E
N
I
S
M
Site 26
Y289
M
V
E
G
L
K
L
Y
S
E
M
E
Q
L
K
Site 27
Y309
I
E
N
P
L
L
R
Y
V
F
G
Y
Q
K
N
Site 28
Y313
L
L
R
Y
V
F
G
Y
Q
K
N
S
N
I
Q
Site 29
S327
Q
A
K
G
V
R
S
S
G
Q
K
I
T
H
V
Site 30
T332
R
S
S
G
Q
K
I
T
H
V
V
S
S
T
M
Site 31
T349
G
L
L
R
S
L
L
T
D
R
L
C
Q
E
P
Site 32
S367
E
R
E
I
Q
F
H
S
D
P
L
S
A
I
N
Site 33
S371
Q
F
H
S
D
P
L
S
A
I
N
A
C
F
E
Site 34
S400
G
T
F
S
I
A
D
S
I
E
L
E
G
Y
G
Site 35
Y406
D
S
I
E
L
E
G
Y
G
L
P
D
D
I
V
Site 36
T422
E
K
R
G
K
G
D
T
F
V
D
C
T
G
A
Site 37
T470
Q
C
E
T
T
G
V
T
V
R
T
S
A
E
F
Site 38
S474
T
G
V
T
V
R
T
S
A
E
F
L
M
K
N
Site 39
Y485
L
M
K
N
S
D
L
Y
G
A
K
G
A
G
I
Site 40
Y495
K
G
A
G
I
E
I
Y
P
G
S
Q
C
T
L
Site 41
S498
G
I
E
I
Y
P
G
S
Q
C
T
L
S
D
N
Site 42
T501
I
Y
P
G
S
Q
C
T
L
S
D
N
G
I
H
Site 43
Y524
K
D
F
L
D
E
H
Y
D
I
P
K
I
S
M
Site 44
T573
N
K
A
L
K
I
Q
T
S
G
E
P
D
V
A
Site 45
S574
K
A
L
K
I
Q
T
S
G
E
P
D
V
A
E
Site 46
S605
L
C
A
R
T
D
P
S
E
Q
V
E
G
N
C
Site 47
S634
Q
I
K
K
K
R
L
S
E
L
G
I
T
Q
A
Site 48
T639
R
L
S
E
L
G
I
T
Q
A
D
D
N
L
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation