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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCPH1
Full Name:
Microcephalin
Alias:
BRCT-repeat inhibitor of TERT expression 1; BRIT1; MCT; Microcephaly, primary autosomal recessive 1
Type:
Cell cycle regulatory protein
Mass (Da):
92772
Number AA:
835
UniProt ID:
Q8NEM0
International Prot ID:
IPI00002374
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005813
GO:0005815
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
A
Y
V
E
V
W
S
S
N
G
T
E
N
Y
S
Site 2
T21
E
V
W
S
S
N
G
T
E
N
Y
S
K
T
F
Site 3
S25
S
N
G
T
E
N
Y
S
K
T
F
T
T
Q
L
Site 4
T27
G
T
E
N
Y
S
K
T
F
T
T
Q
L
V
D
Site 5
T29
E
N
Y
S
K
T
F
T
T
Q
L
V
D
M
G
Site 6
T42
M
G
A
K
V
S
K
T
F
N
K
Q
V
T
H
Site 7
Y56
H
V
I
F
K
D
G
Y
Q
S
T
W
D
K
A
Site 8
S72
K
R
G
V
K
L
V
S
V
L
W
V
E
K
C
Site 9
S102
N
M
N
E
H
L
S
S
L
I
K
K
K
R
K
Site 10
T120
P
K
D
F
N
F
K
T
P
E
N
D
K
R
F
Site 11
T143
K
E
L
Q
R
Q
K
T
N
L
D
D
D
V
P
Site 12
T163
S
N
G
S
L
I
Y
T
P
T
I
E
I
N
S
Site 13
T165
G
S
L
I
Y
T
P
T
I
E
I
N
S
S
H
Site 14
S171
P
T
I
E
I
N
S
S
H
H
S
A
M
E
K
Site 15
S174
E
I
N
S
S
H
H
S
A
M
E
K
R
L
Q
Site 16
S191
K
E
K
R
E
N
L
S
P
T
S
S
Q
M
I
Site 17
S194
R
E
N
L
S
P
T
S
S
Q
M
I
Q
Q
S
Site 18
S195
E
N
L
S
P
T
S
S
Q
M
I
Q
Q
S
H
Site 19
S201
S
S
Q
M
I
Q
Q
S
H
D
N
P
S
N
S
Site 20
S206
Q
Q
S
H
D
N
P
S
N
S
L
C
E
A
P
Site 21
S208
S
H
D
N
P
S
N
S
L
C
E
A
P
L
N
Site 22
T220
P
L
N
I
S
R
D
T
L
C
S
D
E
Y
F
Site 23
S223
I
S
R
D
T
L
C
S
D
E
Y
F
A
G
G
Site 24
Y226
D
T
L
C
S
D
E
Y
F
A
G
G
L
H
S
Site 25
S234
F
A
G
G
L
H
S
S
F
D
D
L
C
G
N
Site 26
S254
Q
E
R
K
L
E
G
S
I
N
D
I
K
S
D
Site 27
S276
L
K
A
N
N
I
H
S
S
P
S
F
T
H
L
Site 28
S277
K
A
N
N
I
H
S
S
P
S
F
T
H
L
D
Site 29
S279
N
N
I
H
S
S
P
S
F
T
H
L
D
K
S
Site 30
T281
I
H
S
S
P
S
F
T
H
L
D
K
S
S
P
Site 31
S286
S
F
T
H
L
D
K
S
S
P
Q
K
F
L
S
Site 32
S287
F
T
H
L
D
K
S
S
P
Q
K
F
L
S
N
Site 33
S293
S
S
P
Q
K
F
L
S
N
L
S
K
E
E
I
Site 34
T312
N
I
A
G
K
V
V
T
P
H
Q
K
Q
A
A
Site 35
S322
Q
K
Q
A
A
G
M
S
Q
E
T
F
E
E
K
Site 36
T325
A
A
G
M
S
Q
E
T
F
E
E
K
Y
R
L
Site 37
S333
F
E
E
K
Y
R
L
S
P
T
L
S
S
T
K
Site 38
T335
E
K
Y
R
L
S
P
T
L
S
S
T
K
G
H
Site 39
S337
Y
R
L
S
P
T
L
S
S
T
K
G
H
L
L
Site 40
T339
L
S
P
T
L
S
S
T
K
G
H
L
L
I
H
Site 41
S347
K
G
H
L
L
I
H
S
R
P
R
S
S
S
V
Site 42
S351
L
I
H
S
R
P
R
S
S
S
V
K
R
K
R
Site 43
S352
I
H
S
R
P
R
S
S
S
V
K
R
K
R
V
Site 44
S353
H
S
R
P
R
S
S
S
V
K
R
K
R
V
S
Site 45
S360
S
V
K
R
K
R
V
S
H
G
S
H
S
P
P
Site 46
S363
R
K
R
V
S
H
G
S
H
S
P
P
K
E
K
Site 47
S365
R
V
S
H
G
S
H
S
P
P
K
E
K
C
K
Site 48
S376
E
K
C
K
R
K
R
S
T
R
R
S
I
M
P
Site 49
T377
K
C
K
R
K
R
S
T
R
R
S
I
M
P
R
Site 50
S380
R
K
R
S
T
R
R
S
I
M
P
R
L
Q
L
Site 51
S390
P
R
L
Q
L
C
R
S
E
G
R
L
Q
H
V
Site 52
S406
G
P
A
L
E
A
L
S
C
G
E
S
S
Y
D
Site 53
S410
E
A
L
S
C
G
E
S
S
Y
D
D
Y
F
S
Site 54
S411
A
L
S
C
G
E
S
S
Y
D
D
Y
F
S
P
Site 55
Y412
L
S
C
G
E
S
S
Y
D
D
Y
F
S
P
D
Site 56
Y415
G
E
S
S
Y
D
D
Y
F
S
P
D
N
L
K
Site 57
S417
S
S
Y
D
D
Y
F
S
P
D
N
L
K
E
R
Site 58
S426
D
N
L
K
E
R
Y
S
E
N
L
P
P
E
S
Site 59
S433
S
E
N
L
P
P
E
S
Q
L
P
S
S
P
A
Site 60
S437
P
P
E
S
Q
L
P
S
S
P
A
Q
L
S
C
Site 61
S438
P
E
S
Q
L
P
S
S
P
A
Q
L
S
C
R
Site 62
S443
P
S
S
P
A
Q
L
S
C
R
S
L
S
K
K
Site 63
S446
P
A
Q
L
S
C
R
S
L
S
K
K
E
R
T
Site 64
S448
Q
L
S
C
R
S
L
S
K
K
E
R
T
S
I
Site 65
S454
L
S
K
K
E
R
T
S
I
F
E
M
S
D
F
Site 66
S459
R
T
S
I
F
E
M
S
D
F
S
C
V
G
K
Site 67
S462
I
F
E
M
S
D
F
S
C
V
G
K
K
T
R
Site 68
T470
C
V
G
K
K
T
R
T
V
D
I
T
N
F
T
Site 69
T474
K
T
R
T
V
D
I
T
N
F
T
A
K
T
I
Site 70
S482
N
F
T
A
K
T
I
S
S
P
R
K
T
G
N
Site 71
S483
F
T
A
K
T
I
S
S
P
R
K
T
G
N
G
Site 72
T487
T
I
S
S
P
R
K
T
G
N
G
E
G
R
A
Site 73
T495
G
N
G
E
G
R
A
T
S
S
C
V
T
S
A
Site 74
S496
N
G
E
G
R
A
T
S
S
C
V
T
S
A
P
Site 75
S497
G
E
G
R
A
T
S
S
C
V
T
S
A
P
E
Site 76
T500
R
A
T
S
S
C
V
T
S
A
P
E
E
A
L
Site 77
S501
A
T
S
S
C
V
T
S
A
P
E
E
A
L
R
Site 78
Y527
P
E
G
N
G
F
S
Y
T
I
E
D
P
A
L
Site 79
T543
K
G
H
D
D
D
L
T
P
L
E
G
S
L
E
Site 80
S548
D
L
T
P
L
E
G
S
L
E
E
M
K
E
A
Site 81
S560
K
E
A
V
G
L
K
S
T
Q
N
K
G
T
T
Site 82
T561
E
A
V
G
L
K
S
T
Q
N
K
G
T
T
S
Site 83
T566
K
S
T
Q
N
K
G
T
T
S
K
I
S
N
S
Site 84
S568
T
Q
N
K
G
T
T
S
K
I
S
N
S
S
E
Site 85
S571
K
G
T
T
S
K
I
S
N
S
S
E
G
E
A
Site 86
S580
S
S
E
G
E
A
Q
S
E
H
E
P
C
F
I
Site 87
T594
I
V
D
C
N
M
E
T
S
T
E
E
K
E
N
Site 88
T596
D
C
N
M
E
T
S
T
E
E
K
E
N
L
P
Site 89
Y606
K
E
N
L
P
G
G
Y
S
G
S
V
K
N
R
Site 90
S607
E
N
L
P
G
G
Y
S
G
S
V
K
N
R
P
Site 91
S609
L
P
G
G
Y
S
G
S
V
K
N
R
P
T
R
Site 92
T615
G
S
V
K
N
R
P
T
R
H
D
V
L
D
D
Site 93
S623
R
H
D
V
L
D
D
S
C
D
G
F
K
D
L
Site 94
S640
P
H
E
E
L
K
K
S
G
R
G
K
K
P
T
Site 95
T647
S
G
R
G
K
K
P
T
R
T
L
V
M
T
S
Site 96
T649
R
G
K
K
P
T
R
T
L
V
M
T
S
M
P
Site 97
T653
P
T
R
T
L
V
M
T
S
M
P
S
E
K
Q
Site 98
T684
P
D
V
C
E
T
T
T
H
V
L
S
G
K
P
Site 99
S724
L
E
L
G
H
W
I
S
E
E
P
F
E
L
S
Site 100
S731
S
E
E
P
F
E
L
S
H
H
F
P
A
A
P
Site 101
S742
P
A
A
P
L
C
R
S
E
C
H
L
S
A
G
Site 102
S747
C
R
S
E
C
H
L
S
A
G
P
Y
R
G
T
Site 103
T754
S
A
G
P
Y
R
G
T
L
F
A
D
Q
P
V
Site 104
S787
H
L
C
G
G
R
V
S
Q
V
P
R
Q
A
S
Site 105
S794
S
Q
V
P
R
Q
A
S
I
V
I
G
P
Y
S
Site 106
S801
S
I
V
I
G
P
Y
S
G
K
K
K
A
T
V
Site 107
T807
Y
S
G
K
K
K
A
T
V
K
Y
L
S
E
K
Site 108
Y810
K
K
K
A
T
V
K
Y
L
S
E
K
W
V
L
Site 109
T821
K
W
V
L
D
S
I
T
Q
H
K
V
C
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation