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Updated November 2019
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Protein Info
Short Name:
TTC16
Full Name:
Tetratricopeptide repeat protein 16
Alias:
Type:
Mass (Da):
98309
Number AA:
873
UniProt ID:
Q8NEE8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T56
K
P
K
V
T
G
L
T
V
P
L
K
V
R
E
Site 2
Y64
V
P
L
K
V
R
E
Y
Y
S
R
G
Q
Q
C
Site 3
Y65
P
L
K
V
R
E
Y
Y
S
R
G
Q
Q
C
L
Site 4
Y98
D
P
Q
L
V
D
F
Y
A
L
R
A
E
A
Y
Site 5
S113
L
Q
L
C
D
F
S
S
A
A
Q
N
L
R
R
Site 6
Y122
A
Q
N
L
R
R
A
Y
S
L
Q
Q
D
N
C
Site 7
S123
Q
N
L
R
R
A
Y
S
L
Q
Q
D
N
C
K
Site 8
T191
K
Q
H
Q
A
C
L
T
L
I
T
N
E
L
K
Site 9
T202
N
E
L
K
Q
D
T
T
N
A
D
V
Y
I
F
Site 10
Y207
D
T
T
N
A
D
V
Y
I
F
R
A
R
L
Y
Site 11
Y214
Y
I
F
R
A
R
L
Y
N
F
L
Q
K
P
H
Site 12
S286
E
N
N
P
L
D
P
S
L
F
L
F
R
G
T
Site 13
T293
S
L
F
L
F
R
G
T
M
Y
R
R
L
Q
E
Site 14
Y295
F
L
F
R
G
T
M
Y
R
R
L
Q
E
F
D
Site 15
T316
L
K
V
L
D
M
V
T
E
D
Q
E
D
M
V
Site 16
T333
A
Q
R
Q
L
L
L
T
Y
N
D
F
A
V
H
Site 17
Y368
E
Q
Q
E
K
G
L
Y
I
N
R
G
D
C
F
Site 18
S395
Y
Q
Q
A
L
A
L
S
P
Q
D
E
G
A
N
Site 19
T403
P
Q
D
E
G
A
N
T
R
M
G
L
L
Q
E
Site 20
S430
Q
K
A
E
N
H
F
S
T
A
I
R
H
N
P
Site 21
Y443
N
P
Q
K
A
Q
Y
Y
L
Y
R
A
K
S
R
Site 22
Y445
Q
K
A
Q
Y
Y
L
Y
R
A
K
S
R
Q
L
Site 23
S449
Y
Y
L
Y
R
A
K
S
R
Q
L
L
Q
N
I
Site 24
T465
G
A
R
Q
D
V
A
T
V
L
L
L
N
P
K
Site 25
S512
L
E
Q
M
V
E
G
S
L
Q
A
G
S
P
Q
Site 26
S517
E
G
S
L
Q
A
G
S
P
Q
G
I
V
G
M
Site 27
S541
K
A
L
A
L
Q
H
S
W
K
Q
G
E
P
L
Site 28
T558
T
S
E
E
L
K
A
T
P
E
I
P
Q
V
K
Site 29
S568
I
P
Q
V
K
P
G
S
S
E
G
E
A
E
A
Site 30
S592
E
K
K
E
E
K
K
S
E
L
I
P
S
K
V
Site 31
S597
K
K
S
E
L
I
P
S
K
V
A
S
L
S
D
Site 32
S603
P
S
K
V
A
S
L
S
D
S
Y
L
D
Q
T
Site 33
S605
K
V
A
S
L
S
D
S
Y
L
D
Q
T
S
S
Site 34
Y606
V
A
S
L
S
D
S
Y
L
D
Q
T
S
S
A
Site 35
T610
S
D
S
Y
L
D
Q
T
S
S
A
S
S
M
S
Site 36
S611
D
S
Y
L
D
Q
T
S
S
A
S
S
M
S
F
Site 37
S612
S
Y
L
D
Q
T
S
S
A
S
S
M
S
F
R
Site 38
S615
D
Q
T
S
S
A
S
S
M
S
F
R
T
T
G
Site 39
S617
T
S
S
A
S
S
M
S
F
R
T
T
G
T
S
Site 40
T621
S
S
M
S
F
R
T
T
G
T
S
E
T
E
M
Site 41
S624
S
F
R
T
T
G
T
S
E
T
E
M
S
A
I
Site 42
S629
G
T
S
E
T
E
M
S
A
I
C
Q
E
Y
R
Site 43
T638
I
C
Q
E
Y
R
S
T
S
A
T
A
V
T
F
Site 44
S639
C
Q
E
Y
R
S
T
S
A
T
A
V
T
F
S
Site 45
T641
E
Y
R
S
T
S
A
T
A
V
T
F
S
D
S
Site 46
T644
S
T
S
A
T
A
V
T
F
S
D
S
S
L
L
Site 47
S649
A
V
T
F
S
D
S
S
L
L
K
T
Q
S
S
Site 48
T653
S
D
S
S
L
L
K
T
Q
S
S
D
S
G
N
Site 49
S655
S
S
L
L
K
T
Q
S
S
D
S
G
N
N
R
Site 50
S656
S
L
L
K
T
Q
S
S
D
S
G
N
N
R
E
Site 51
T675
G
P
R
K
I
K
A
T
Q
G
Q
R
Q
S
L
Site 52
S681
A
T
Q
G
Q
R
Q
S
L
S
K
T
E
P
T
Site 53
S683
Q
G
Q
R
Q
S
L
S
K
T
E
P
T
Q
S
Site 54
T685
Q
R
Q
S
L
S
K
T
E
P
T
Q
S
Q
R
Site 55
T688
S
L
S
K
T
E
P
T
Q
S
Q
R
R
N
S
Site 56
S690
S
K
T
E
P
T
Q
S
Q
R
R
N
S
S
K
Site 57
S695
T
Q
S
Q
R
R
N
S
S
K
T
K
A
T
I
Site 58
S696
Q
S
Q
R
R
N
S
S
K
T
K
A
T
I
H
Site 59
T698
Q
R
R
N
S
S
K
T
K
A
T
I
H
K
R
Site 60
S707
A
T
I
H
K
R
N
S
S
K
T
K
A
T
Q
Site 61
S708
T
I
H
K
R
N
S
S
K
T
K
A
T
Q
S
Site 62
T710
H
K
R
N
S
S
K
T
K
A
T
Q
S
Q
R
Site 63
S715
S
K
T
K
A
T
Q
S
Q
R
R
N
S
S
K
Site 64
S720
T
Q
S
Q
R
R
N
S
S
K
T
R
A
T
Q
Site 65
S721
Q
S
Q
R
R
N
S
S
K
T
R
A
T
Q
G
Site 66
T723
Q
R
R
N
S
S
K
T
R
A
T
Q
G
Q
G
Site 67
T726
N
S
S
K
T
R
A
T
Q
G
Q
G
Q
S
S
Site 68
S734
Q
G
Q
G
Q
S
S
S
K
T
E
A
T
Q
G
Site 69
T736
Q
G
Q
S
S
S
K
T
E
A
T
Q
G
Q
R
Site 70
S745
A
T
Q
G
Q
R
Q
S
S
S
E
I
E
A
T
Site 71
S746
T
Q
G
Q
R
Q
S
S
S
E
I
E
A
T
Q
Site 72
S747
Q
G
Q
R
Q
S
S
S
E
I
E
A
T
Q
G
Site 73
T752
S
S
S
E
I
E
A
T
Q
G
P
R
Q
E
P
Site 74
S760
Q
G
P
R
Q
E
P
S
K
T
K
T
T
R
S
Site 75
T762
P
R
Q
E
P
S
K
T
K
T
T
R
S
P
R
Site 76
T764
Q
E
P
S
K
T
K
T
T
R
S
P
R
Q
R
Site 77
S767
S
K
T
K
T
T
R
S
P
R
Q
R
P
R
K
Site 78
S782
V
K
A
A
R
G
R
S
W
R
P
S
K
V
D
Site 79
S786
R
G
R
S
W
R
P
S
K
V
D
A
T
Q
G
Site 80
T791
R
P
S
K
V
D
A
T
Q
G
R
S
R
G
L
Site 81
S801
R
S
R
G
L
L
R
S
S
T
K
T
E
A
F
Site 82
S802
S
R
G
L
L
R
S
S
T
K
T
E
A
F
Y
Site 83
T803
R
G
L
L
R
S
S
T
K
T
E
A
F
Y
D
Site 84
T805
L
L
R
S
S
T
K
T
E
A
F
Y
D
S
N
Site 85
Y809
S
T
K
T
E
A
F
Y
D
S
N
W
S
L
S
Site 86
S811
K
T
E
A
F
Y
D
S
N
W
S
L
S
K
T
Site 87
S814
A
F
Y
D
S
N
W
S
L
S
K
T
E
Y
A
Site 88
S816
Y
D
S
N
W
S
L
S
K
T
E
Y
A
Q
G
Site 89
T818
S
N
W
S
L
S
K
T
E
Y
A
Q
G
Q
G
Site 90
Y820
W
S
L
S
K
T
E
Y
A
Q
G
Q
G
Q
R
Site 91
S829
Q
G
Q
G
Q
R
S
S
K
A
E
G
A
Q
G
Site 92
S838
A
E
G
A
Q
G
K
S
Q
G
M
S
S
T
S
Site 93
S842
Q
G
K
S
Q
G
M
S
S
T
S
S
K
A
E
Site 94
S843
G
K
S
Q
G
M
S
S
T
S
S
K
A
E
S
Site 95
S845
S
Q
G
M
S
S
T
S
S
K
A
E
S
T
W
Site 96
S846
Q
G
M
S
S
T
S
S
K
A
E
S
T
W
G
Site 97
S850
S
T
S
S
K
A
E
S
T
W
G
P
S
P
S
Site 98
T851
T
S
S
K
A
E
S
T
W
G
P
S
P
S
L
Site 99
S855
A
E
S
T
W
G
P
S
P
S
L
S
K
T
E
Site 100
S857
S
T
W
G
P
S
P
S
L
S
K
T
E
V
D
Site 101
S859
W
G
P
S
P
S
L
S
K
T
E
V
D
Q
D
Site 102
T861
P
S
P
S
L
S
K
T
E
V
D
Q
D
L
T
Site 103
Y869
E
V
D
Q
D
L
T
Y
Y
E
A
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation