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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3C3
Full Name:
Phosphatidylinositol 3-kinase catalytic subunit type 3
Alias:
EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; Phosphoinositide-3-kinase, class 3; PK3C3; Vps34
Type:
EC 2.7.1.137; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Mass (Da):
101549
Number AA:
887
UniProt ID:
Q8NEB9
International Prot ID:
IPI00299755
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
G
E
A
E
K
F
H
Y
I
Y
S
C
D
L
D
Site 2
Y11
A
E
K
F
H
Y
I
Y
S
C
D
L
D
I
N
Site 3
S25
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Site 4
S34
E
G
K
R
E
Q
K
S
Y
K
A
V
L
E
D
Site 5
Y35
G
K
R
E
Q
K
S
Y
K
A
V
L
E
D
P
Site 6
Y50
M
L
K
F
S
G
L
Y
Q
E
T
C
S
D
L
Site 7
S77
L
A
L
P
V
R
T
S
Y
K
A
F
S
T
R
Site 8
Y78
A
L
P
V
R
T
S
Y
K
A
F
S
T
R
W
Site 9
S154
P
N
V
E
A
D
G
S
E
P
T
K
T
P
G
Site 10
T159
D
G
S
E
P
T
K
T
P
G
R
T
S
S
T
Site 11
T163
P
T
K
T
P
G
R
T
S
S
T
L
S
E
D
Site 12
S164
T
K
T
P
G
R
T
S
S
T
L
S
E
D
Q
Site 13
S165
K
T
P
G
R
T
S
S
T
L
S
E
D
Q
M
Site 14
T166
T
P
G
R
T
S
S
T
L
S
E
D
Q
M
S
Site 15
S168
G
R
T
S
S
T
L
S
E
D
Q
M
S
R
L
Site 16
S173
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Site 17
T179
M
S
R
L
A
K
L
T
K
A
H
R
Q
G
H
Site 18
S207
E
I
E
M
I
N
E
S
E
K
R
S
S
N
F
Site 19
S211
I
N
E
S
E
K
R
S
S
N
F
M
Y
L
M
Site 20
S212
N
E
S
E
K
R
S
S
N
F
M
Y
L
M
V
Site 21
Y216
K
R
S
S
N
F
M
Y
L
M
V
E
F
R
C
Site 22
Y231
V
K
C
D
D
K
E
Y
G
I
V
Y
Y
E
K
Site 23
Y235
D
K
E
Y
G
I
V
Y
Y
E
K
D
G
D
E
Site 24
Y236
K
E
Y
G
I
V
Y
Y
E
K
D
G
D
E
S
Site 25
S244
E
K
D
G
D
E
S
S
P
I
L
T
S
F
E
Site 26
S261
K
V
P
D
P
Q
M
S
M
E
N
L
V
E
S
Site 27
S268
S
M
E
N
L
V
E
S
K
H
H
K
L
A
R
Site 28
S276
K
H
H
K
L
A
R
S
L
R
S
G
P
S
D
Site 29
S282
R
S
L
R
S
G
P
S
D
H
D
L
K
P
N
Site 30
S301
D
Q
L
N
I
I
V
S
Y
P
P
T
K
Q
L
Site 31
T305
I
I
V
S
Y
P
P
T
K
Q
L
T
Y
E
E
Site 32
Y322
L
V
W
K
F
R
Y
Y
L
T
N
Q
E
K
A
Site 33
S363
K
P
M
D
V
E
D
S
L
E
L
L
S
S
H
Site 34
S369
D
S
L
E
L
L
S
S
H
Y
T
N
P
T
V
Site 35
Y371
L
E
L
L
S
S
H
Y
T
N
P
T
V
R
R
Site 36
T372
E
L
L
S
S
H
Y
T
N
P
T
V
R
R
Y
Site 37
T375
S
S
H
Y
T
N
P
T
V
R
R
Y
A
V
A
Site 38
Y379
T
N
P
T
V
R
R
Y
A
V
A
R
L
R
Q
Site 39
Y395
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Site 40
Y405
Q
L
V
Q
A
L
K
Y
E
N
F
D
D
I
K
Site 41
S422
L
E
P
T
K
K
D
S
Q
S
S
V
S
E
N
Site 42
S424
P
T
K
K
D
S
Q
S
S
V
S
E
N
V
S
Site 43
S425
T
K
K
D
S
Q
S
S
V
S
E
N
V
S
N
Site 44
S427
K
D
S
Q
S
S
V
S
E
N
V
S
N
S
G
Site 45
S431
S
S
V
S
E
N
V
S
N
S
G
I
N
S
A
Site 46
S433
V
S
E
N
V
S
N
S
G
I
N
S
A
E
I
Site 47
S437
V
S
N
S
G
I
N
S
A
E
I
D
S
S
Q
Site 48
S443
N
S
A
E
I
D
S
S
Q
I
I
T
S
P
L
Site 49
S448
D
S
S
Q
I
I
T
S
P
L
P
S
V
S
S
Site 50
S452
I
I
T
S
P
L
P
S
V
S
S
P
P
P
A
Site 51
S454
T
S
P
L
P
S
V
S
S
P
P
P
A
S
K
Site 52
S455
S
P
L
P
S
V
S
S
P
P
P
A
S
K
T
Site 53
S460
V
S
S
P
P
P
A
S
K
T
K
E
V
P
D
Site 54
T462
S
P
P
P
A
S
K
T
K
E
V
P
D
G
E
Site 55
S487
I
S
R
A
C
K
N
S
T
L
A
N
Y
L
Y
Site 56
T488
S
R
A
C
K
N
S
T
L
A
N
Y
L
Y
W
Site 57
T506
V
E
C
E
D
Q
D
T
Q
Q
R
D
P
K
T
Site 58
T513
T
Q
Q
R
D
P
K
T
H
E
M
Y
L
N
V
Site 59
Y517
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
Site 60
S525
L
N
V
M
R
R
F
S
Q
A
L
L
K
G
D
Site 61
S534
A
L
L
K
G
D
K
S
V
R
V
M
R
S
L
Site 62
S563
M
K
A
V
Q
R
E
S
G
N
R
K
K
K
N
Site 63
S586
D
N
E
K
M
N
L
S
D
V
E
L
I
P
L
Site 64
Y631
K
T
E
D
G
G
K
Y
P
V
I
F
K
H
G
Site 65
T668
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Site 66
T696
P
V
A
E
V
L
D
T
E
G
S
I
Q
N
F
Site 67
S699
E
V
L
D
T
E
G
S
I
Q
N
F
F
R
K
Site 68
Y707
I
Q
N
F
F
R
K
Y
A
P
S
E
N
G
P
Site 69
S710
F
F
R
K
Y
A
P
S
E
N
G
P
N
G
I
Site 70
Y725
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
Site 71
T752
H
L
D
N
L
L
L
T
K
T
G
K
L
F
H
Site 72
T754
D
N
L
L
L
T
K
T
G
K
L
F
H
I
D
Site 73
Y764
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
K
Site 74
S792
E
G
M
G
G
T
Q
S
E
Q
Y
Q
E
F
R
Site 75
Y795
G
G
T
Q
S
E
Q
Y
Q
E
F
R
K
Q
C
Site 76
Y803
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
Site 77
T838
I
A
L
E
P
D
K
T
V
K
K
V
Q
D
K
Site 78
S851
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
Site 79
Y858
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
Site 80
S861
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
H
Site 81
Y884
Q
I
H
K
F
A
Q
Y
W
R
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation