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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RGS22
Full Name:
Regulator of G-protein signaling 22
Alias:
Type:
Uncharacterized
Mass (Da):
147163
Number AA:
1264
UniProt ID:
Q8NE09
International Prot ID:
IPI00257450
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0009968
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
P
E
K
R
L
T
A
E
P
P
T
I
T
Site 2
S21
T
E
E
E
F
E
D
S
L
A
T
D
D
F
L
Site 3
S37
D
Y
F
N
E
F
L
S
L
P
T
F
S
E
A
Site 4
Y82
Q
Q
P
R
N
P
I
Y
D
V
V
R
K
G
K
Site 5
T105
N
A
P
D
E
D
E
T
I
N
V
N
Y
N
I
Site 6
Y110
D
E
T
I
N
V
N
Y
N
I
M
C
L
S
R
Site 7
S135
R
L
P
A
F
L
E
S
D
C
Y
F
E
Y
R
Site 8
Y138
A
F
L
E
S
D
C
Y
F
E
Y
R
L
A
K
Site 9
Y141
E
S
D
C
Y
F
E
Y
R
L
A
K
L
V
S
Site 10
S148
Y
R
L
A
K
L
V
S
Q
V
R
W
S
K
S
Site 11
S153
L
V
S
Q
V
R
W
S
K
S
G
M
N
F
T
Site 12
S155
S
Q
V
R
W
S
K
S
G
M
N
F
T
V
G
Site 13
T160
S
K
S
G
M
N
F
T
V
G
S
N
F
S
P
Site 14
S166
F
T
V
G
S
N
F
S
P
W
I
V
K
K
P
Site 15
S175
W
I
V
K
K
P
P
S
L
P
P
P
A
T
E
Site 16
T181
P
S
L
P
P
P
A
T
E
E
D
N
L
V
I
Site 17
T202
S
L
G
E
A
S
Y
T
Q
T
K
D
W
F
A
Site 18
T204
G
E
A
S
Y
T
Q
T
K
D
W
F
A
L
A
Site 19
S214
W
F
A
L
A
K
Q
S
Q
Q
T
V
S
T
F
Site 20
T217
L
A
K
Q
S
Q
Q
T
V
S
T
F
S
L
P
Site 21
S219
K
Q
S
Q
Q
T
V
S
T
F
S
L
P
C
C
Site 22
Y229
S
L
P
C
C
V
P
Y
N
K
L
K
S
P
A
Site 23
S234
V
P
Y
N
K
L
K
S
P
A
I
S
S
V
S
Site 24
S238
K
L
K
S
P
A
I
S
S
V
S
E
N
F
I
Site 25
S241
S
P
A
I
S
S
V
S
E
N
F
I
F
D
D
Site 26
S259
P
R
T
K
K
D
P
S
K
T
N
K
L
I
S
Site 27
T261
T
K
K
D
P
S
K
T
N
K
L
I
S
E
F
Site 28
S266
S
K
T
N
K
L
I
S
E
F
E
E
E
E
G
Site 29
S279
E
G
E
E
E
E
V
S
V
S
L
Q
D
T
P
Site 30
S281
E
E
E
E
V
S
V
S
L
Q
D
T
P
S
Q
Site 31
T285
V
S
V
S
L
Q
D
T
P
S
Q
A
L
L
R
Site 32
S287
V
S
L
Q
D
T
P
S
Q
A
L
L
R
V
Y
Site 33
Y294
S
Q
A
L
L
R
V
Y
L
E
K
K
Q
D
V
Site 34
S304
K
K
Q
D
V
D
E
S
L
T
M
H
F
S
T
Site 35
T306
Q
D
V
D
E
S
L
T
M
H
F
S
T
C
E
Site 36
S310
E
S
L
T
M
H
F
S
T
C
E
E
F
L
S
Site 37
T311
S
L
T
M
H
F
S
T
C
E
E
F
L
S
S
Site 38
T339
V
G
K
P
V
G
E
T
P
D
Y
I
N
F
N
Site 39
Y342
P
V
G
E
T
P
D
Y
I
N
F
N
N
I
T
Site 40
S367
I
H
G
K
N
F
L
S
E
L
V
Q
T
T
K
Site 41
S377
V
Q
T
T
K
E
R
S
E
E
I
E
Q
T
S
Site 42
T383
R
S
E
E
I
E
Q
T
S
L
S
S
K
N
E
Site 43
S384
S
E
E
I
E
Q
T
S
L
S
S
K
N
E
S
Site 44
S386
E
I
E
Q
T
S
L
S
S
K
N
E
S
A
G
Site 45
S391
S
L
S
S
K
N
E
S
A
G
P
E
S
R
A
Site 46
S396
N
E
S
A
G
P
E
S
R
A
D
W
C
I
S
Site 47
S403
S
R
A
D
W
C
I
S
H
R
T
Y
D
I
G
Site 48
Y407
W
C
I
S
H
R
T
Y
D
I
G
N
R
K
E
Site 49
Y460
L
E
K
M
K
K
C
Y
L
V
S
N
G
D
Y
Site 50
Y467
Y
L
V
S
N
G
D
Y
Y
L
S
A
E
I
L
Site 51
S470
S
N
G
D
Y
Y
L
S
A
E
I
L
S
K
F
Site 52
S483
K
F
K
L
L
D
G
S
Q
W
N
E
E
H
L
Site 53
S495
E
H
L
R
N
I
Q
S
E
V
L
K
P
L
L
Site 54
T512
W
A
P
R
F
C
V
T
H
S
A
S
T
K
Y
Site 55
S514
P
R
F
C
V
T
H
S
A
S
T
K
Y
A
S
Site 56
Y519
T
H
S
A
S
T
K
Y
A
S
A
E
L
K
F
Site 57
T546
D
P
F
P
Q
M
A
T
L
L
P
L
R
P
K
Site 58
S554
L
L
P
L
R
P
K
S
C
I
P
Q
I
P
E
Site 59
S568
E
I
Q
K
E
E
F
S
L
S
Q
P
P
K
S
Site 60
S570
Q
K
E
E
F
S
L
S
Q
P
P
K
S
P
N
Site 61
S575
S
L
S
Q
P
P
K
S
P
N
K
S
P
E
V
Site 62
S579
P
P
K
S
P
N
K
S
P
E
V
K
T
A
T
Site 63
T584
N
K
S
P
E
V
K
T
A
T
Q
K
P
W
K
Site 64
T586
S
P
E
V
K
T
A
T
Q
K
P
W
K
R
E
Site 65
Y596
P
W
K
R
E
L
L
Y
P
G
S
S
K
D
D
Site 66
S599
R
E
L
L
Y
P
G
S
S
K
D
D
V
I
E
Site 67
S600
E
L
L
Y
P
G
S
S
K
D
D
V
I
E
K
Site 68
S609
D
D
V
I
E
K
G
S
K
Y
M
S
E
S
S
Site 69
Y611
V
I
E
K
G
S
K
Y
M
S
E
S
S
K
V
Site 70
S613
E
K
G
S
K
Y
M
S
E
S
S
K
V
I
H
Site 71
S616
S
K
Y
M
S
E
S
S
K
V
I
H
L
T
S
Site 72
Y639
K
P
Q
L
D
R
R
Y
A
Y
T
E
E
P
R
Site 73
Y641
Q
L
D
R
R
Y
A
Y
T
E
E
P
R
V
K
Site 74
T642
L
D
R
R
Y
A
Y
T
E
E
P
R
V
K
T
Site 75
T649
T
E
E
P
R
V
K
T
V
S
D
V
G
A
L
Site 76
S651
E
P
R
V
K
T
V
S
D
V
G
A
L
G
G
Site 77
S659
D
V
G
A
L
G
G
S
D
M
E
N
L
L
Q
Site 78
Y669
E
N
L
L
Q
S
L
Y
V
E
N
R
A
G
F
Site 79
Y695
K
L
W
K
N
S
V
Y
F
W
F
D
L
Q
A
Site 80
T711
H
Q
L
F
Y
Q
E
T
L
Q
P
F
K
V
C
Site 81
Y748
Q
E
K
K
K
E
I
Y
M
K
I
Q
P
P
F
Site 82
T775
L
L
L
L
E
P
W
T
K
M
V
K
S
D
Q
Site 83
T800
E
T
R
Q
L
D
S
T
Y
F
R
K
L
Q
A
Site 84
Y801
T
R
Q
L
D
S
T
Y
F
R
K
L
Q
A
L
Site 85
T812
L
Q
A
L
H
K
E
T
F
S
K
K
A
E
D
Site 86
T820
F
S
K
K
A
E
D
T
T
C
E
I
G
T
G
Site 87
T821
S
K
K
A
E
D
T
T
C
E
I
G
T
G
I
Site 88
S830
E
I
G
T
G
I
L
S
L
S
N
V
S
K
R
Site 89
S832
G
T
G
I
L
S
L
S
N
V
S
K
R
T
E
Site 90
S835
I
L
S
L
S
N
V
S
K
R
T
E
Y
W
D
Site 91
Y840
N
V
S
K
R
T
E
Y
W
D
N
V
P
A
E
Site 92
T872
H
F
R
Q
F
L
E
T
H
S
S
S
M
D
L
Site 93
S874
R
Q
F
L
E
T
H
S
S
S
M
D
L
M
C
Site 94
T892
I
E
Q
F
R
R
I
T
Y
R
D
R
N
Q
R
Site 95
Y893
E
Q
F
R
R
I
T
Y
R
D
R
N
Q
R
K
Site 96
S903
R
N
Q
R
K
A
K
S
I
Y
I
K
N
K
Y
Site 97
Y910
S
I
Y
I
K
N
K
Y
L
N
K
K
Y
F
F
Site 98
Y915
N
K
Y
L
N
K
K
Y
F
F
G
P
N
S
P
Site 99
S921
K
Y
F
F
G
P
N
S
P
A
S
L
Y
Q
Q
Site 100
S924
F
G
P
N
S
P
A
S
L
Y
Q
Q
N
Q
V
Site 101
Y926
P
N
S
P
A
S
L
Y
Q
Q
N
Q
V
M
H
Site 102
S1016
E
S
K
W
I
S
S
S
C
K
I
I
A
F
R
Site 103
T1031
K
A
L
L
N
P
V
T
S
R
Q
F
Q
R
F
Site 104
Y1114
H
R
K
E
L
G
P
Y
V
F
R
E
A
Q
M
Site 105
S1148
L
T
D
E
N
I
M
S
V
L
E
R
R
Q
E
Site 106
Y1156
V
L
E
R
R
Q
E
Y
N
K
Q
K
K
K
L
Site 107
S1171
A
V
L
E
D
E
K
S
G
K
D
G
I
K
Q
Site 108
Y1179
G
K
D
G
I
K
Q
Y
A
N
T
S
V
P
A
Site 109
S1183
I
K
Q
Y
A
N
T
S
V
P
A
I
K
T
A
Site 110
Y1202
S
F
L
G
L
Q
P
Y
G
R
Q
P
T
W
C
Site 111
Y1210
G
R
Q
P
T
W
C
Y
S
K
Y
I
E
A
L
Site 112
Y1213
P
T
W
C
Y
S
K
Y
I
E
A
L
E
Q
E
Site 113
T1242
F
A
G
L
Q
P
L
T
N
F
K
A
S
S
S
Site 114
S1247
P
L
T
N
F
K
A
S
S
S
T
M
S
L
K
Site 115
S1248
L
T
N
F
K
A
S
S
S
T
M
S
L
K
K
Site 116
S1249
T
N
F
K
A
S
S
S
T
M
S
L
K
K
N
Site 117
S1252
K
A
S
S
S
T
M
S
L
K
K
N
M
S
A
Site 118
S1258
M
S
L
K
K
N
M
S
A
H
S
S
Q
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation