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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BEND2
Full Name:
BEN domain-containing protein 2
Alias:
Type:
Mass (Da):
87919
Number AA:
799
UniProt ID:
Q8NDZ0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
E
Q
D
F
V
I
I
T
V
D
D
S
D
D
N
Site 2
S18
V
I
I
T
V
D
D
S
D
D
N
N
D
C
S
Site 3
S25
S
D
D
N
N
D
C
S
I
E
M
V
E
V
S
Site 4
S32
S
I
E
M
V
E
V
S
E
T
A
D
N
S
T
Site 5
T34
E
M
V
E
V
S
E
T
A
D
N
S
T
N
D
Site 6
S46
T
N
D
I
A
D
D
S
T
Y
V
T
A
D
N
Site 7
T47
N
D
I
A
D
D
S
T
Y
V
T
A
D
N
P
Site 8
Y48
D
I
A
D
D
S
T
Y
V
T
A
D
N
P
T
Site 9
T50
A
D
D
S
T
Y
V
T
A
D
N
P
T
D
D
Site 10
T58
A
D
N
P
T
D
D
T
A
T
Q
P
N
F
P
Site 11
T60
N
P
T
D
D
T
A
T
Q
P
N
F
P
G
G
Site 12
S78
H
H
R
P
L
Q
M
S
Y
G
S
G
S
V
T
Site 13
Y79
H
R
P
L
Q
M
S
Y
G
S
G
S
V
T
Q
Site 14
S81
P
L
Q
M
S
Y
G
S
G
S
V
T
Q
A
G
Site 15
S83
Q
M
S
Y
G
S
G
S
V
T
Q
A
G
V
Q
Site 16
T85
S
Y
G
S
G
S
V
T
Q
A
G
V
Q
W
H
Site 17
S96
V
Q
W
H
D
H
S
S
L
Q
P
Q
P
L
G
Site 18
S111
L
K
Q
F
F
H
L
S
L
P
S
S
W
D
D
Site 19
S115
F
H
L
S
L
P
S
S
W
D
D
R
R
T
P
Site 20
T121
S
S
W
D
D
R
R
T
P
P
C
P
V
A
H
Site 21
Y145
H
P
V
H
L
R
R
Y
S
Y
N
S
E
E
V
Site 22
S146
P
V
H
L
R
R
Y
S
Y
N
S
E
E
V
D
Site 23
Y147
V
H
L
R
R
Y
S
Y
N
S
E
E
V
D
F
Site 24
S149
L
R
R
Y
S
Y
N
S
E
E
V
D
F
P
K
Site 25
Y161
F
P
K
R
G
R
F
Y
T
P
E
V
Q
S
S
Site 26
T162
P
K
R
G
R
F
Y
T
P
E
V
Q
S
S
I
Site 27
S168
Y
T
P
E
V
Q
S
S
I
S
P
P
A
E
R
Site 28
S170
P
E
V
Q
S
S
I
S
P
P
A
E
R
Q
E
Site 29
T178
P
P
A
E
R
Q
E
T
H
A
W
A
S
P
A
Site 30
S183
Q
E
T
H
A
W
A
S
P
A
V
T
S
L
E
Site 31
S203
E
L
Q
E
A
D
L
S
E
S
L
S
Y
P
R
Site 32
S205
Q
E
A
D
L
S
E
S
L
S
Y
P
R
I
V
Site 33
S207
A
D
L
S
E
S
L
S
Y
P
R
I
V
S
S
Site 34
Y208
D
L
S
E
S
L
S
Y
P
R
I
V
S
S
S
Site 35
S213
L
S
Y
P
R
I
V
S
S
S
S
L
Q
Q
Y
Site 36
S214
S
Y
P
R
I
V
S
S
S
S
L
Q
Q
Y
V
Site 37
S215
Y
P
R
I
V
S
S
S
S
L
Q
Q
Y
V
A
Site 38
S216
P
R
I
V
S
S
S
S
L
Q
Q
Y
V
A
Q
Site 39
Y220
S
S
S
S
L
Q
Q
Y
V
A
Q
G
G
S
F
Site 40
S238
G
M
P
W
N
F
I
S
G
G
A
E
S
T
N
Site 41
S267
A
V
L
S
R
R
E
S
S
L
A
N
N
P
G
Site 42
S268
V
L
S
R
R
E
S
S
L
A
N
N
P
G
V
Site 43
S294
V
G
P
G
R
A
L
S
S
F
C
F
H
P
N
Site 44
S295
G
P
G
R
A
L
S
S
F
C
F
H
P
N
L
Site 45
S311
M
P
E
R
P
A
N
S
S
K
N
S
T
E
T
Site 46
S312
P
E
R
P
A
N
S
S
K
N
S
T
E
T
A
Site 47
S315
P
A
N
S
S
K
N
S
T
E
T
A
N
Y
P
Site 48
T316
A
N
S
S
K
N
S
T
E
T
A
N
Y
P
T
Site 49
Y321
N
S
T
E
T
A
N
Y
P
T
L
M
G
N
Y
Site 50
T333
G
N
Y
N
G
Q
N
T
A
S
L
S
V
F
I
Site 51
S335
Y
N
G
Q
N
T
A
S
L
S
V
F
I
P
P
Site 52
T356
I
L
T
E
M
P
G
T
T
E
T
N
V
E
N
Site 53
S365
E
T
N
V
E
N
N
S
Q
T
V
Y
Y
P
A
Site 54
Y369
E
N
N
S
Q
T
V
Y
Y
P
A
L
S
G
N
Site 55
Y370
N
N
S
Q
T
V
Y
Y
P
A
L
S
G
N
T
Site 56
S374
T
V
Y
Y
P
A
L
S
G
N
T
S
A
P
Y
Site 57
S378
P
A
L
S
G
N
T
S
A
P
Y
P
A
S
S
Site 58
Y381
S
G
N
T
S
A
P
Y
P
A
S
S
Y
L
P
Site 59
S384
T
S
A
P
Y
P
A
S
S
Y
L
P
I
T
S
Site 60
S385
S
A
P
Y
P
A
S
S
Y
L
P
I
T
S
N
Site 61
Y386
A
P
Y
P
A
S
S
Y
L
P
I
T
S
N
F
Site 62
T390
A
S
S
Y
L
P
I
T
S
N
F
E
S
G
P
Site 63
S391
S
S
Y
L
P
I
T
S
N
F
E
S
G
P
Q
Site 64
S395
P
I
T
S
N
F
E
S
G
P
Q
M
S
Y
G
Site 65
S400
F
E
S
G
P
Q
M
S
Y
G
T
M
S
Y
S
Site 66
Y401
E
S
G
P
Q
M
S
Y
G
T
M
S
Y
S
T
Site 67
T403
G
P
Q
M
S
Y
G
T
M
S
Y
S
T
E
M
Site 68
S420
N
C
D
Q
D
D
A
S
A
S
A
C
L
T
P
Site 69
S422
D
Q
D
D
A
S
A
S
A
C
L
T
P
D
F
Site 70
T442
N
I
L
V
K
V
D
T
N
T
E
N
S
V
N
Site 71
T444
L
V
K
V
D
T
N
T
E
N
S
V
N
T
M
Site 72
S447
V
D
T
N
T
E
N
S
V
N
T
M
N
R
S
Site 73
T450
N
T
E
N
S
V
N
T
M
N
R
S
T
L
L
Site 74
T455
V
N
T
M
N
R
S
T
L
L
D
S
D
S
G
Site 75
S459
N
R
S
T
L
L
D
S
D
S
G
Q
D
S
S
Site 76
S461
S
T
L
L
D
S
D
S
G
Q
D
S
S
S
S
Site 77
S465
D
S
D
S
G
Q
D
S
S
S
S
S
V
C
I
Site 78
S466
S
D
S
G
Q
D
S
S
S
S
S
V
C
I
P
Site 79
S467
D
S
G
Q
D
S
S
S
S
S
V
C
I
P
P
Site 80
S468
S
G
Q
D
S
S
S
S
S
V
C
I
P
P
K
Site 81
S469
G
Q
D
S
S
S
S
S
V
C
I
P
P
K
Y
Site 82
Y476
S
V
C
I
P
P
K
Y
G
Y
L
G
D
P
K
Site 83
S523
K
E
I
L
I
S
S
S
V
D
I
H
L
K
D
Site 84
S531
V
D
I
H
L
K
D
S
Q
S
L
D
P
N
K
Site 85
S533
I
H
L
K
D
S
Q
S
L
D
P
N
K
M
A
Site 86
T549
L
R
E
Y
L
A
T
T
F
P
T
C
D
L
H
Site 87
S578
S
M
I
Y
C
L
C
S
E
G
K
S
T
P
K
Site 88
S582
C
L
C
S
E
G
K
S
T
P
K
T
V
R
K
Site 89
T583
L
C
S
E
G
K
S
T
P
K
T
V
R
K
N
Site 90
T586
E
G
K
S
T
P
K
T
V
R
K
N
K
K
R
Site 91
T594
V
R
K
N
K
K
R
T
N
R
V
A
S
A
S
Site 92
S599
K
R
T
N
R
V
A
S
A
S
A
D
R
N
D
Site 93
S601
T
N
R
V
A
S
A
S
A
D
R
N
D
Q
R
Site 94
S638
K
R
N
L
Q
P
N
S
N
A
I
P
E
G
M
Site 95
S649
P
E
G
M
R
E
P
S
T
D
N
P
E
E
P
Site 96
T650
E
G
M
R
E
P
S
T
D
N
P
E
E
P
G
Site 97
Y662
E
P
G
E
A
W
S
Y
F
G
R
P
W
R
N
Site 98
S689
T
K
S
C
A
S
L
S
A
R
Y
L
I
Q
K
Site 99
S725
A
L
D
P
N
K
I
S
A
L
R
E
F
L
Q
Site 100
Y735
R
E
F
L
Q
E
N
Y
P
I
C
D
L
S
E
Site 101
S749
E
N
G
R
D
W
K
S
C
V
T
S
I
N
S
Site 102
T752
R
D
W
K
S
C
V
T
S
I
N
S
G
I
R
Site 103
S753
D
W
K
S
C
V
T
S
I
N
S
G
I
R
S
Site 104
S756
S
C
V
T
S
I
N
S
G
I
R
S
L
R
H
Site 105
S760
S
I
N
S
G
I
R
S
L
R
H
D
V
R
R
Site 106
S772
V
R
R
A
E
A
R
S
Q
S
L
P
A
V
T
Site 107
S774
R
A
E
A
R
S
Q
S
L
P
A
V
T
P
P
Site 108
T779
S
Q
S
L
P
A
V
T
P
P
E
L
E
Q
E
Site 109
T795
K
P
G
D
P
D
A
T
D
P
S
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation