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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSD4
Full Name:
PH and SEC7 domain-containing protein 4
Alias:
ADP-ribosylation factor guanine nucleotide-exchange factor 6; EFA6B; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B; Pleckstrin and Sec7 domain containing 4; Pleckstrin homology and SEC7 domain-containing protein 4; SEC7 homolog; Telomeric of interleukin-1 cluster protein; TIC
Type:
Guanine nucleotide exchange factor, ARF
Mass (Da):
116249
Number AA:
1056
UniProt ID:
Q8NDX1
International Prot ID:
IPI00784499
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
N
L
Y
L
G
D
S
L
E
P
H
P
G
E
Site 2
T36
P
G
E
C
P
R
E
T
C
S
H
E
D
P
P
Site 3
S38
E
C
P
R
E
T
C
S
H
E
D
P
P
E
P
Site 4
T50
P
E
P
F
E
E
Q
T
W
A
T
D
P
P
E
Site 5
T53
F
E
E
Q
T
W
A
T
D
P
P
E
P
T
R
Site 6
T73
W
G
S
G
V
E
L
T
H
L
G
S
W
V
H
Site 7
S77
V
E
L
T
H
L
G
S
W
V
H
Q
D
G
L
Site 8
T94
C
Q
E
Q
T
R
A
T
D
P
P
E
S
T
R
Site 9
S99
R
A
T
D
P
P
E
S
T
R
Q
D
A
P
P
Site 10
S109
Q
D
A
P
P
W
G
S
G
V
E
L
T
H
L
Site 11
T114
W
G
S
G
V
E
L
T
H
L
G
S
P
S
A
Site 12
S118
V
E
L
T
H
L
G
S
P
S
A
Q
R
E
H
Site 13
S120
L
T
H
L
G
S
P
S
A
Q
R
E
H
R
Q
Site 14
T129
Q
R
E
H
R
Q
N
T
A
S
P
G
S
P
V
Site 15
S131
E
H
R
Q
N
T
A
S
P
G
S
P
V
N
S
Site 16
S134
Q
N
T
A
S
P
G
S
P
V
N
S
H
L
P
Site 17
S138
S
P
G
S
P
V
N
S
H
L
P
G
S
P
K
Site 18
S143
V
N
S
H
L
P
G
S
P
K
Q
N
R
S
T
Site 19
S149
G
S
P
K
Q
N
R
S
T
S
T
Q
V
V
F
Site 20
T150
S
P
K
Q
N
R
S
T
S
T
Q
V
V
F
W
Site 21
S151
P
K
Q
N
R
S
T
S
T
Q
V
V
F
W
A
Site 22
T177
L
E
E
E
L
E
K
T
E
G
L
K
A
G
L
Site 23
T199
P
V
D
L
P
G
D
T
G
L
H
S
S
P
P
Site 24
S203
P
G
D
T
G
L
H
S
S
P
P
E
N
E
D
Site 25
S204
G
D
T
G
L
H
S
S
P
P
E
N
E
D
S
Site 26
S211
S
P
P
E
N
E
D
S
G
E
D
S
S
E
P
Site 27
S215
N
E
D
S
G
E
D
S
S
E
P
E
G
E
G
Site 28
S216
E
D
S
G
E
D
S
S
E
P
E
G
E
G
Q
Site 29
T230
Q
A
W
L
R
E
G
T
P
D
S
S
P
Q
W
Site 30
S233
L
R
E
G
T
P
D
S
S
P
Q
W
G
A
E
Site 31
S234
R
E
G
T
P
D
S
S
P
Q
W
G
A
E
E
Site 32
S247
E
E
E
S
M
F
F
S
N
P
L
F
L
A
S
Site 33
S254
S
N
P
L
F
L
A
S
P
C
S
E
N
S
A
Site 34
S257
L
F
L
A
S
P
C
S
E
N
S
A
S
G
E
Site 35
S260
A
S
P
C
S
E
N
S
A
S
G
E
C
F
S
Site 36
S262
P
C
S
E
N
S
A
S
G
E
C
F
S
W
G
Site 37
S267
S
A
S
G
E
C
F
S
W
G
A
S
D
S
H
Site 38
S271
E
C
F
S
W
G
A
S
D
S
H
A
G
V
R
Site 39
S273
F
S
W
G
A
S
D
S
H
A
G
V
R
T
G
Site 40
T279
D
S
H
A
G
V
R
T
G
P
E
S
P
A
T
Site 41
S283
G
V
R
T
G
P
E
S
P
A
T
L
E
P
P
Site 42
T286
T
G
P
E
S
P
A
T
L
E
P
P
L
P
E
Site 43
T295
E
P
P
L
P
E
D
T
V
L
W
E
L
E
S
Site 44
S302
T
V
L
W
E
L
E
S
E
P
D
L
G
D
G
Site 45
T317
A
A
I
S
G
H
C
T
P
P
F
P
V
P
I
Site 46
S351
A
P
P
G
H
G
E
S
E
G
D
R
L
G
P
Site 47
S361
D
R
L
G
P
A
P
S
A
A
P
C
V
D
E
Site 48
S374
D
E
A
L
T
W
E
S
G
C
V
G
S
D
L
Site 49
S393
H
P
V
Q
P
W
A
S
L
S
P
E
G
W
Q
Site 50
S395
V
Q
P
W
A
S
L
S
P
E
G
W
Q
R
G
Site 51
T410
G
P
F
W
P
Q
V
T
L
N
S
Q
D
R
D
Site 52
S413
W
P
Q
V
T
L
N
S
Q
D
R
D
E
R
E
Site 53
S427
E
G
G
H
P
Q
E
S
L
P
C
T
L
A
P
Site 54
T431
P
Q
E
S
L
P
C
T
L
A
P
C
P
W
R
Site 55
S439
L
A
P
C
P
W
R
S
P
A
S
S
P
E
P
Site 56
S442
C
P
W
R
S
P
A
S
S
P
E
P
S
S
P
Site 57
S443
P
W
R
S
P
A
S
S
P
E
P
S
S
P
E
Site 58
S447
P
A
S
S
P
E
P
S
S
P
E
S
E
S
R
Site 59
S448
A
S
S
P
E
P
S
S
P
E
S
E
S
R
G
Site 60
S451
P
E
P
S
S
P
E
S
E
S
R
G
P
G
P
Site 61
S453
P
S
S
P
E
S
E
S
R
G
P
G
P
R
P
Site 62
S461
R
G
P
G
P
R
P
S
P
A
S
S
Q
E
G
Site 63
S464
G
P
R
P
S
P
A
S
S
Q
E
G
S
P
Q
Site 64
S465
P
R
P
S
P
A
S
S
Q
E
G
S
P
Q
L
Site 65
S469
P
A
S
S
Q
E
G
S
P
Q
L
Q
H
H
S
Site 66
S476
S
P
Q
L
Q
H
H
S
S
G
I
L
P
K
W
Site 67
S477
P
Q
L
Q
H
H
S
S
G
I
L
P
K
W
T
Site 68
T484
S
G
I
L
P
K
W
T
L
D
A
S
Q
S
S
Site 69
S488
P
K
W
T
L
D
A
S
Q
S
S
L
L
E
T
Site 70
S490
W
T
L
D
A
S
Q
S
S
L
L
E
T
D
G
Site 71
S491
T
L
D
A
S
Q
S
S
L
L
E
T
D
G
E
Site 72
T495
S
Q
S
S
L
L
E
T
D
G
E
Q
P
S
S
Site 73
S501
E
T
D
G
E
Q
P
S
S
L
K
K
K
E
A
Site 74
S502
T
D
G
E
Q
P
S
S
L
K
K
K
E
A
G
Site 75
S520
K
P
G
E
E
V
K
S
E
G
T
A
R
P
A
Site 76
T523
E
E
V
K
S
E
G
T
A
R
P
A
E
T
G
Site 77
S540
Q
P
D
I
H
L
T
S
A
E
H
E
N
L
R
Site 78
T548
A
E
H
E
N
L
R
T
P
M
N
S
S
W
L
Site 79
S552
N
L
R
T
P
M
N
S
S
W
L
P
G
S
P
Site 80
S553
L
R
T
P
M
N
S
S
W
L
P
G
S
P
M
Site 81
S558
N
S
S
W
L
P
G
S
P
M
P
Q
A
Q
S
Site 82
S565
S
P
M
P
Q
A
Q
S
P
E
E
G
Q
R
P
Site 83
Y596
W
N
L
A
S
R
L
Y
R
L
E
G
F
R
K
Site 84
S604
R
L
E
G
F
R
K
S
E
V
A
A
Y
L
Q
Site 85
Y609
R
K
S
E
V
A
A
Y
L
Q
K
N
N
D
F
Site 86
Y624
S
R
A
V
A
E
E
Y
L
S
F
F
Q
F
G
Site 87
S634
F
F
Q
F
G
G
Q
S
L
D
R
A
L
R
S
Site 88
Y660
Q
E
R
E
R
I
L
Y
Q
F
S
R
R
F
H
Site 89
Y730
K
E
L
L
K
A
L
Y
W
S
I
R
S
E
K
Site 90
S732
L
L
K
A
L
Y
W
S
I
R
S
E
K
L
E
Site 91
T747
W
A
V
D
E
E
D
T
A
R
P
E
K
A
Q
Site 92
S756
R
P
E
K
A
Q
P
S
L
P
A
G
K
M
S
Site 93
T774
L
Q
L
A
Q
D
P
T
V
P
T
Y
K
Q
G
Site 94
Y778
Q
D
P
T
V
P
T
Y
K
Q
G
I
L
A
R
Site 95
T796
Q
D
A
D
G
K
K
T
P
W
G
K
R
G
W
Site 96
S845
E
P
V
G
V
H
H
S
L
A
T
P
A
T
H
Site 97
T848
G
V
H
H
S
L
A
T
P
A
T
H
Y
T
K
Site 98
T851
H
S
L
A
T
P
A
T
H
Y
T
K
K
P
H
Site 99
T854
A
T
P
A
T
H
Y
T
K
K
P
H
V
F
Q
Site 100
Y870
R
T
A
D
W
R
L
Y
L
F
Q
A
P
T
A
Site 101
S905
P
F
P
A
A
V
G
S
Q
R
R
F
V
R
P
Site 102
S921
L
P
V
G
P
A
Q
S
S
L
E
E
Q
H
R
Site 103
S922
P
V
G
P
A
Q
S
S
L
E
E
Q
H
R
S
Site 104
S929
S
L
E
E
Q
H
R
S
H
E
N
C
L
D
A
Site 105
Y967
E
H
R
L
R
K
E
Y
L
E
Y
E
K
T
R
Site 106
Y970
L
R
K
E
Y
L
E
Y
E
K
T
R
Y
E
T
Site 107
T973
E
Y
L
E
Y
E
K
T
R
Y
E
T
Y
V
Q
Site 108
Y975
L
E
Y
E
K
T
R
Y
E
T
Y
V
Q
L
L
Site 109
T977
Y
E
K
T
R
Y
E
T
Y
V
Q
L
L
V
A
Site 110
Y978
E
K
T
R
Y
E
T
Y
V
Q
L
L
V
A
R
Site 111
S990
V
A
R
L
H
C
P
S
D
A
L
D
L
W
E
Site 112
T1007
L
G
R
E
A
G
G
T
R
E
P
K
L
S
L
Site 113
S1013
G
T
R
E
P
K
L
S
L
K
K
S
H
S
S
Site 114
S1017
P
K
L
S
L
K
K
S
H
S
S
P
S
L
H
Site 115
S1019
L
S
L
K
K
S
H
S
S
P
S
L
H
Q
D
Site 116
S1020
S
L
K
K
S
H
S
S
P
S
L
H
Q
D
E
Site 117
S1022
K
K
S
H
S
S
P
S
L
H
Q
D
E
A
P
Site 118
T1031
H
Q
D
E
A
P
T
T
A
K
V
K
R
N
I
Site 119
S1039
A
K
V
K
R
N
I
S
E
R
R
T
Y
R
K
Site 120
T1043
R
N
I
S
E
R
R
T
Y
R
K
I
I
P
K
Site 121
Y1044
N
I
S
E
R
R
T
Y
R
K
I
I
P
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation