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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMC1B
Full Name:
Structural maintenance of chromosomes protein 1B
Alias:
Type:
Mass (Da):
143908
Number AA:
1235
UniProt ID:
Q8NDV3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
L
V
E
N
F
K
S
W
R
G
R
Q
V
I
Site 2
S36
C
I
I
G
P
N
G
S
G
K
S
N
V
M
D
Site 3
S39
G
P
N
G
S
G
K
S
N
V
M
D
A
L
S
Site 4
Y84
S
A
S
V
K
I
I
Y
V
E
E
S
G
E
E
Site 5
S88
K
I
I
Y
V
E
E
S
G
E
E
K
T
F
A
Site 6
T93
E
E
S
G
E
E
K
T
F
A
R
I
I
R
G
Site 7
S113
R
F
N
D
N
L
V
S
R
S
V
Y
I
A
E
Site 8
S115
N
D
N
L
V
S
R
S
V
Y
I
A
E
L
E
Site 9
S142
V
F
Q
G
T
V
E
S
I
S
V
K
K
P
K
Site 10
S144
Q
G
T
V
E
S
I
S
V
K
K
P
K
E
R
Site 11
S159
T
Q
F
F
E
E
I
S
T
S
G
E
L
I
G
Site 12
S161
F
F
E
E
I
S
T
S
G
E
L
I
G
E
Y
Site 13
Y168
S
G
E
L
I
G
E
Y
E
E
K
K
R
K
L
Site 14
Y209
E
K
E
E
A
E
R
Y
Q
S
L
L
E
E
L
Site 15
S211
E
E
A
E
R
Y
Q
S
L
L
E
E
L
K
M
Site 16
Y229
Q
L
Q
L
F
Q
L
Y
H
N
E
K
K
I
H
Site 17
S250
E
H
V
N
R
D
L
S
V
K
R
E
S
L
S
Site 18
S255
D
L
S
V
K
R
E
S
L
S
H
H
E
N
I
Site 19
S257
S
V
K
R
E
S
L
S
H
H
E
N
I
V
K
Site 20
T280
L
T
R
Q
L
Q
Q
T
E
K
E
L
K
S
V
Site 21
S286
Q
T
E
K
E
L
K
S
V
E
T
L
L
N
Q
Site 22
Y298
L
N
Q
K
R
P
Q
Y
I
K
A
K
E
N
T
Site 23
S318
K
L
D
V
A
K
K
S
I
K
D
S
E
K
Q
Site 24
S322
A
K
K
S
I
K
D
S
E
K
Q
C
S
K
Q
Site 25
S327
K
D
S
E
K
Q
C
S
K
Q
E
D
D
I
K
Site 26
S349
D
L
D
A
A
W
R
S
F
E
K
Q
I
E
E
Site 27
S370
R
D
I
E
L
E
A
S
Q
L
D
R
Y
K
E
Site 28
Y375
E
A
S
Q
L
D
R
Y
K
E
L
K
E
Q
V
Site 29
T388
Q
V
R
K
K
V
A
T
M
T
Q
Q
L
E
K
Site 30
T402
K
L
Q
W
E
Q
K
T
D
E
E
R
L
A
F
Site 31
Y441
R
I
E
K
L
E
E
Y
T
K
T
C
M
D
C
Site 32
T444
K
L
E
E
Y
T
K
T
C
M
D
C
L
K
E
Site 33
T466
L
V
D
E
I
E
K
T
K
S
R
M
S
E
F
Site 34
S468
D
E
I
E
K
T
K
S
R
M
S
E
F
N
E
Site 35
S471
E
K
T
K
S
R
M
S
E
F
N
E
E
L
N
Site 36
Y511
L
E
H
L
K
R
L
Y
P
D
S
V
F
G
R
Site 37
S514
L
K
R
L
Y
P
D
S
V
F
G
R
L
F
D
Site 38
T543
K
V
F
G
R
F
I
T
A
I
V
V
A
S
E
Site 39
T569
E
E
R
A
E
P
E
T
F
L
A
L
D
Y
L
Site 40
S631
E
A
R
H
I
A
L
S
G
P
E
R
Q
K
T
Site 41
T638
S
G
P
E
R
Q
K
T
V
A
L
D
G
T
L
Site 42
T644
K
T
V
A
L
D
G
T
L
F
L
K
S
G
V
Site 43
S653
F
L
K
S
G
V
I
S
G
G
S
S
D
L
K
Site 44
S657
G
V
I
S
G
G
S
S
D
L
K
Y
K
A
R
Site 45
Y661
G
G
S
S
D
L
K
Y
K
A
R
C
W
D
E
Site 46
S679
K
N
L
R
D
R
R
S
Q
K
I
Q
E
L
K
Site 47
T691
E
L
K
G
L
M
K
T
L
R
K
E
T
D
L
Site 48
T696
M
K
T
L
R
K
E
T
D
L
K
Q
I
Q
T
Site 49
Y714
G
T
Q
T
R
L
K
Y
S
Q
N
E
L
E
M
Site 50
S715
T
Q
T
R
L
K
Y
S
Q
N
E
L
E
M
I
Site 51
Y731
K
K
H
L
V
A
F
Y
Q
E
Q
S
Q
L
Q
Site 52
S735
V
A
F
Y
Q
E
Q
S
Q
L
Q
S
E
L
L
Site 53
S739
Q
E
Q
S
Q
L
Q
S
E
L
L
N
I
E
S
Site 54
S752
E
S
Q
C
I
M
L
S
E
G
I
K
E
R
Q
Site 55
Y808
Q
E
I
D
Q
K
R
Y
F
Y
K
K
M
L
T
Site 56
Y810
I
D
Q
K
R
Y
F
Y
K
K
M
L
T
R
L
Site 57
Y823
R
L
N
V
Q
L
E
Y
S
R
S
H
L
K
K
Site 58
S826
V
Q
L
E
Y
S
R
S
H
L
K
K
K
L
N
Site 59
T837
K
K
L
N
K
I
N
T
L
K
E
T
I
Q
K
Site 60
T862
A
E
E
N
C
L
Q
T
V
N
E
L
M
A
K
Site 61
T879
Q
L
K
D
I
R
V
T
Q
N
S
S
A
E
K
Site 62
S882
D
I
R
V
T
Q
N
S
S
A
E
K
V
Q
T
Site 63
T889
S
S
A
E
K
V
Q
T
Q
I
E
E
E
R
K
Site 64
S914
K
L
Q
K
E
V
V
S
I
Q
T
S
L
E
Q
Site 65
S918
E
V
V
S
I
Q
T
S
L
E
Q
K
R
L
E
Site 66
S961
E
M
G
T
E
A
E
S
T
Q
A
T
I
D
I
Site 67
T962
M
G
T
E
A
E
S
T
Q
A
T
I
D
I
Y
Site 68
T965
E
A
E
S
T
Q
A
T
I
D
I
Y
E
K
E
Site 69
Y969
T
Q
A
T
I
D
I
Y
E
K
E
E
A
F
E
Site 70
Y979
E
E
A
F
E
I
D
Y
S
S
L
K
E
D
L
Site 71
S980
E
A
F
E
I
D
Y
S
S
L
K
E
D
L
K
Site 72
S981
A
F
E
I
D
Y
S
S
L
K
E
D
L
K
A
Site 73
S991
E
D
L
K
A
L
Q
S
D
Q
E
I
E
A
H
Site 74
T1016
Q
E
D
I
L
L
K
T
A
A
P
N
L
R
A
Site 75
T1029
R
A
L
E
N
L
K
T
V
R
D
K
F
Q
E
Site 76
S1037
V
R
D
K
F
Q
E
S
T
D
A
F
E
A
S
Site 77
Y1063
E
Q
V
K
K
R
R
Y
D
L
F
T
Q
C
F
Site 78
Y1081
S
I
S
I
D
Q
I
Y
K
K
L
C
R
N
N
Site 79
S1089
K
K
L
C
R
N
N
S
A
Q
A
F
L
S
P
Site 80
S1095
N
S
A
Q
A
F
L
S
P
E
N
P
E
E
P
Site 81
Y1103
P
E
N
P
E
E
P
Y
L
E
G
I
S
Y
N
Site 82
Y1109
P
Y
L
E
G
I
S
Y
N
C
V
A
P
G
K
Site 83
S1125
F
M
P
M
D
N
L
S
G
G
E
K
C
V
A
Site 84
T1161
V
D
A
A
L
D
N
T
N
I
G
K
V
S
S
Site 85
S1168
T
N
I
G
K
V
S
S
Y
I
K
E
Q
T
Q
Site 86
T1174
S
S
Y
I
K
E
Q
T
Q
D
Q
F
Q
M
I
Site 87
Y1190
I
S
L
K
E
E
F
Y
S
R
A
D
A
L
I
Site 88
S1191
S
L
K
E
E
F
Y
S
R
A
D
A
L
I
G
Site 89
Y1203
L
I
G
I
Y
P
E
Y
D
D
C
M
F
S
R
Site 90
S1217
R
V
L
T
L
D
L
S
Q
Y
P
D
T
E
G
Site 91
Y1219
L
T
L
D
L
S
Q
Y
P
D
T
E
G
Q
E
Site 92
T1222
D
L
S
Q
Y
P
D
T
E
G
Q
E
S
S
K
Site 93
S1227
P
D
T
E
G
Q
E
S
S
K
R
H
G
E
S
Site 94
S1228
D
T
E
G
Q
E
S
S
K
R
H
G
E
S
R
Site 95
S1234
S
S
K
R
H
G
E
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation