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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ICA1L
Full Name:
Islet cell autoantigen 1-like protein
Alias:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein
Type:
Mass (Da):
54407
Number AA:
482
UniProt ID:
Q8NDH6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
R
P
E
D
N
Q
S
V
V
R
R
M
Q
K
Site 2
Y23
V
R
R
M
Q
K
K
Y
W
K
T
K
Q
V
F
Site 3
S45
E
D
E
H
L
V
A
S
D
A
E
L
D
A
K
Site 4
S58
A
K
L
E
V
F
H
S
V
Q
E
T
C
T
E
Site 5
S81
Q
L
R
L
N
V
I
S
E
E
E
N
E
L
G
Site 6
T100
F
Q
A
E
R
D
A
T
Q
A
G
K
M
M
D
Site 7
T109
A
G
K
M
M
D
A
T
G
K
A
L
C
S
S
Site 8
S115
A
T
G
K
A
L
C
S
S
A
K
Q
R
L
A
Site 9
S116
T
G
K
A
L
C
S
S
A
K
Q
R
L
A
L
Site 10
T125
K
Q
R
L
A
L
C
T
P
L
S
R
L
K
Q
Site 11
T136
R
L
K
Q
E
V
A
T
F
S
Q
R
A
V
S
Site 12
S138
K
Q
E
V
A
T
F
S
Q
R
A
V
S
D
T
Site 13
S143
T
F
S
Q
R
A
V
S
D
T
L
M
T
I
N
Site 14
T145
S
Q
R
A
V
S
D
T
L
M
T
I
N
R
M
Site 15
T157
N
R
M
E
Q
A
R
T
E
Y
R
G
A
L
L
Site 16
Y159
M
E
Q
A
R
T
E
Y
R
G
A
L
L
W
M
Site 17
S170
L
L
W
M
K
D
V
S
Q
E
L
D
P
D
T
Site 18
T177
S
Q
E
L
D
P
D
T
L
K
Q
M
E
K
F
Site 19
S194
V
Q
M
Q
V
R
N
S
K
A
S
F
D
K
L
Site 20
S197
Q
V
R
N
S
K
A
S
F
D
K
L
K
M
D
Site 21
S215
K
V
D
L
L
G
A
S
R
C
N
M
L
S
H
Site 22
S221
A
S
R
C
N
M
L
S
H
S
L
T
T
Y
Q
Site 23
T225
N
M
L
S
H
S
L
T
T
Y
Q
R
T
L
L
Site 24
Y227
L
S
H
S
L
T
T
Y
Q
R
T
L
L
G
F
Site 25
Y255
A
C
I
G
F
H
P
Y
D
F
V
A
L
K
Q
Site 26
T266
A
L
K
Q
L
Q
D
T
P
S
K
I
S
E
D
Site 27
S268
K
Q
L
Q
D
T
P
S
K
I
S
E
D
N
K
Site 28
S293
Q
L
N
K
L
V
L
S
D
E
E
A
S
F
E
Site 29
S298
V
L
S
D
E
E
A
S
F
E
S
E
Q
A
N
Site 30
S313
K
D
H
N
E
K
H
S
Q
M
R
E
F
G
A
Site 31
S324
E
F
G
A
P
Q
F
S
N
S
E
N
V
A
K
Site 32
S326
G
A
P
Q
F
S
N
S
E
N
V
A
K
D
L
Site 33
S337
A
K
D
L
P
V
D
S
L
E
G
E
D
F
E
Site 34
S348
E
D
F
E
K
E
F
S
F
L
N
N
L
L
S
Site 35
S355
S
F
L
N
N
L
L
S
S
G
S
S
S
T
S
Site 36
S356
F
L
N
N
L
L
S
S
G
S
S
S
T
S
E
Site 37
S358
N
N
L
L
S
S
G
S
S
S
T
S
E
F
T
Site 38
S359
N
L
L
S
S
G
S
S
S
T
S
E
F
T
Q
Site 39
S360
L
L
S
S
G
S
S
S
T
S
E
F
T
Q
E
Site 40
S362
S
S
G
S
S
S
T
S
E
F
T
Q
E
C
Q
Site 41
T370
E
F
T
Q
E
C
Q
T
A
F
G
S
P
S
A
Site 42
S374
E
C
Q
T
A
F
G
S
P
S
A
S
L
T
S
Site 43
S376
Q
T
A
F
G
S
P
S
A
S
L
T
S
Q
E
Site 44
S378
A
F
G
S
P
S
A
S
L
T
S
Q
E
P
S
Site 45
T380
G
S
P
S
A
S
L
T
S
Q
E
P
S
M
G
Site 46
S381
S
P
S
A
S
L
T
S
Q
E
P
S
M
G
S
Site 47
S385
S
L
T
S
Q
E
P
S
M
G
S
E
P
L
A
Site 48
S388
S
Q
E
P
S
M
G
S
E
P
L
A
H
S
S
Site 49
S394
G
S
E
P
L
A
H
S
S
R
F
L
P
S
Q
Site 50
S395
S
E
P
L
A
H
S
S
R
F
L
P
S
Q
L
Site 51
S400
H
S
S
R
F
L
P
S
Q
L
F
D
L
G
F
Site 52
S418
G
A
F
N
N
W
V
S
Q
E
E
S
E
L
C
Site 53
S422
N
W
V
S
Q
E
E
S
E
L
C
L
S
H
T
Site 54
S427
E
E
S
E
L
C
L
S
H
T
D
N
Q
P
V
Site 55
T429
S
E
L
C
L
S
H
T
D
N
Q
P
V
P
S
Site 56
S436
T
D
N
Q
P
V
P
S
Q
S
P
K
K
L
T
Site 57
S438
N
Q
P
V
P
S
Q
S
P
K
K
L
T
R
S
Site 58
T443
S
Q
S
P
K
K
L
T
R
S
P
N
N
G
N
Site 59
S445
S
P
K
K
L
T
R
S
P
N
N
G
N
Q
D
Site 60
S467
F
A
D
L
D
P
L
S
N
P
D
A
I
G
H
Site 61
S475
N
P
D
A
I
G
H
S
D
D
E
L
L
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation