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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDPR
Full Name:
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Alias:
cDNA FLJ10079 fis, clone HEMBA1001896, weakly similar to DIMETHYLGLYCINE DEHYDROGENASE; Pdpr; Pyruvate dehydrogenase phosphatase regulatory
Type:
Mass (Da):
99364
Number AA:
879
UniProt ID:
Q8NCN5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004047
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0006546
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
M
F
Y
R
L
L
S
I
V
G
Site 2
S16
I
V
G
R
Q
R
A
S
P
G
W
Q
N
W
S
Site 3
S23
S
P
G
W
Q
N
W
S
S
A
R
N
S
T
S
Site 4
S24
P
G
W
Q
N
W
S
S
A
R
N
S
T
S
A
Site 5
S28
N
W
S
S
A
R
N
S
T
S
A
A
E
A
R
Site 6
T29
W
S
S
A
R
N
S
T
S
A
A
E
A
R
S
Site 7
S30
S
S
A
R
N
S
T
S
A
A
E
A
R
S
M
Site 8
S36
T
S
A
A
E
A
R
S
M
A
L
P
T
Q
A
Site 9
T41
A
R
S
M
A
L
P
T
Q
A
Q
V
V
I
C
Site 10
S56
G
G
G
I
T
G
T
S
V
A
Y
H
L
S
K
Site 11
T96
L
S
T
A
R
H
L
T
I
E
Q
K
M
A
D
Site 12
Y104
I
E
Q
K
M
A
D
Y
S
N
K
L
Y
Y
Q
Site 13
Y109
A
D
Y
S
N
K
L
Y
Y
Q
L
E
Q
E
T
Site 14
Y110
D
Y
S
N
K
L
Y
Y
Q
L
E
Q
E
T
G
Site 15
Y122
E
T
G
I
Q
T
G
Y
T
R
T
G
S
I
F
Site 16
S127
T
G
Y
T
R
T
G
S
I
F
L
A
Q
T
Q
Site 17
S139
Q
T
Q
D
R
L
I
S
L
K
R
I
N
A
G
Site 18
Y207
S
Q
N
G
V
Q
I
Y
D
R
T
S
V
L
H
Site 19
Y236
K
G
Q
I
E
C
Q
Y
F
V
N
C
A
G
Q
Site 20
S251
W
A
Y
E
L
G
L
S
N
E
E
P
V
S
I
Site 21
S257
L
S
N
E
E
P
V
S
I
P
L
H
A
C
E
Site 22
T275
L
L
T
R
P
L
E
T
P
L
Q
S
S
T
P
Site 23
T281
E
T
P
L
Q
S
S
T
P
T
I
V
D
A
D
Site 24
T283
P
L
Q
S
S
T
P
T
I
V
D
A
D
G
R
Site 25
Y292
V
D
A
D
G
R
I
Y
I
R
N
W
Q
G
G
Site 26
S302
N
W
Q
G
G
I
L
S
G
G
F
E
K
N
P
Site 27
S337
D
H
F
E
P
L
L
S
S
L
L
R
R
M
P
Site 28
S338
H
F
E
P
L
L
S
S
L
L
R
R
M
P
E
Site 29
T360
K
L
V
N
C
P
E
T
F
T
P
D
M
R
C
Site 30
S390
G
M
N
S
A
G
L
S
F
G
G
G
A
G
K
Site 31
S425
K
R
F
G
A
L
Q
S
S
R
T
F
L
R
H
Site 32
S426
R
F
G
A
L
Q
S
S
R
T
F
L
R
H
R
Site 33
T428
G
A
L
Q
S
S
R
T
F
L
R
H
R
V
M
Site 34
Y442
M
E
V
M
P
L
M
Y
D
L
K
V
P
R
W
Site 35
T453
V
P
R
W
D
F
Q
T
G
R
Q
L
R
T
S
Site 36
S460
T
G
R
Q
L
R
T
S
P
L
Y
D
R
L
D
Site 37
Y463
Q
L
R
T
S
P
L
Y
D
R
L
D
A
Q
G
Site 38
Y484
H
G
F
E
R
P
K
Y
F
V
P
P
D
K
D
Site 39
T500
L
A
L
E
Q
S
K
T
F
Y
K
P
D
W
F
Site 40
Y502
L
E
Q
S
K
T
F
Y
K
P
D
W
F
D
I
Site 41
T537
T
K
F
E
I
T
S
T
G
D
Q
A
L
E
V
Site 42
Y547
Q
A
L
E
V
L
Q
Y
L
F
S
N
D
L
D
Site 43
Y572
M
L
N
E
G
G
G
Y
E
N
D
C
S
I
A
Site 44
S577
G
G
Y
E
N
D
C
S
I
A
R
L
N
K
R
Site 45
S585
I
A
R
L
N
K
R
S
F
F
M
I
S
P
T
Site 46
S590
K
R
S
F
F
M
I
S
P
T
D
Q
Q
V
H
Site 47
T618
N
L
L
L
E
D
V
T
W
K
Y
T
A
L
N
Site 48
Y640
D
V
L
S
E
L
S
Y
A
P
M
T
P
D
H
Site 49
T644
E
L
S
Y
A
P
M
T
P
D
H
F
P
S
L
Site 50
S668
A
N
G
I
R
V
M
S
M
T
H
T
G
E
P
Site 51
T670
G
I
R
V
M
S
M
T
H
T
G
E
P
G
F
Site 52
T672
R
V
M
S
M
T
H
T
G
E
P
G
F
M
L
Site 53
Y700
V
M
S
V
G
Q
K
Y
G
I
R
N
A
G
Y
Site 54
Y707
Y
G
I
R
N
A
G
Y
Y
A
L
R
S
L
R
Site 55
Y708
G
I
R
N
A
G
Y
Y
A
L
R
S
L
R
I
Site 56
S712
A
G
Y
Y
A
L
R
S
L
R
I
E
K
F
F
Site 57
T731
Q
D
I
N
N
L
T
T
P
L
E
C
G
R
E
Site 58
S739
P
L
E
C
G
R
E
S
R
V
K
L
E
K
G
Site 59
Y764
Q
Q
K
Q
N
G
V
Y
K
R
L
T
M
F
I
Site 60
Y790
P
W
W
G
E
P
I
Y
R
N
G
Q
Y
V
G
Site 61
Y795
P
I
Y
R
N
G
Q
Y
V
G
K
T
T
S
S
Site 62
T799
N
G
Q
Y
V
G
K
T
T
S
S
A
Y
S
Y
Site 63
S801
Q
Y
V
G
K
T
T
S
S
A
Y
S
Y
S
L
Site 64
S802
Y
V
G
K
T
T
S
S
A
Y
S
Y
S
L
E
Site 65
S805
K
T
T
S
S
A
Y
S
Y
S
L
E
R
H
V
Site 66
S807
T
S
S
A
Y
S
Y
S
L
E
R
H
V
C
L
Site 67
S821
L
G
F
V
H
N
F
S
E
D
T
G
E
E
Q
Site 68
T831
T
G
E
E
Q
V
V
T
A
D
F
I
N
R
G
Site 69
Y840
D
F
I
N
R
G
E
Y
E
I
D
I
A
G
Y
Site 70
S860
A
K
L
Y
P
V
A
S
L
F
T
Q
K
R
R
Site 71
S874
R
K
D
D
M
E
L
S
D
L
H
G
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation