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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HJURP
Full Name:
Holliday junction recognition protein
Alias:
14-3-3-associated AKT substrate; DKFZp762E1312; FAKTS; Fetal liver expressing gene 1; FLJ90328; HFLEG1; URLC9
Type:
Uncharacterized protein
Mass (Da):
83539
Number AA:
748
UniProt ID:
Q8NCD3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0042393
PhosphoSite+
KinaseNET
Biological Process:
GO:0034080
GO:0007049
GO:0034509
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
L
Q
K
L
R
A
S
R
R
R
F
Q
R
R
Site 2
Y40
M
Q
R
L
I
E
K
Y
N
Q
P
F
E
D
T
Site 3
T47
Y
N
Q
P
F
E
D
T
P
V
V
Q
M
A
T
Site 4
Y57
V
Q
M
A
T
L
T
Y
E
T
P
Q
G
L
R
Site 5
T59
M
A
T
L
T
Y
E
T
P
Q
G
L
R
I
W
Site 6
S82
N
E
G
E
I
Q
D
S
S
M
K
P
A
D
R
Site 7
S83
E
G
E
I
Q
D
S
S
M
K
P
A
D
R
T
Site 8
S93
P
A
D
R
T
D
G
S
V
Q
A
A
A
W
G
Site 9
S105
A
W
G
P
E
L
P
S
H
R
T
V
L
G
A
Site 10
S114
R
T
V
L
G
A
D
S
K
S
G
E
V
D
A
Site 11
S116
V
L
G
A
D
S
K
S
G
E
V
D
A
T
S
Site 12
T122
K
S
G
E
V
D
A
T
S
D
Q
E
E
S
V
Site 13
S123
S
G
E
V
D
A
T
S
D
Q
E
E
S
V
A
Site 14
S128
A
T
S
D
Q
E
E
S
V
A
W
A
L
A
P
Site 15
S140
L
A
P
A
V
P
Q
S
P
L
K
N
E
L
R
Site 16
Y150
K
N
E
L
R
R
K
Y
L
T
Q
V
D
I
L
Site 17
T152
E
L
R
R
K
Y
L
T
Q
V
D
I
L
L
Q
Site 18
Y163
I
L
L
Q
G
A
E
Y
F
E
C
A
G
N
R
Site 19
T178
A
G
R
D
V
R
V
T
P
L
P
S
L
A
S
Site 20
S185
T
P
L
P
S
L
A
S
P
A
V
P
A
P
G
Site 21
Y193
P
A
V
P
A
P
G
Y
C
S
R
I
S
R
K
Site 22
S195
V
P
A
P
G
Y
C
S
R
I
S
R
K
S
P
Site 23
S198
P
G
Y
C
S
R
I
S
R
K
S
P
G
D
P
Site 24
S201
C
S
R
I
S
R
K
S
P
G
D
P
A
K
P
Site 25
S210
G
D
P
A
K
P
A
S
S
P
R
E
W
D
P
Site 26
S211
D
P
A
K
P
A
S
S
P
R
E
W
D
P
L
Site 27
S221
E
W
D
P
L
H
P
S
S
T
D
M
A
L
V
Site 28
S222
W
D
P
L
H
P
S
S
T
D
M
A
L
V
P
Site 29
S233
A
L
V
P
R
N
D
S
L
S
L
Q
E
T
S
Site 30
S235
V
P
R
N
D
S
L
S
L
Q
E
T
S
S
S
Site 31
T239
D
S
L
S
L
Q
E
T
S
S
S
S
F
L
S
Site 32
S240
S
L
S
L
Q
E
T
S
S
S
S
F
L
S
S
Site 33
S241
L
S
L
Q
E
T
S
S
S
S
F
L
S
S
Q
Site 34
S242
S
L
Q
E
T
S
S
S
S
F
L
S
S
Q
P
Site 35
S243
L
Q
E
T
S
S
S
S
F
L
S
S
Q
P
F
Site 36
S246
T
S
S
S
S
F
L
S
S
Q
P
F
E
D
D
Site 37
S247
S
S
S
S
F
L
S
S
Q
P
F
E
D
D
D
Site 38
S272
A
G
M
L
H
S
M
S
R
L
L
S
T
K
P
Site 39
S276
H
S
M
S
R
L
L
S
T
K
P
S
S
I
I
Site 40
T277
S
M
S
R
L
L
S
T
K
P
S
S
I
I
S
Site 41
S280
R
L
L
S
T
K
P
S
S
I
I
S
T
K
T
Site 42
S284
T
K
P
S
S
I
I
S
T
K
T
F
I
M
Q
Site 43
T285
K
P
S
S
I
I
S
T
K
T
F
I
M
Q
N
Site 44
Y301
N
S
R
R
R
H
R
Y
K
S
R
M
N
K
T
Site 45
T308
Y
K
S
R
M
N
K
T
Y
C
K
G
A
R
R
Site 46
Y309
K
S
R
M
N
K
T
Y
C
K
G
A
R
R
S
Site 47
S316
Y
C
K
G
A
R
R
S
Q
R
S
S
K
E
N
Site 48
S319
G
A
R
R
S
Q
R
S
S
K
E
N
F
I
P
Site 49
S320
A
R
R
S
Q
R
S
S
K
E
N
F
I
P
C
Site 50
S328
K
E
N
F
I
P
C
S
E
P
V
K
G
T
G
Site 51
S347
C
K
N
V
L
D
V
S
C
R
K
T
G
L
K
Site 52
T351
L
D
V
S
C
R
K
T
G
L
K
L
E
K
A
Site 53
T380
S
W
K
E
R
K
V
T
P
S
K
Y
S
S
L
Site 54
S382
K
E
R
K
V
T
P
S
K
Y
S
S
L
I
Y
Site 55
Y384
R
K
V
T
P
S
K
Y
S
S
L
I
Y
F
D
Site 56
S386
V
T
P
S
K
Y
S
S
L
I
Y
F
D
S
S
Site 57
Y389
S
K
Y
S
S
L
I
Y
F
D
S
S
A
T
Y
Site 58
S392
S
S
L
I
Y
F
D
S
S
A
T
Y
N
L
D
Site 59
S393
S
L
I
Y
F
D
S
S
A
T
Y
N
L
D
E
Site 60
Y396
Y
F
D
S
S
A
T
Y
N
L
D
E
E
N
R
Site 61
T406
D
E
E
N
R
F
R
T
L
K
W
L
I
S
P
Site 62
S412
R
T
L
K
W
L
I
S
P
V
K
I
V
S
R
Site 63
T421
V
K
I
V
S
R
P
T
I
R
Q
G
H
G
E
Site 64
Y445
F
D
Q
L
H
R
E
Y
C
L
S
P
R
N
Q
Site 65
S448
L
H
R
E
Y
C
L
S
P
R
N
Q
P
R
R
Site 66
S473
M
Y
R
G
G
P
A
S
P
G
G
L
Q
G
L
Site 67
T482
G
G
L
Q
G
L
E
T
R
R
L
S
L
P
S
Site 68
S486
G
L
E
T
R
R
L
S
L
P
S
S
K
A
K
Site 69
S489
T
R
R
L
S
L
P
S
S
K
A
K
A
K
S
Site 70
S490
R
R
L
S
L
P
S
S
K
A
K
A
K
S
L
Site 71
S496
S
S
K
A
K
A
K
S
L
S
E
A
F
E
N
Site 72
S498
K
A
K
A
K
S
L
S
E
A
F
E
N
L
G
Site 73
S518
A
G
R
C
L
P
K
S
D
S
S
S
S
L
P
Site 74
S520
R
C
L
P
K
S
D
S
S
S
S
L
P
K
T
Site 75
S522
L
P
K
S
D
S
S
S
S
L
P
K
T
N
P
Site 76
S523
P
K
S
D
S
S
S
S
L
P
K
T
N
P
T
Site 77
T527
S
S
S
S
L
P
K
T
N
P
T
H
S
A
T
Site 78
T530
S
L
P
K
T
N
P
T
H
S
A
T
R
P
Q
Site 79
S532
P
K
T
N
P
T
H
S
A
T
R
P
Q
Q
T
Site 80
S540
A
T
R
P
Q
Q
T
S
D
L
H
V
Q
G
N
Site 81
S555
S
S
G
I
F
R
K
S
V
S
P
S
K
T
L
Site 82
S557
G
I
F
R
K
S
V
S
P
S
K
T
L
S
V
Site 83
S559
F
R
K
S
V
S
P
S
K
T
L
S
V
P
D
Site 84
T561
K
S
V
S
P
S
K
T
L
S
V
P
D
K
E
Site 85
S563
V
S
P
S
K
T
L
S
V
P
D
K
E
V
P
Site 86
Y577
P
G
H
G
R
N
R
Y
D
E
I
K
E
E
F
Site 87
Y591
F
D
K
L
H
Q
K
Y
C
L
K
S
P
G
Q
Site 88
S595
H
Q
K
Y
C
L
K
S
P
G
Q
M
T
V
P
Site 89
Y618
K
A
S
M
E
V
R
Y
Q
T
E
G
F
L
G
Site 90
T620
S
M
E
V
R
Y
Q
T
E
G
F
L
G
K
L
Site 91
S641
Q
G
F
Q
K
L
P
S
S
P
L
G
C
R
K
Site 92
S642
G
F
Q
K
L
P
S
S
P
L
G
C
R
K
S
Site 93
S649
S
P
L
G
C
R
K
S
L
L
G
S
T
A
I
Site 94
S653
C
R
K
S
L
L
G
S
T
A
I
E
A
P
S
Site 95
T669
T
C
V
A
R
A
I
T
R
D
G
T
R
D
H
Site 96
T673
R
A
I
T
R
D
G
T
R
D
H
Q
F
P
A
Site 97
S686
P
A
K
R
P
R
L
S
E
P
Q
G
S
G
R
Site 98
S691
R
L
S
E
P
Q
G
S
G
R
Q
G
N
S
L
Site 99
S697
G
S
G
R
Q
G
N
S
L
G
A
S
D
G
V
Site 100
S701
Q
G
N
S
L
G
A
S
D
G
V
D
N
T
V
Site 101
T707
A
S
D
G
V
D
N
T
V
R
P
G
D
Q
G
Site 102
S715
V
R
P
G
D
Q
G
S
S
S
Q
P
N
S
E
Site 103
S717
P
G
D
Q
G
S
S
S
Q
P
N
S
E
E
R
Site 104
S721
G
S
S
S
Q
P
N
S
E
E
R
G
E
N
T
Site 105
S729
E
E
R
G
E
N
T
S
Y
R
M
E
E
K
S
Site 106
Y730
E
R
G
E
N
T
S
Y
R
M
E
E
K
S
D
Site 107
S736
S
Y
R
M
E
E
K
S
D
F
M
L
E
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation