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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNDC5
Full Name:
Thioredoxin domain-containing protein 5
Alias:
EndoPDI; ERP46; Thioredoxin domain containing 5; UNQ364
Type:
Mass (Da):
47629
Number AA:
432
UniProt ID:
Q8NBS9
International Prot ID:
IPI00171438
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0016853
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0045454
GO:0016044
Phosida
TranscriptoNet
STRING
Kinexus Products
Thioredoxin domain-containing protein 5 pan-specific antibody AB-NN363-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN363-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S62
E
D
G
Q
D
P
H
S
K
H
L
Y
T
A
D
Site 2
Y66
D
P
H
S
K
H
L
Y
T
A
D
M
F
T
H
Site 3
Y106
W
N
D
L
G
D
K
Y
N
S
M
E
D
A
K
Site 4
S108
D
L
G
D
K
Y
N
S
M
E
D
A
K
V
Y
Site 5
Y115
S
M
E
D
A
K
V
Y
V
A
K
V
D
C
T
Site 6
S125
K
V
D
C
T
A
H
S
D
V
C
S
A
Q
G
Site 7
S129
T
A
H
S
D
V
C
S
A
Q
G
V
R
G
Y
Site 8
Y136
S
A
Q
G
V
R
G
Y
P
T
L
K
L
F
K
Site 9
T138
Q
G
V
R
G
Y
P
T
L
K
L
F
K
P
G
Site 10
Y151
P
G
Q
E
A
V
K
Y
Q
G
P
R
D
F
Q
Site 11
T159
Q
G
P
R
D
F
Q
T
L
E
N
W
M
L
Q
Site 12
T174
T
L
N
E
E
P
V
T
P
E
P
E
V
E
P
Site 13
S183
E
P
E
V
E
P
P
S
A
P
E
L
K
Q
G
Site 14
Y192
P
E
L
K
Q
G
L
Y
E
L
S
A
S
N
F
Site 15
S195
K
Q
G
L
Y
E
L
S
A
S
N
F
E
L
H
Site 16
T239
L
G
L
E
H
S
E
T
V
K
I
G
K
V
D
Site 17
T248
K
I
G
K
V
D
C
T
Q
H
Y
E
L
C
S
Site 18
Y251
K
V
D
C
T
Q
H
Y
E
L
C
S
G
N
Q
Site 19
Y262
S
G
N
Q
V
R
G
Y
P
T
L
L
W
F
R
Site 20
Y277
D
G
K
K
V
D
Q
Y
K
G
K
R
D
L
E
Site 21
S285
K
G
K
R
D
L
E
S
L
R
E
Y
V
E
S
Site 22
Y289
D
L
E
S
L
R
E
Y
V
E
S
Q
L
Q
R
Site 23
S292
S
L
R
E
Y
V
E
S
Q
L
Q
R
T
E
T
Site 24
T299
S
Q
L
Q
R
T
E
T
G
A
T
E
T
V
T
Site 25
T302
Q
R
T
E
T
G
A
T
E
T
V
T
P
S
E
Site 26
T304
T
E
T
G
A
T
E
T
V
T
P
S
E
A
P
Site 27
T323
E
P
E
A
D
K
G
T
V
L
A
L
T
E
N
Site 28
T328
K
G
T
V
L
A
L
T
E
N
N
F
D
D
T
Site 29
T335
T
E
N
N
F
D
D
T
I
A
E
G
I
T
F
Site 30
S364
A
P
T
W
E
E
L
S
K
K
E
F
P
G
L
Site 31
T382
K
I
A
E
V
D
C
T
A
E
R
N
I
C
S
Site 32
Y391
E
R
N
I
C
S
K
Y
S
V
R
G
Y
P
T
Site 33
S392
R
N
I
C
S
K
Y
S
V
R
G
Y
P
T
L
Site 34
Y396
S
K
Y
S
V
R
G
Y
P
T
L
L
L
F
R
Site 35
S409
F
R
G
G
K
K
V
S
E
H
S
G
G
R
D
Site 36
S412
G
K
K
V
S
E
H
S
G
G
R
D
L
D
S
Site 37
S419
S
G
G
R
D
L
D
S
L
H
R
F
V
L
S
Site 38
S426
S
L
H
R
F
V
L
S
Q
A
K
D
E
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation