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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL23
Full Name:
Kelch-like protein 23
Alias:
Type:
Mass (Da):
63923
Number AA:
558
UniProt ID:
Q8NBE8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
L
K
G
Q
E
D
Y
I
Y
L
F
K
D
S
Site 2
Y11
K
G
Q
E
D
Y
I
Y
L
F
K
D
S
T
H
Site 3
T17
I
Y
L
F
K
D
S
T
H
P
V
D
F
L
D
Site 4
Y96
E
G
L
V
N
Y
A
Y
T
S
Q
I
E
I
T
Site 5
S98
L
V
N
Y
A
Y
T
S
Q
I
E
I
T
K
R
Site 6
S121
A
D
L
L
Q
F
L
S
V
K
K
A
C
E
R
Site 7
S158
C
P
E
L
E
K
E
S
R
R
I
L
C
S
K
Site 8
S164
E
S
R
R
I
L
C
S
K
F
K
E
V
W
Q
Site 9
S193
I
L
S
R
K
N
L
S
V
W
K
E
E
A
I
Site 10
Y220
E
N
R
I
E
C
L
Y
N
L
L
S
Y
I
N
Site 11
S244
T
A
L
G
L
Q
R
S
C
L
L
T
E
N
K
Site 12
T248
L
Q
R
S
C
L
L
T
E
N
K
I
R
S
L
Site 13
Y257
N
K
I
R
S
L
I
Y
N
A
L
N
P
M
H
Site 14
S268
N
P
M
H
K
E
I
S
Q
R
S
T
A
T
M
Site 15
T272
K
E
I
S
Q
R
S
T
A
T
M
Y
I
I
G
Site 16
Y276
Q
R
S
T
A
T
M
Y
I
I
G
G
Y
Y
W
Site 17
Y308
Q
G
A
E
I
P
D
Y
T
R
E
S
Y
G
V
Site 18
T309
G
A
E
I
P
D
Y
T
R
E
S
Y
G
V
T
Site 19
S312
I
P
D
Y
T
R
E
S
Y
G
V
T
C
L
G
Site 20
Y313
P
D
Y
T
R
E
S
Y
G
V
T
C
L
G
P
Site 21
T316
T
R
E
S
Y
G
V
T
C
L
G
P
N
I
Y
Site 22
Y323
T
C
L
G
P
N
I
Y
V
T
G
G
Y
R
T
Site 23
Y342
A
L
D
T
V
W
I
Y
N
S
E
S
D
E
W
Site 24
T350
N
S
E
S
D
E
W
T
E
G
L
P
M
L
N
Site 25
Y389
P
A
E
E
A
E
F
Y
D
P
L
K
E
K
W
Site 26
Y433
G
Y
R
G
S
C
T
Y
D
K
V
Q
S
Y
N
Site 27
Y439
T
Y
D
K
V
Q
S
Y
N
S
D
I
N
E
W
Site 28
S441
D
K
V
Q
S
Y
N
S
D
I
N
E
W
S
L
Site 29
S447
N
S
D
I
N
E
W
S
L
I
T
S
S
P
H
Site 30
T450
I
N
E
W
S
L
I
T
S
S
P
H
P
E
Y
Site 31
S451
N
E
W
S
L
I
T
S
S
P
H
P
E
Y
G
Site 32
S452
E
W
S
L
I
T
S
S
P
H
P
E
Y
G
L
Site 33
Y457
T
S
S
P
H
P
E
Y
G
L
C
S
V
P
F
Site 34
S461
H
P
E
Y
G
L
C
S
V
P
F
E
N
K
L
Site 35
Y469
V
P
F
E
N
K
L
Y
L
V
G
G
Q
T
T
Site 36
T478
V
G
G
Q
T
T
I
T
E
C
Y
D
P
E
Q
Site 37
T513
M
N
G
C
I
Y
V
T
G
G
Y
S
Y
S
K
Site 38
S519
V
T
G
G
Y
S
Y
S
K
G
T
Y
L
Q
S
Site 39
Y523
Y
S
Y
S
K
G
T
Y
L
Q
S
I
E
K
Y
Site 40
S526
S
K
G
T
Y
L
Q
S
I
E
K
Y
D
P
D
Site 41
Y530
Y
L
Q
S
I
E
K
Y
D
P
D
L
N
K
W
Site 42
S545
E
I
V
G
N
L
P
S
A
M
R
S
H
G
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation