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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AOF1
Full Name:
Lysine-specific histone demethylase 1B
Alias:
EC 1.-.-.-; OTTHUMP00000179126
Type:
Mass (Da):
92226
Number AA:
823
UniProt ID:
Q8NB78
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016491
GO:0008270
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006118
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
T
P
R
G
R
T
K
K
K
A
S
F
D
Site 2
S13
G
R
T
K
K
K
A
S
F
D
H
S
P
D
S
Site 3
S17
K
K
A
S
F
D
H
S
P
D
S
L
P
L
R
Site 4
S20
S
F
D
H
S
P
D
S
L
P
L
R
S
S
G
Site 5
S26
D
S
L
P
L
R
S
S
G
R
Q
A
K
K
K
Site 6
S46
D
E
D
E
D
G
G
S
E
K
K
Y
R
K
C
Site 7
Y50
D
G
G
S
E
K
K
Y
R
K
C
E
K
A
G
Site 8
S70
P
V
C
F
A
S
A
S
E
R
C
A
K
N
G
Site 9
Y78
E
R
C
A
K
N
G
Y
T
S
R
W
Y
H
L
Site 10
Y83
N
G
Y
T
S
R
W
Y
H
L
S
C
G
E
H
Site 11
Y99
C
N
E
C
F
D
H
Y
Y
R
S
H
K
D
G
Site 12
Y100
N
E
C
F
D
H
Y
Y
R
S
H
K
D
G
Y
Site 13
Y107
Y
R
S
H
K
D
G
Y
D
K
Y
T
T
W
K
Site 14
Y110
H
K
D
G
Y
D
K
Y
T
T
W
K
K
I
W
Site 15
T123
I
W
T
S
N
G
K
T
E
P
S
P
K
A
F
Site 16
S126
S
N
G
K
T
E
P
S
P
K
A
F
M
A
D
Site 17
T154
C
R
K
W
R
Q
L
T
K
E
I
Q
L
T
P
Site 18
T160
L
T
K
E
I
Q
L
T
P
Q
I
A
K
T
Y
Site 19
T166
L
T
P
Q
I
A
K
T
Y
R
C
G
M
K
P
Site 20
T175
R
C
G
M
K
P
N
T
A
I
K
P
E
T
S
Site 21
S182
T
A
I
K
P
E
T
S
D
H
C
S
L
P
E
Site 22
S186
P
E
T
S
D
H
C
S
L
P
E
D
L
R
V
Site 23
S231
Y
P
D
C
V
G
M
S
P
S
C
T
S
T
N
Site 24
S233
D
C
V
G
M
S
P
S
C
T
S
T
N
R
A
Site 25
T235
V
G
M
S
P
S
C
T
S
T
N
R
A
A
A
Site 26
T237
M
S
P
S
C
T
S
T
N
R
A
A
A
T
G
Site 27
T243
S
T
N
R
A
A
A
T
G
N
A
S
P
G
K
Site 28
S247
A
A
A
T
G
N
A
S
P
G
K
L
E
H
S
Site 29
S254
S
P
G
K
L
E
H
S
K
A
A
L
S
V
H
Site 30
S259
E
H
S
K
A
A
L
S
V
H
V
P
G
M
N
Site 31
Y268
H
V
P
G
M
N
R
Y
F
Q
P
F
Y
Q
P
Site 32
Y273
N
R
Y
F
Q
P
F
Y
Q
P
N
E
C
G
K
Site 33
Y295
V
M
E
L
D
E
L
Y
E
F
P
E
Y
S
R
Site 34
Y300
E
L
Y
E
F
P
E
Y
S
R
D
P
T
M
Y
Site 35
T305
P
E
Y
S
R
D
P
T
M
Y
L
A
L
R
N
Site 36
Y307
Y
S
R
D
P
T
M
Y
L
A
L
R
N
L
I
Site 37
T327
T
N
C
K
E
A
L
T
P
Q
K
C
I
P
H
Site 38
Y354
Q
E
V
E
R
I
L
Y
F
M
T
R
K
G
L
Site 39
Y374
L
S
V
G
A
D
Q
Y
L
L
P
K
D
Y
H
Site 40
Y380
Q
Y
L
L
P
K
D
Y
H
N
K
S
V
I
I
Site 41
S384
P
K
D
Y
H
N
K
S
V
I
I
I
G
A
G
Site 42
S426
G
R
V
W
D
D
K
S
F
K
G
V
T
V
G
Site 43
T431
D
K
S
F
K
G
V
T
V
G
R
G
A
Q
I
Site 44
T475
I
Q
E
G
G
R
I
T
D
P
T
I
D
K
R
Site 45
T478
G
G
R
I
T
D
P
T
I
D
K
R
M
D
F
Site 46
S495
N
A
L
L
D
V
V
S
E
W
R
K
D
K
T
Site 47
T502
S
E
W
R
K
D
K
T
Q
L
Q
D
V
P
L
Site 48
S524
Y
K
A
F
I
K
E
S
G
I
Q
F
S
E
L
Site 49
Y545
F
H
L
S
N
L
E
Y
A
C
G
S
N
L
H
Site 50
S555
G
S
N
L
H
Q
V
S
A
R
S
W
D
H
N
Site 51
T573
A
Q
F
A
G
D
H
T
L
L
T
P
G
Y
S
Site 52
S596
G
L
D
I
Q
L
K
S
P
Q
V
Q
C
I
D
Site 53
Y604
P
Q
V
Q
C
I
D
Y
S
G
D
E
V
Q
V
Site 54
T612
S
G
D
E
V
Q
V
T
T
T
D
G
T
G
Y
Site 55
S620
T
T
D
G
T
G
Y
S
A
Q
K
V
L
V
T
Site 56
S645
I
Q
F
N
P
P
L
S
E
K
K
M
K
A
I
Site 57
S688
F
F
G
H
V
P
P
S
A
S
K
R
G
L
F
Site 58
S690
G
H
V
P
P
S
A
S
K
R
G
L
F
A
V
Site 59
Y699
R
G
L
F
A
V
F
Y
D
M
D
P
Q
K
K
Site 60
S708
M
D
P
Q
K
K
H
S
V
L
M
S
V
I
A
Site 61
S721
I
A
G
E
A
V
A
S
V
R
T
L
D
D
K
Site 62
T751
E
Q
E
V
P
D
P
T
K
Y
F
V
T
R
W
Site 63
Y753
E
V
P
D
P
T
K
Y
F
V
T
R
W
S
T
Site 64
Y768
D
P
W
I
Q
M
A
Y
S
F
V
K
T
G
G
Site 65
T773
M
A
Y
S
F
V
K
T
G
G
S
G
E
A
Y
Site 66
S776
S
F
V
K
T
G
G
S
G
E
A
Y
D
I
I
Site 67
Y780
T
G
G
S
G
E
A
Y
D
I
I
A
E
D
I
Site 68
T798
V
F
F
A
G
E
A
T
N
R
H
F
P
Q
T
Site 69
T805
T
N
R
H
F
P
Q
T
V
T
G
A
Y
L
S
Site 70
S812
T
V
T
G
A
Y
L
S
G
V
R
E
A
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation