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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQUB
Full Name:
IQ and ubiquitin-like domain-containing protein
Alias:
Type:
Mass (Da):
92581
Number AA:
791
UniProt ID:
Q8NA54
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
N
Q
Q
E
K
Y
E
A
Q
N
I
V
N
Site 2
S16
E
A
Q
N
I
V
N
S
T
E
E
S
D
D
A
Site 3
S20
I
V
N
S
T
E
E
S
D
D
A
F
D
T
V
Site 4
T26
E
S
D
D
A
F
D
T
V
T
I
P
V
P
S
Site 5
T28
D
D
A
F
D
T
V
T
I
P
V
P
S
E
E
Site 6
S33
T
V
T
I
P
V
P
S
E
E
P
Q
E
S
D
Site 7
S39
P
S
E
E
P
Q
E
S
D
Q
T
E
E
H
E
Site 8
T42
E
P
Q
E
S
D
Q
T
E
E
H
E
S
G
I
Site 9
S47
D
Q
T
E
E
H
E
S
G
I
E
Q
F
S
E
Site 10
S53
E
S
G
I
E
Q
F
S
E
S
H
A
I
H
V
Site 11
S64
A
I
H
V
E
E
Q
S
D
Q
S
F
S
S
L
Site 12
S67
V
E
E
Q
S
D
Q
S
F
S
S
L
E
P
D
Site 13
S70
Q
S
D
Q
S
F
S
S
L
E
P
D
N
E
Q
Site 14
S84
Q
L
M
E
E
V
I
S
P
R
Q
V
S
Y
T
Site 15
S89
V
I
S
P
R
Q
V
S
Y
T
P
Q
H
H
E
Site 16
T91
S
P
R
Q
V
S
Y
T
P
Q
H
H
E
K
Q
Site 17
Y99
P
Q
H
H
E
K
Q
Y
A
M
Q
R
P
N
D
Site 18
S108
M
Q
R
P
N
D
D
S
L
A
F
L
D
K
I
Site 19
S117
A
F
L
D
K
I
K
S
V
K
E
S
L
Q
E
Site 20
S121
K
I
K
S
V
K
E
S
L
Q
E
S
V
E
D
Site 21
S125
V
K
E
S
L
Q
E
S
V
E
D
S
L
A
T
Site 22
Y156
K
V
D
T
I
L
K
Y
L
K
D
H
F
S
H
Site 23
S162
K
Y
L
K
D
H
F
S
H
L
L
G
I
P
H
Site 24
S177
S
V
L
Q
I
R
Y
S
G
K
I
L
K
N
N
Site 25
T186
K
I
L
K
N
N
E
T
L
V
Q
H
G
V
K
Site 26
Y210
F
S
T
N
P
D
L
Y
P
V
R
R
I
D
G
Site 27
Y236
V
Q
T
G
L
D
Q
Y
Q
Q
V
P
V
E
I
Site 28
Y265
H
K
V
T
G
V
E
Y
H
N
A
G
T
Q
T
Site 29
S282
K
R
I
P
E
R
L
S
I
F
C
R
D
T
Q
Site 30
T288
L
S
I
F
C
R
D
T
Q
T
V
F
Q
K
K
Site 31
T290
I
F
C
R
D
T
Q
T
V
F
Q
K
K
N
L
Site 32
Y314
Q
M
T
N
I
G
V
Y
V
S
N
M
T
D
K
Site 33
T324
N
M
T
D
K
L
V
T
P
G
K
Y
F
S
A
Site 34
Y328
K
L
V
T
P
G
K
Y
F
S
A
A
E
Y
H
Site 35
S330
V
T
P
G
K
Y
F
S
A
A
E
Y
H
A
Q
Site 36
Y334
K
Y
F
S
A
A
E
Y
H
A
Q
R
L
K
A
Site 37
Y348
A
V
I
V
I
Q
T
Y
Y
R
Q
W
H
A
K
Site 38
S366
E
N
L
R
R
Q
K
S
L
R
L
E
W
E
T
Site 39
T373
S
L
R
L
E
W
E
T
Q
Q
E
L
R
K
I
Site 40
Y391
E
E
W
I
K
L
D
Y
H
R
R
H
N
P
K
Site 41
T399
H
R
R
H
N
P
K
T
N
E
D
F
E
F
L
Site 42
Y407
N
E
D
F
E
F
L
Y
N
A
L
E
F
W
R
Site 43
S424
E
L
T
R
I
N
Q
S
F
T
G
A
E
R
K
Site 44
Y453
A
S
I
G
R
H
R
Y
I
A
Y
M
A
N
Q
Site 45
T479
S
A
P
K
I
W
R
T
P
N
G
K
T
I
E
Site 46
T489
G
K
T
I
E
M
D
T
Q
F
T
I
R
A
R
Site 47
Y502
A
R
E
L
Q
N
I
Y
K
C
I
M
L
K
N
Site 48
S511
C
I
M
L
K
N
I
S
Q
D
E
R
L
D
V
Site 49
T521
E
R
L
D
V
L
L
T
L
K
H
T
V
K
E
Site 50
T525
V
L
L
T
L
K
H
T
V
K
E
H
E
C
K
Site 51
T534
K
E
H
E
C
K
L
T
Q
E
I
L
E
L
I
Site 52
Y584
F
N
P
E
V
A
K
Y
L
K
V
P
Q
D
P
Site 53
Y595
P
Q
D
P
L
K
F
Y
K
K
I
Y
F
C
H
Site 54
Y599
L
K
F
Y
K
K
I
Y
F
C
H
S
C
Q
L
Site 55
Y607
F
C
H
S
C
Q
L
Y
L
P
S
T
E
F
S
Site 56
S610
S
C
Q
L
Y
L
P
S
T
E
F
S
V
S
S
Site 57
T611
C
Q
L
Y
L
P
S
T
E
F
S
V
S
S
T
Site 58
S614
Y
L
P
S
T
E
F
S
V
S
S
T
S
R
R
Site 59
S616
P
S
T
E
F
S
V
S
S
T
S
R
R
I
Y
Site 60
S617
S
T
E
F
S
V
S
S
T
S
R
R
I
Y
R
Site 61
T618
T
E
F
S
V
S
S
T
S
R
R
I
Y
R
C
Site 62
S619
E
F
S
V
S
S
T
S
R
R
I
Y
R
C
R
Site 63
Y623
S
S
T
S
R
R
I
Y
R
C
R
N
C
I
N
Site 64
S640
N
E
A
Q
K
R
E
S
F
L
K
Y
K
C
L
Site 65
Y644
K
R
E
S
F
L
K
Y
K
C
L
L
Q
Q
L
Site 66
Y652
K
C
L
L
Q
Q
L
Y
Y
T
E
A
D
Y
E
Site 67
Y658
L
Y
Y
T
E
A
D
Y
E
D
D
S
K
I
A
Site 68
S662
E
A
D
Y
E
D
D
S
K
I
A
F
L
M
Q
Site 69
Y675
M
Q
L
Q
D
I
Q
Y
L
T
E
N
I
W
A
Site 70
S685
E
N
I
W
A
S
Q
S
V
L
S
A
C
D
N
Site 71
S688
W
A
S
Q
S
V
L
S
A
C
D
N
L
S
D
Site 72
S728
A
A
H
L
K
L
T
S
I
E
E
G
Y
E
R
Site 73
Y733
L
T
S
I
E
E
G
Y
E
R
S
F
I
H
K
Site 74
S736
I
E
E
G
Y
E
R
S
F
I
H
K
I
K
H
Site 75
Y775
I
D
E
I
R
W
K
Y
H
S
D
T
T
P
K
Site 76
T779
R
W
K
Y
H
S
D
T
T
P
K
I
I
E
S
Site 77
T780
W
K
Y
H
S
D
T
T
P
K
I
I
E
S
Q
Site 78
S786
T
T
P
K
I
I
E
S
Q
R
P
P
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation