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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM123C
Full Name:
Protein FAM123C
Alias:
Type:
Mass (Da):
90455
Number AA:
861
UniProt ID:
Q8N944
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
L
K
R
G
K
T
F
I
K
S
S
L
Q
Site 2
S12
R
G
K
T
F
I
K
S
S
L
Q
V
S
H
E
Site 3
S13
G
K
T
F
I
K
S
S
L
Q
V
S
H
E
K
Site 4
S17
I
K
S
S
L
Q
V
S
H
E
K
P
P
D
P
Site 5
S38
R
E
G
T
G
P
W
S
V
L
P
G
G
Q
Q
Site 6
S49
G
G
Q
Q
R
P
H
S
E
K
G
P
Q
A
S
Site 7
S56
S
E
K
G
P
Q
A
S
P
S
A
Q
E
Y
D
Site 8
S58
K
G
P
Q
A
S
P
S
A
Q
E
Y
D
R
C
Site 9
Y62
A
S
P
S
A
Q
E
Y
D
R
C
P
N
K
G
Site 10
T94
K
P
V
R
K
C
K
T
H
D
S
M
S
G
A
Site 11
S97
R
K
C
K
T
H
D
S
M
S
G
A
G
R
A
Site 12
S99
C
K
T
H
D
S
M
S
G
A
G
R
A
T
A
Site 13
S116
G
Q
L
V
G
S
A
S
F
P
G
S
P
G
S
Site 14
S120
G
S
A
S
F
P
G
S
P
G
S
R
R
M
I
Site 15
S123
S
F
P
G
S
P
G
S
R
R
M
I
D
Y
R
Site 16
Y129
G
S
R
R
M
I
D
Y
R
H
F
V
P
Q
M
Site 17
S152
S
I
P
R
K
R
I
S
L
K
R
P
K
K
C
Site 18
T171
F
H
I
R
R
N
K
T
E
D
L
A
S
L
A
Site 19
S176
N
K
T
E
D
L
A
S
L
A
A
E
G
K
S
Site 20
S183
S
L
A
A
E
G
K
S
L
P
S
P
G
D
P
Site 21
S186
A
E
G
K
S
L
P
S
P
G
D
P
S
D
P
Site 22
S191
L
P
S
P
G
D
P
S
D
P
G
G
R
R
S
Site 23
S198
S
D
P
G
G
R
R
S
K
A
F
L
P
P
G
Site 24
S243
E
D
V
A
S
L
Q
S
F
D
S
L
T
G
C
Site 25
S258
G
E
V
F
A
D
E
S
S
V
P
S
L
E
L
Site 26
S259
E
V
F
A
D
E
S
S
V
P
S
L
E
L
N
Site 27
S262
A
D
E
S
S
V
P
S
L
E
L
N
E
G
P
Site 28
S271
E
L
N
E
G
P
E
S
P
T
Q
A
A
Q
G
Site 29
S291
P
R
G
P
L
Q
G
S
V
E
Q
L
A
S
P
Site 30
S297
G
S
V
E
Q
L
A
S
P
A
Q
N
E
A
S
Site 31
S304
S
P
A
Q
N
E
A
S
D
F
T
R
F
W
D
Site 32
T307
Q
N
E
A
S
D
F
T
R
F
W
D
S
V
N
Site 33
S312
D
F
T
R
F
W
D
S
V
N
R
S
V
R
Q
Site 34
S316
F
W
D
S
V
N
R
S
V
R
Q
Q
Q
R
A
Site 35
S330
A
L
L
G
P
W
L
S
G
P
Q
G
T
D
R
Site 36
T344
R
D
Q
P
R
L
D
T
A
G
L
A
E
L
P
Site 37
S360
C
P
C
R
D
P
R
S
G
S
K
A
S
S
I
Site 38
S362
C
R
D
P
R
S
G
S
K
A
S
S
I
D
T
Site 39
S366
R
S
G
S
K
A
S
S
I
D
T
G
T
P
K
Site 40
T369
S
K
A
S
S
I
D
T
G
T
P
K
S
E
Q
Site 41
T371
A
S
S
I
D
T
G
T
P
K
S
E
Q
P
E
Site 42
S374
I
D
T
G
T
P
K
S
E
Q
P
E
S
V
S
Site 43
S379
P
K
S
E
Q
P
E
S
V
S
T
S
D
E
G
Site 44
S381
S
E
Q
P
E
S
V
S
T
S
D
E
G
Y
Y
Site 45
T382
E
Q
P
E
S
V
S
T
S
D
E
G
Y
Y
D
Site 46
S383
Q
P
E
S
V
S
T
S
D
E
G
Y
Y
D
S
Site 47
Y387
V
S
T
S
D
E
G
Y
Y
D
S
F
S
P
G
Site 48
Y388
S
T
S
D
E
G
Y
Y
D
S
F
S
P
G
L
Site 49
S390
S
D
E
G
Y
Y
D
S
F
S
P
G
L
E
E
Site 50
S392
E
G
Y
Y
D
S
F
S
P
G
L
E
E
D
K
Site 51
S404
E
D
K
K
E
A
E
S
P
G
T
P
A
A
T
Site 52
T407
K
E
A
E
S
P
G
T
P
A
A
T
F
P
R
Site 53
T411
S
P
G
T
P
A
A
T
F
P
R
D
S
Y
S
Site 54
S416
A
A
T
F
P
R
D
S
Y
S
G
D
A
L
Y
Site 55
Y417
A
T
F
P
R
D
S
Y
S
G
D
A
L
Y
E
Site 56
S418
T
F
P
R
D
S
Y
S
G
D
A
L
Y
E
L
Site 57
Y423
S
Y
S
G
D
A
L
Y
E
L
F
H
D
P
S
Site 58
S430
Y
E
L
F
H
D
P
S
E
G
P
L
G
P
S
Site 59
S437
S
E
G
P
L
G
P
S
P
D
D
D
L
C
V
Site 60
S445
P
D
D
D
L
C
V
S
E
S
L
S
G
P
A
Site 61
S480
A
P
G
P
D
L
L
S
Q
G
F
L
Q
S
S
Site 62
S486
L
S
Q
G
F
L
Q
S
S
W
K
G
K
E
C
Site 63
S487
S
Q
G
F
L
Q
S
S
W
K
G
K
E
C
L
Site 64
T505
C
D
T
E
L
A
I
T
M
G
I
V
S
W
L
Site 65
T517
S
W
L
R
R
G
P
T
P
R
A
P
P
T
P
Site 66
T523
P
T
P
R
A
P
P
T
P
G
Q
P
A
A
P
Site 67
S533
Q
P
A
A
P
P
G
S
Q
G
A
P
R
A
P
Site 68
T541
Q
G
A
P
R
A
P
T
E
K
L
G
G
R
E
Site 69
S552
G
G
R
E
G
L
A
S
D
A
G
G
A
T
V
Site 70
T558
A
S
D
A
G
G
A
T
V
C
S
A
P
S
R
Site 71
T594
G
A
T
Q
G
T
G
T
L
S
R
D
A
S
R
Site 72
S596
T
Q
G
T
G
T
L
S
R
D
A
S
R
E
E
Site 73
S600
G
T
L
S
R
D
A
S
R
E
E
E
T
R
G
Site 74
S609
E
E
E
T
R
G
H
S
E
G
L
F
S
S
M
Site 75
S614
G
H
S
E
G
L
F
S
S
M
E
S
A
A
T
Site 76
S615
H
S
E
G
L
F
S
S
M
E
S
A
A
T
S
Site 77
S618
G
L
F
S
S
M
E
S
A
A
T
S
T
T
D
Site 78
T621
S
S
M
E
S
A
A
T
S
T
T
D
T
S
G
Site 79
S622
S
M
E
S
A
A
T
S
T
T
D
T
S
G
K
Site 80
T626
A
A
T
S
T
T
D
T
S
G
K
N
K
A
P
Site 81
S636
K
N
K
A
P
V
P
S
T
W
P
C
S
Q
K
Site 82
T637
N
K
A
P
V
P
S
T
W
P
C
S
Q
K
E
Site 83
S641
V
P
S
T
W
P
C
S
Q
K
E
P
G
P
P
Site 84
T666
R
P
G
H
G
G
D
T
L
D
A
E
P
M
L
Site 85
S703
P
P
R
Q
D
M
G
S
G
L
F
G
Q
R
W
Site 86
S722
D
M
L
E
Q
K
Q
S
S
S
S
P
S
M
T
Site 87
S723
M
L
E
Q
K
Q
S
S
S
S
P
S
M
T
T
Site 88
S724
L
E
Q
K
Q
S
S
S
S
P
S
M
T
T
I
Site 89
S725
E
Q
K
Q
S
S
S
S
P
S
M
T
T
I
H
Site 90
S727
K
Q
S
S
S
S
P
S
M
T
T
I
H
G
L
Site 91
T729
S
S
S
S
P
S
M
T
T
I
H
G
L
P
Y
Site 92
T730
S
S
S
P
S
M
T
T
I
H
G
L
P
Y
S
Site 93
S737
T
I
H
G
L
P
Y
S
A
S
T
Q
D
Q
R
Site 94
S739
H
G
L
P
Y
S
A
S
T
Q
D
Q
R
C
R
Site 95
S753
R
D
R
V
Q
D
L
S
W
L
R
V
E
P
T
Site 96
T760
S
W
L
R
V
E
P
T
G
L
G
V
Q
A
W
Site 97
S769
L
G
V
Q
A
W
A
S
V
E
D
Q
P
L
Q
Site 98
S778
E
D
Q
P
L
Q
L
S
T
E
A
V
E
Q
V
Site 99
S789
V
E
Q
V
A
H
G
S
Q
L
D
S
E
P
R
Site 100
S793
A
H
G
S
Q
L
D
S
E
P
R
S
A
P
A
Site 101
S797
Q
L
D
S
E
P
R
S
A
P
A
A
R
W
S
Site 102
S804
S
A
P
A
A
R
W
S
S
Q
G
H
H
P
E
Site 103
S805
A
P
A
A
R
W
S
S
Q
G
H
H
P
E
S
Site 104
S812
S
Q
G
H
H
P
E
S
L
G
L
T
L
N
S
Site 105
T816
H
P
E
S
L
G
L
T
L
N
S
Q
Q
E
G
Site 106
S819
S
L
G
L
T
L
N
S
Q
Q
E
G
G
V
S
Site 107
S826
S
Q
Q
E
G
G
V
S
A
S
A
P
E
C
R
Site 108
S828
Q
E
G
G
V
S
A
S
A
P
E
C
R
C
S
Site 109
S835
S
A
P
E
C
R
C
S
L
L
A
R
E
G
L
Site 110
S852
G
Q
P
E
V
G
A
S
G
P
A
M
A
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation