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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC46
Full Name:
Coiled-coil domain-containing protein 46
Alias:
Type:
Mass (Da):
112749
Number AA:
955
UniProt ID:
Q8N8E3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T53
K
L
C
E
P
S
G
T
G
A
G
I
M
G
R
Site 2
Y66
G
R
K
N
R
N
L
Y
A
K
L
L
L
H
M
Site 3
T84
G
A
L
E
G
P
F
T
H
R
P
E
P
G
T
Site 4
T91
T
H
R
P
E
P
G
T
L
K
I
L
P
S
Y
Site 5
S100
K
I
L
P
S
Y
M
S
I
Y
F
D
E
P
N
Site 6
Y102
L
P
S
Y
M
S
I
Y
F
D
E
P
N
P
A
Site 7
S115
P
A
R
A
K
G
S
S
P
E
G
L
P
A
W
Site 8
S130
V
L
G
E
L
E
T
S
E
H
K
L
N
E
S
Site 9
S137
S
E
H
K
L
N
E
S
W
K
L
S
S
G
E
Site 10
S141
L
N
E
S
W
K
L
S
S
G
E
D
N
T
L
Site 11
T147
L
S
S
G
E
D
N
T
L
V
Q
S
P
T
D
Site 12
S151
E
D
N
T
L
V
Q
S
P
T
D
V
Y
S
R
Site 13
T153
N
T
L
V
Q
S
P
T
D
V
Y
S
R
E
Q
Site 14
Y156
V
Q
S
P
T
D
V
Y
S
R
E
Q
Y
T
G
Site 15
S157
Q
S
P
T
D
V
Y
S
R
E
Q
Y
T
G
K
Site 16
Y161
D
V
Y
S
R
E
Q
Y
T
G
K
L
R
V
R
Site 17
S169
T
G
K
L
R
V
R
S
H
S
L
S
P
T
H
Site 18
S171
K
L
R
V
R
S
H
S
L
S
P
T
H
R
E
Site 19
S173
R
V
R
S
H
S
L
S
P
T
H
R
E
D
G
Site 20
T175
R
S
H
S
L
S
P
T
H
R
E
D
G
Q
N
Site 21
T184
R
E
D
G
Q
N
I
T
P
K
I
C
E
V
Y
Site 22
Y191
T
P
K
I
C
E
V
Y
S
K
K
S
P
V
S
Site 23
S192
P
K
I
C
E
V
Y
S
K
K
S
P
V
S
L
Site 24
S195
C
E
V
Y
S
K
K
S
P
V
S
L
D
D
S
Site 25
S198
Y
S
K
K
S
P
V
S
L
D
D
S
D
I
E
Site 26
S202
S
P
V
S
L
D
D
S
D
I
E
A
R
L
N
Site 27
S210
D
I
E
A
R
L
N
S
W
N
L
G
I
E
N
Site 28
Y220
L
G
I
E
N
P
R
Y
L
R
Q
K
P
I
P
Site 29
S229
R
Q
K
P
I
P
V
S
L
M
T
P
K
F
S
Site 30
T232
P
I
P
V
S
L
M
T
P
K
F
S
L
R
K
Site 31
S236
S
L
M
T
P
K
F
S
L
R
K
S
S
S
F
Site 32
S240
P
K
F
S
L
R
K
S
S
S
F
H
D
D
H
Site 33
S241
K
F
S
L
R
K
S
S
S
F
H
D
D
H
F
Site 34
S242
F
S
L
R
K
S
S
S
F
H
D
D
H
F
L
Site 35
S250
F
H
D
D
H
F
L
S
R
I
R
E
K
E
L
Site 36
T261
E
K
E
L
D
M
K
T
K
M
M
E
A
K
F
Site 37
T299
N
E
I
E
E
L
K
T
L
Y
R
S
K
Q
H
Site 38
Y301
I
E
E
L
K
T
L
Y
R
S
K
Q
H
E
T
Site 39
T311
K
Q
H
E
T
E
E
T
I
R
K
L
E
K
K
Site 40
T332
D
C
Q
V
I
R
E
T
K
E
D
Q
I
A
E
Site 41
S350
I
C
E
Q
S
T
E
S
L
N
N
D
W
E
K
Site 42
T388
I
Q
E
L
L
E
D
T
N
V
R
L
N
K
M
Site 43
S397
V
R
L
N
K
M
E
S
E
Y
M
A
Q
T
Q
Site 44
Y399
L
N
K
M
E
S
E
Y
M
A
Q
T
Q
S
T
Site 45
T421
E
A
R
V
Q
Q
L
T
G
E
A
E
N
S
N
Site 46
S427
L
T
G
E
A
E
N
S
N
L
Q
R
Q
K
L
Site 47
Y445
K
A
E
L
E
R
C
Y
Q
I
T
C
S
E
L
Site 48
T448
L
E
R
C
Y
Q
I
T
C
S
E
L
Q
E
V
Site 49
T461
E
V
K
A
R
R
N
T
L
H
K
E
K
D
H
Site 50
Y473
K
D
H
L
V
N
D
Y
E
Q
N
M
K
L
L
Site 51
Y484
M
K
L
L
Q
T
K
Y
D
A
D
I
N
L
L
Site 52
S498
L
K
Q
E
H
A
L
S
A
S
K
A
S
S
M
Site 53
S500
Q
E
H
A
L
S
A
S
K
A
S
S
M
I
E
Site 54
S504
L
S
A
S
K
A
S
S
M
I
E
E
L
E
Q
Site 55
S558
K
K
A
H
D
L
Q
S
E
L
D
K
G
K
E
Site 56
T586
K
E
K
E
E
Q
L
T
R
V
T
E
V
Q
R
Site 57
T589
E
E
Q
L
T
R
V
T
E
V
Q
R
L
Q
A
Site 58
Y618
E
L
N
S
E
K
V
Y
A
E
M
K
E
Q
M
Site 59
T633
E
K
V
E
A
D
L
T
R
S
K
S
L
R
E
Site 60
S637
A
D
L
T
R
S
K
S
L
R
E
K
Q
S
K
Site 61
S643
K
S
L
R
E
K
Q
S
K
E
F
L
W
Q
L
Site 62
Y657
L
E
D
I
R
Q
R
Y
E
Q
Q
I
V
E
L
Site 63
T673
L
E
H
E
Q
E
K
T
H
L
L
Q
Q
H
N
Site 64
S685
Q
H
N
A
E
K
D
S
L
V
R
D
H
E
R
Site 65
S742
E
E
L
I
N
V
N
S
Q
R
K
Q
Q
L
V
Site 66
T763
E
E
E
K
Q
R
A
T
R
E
H
E
I
V
V
Site 67
T787
M
K
I
E
L
K
K
T
H
A
A
E
T
E
M
Site 68
T795
H
A
A
E
T
E
M
T
L
E
K
A
N
S
K
Site 69
S801
M
T
L
E
K
A
N
S
K
L
K
Q
I
E
K
Site 70
T811
K
Q
I
E
K
E
Y
T
Q
K
L
A
K
S
S
Site 71
T827
I
I
A
E
L
Q
T
T
I
S
S
L
K
E
E
Site 72
S829
A
E
L
Q
T
T
I
S
S
L
K
E
E
N
S
Site 73
S830
E
L
Q
T
T
I
S
S
L
K
E
E
N
S
Q
Site 74
S836
S
S
L
K
E
E
N
S
Q
Q
Q
L
A
A
E
Site 75
S896
L
Q
H
K
E
L
E
S
Q
E
Q
I
T
Y
I
Site 76
Y902
E
S
Q
E
Q
I
T
Y
I
R
Q
E
Y
E
T
Site 77
Y907
I
T
Y
I
R
Q
E
Y
E
T
K
L
K
G
L
Site 78
T909
Y
I
R
Q
E
Y
E
T
K
L
K
G
L
M
P
Site 79
S918
L
K
G
L
M
P
A
S
L
R
Q
E
L
E
D
Site 80
T926
L
R
Q
E
L
E
D
T
I
S
S
L
K
S
Q
Site 81
S928
Q
E
L
E
D
T
I
S
S
L
K
S
Q
V
N
Site 82
S929
E
L
E
D
T
I
S
S
L
K
S
Q
V
N
F
Site 83
S932
D
T
I
S
S
L
K
S
Q
V
N
F
L
Q
K
Site 84
S942
N
F
L
Q
K
R
A
S
I
L
Q
E
E
L
T
Site 85
T949
S
I
L
Q
E
E
L
T
T
Y
Q
G
R
R
_
Site 86
T950
I
L
Q
E
E
L
T
T
Y
Q
G
R
R
_
_
Site 87
Y951
L
Q
E
E
L
T
T
Y
Q
G
R
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation