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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAF1
Full Name:
RNA polymerase II-associated factor 1 homolog
Alias:
F23149_1; FLJ11123; Pancreatic differentiation protein 2; PD2
Type:
Mass (Da):
59976
Number AA:
531
UniProt ID:
Q8N7H5
International Prot ID:
IPI00300333
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016593
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0033523
GO:0010390
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
E
D
G
H
R
P
N
S
H
R
T
L
P
E
R
Site 2
T22
H
R
P
N
S
H
R
T
L
P
E
R
S
G
V
Site 3
Y51
F
D
P
K
F
I
T
Y
P
F
D
Q
N
R
F
Site 4
Y61
D
Q
N
R
F
V
Q
Y
K
A
T
S
L
E
K
Site 5
S65
F
V
Q
Y
K
A
T
S
L
E
K
Q
H
K
H
Site 6
T76
Q
H
K
H
D
L
L
T
E
P
D
L
G
V
T
Site 7
T91
I
D
L
I
N
P
D
T
Y
R
I
D
P
N
V
Site 8
Y92
D
L
I
N
P
D
T
Y
R
I
D
P
N
V
L
Site 9
S117
E
E
I
Q
A
P
T
S
S
K
R
S
Q
Q
H
Site 10
S118
E
I
Q
A
P
T
S
S
K
R
S
Q
Q
H
A
Site 11
S121
A
P
T
S
S
K
R
S
Q
Q
H
A
K
V
V
Site 12
T134
V
V
P
W
M
R
K
T
E
Y
I
S
T
E
F
Site 13
Y136
P
W
M
R
K
T
E
Y
I
S
T
E
F
N
R
Site 14
T139
R
K
T
E
Y
I
S
T
E
F
N
R
Y
G
I
Site 15
Y144
I
S
T
E
F
N
R
Y
G
I
S
N
E
K
P
Site 16
Y169
Q
F
T
E
E
E
I
Y
K
D
R
D
S
Q
I
Site 17
S174
E
I
Y
K
D
R
D
S
Q
I
T
A
I
E
K
Site 18
T177
K
D
R
D
S
Q
I
T
A
I
E
K
T
F
E
Site 19
T182
Q
I
T
A
I
E
K
T
F
E
D
A
Q
K
S
Site 20
S189
T
F
E
D
A
Q
K
S
I
S
Q
H
Y
S
K
Site 21
S191
E
D
A
Q
K
S
I
S
Q
H
Y
S
K
P
R
Site 22
Y194
Q
K
S
I
S
Q
H
Y
S
K
P
R
V
T
P
Site 23
S195
K
S
I
S
Q
H
Y
S
K
P
R
V
T
P
V
Site 24
T200
H
Y
S
K
P
R
V
T
P
V
E
V
M
P
V
Site 25
S225
C
A
Q
V
I
F
D
S
D
P
A
P
K
D
T
Site 26
S233
D
P
A
P
K
D
T
S
G
A
A
A
L
E
M
Site 27
Y260
E
G
N
Q
F
V
A
Y
F
L
P
V
E
E
T
Site 28
Y281
D
Q
E
E
E
M
D
Y
A
P
D
D
V
Y
D
Site 29
Y287
D
Y
A
P
D
D
V
Y
D
Y
K
I
A
R
E
Site 30
Y289
A
P
D
D
V
Y
D
Y
K
I
A
R
E
Y
N
Site 31
Y295
D
Y
K
I
A
R
E
Y
N
W
N
V
K
N
K
Site 32
Y311
S
K
G
Y
E
E
N
Y
F
F
I
F
R
E
G
Site 33
Y322
F
R
E
G
D
G
V
Y
Y
N
E
L
E
T
R
Site 34
Y323
R
E
G
D
G
V
Y
Y
N
E
L
E
T
R
V
Site 35
S333
L
E
T
R
V
R
L
S
K
R
R
A
K
A
G
Site 36
T345
K
A
G
V
Q
S
G
T
N
A
L
L
V
V
K
Site 37
T386
E
E
E
E
E
M
E
T
E
E
K
E
A
G
G
Site 38
S394
E
E
K
E
A
G
G
S
D
E
E
Q
E
K
G
Site 39
S403
E
E
Q
E
K
G
S
S
S
E
K
E
G
S
E
Site 40
S404
E
Q
E
K
G
S
S
S
E
K
E
G
S
E
D
Site 41
S409
S
S
S
E
K
E
G
S
E
D
E
H
S
G
S
Site 42
S414
E
G
S
E
D
E
H
S
G
S
E
S
E
R
E
Site 43
S416
S
E
D
E
H
S
G
S
E
S
E
R
E
E
G
Site 44
S418
D
E
H
S
G
S
E
S
E
R
E
E
G
D
R
Site 45
S429
E
G
D
R
D
E
A
S
D
K
S
G
S
G
E
Site 46
S432
R
D
E
A
S
D
K
S
G
S
G
E
D
E
S
Site 47
S434
E
A
S
D
K
S
G
S
G
E
D
E
S
S
E
Site 48
S439
S
G
S
G
E
D
E
S
S
E
D
E
A
R
A
Site 49
S440
G
S
G
E
D
E
S
S
E
D
E
A
R
A
A
Site 50
S456
D
K
E
E
I
F
G
S
D
A
D
S
E
D
D
Site 51
S460
I
F
G
S
D
A
D
S
E
D
D
A
D
S
D
Site 52
S466
D
S
E
D
D
A
D
S
D
D
E
D
R
G
Q
Site 53
S478
R
G
Q
A
Q
G
G
S
D
N
D
S
D
S
G
Site 54
S482
Q
G
G
S
D
N
D
S
D
S
G
S
N
G
G
Site 55
S484
G
S
D
N
D
S
D
S
G
S
N
G
G
G
Q
Site 56
S486
D
N
D
S
D
S
G
S
N
G
G
G
Q
R
S
Site 57
S493
S
N
G
G
G
Q
R
S
R
S
H
S
R
S
A
Site 58
S495
G
G
G
Q
R
S
R
S
H
S
R
S
A
S
P
Site 59
S497
G
Q
R
S
R
S
H
S
R
S
A
S
P
F
P
Site 60
S499
R
S
R
S
H
S
R
S
A
S
P
F
P
S
G
Site 61
S501
R
S
H
S
R
S
A
S
P
F
P
S
G
S
E
Site 62
S505
R
S
A
S
P
F
P
S
G
S
E
H
S
A
Q
Site 63
S507
A
S
P
F
P
S
G
S
E
H
S
A
Q
E
D
Site 64
S516
H
S
A
Q
E
D
G
S
E
A
A
A
S
D
S
Site 65
S521
D
G
S
E
A
A
A
S
D
S
S
E
A
D
S
Site 66
S523
S
E
A
A
A
S
D
S
S
E
A
D
S
D
S
Site 67
S524
E
A
A
A
S
D
S
S
E
A
D
S
D
S
D
Site 68
S528
S
D
S
S
E
A
D
S
D
S
D
_
_
_
_
Site 69
S530
S
S
E
A
D
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation