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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHDC1
Full Name:
Kelch domain-containing protein 1
Alias:
Type:
Mass (Da):
46720
Number AA:
406
UniProt ID:
Q8N7A1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y31
F
L
Y
V
W
G
G
Y
V
S
I
E
D
N
E
Site 2
Y40
S
I
E
D
N
E
V
Y
L
P
N
D
E
I
W
Site 3
Y49
P
N
D
E
I
W
T
Y
D
I
D
S
G
L
W
Site 4
S68
M
E
G
E
L
P
A
S
M
S
G
S
C
G
A
Site 5
Y87
K
L
Y
I
F
G
G
Y
D
D
K
G
Y
S
N
Site 6
Y92
G
G
Y
D
D
K
G
Y
S
N
R
L
Y
F
V
Site 7
Y97
K
G
Y
S
N
R
L
Y
F
V
N
L
R
T
R
Site 8
T107
N
L
R
T
R
D
E
T
Y
I
W
E
K
I
T
Site 9
Y108
L
R
T
R
D
E
T
Y
I
W
E
K
I
T
D
Site 10
T122
D
F
E
G
Q
P
P
T
P
R
D
K
L
S
C
Site 11
Y132
D
K
L
S
C
W
V
Y
K
D
R
L
I
Y
F
Site 12
Y138
V
Y
K
D
R
L
I
Y
F
G
G
Y
G
C
R
Site 13
Y142
R
L
I
Y
F
G
G
Y
G
C
R
R
H
S
E
Site 14
T201
P
Q
P
R
A
A
H
T
C
A
V
L
G
N
K
Site 15
T219
F
G
G
R
V
L
Q
T
R
M
N
D
L
H
Y
Site 16
Y226
T
R
M
N
D
L
H
Y
L
N
L
D
T
W
T
Site 17
T239
W
T
W
S
G
R
I
T
I
N
G
E
S
P
K
Site 18
S244
R
I
T
I
N
G
E
S
P
K
H
R
S
W
H
Site 19
S249
G
E
S
P
K
H
R
S
W
H
T
L
T
P
I
Site 20
T254
H
R
S
W
H
T
L
T
P
I
A
D
D
K
L
Site 21
S275
S
A
D
N
I
P
L
S
D
G
W
I
H
N
V
Site 22
T291
T
N
C
W
K
Q
L
T
H
L
P
K
T
R
P
Site 23
T296
Q
L
T
H
L
P
K
T
R
P
R
L
W
H
T
Site 24
T338
N
D
L
L
I
F
Q
T
Q
P
Y
S
L
L
R
Site 25
S342
I
F
Q
T
Q
P
Y
S
L
L
R
S
C
L
D
Site 26
S346
Q
P
Y
S
L
L
R
S
C
L
D
C
I
G
K
Site 27
S360
K
N
S
I
M
L
E
S
Q
I
S
L
L
P
P
Site 28
Y400
K
E
E
T
E
N
K
Y
Q
W
I
S
S
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation