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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AOPEP
Full Name:
Aminopeptidase O
Alias:
Type:
Mass (Da):
93572
Number AA:
819
UniProt ID:
Q8N6M6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
D
L
D
V
D
F
E
S
Q
V
I
E
G
T
I
Site 2
S58
N
R
F
K
K
Q
N
S
S
I
E
E
A
C
Q
Site 3
S59
R
F
K
K
Q
N
S
S
I
E
E
A
C
Q
S
Site 4
S66
S
I
E
E
A
C
Q
S
E
S
N
K
A
C
K
Site 5
T85
E
P
C
H
I
P
V
T
N
A
R
T
F
S
S
Site 6
T89
I
P
V
T
N
A
R
T
F
S
S
E
M
E
Y
Site 7
S91
V
T
N
A
R
T
F
S
S
E
M
E
Y
N
D
Site 8
Y96
T
F
S
S
E
M
E
Y
N
D
F
A
I
C
S
Site 9
S110
S
K
G
E
K
D
T
S
D
K
D
G
N
H
D
Site 10
S123
H
D
N
Q
E
H
A
S
G
I
S
S
S
K
Y
Site 11
S126
Q
E
H
A
S
G
I
S
S
S
K
Y
C
C
D
Site 12
S127
E
H
A
S
G
I
S
S
S
K
Y
C
C
D
T
Site 13
S128
H
A
S
G
I
S
S
S
K
Y
C
C
D
T
G
Site 14
Y130
S
G
I
S
S
S
K
Y
C
C
D
T
G
N
H
Site 15
T134
S
S
K
Y
C
C
D
T
G
N
H
G
S
E
D
Site 16
S173
G
L
E
K
F
T
R
S
P
E
L
T
V
V
S
Site 17
T177
F
T
R
S
P
E
L
T
V
V
S
E
E
F
R
Site 18
Y205
R
W
R
E
Q
L
D
Y
Y
A
R
C
S
Q
A
Site 19
Y206
W
R
E
Q
L
D
Y
Y
A
R
C
S
Q
A
P
Site 20
S210
L
D
Y
Y
A
R
C
S
Q
A
P
G
C
G
E
Site 21
T224
E
L
L
F
D
T
D
T
W
S
L
Q
I
R
K
Site 22
S226
L
F
D
T
D
T
W
S
L
Q
I
R
K
T
G
Site 23
T232
W
S
L
Q
I
R
K
T
G
A
Q
T
A
T
D
Site 24
T238
K
T
G
A
Q
T
A
T
D
F
P
H
A
I
R
Site 25
Y248
P
H
A
I
R
I
W
Y
K
T
K
P
E
G
R
Site 26
T250
A
I
R
I
W
Y
K
T
K
P
E
G
R
S
V
Site 27
T258
K
P
E
G
R
S
V
T
W
T
S
D
Q
S
G
Site 28
T260
E
G
R
S
V
T
W
T
S
D
Q
S
G
R
P
Site 29
S261
G
R
S
V
T
W
T
S
D
Q
S
G
R
P
C
Site 30
Y270
Q
S
G
R
P
C
V
Y
T
V
G
S
P
I
N
Site 31
T271
S
G
R
P
C
V
Y
T
V
G
S
P
I
N
N
Site 32
S313
V
L
M
S
G
E
N
S
A
K
P
T
Q
L
W
Site 33
T317
G
E
N
S
A
K
P
T
Q
L
W
E
E
C
S
Site 34
S356
M
K
M
E
T
W
S
S
N
D
L
A
T
E
R
Site 35
T361
W
S
S
N
D
L
A
T
E
R
P
F
S
P
S
Site 36
S366
L
A
T
E
R
P
F
S
P
S
E
A
N
F
R
Site 37
S368
T
E
R
P
F
S
P
S
E
A
N
F
R
H
V
Site 38
S391
P
C
R
F
Q
N
A
S
A
T
T
Q
E
I
I
Site 39
T496
A
I
G
A
R
D
W
T
E
E
W
L
S
E
G
Site 40
Y522
T
A
Q
Q
L
A
P
Y
E
A
R
E
Q
Q
E
Site 41
S546
L
Q
D
E
M
Q
C
S
P
E
E
M
Q
V
L
Site 42
S556
E
M
Q
V
L
R
P
S
K
D
K
T
G
H
T
Site 43
T560
L
R
P
S
K
D
K
T
G
H
T
S
D
S
G
Site 44
S564
K
D
K
T
G
H
T
S
D
S
G
A
S
V
I
Site 45
S566
K
T
G
H
T
S
D
S
G
A
S
V
I
K
H
Site 46
T604
A
K
R
L
G
D
E
T
Y
F
S
F
L
R
K
Site 47
Y605
K
R
L
G
D
E
T
Y
F
S
F
L
R
K
F
Site 48
S607
L
G
D
E
T
Y
F
S
F
L
R
K
F
V
H
Site 49
S643
E
E
K
R
L
E
L
S
V
E
N
I
Y
Q
D
Site 50
Y648
E
L
S
V
E
N
I
Y
Q
D
W
L
E
S
S
Site 51
T723
E
H
L
L
E
Q
K
T
L
S
P
R
T
L
Q
Site 52
S725
L
L
E
Q
K
T
L
S
P
R
T
L
Q
S
L
Site 53
S731
L
S
P
R
T
L
Q
S
L
Q
R
T
Y
H
L
Site 54
Y736
L
Q
S
L
Q
R
T
Y
H
L
Q
D
Q
D
A
Site 55
Y762
K
H
K
F
T
K
A
Y
K
S
V
E
R
F
L
Site 56
S764
K
F
T
K
A
Y
K
S
V
E
R
F
L
Q
E
Site 57
S786
L
Y
G
E
L
M
V
S
E
D
A
R
Q
Q
Q
Site 58
T802
A
R
R
C
F
E
R
T
K
E
Q
M
D
R
S
Site 59
S810
K
E
Q
M
D
R
S
S
A
Q
V
V
A
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation