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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGSF1
Full Name:
Immunoglobulin superfamily member 1
Alias:
Immunoglobulin-like domain-containing protein 1;Inhibin-binding protein;Pituitary gland-specific factor 2;p120
Type:
Mass (Da):
148936
Number AA:
1336
UniProt ID:
Q8N6C5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
R
M
S
L
G
M
T
S
I
V
M
D
P
Q
P
Site 2
Y46
E
L
W
I
E
S
N
Y
P
Q
A
P
W
E
N
Site 3
S60
N
I
T
L
W
C
R
S
P
S
R
I
S
S
K
Site 4
S62
T
L
W
C
R
S
P
S
R
I
S
S
K
F
L
Site 5
S65
C
R
S
P
S
R
I
S
S
K
F
L
L
L
K
Site 6
S66
R
S
P
S
R
I
S
S
K
F
L
L
L
K
D
Site 7
T75
F
L
L
L
K
D
K
T
Q
M
T
W
I
R
P
Site 8
T78
L
K
D
K
T
Q
M
T
W
I
R
P
S
H
K
Site 9
Y104
T
E
S
N
A
G
L
Y
R
C
C
Y
W
K
E
Site 10
S115
Y
W
K
E
T
G
W
S
K
P
S
K
V
L
E
Site 11
Y168
F
M
L
F
K
E
G
Y
A
E
P
V
D
Y
Q
Site 12
Y174
G
Y
A
E
P
V
D
Y
Q
V
P
T
G
T
M
Site 13
T190
I
F
S
I
D
N
L
T
P
E
D
E
G
V
Y
Site 14
Y197
T
P
E
D
E
G
V
Y
I
C
R
T
H
I
Q
Site 15
T208
T
H
I
Q
M
L
P
T
L
W
S
E
P
S
N
Site 16
S211
Q
M
L
P
T
L
W
S
E
P
S
N
P
L
K
Site 17
S214
P
T
L
W
S
E
P
S
N
P
L
K
L
V
V
Site 18
T229
A
G
L
Y
P
K
P
T
L
T
A
H
P
G
P
Site 19
T231
L
Y
P
K
P
T
L
T
A
H
P
G
P
I
M
Site 20
Y253
L
R
C
Q
G
P
I
Y
G
M
T
F
A
L
M
Site 21
S268
R
V
E
D
L
E
K
S
F
Y
H
K
K
T
I
Site 22
Y270
E
D
L
E
K
S
F
Y
H
K
K
T
I
K
N
Site 23
T274
K
S
F
Y
H
K
K
T
I
K
N
E
A
N
F
Site 24
S285
E
A
N
F
F
F
Q
S
L
K
I
Q
D
T
G
Site 25
Y294
K
I
Q
D
T
G
H
Y
L
C
F
Y
Y
D
A
Site 26
Y298
T
G
H
Y
L
C
F
Y
Y
D
A
S
Y
R
G
Site 27
Y299
G
H
Y
L
C
F
Y
Y
D
A
S
Y
R
G
S
Site 28
Y303
C
F
Y
Y
D
A
S
Y
R
G
S
L
L
S
D
Site 29
S306
Y
D
A
S
Y
R
G
S
L
L
S
D
V
L
K
Site 30
T323
V
T
D
T
F
P
K
T
W
L
L
A
R
P
S
Site 31
S330
T
W
L
L
A
R
P
S
A
V
V
Q
M
G
Q
Site 32
S340
V
Q
M
G
Q
N
V
S
L
R
C
R
G
P
V
Site 33
Y355
D
G
V
G
L
A
L
Y
K
K
G
E
D
K
P
Site 34
S370
L
Q
F
L
D
A
T
S
I
D
D
N
T
S
F
Site 35
T375
A
T
S
I
D
D
N
T
S
F
F
L
N
N
V
Site 36
S376
T
S
I
D
D
N
T
S
F
F
L
N
N
V
T
Site 37
T383
S
F
F
L
N
N
V
T
Y
S
D
T
G
I
Y
Site 38
Y384
F
F
L
N
N
V
T
Y
S
D
T
G
I
Y
S
Site 39
Y394
T
G
I
Y
S
C
H
Y
L
L
T
W
K
T
S
Site 40
T400
H
Y
L
L
T
W
K
T
S
I
R
M
P
S
H
Site 41
S406
K
T
S
I
R
M
P
S
H
N
T
V
E
L
M
Site 42
S422
V
D
K
P
P
K
P
S
L
S
A
W
P
S
T
Site 43
S424
K
P
P
K
P
S
L
S
A
W
P
S
T
V
F
Site 44
S428
P
S
L
S
A
W
P
S
T
V
F
K
L
G
K
Site 45
S451
S
H
P
V
L
E
F
S
L
E
W
E
E
R
E
Site 46
T459
L
E
W
E
E
R
E
T
F
Q
K
F
S
V
N
Site 47
S472
V
N
G
D
F
I
I
S
N
V
D
G
K
G
T
Site 48
T479
S
N
V
D
G
K
G
T
G
T
Y
S
C
S
Y
Site 49
T481
V
D
G
K
G
T
G
T
Y
S
C
S
Y
R
V
Site 50
Y482
D
G
K
G
T
G
T
Y
S
C
S
Y
R
V
E
Site 51
S483
G
K
G
T
G
T
Y
S
C
S
Y
R
V
E
T
Site 52
S485
G
T
G
T
Y
S
C
S
Y
R
V
E
T
H
P
Site 53
S496
E
T
H
P
N
I
W
S
H
R
S
E
P
L
K
Site 54
S499
P
N
I
W
S
H
R
S
E
P
L
K
L
M
G
Site 55
Y515
A
G
Y
L
T
W
N
Y
V
L
N
E
A
I
R
Site 56
T589
E
T
E
I
V
M
P
T
P
K
P
E
L
W
A
Site 57
T609
L
A
P
W
K
N
L
T
L
W
C
R
S
P
S
Site 58
S614
N
L
T
L
W
C
R
S
P
S
G
S
T
K
E
Site 59
S616
T
L
W
C
R
S
P
S
G
S
T
K
E
F
V
Site 60
S618
W
C
R
S
P
S
G
S
T
K
E
F
V
L
L
Site 61
S638
W
I
A
T
R
P
A
S
E
Q
V
R
A
A
F
Site 62
T651
A
F
P
L
G
A
L
T
Q
S
H
T
G
S
Y
Site 63
S653
P
L
G
A
L
T
Q
S
H
T
G
S
Y
H
C
Site 64
T655
G
A
L
T
Q
S
H
T
G
S
Y
H
C
H
S
Site 65
S669
S
W
E
E
M
A
V
S
E
P
S
E
A
L
E
Site 66
S691
P
K
P
V
I
S
A
S
P
T
I
R
G
Q
E
Site 67
T693
P
V
I
S
A
S
P
T
I
R
G
Q
E
L
Q
Site 68
Y715
A
G
M
G
F
A
L
Y
K
E
G
E
Q
E
P
Site 69
T736
V
G
R
E
A
F
F
T
I
Q
R
M
E
D
K
Site 70
S749
D
K
D
E
G
N
Y
S
C
R
T
H
T
E
K
Site 71
T754
N
Y
S
C
R
T
H
T
E
K
R
P
F
K
W
Site 72
S762
E
K
R
P
F
K
W
S
E
P
S
E
P
L
E
Site 73
Y776
E
L
V
I
K
E
M
Y
P
K
P
F
F
K
T
Site 74
T796
V
T
P
G
A
R
V
T
F
N
C
S
T
P
H
Site 75
Y811
Q
H
M
S
F
I
L
Y
K
D
G
S
E
I
A
Site 76
S815
F
I
L
Y
K
D
G
S
E
I
A
S
S
D
R
Site 77
S819
K
D
G
S
E
I
A
S
S
D
R
S
W
A
S
Site 78
S820
D
G
S
E
I
A
S
S
D
R
S
W
A
S
P
Site 79
S823
E
I
A
S
S
D
R
S
W
A
S
P
G
A
S
Site 80
S826
S
S
D
R
S
W
A
S
P
G
A
S
A
A
H
Site 81
Y847
G
I
G
D
G
G
N
Y
S
C
R
Y
Y
D
F
Site 82
Y851
G
G
N
Y
S
C
R
Y
Y
D
F
S
I
W
S
Site 83
Y852
G
N
Y
S
C
R
Y
Y
D
F
S
I
W
S
E
Site 84
S858
Y
Y
D
F
S
I
W
S
E
P
S
D
P
V
E
Site 85
T869
D
P
V
E
L
V
V
T
E
F
Y
P
K
P
T
Site 86
S919
H
V
P
L
Q
F
R
S
V
S
G
N
S
A
D
Site 87
S921
P
L
Q
F
R
S
V
S
G
N
S
A
D
F
L
Site 88
S924
F
R
S
V
S
G
N
S
A
D
F
L
L
H
T
Site 89
T931
S
A
D
F
L
L
H
T
V
G
A
E
D
S
G
Site 90
Y944
S
G
N
Y
S
C
I
Y
Y
E
T
T
M
S
N
Site 91
Y945
G
N
Y
S
C
I
Y
Y
E
T
T
M
S
N
R
Site 92
S950
I
Y
Y
E
T
T
M
S
N
R
G
S
Y
L
S
Site 93
S954
T
T
M
S
N
R
G
S
Y
L
S
M
P
L
M
Site 94
S979
W
L
F
A
E
P
S
S
V
V
P
M
G
Q
N
Site 95
T1009
L
H
K
E
G
E
A
T
S
M
Q
L
W
G
S
Site 96
S1016
T
S
M
Q
L
W
G
S
T
S
N
D
G
A
F
Site 97
S1018
M
Q
L
W
G
S
T
S
N
D
G
A
F
P
I
Site 98
T1026
N
D
G
A
F
P
I
T
N
I
S
G
T
S
M
Site 99
S1029
A
F
P
I
T
N
I
S
G
T
S
M
G
R
Y
Site 100
Y1036
S
G
T
S
M
G
R
Y
S
C
C
Y
H
P
D
Site 101
S1068
T
G
L
L
P
K
P
S
L
L
A
Q
P
G
P
Site 102
S1094
C
Q
G
E
L
P
D
S
T
F
V
L
L
K
E
Site 103
T1095
Q
G
E
L
P
D
S
T
F
V
L
L
K
E
G
Site 104
S1113
P
L
E
Q
Q
R
P
S
G
Y
R
A
D
F
W
Site 105
S1129
P
A
V
R
G
E
D
S
G
I
Y
S
C
V
Y
Site 106
Y1132
R
G
E
D
S
G
I
Y
S
C
V
Y
Y
L
D
Site 107
S1133
G
E
D
S
G
I
Y
S
C
V
Y
Y
L
D
S
Site 108
S1140
S
C
V
Y
Y
L
D
S
T
P
F
A
A
S
N
Site 109
T1141
C
V
Y
Y
L
D
S
T
P
F
A
A
S
N
H
Site 110
S1146
D
S
T
P
F
A
A
S
N
H
S
D
S
L
E
Site 111
S1149
P
F
A
A
S
N
H
S
D
S
L
E
I
W
V
Site 112
S1151
A
A
S
N
H
S
D
S
L
E
I
W
V
T
D
Site 113
T1157
D
S
L
E
I
W
V
T
D
K
P
P
K
P
S
Site 114
S1164
T
D
K
P
P
K
P
S
L
S
A
W
P
S
T
Site 115
S1166
K
P
P
K
P
S
L
S
A
W
P
S
T
M
F
Site 116
S1170
P
S
L
S
A
W
P
S
T
M
F
K
L
G
K
Site 117
T1171
S
L
S
A
W
P
S
T
M
F
K
L
G
K
D
Site 118
T1180
F
K
L
G
K
D
I
T
L
Q
C
R
G
P
L
Site 119
Y1224
E
G
K
G
I
G
N
Y
S
C
S
Y
R
L
Q
Site 120
S1225
G
K
G
I
G
N
Y
S
C
S
Y
R
L
Q
A
Site 121
Y1233
C
S
Y
R
L
Q
A
Y
P
D
I
W
S
E
P
Site 122
S1238
Q
A
Y
P
D
I
W
S
E
P
S
D
P
L
E
Site 123
S1241
P
D
I
W
S
E
P
S
D
P
L
E
L
V
G
Site 124
S1266
V
G
N
I
V
R
S
S
L
I
V
V
V
V
V
Site 125
T1291
K
K
W
P
R
L
R
T
R
G
S
E
T
D
G
Site 126
S1294
P
R
L
R
T
R
G
S
E
T
D
G
R
D
Q
Site 127
T1302
E
T
D
G
R
D
Q
T
I
A
L
E
E
C
N
Site 128
T1316
N
Q
E
G
E
P
G
T
P
A
N
S
P
S
S
Site 129
S1320
E
P
G
T
P
A
N
S
P
S
S
T
S
Q
R
Site 130
S1322
G
T
P
A
N
S
P
S
S
T
S
Q
R
I
S
Site 131
S1323
T
P
A
N
S
P
S
S
T
S
Q
R
I
S
V
Site 132
T1324
P
A
N
S
P
S
S
T
S
Q
R
I
S
V
E
Site 133
S1325
A
N
S
P
S
S
T
S
Q
R
I
S
V
E
L
Site 134
S1329
S
S
T
S
Q
R
I
S
V
E
L
P
V
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation