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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM57
Full Name:
Macoilin
Alias:
FLJ10747; MACOI; Transmembrane protein 57
Type:
Cell surface
Mass (Da):
76178
Number AA:
664
UniProt ID:
Q8N5G2
International Prot ID:
IPI00296938
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
R
R
N
A
D
C
S
K
L
R
R
P
L
K
Site 2
T21
P
L
K
R
N
R
I
T
E
G
I
Y
G
S
T
Site 3
Y66
W
L
F
I
R
S
V
Y
D
S
F
R
Y
Q
G
Site 4
S68
F
I
R
S
V
Y
D
S
F
R
Y
Q
G
L
A
Site 5
S172
T
L
G
F
G
F
K
S
Y
V
S
Y
K
M
R
Site 6
Y173
L
G
F
G
F
K
S
Y
V
S
Y
K
M
R
L
Site 7
S175
F
G
F
K
S
Y
V
S
Y
K
M
R
L
R
K
Site 8
Y176
G
F
K
S
Y
V
S
Y
K
M
R
L
R
K
Q
Site 9
Y193
V
Q
K
E
N
E
F
Y
M
Q
L
L
Q
Q
A
Site 10
S227
K
G
L
P
D
M
D
S
S
I
L
I
H
H
N
Site 11
S228
G
L
P
D
M
D
S
S
I
L
I
H
H
N
G
Site 12
S244
I
P
A
N
K
K
L
S
T
T
L
P
E
I
E
Site 13
T245
P
A
N
K
K
L
S
T
T
L
P
E
I
E
Y
Site 14
Y252
T
T
L
P
E
I
E
Y
R
E
K
G
K
E
K
Site 15
S281
N
I
L
Q
P
V
D
S
K
I
Q
E
I
E
Y
Site 16
Y288
S
K
I
Q
E
I
E
Y
M
E
N
H
I
N
S
Site 17
S305
L
N
N
D
L
V
G
S
T
E
N
L
L
K
E
Site 18
T306
N
N
D
L
V
G
S
T
E
N
L
L
K
E
D
Site 19
S314
E
N
L
L
K
E
D
S
C
T
A
S
S
K
N
Site 20
T316
L
L
K
E
D
S
C
T
A
S
S
K
N
Y
K
Site 21
S318
K
E
D
S
C
T
A
S
S
K
N
Y
K
N
A
Site 22
Y322
C
T
A
S
S
K
N
Y
K
N
A
S
G
V
V
Site 23
S326
S
K
N
Y
K
N
A
S
G
V
V
N
S
S
P
Site 24
S331
N
A
S
G
V
V
N
S
S
P
R
S
H
S
A
Site 25
S332
A
S
G
V
V
N
S
S
P
R
S
H
S
A
T
Site 26
S335
V
V
N
S
S
P
R
S
H
S
A
T
N
G
S
Site 27
S337
N
S
S
P
R
S
H
S
A
T
N
G
S
I
P
Site 28
T339
S
P
R
S
H
S
A
T
N
G
S
I
P
S
S
Site 29
S342
S
H
S
A
T
N
G
S
I
P
S
S
S
S
K
Site 30
S345
A
T
N
G
S
I
P
S
S
S
S
K
N
E
K
Site 31
S346
T
N
G
S
I
P
S
S
S
S
K
N
E
K
K
Site 32
S347
N
G
S
I
P
S
S
S
S
K
N
E
K
K
Q
Site 33
S348
G
S
I
P
S
S
S
S
K
N
E
K
K
Q
K
Site 34
T357
N
E
K
K
Q
K
C
T
S
K
S
P
S
T
H
Site 35
S358
E
K
K
Q
K
C
T
S
K
S
P
S
T
H
K
Site 36
S360
K
Q
K
C
T
S
K
S
P
S
T
H
K
D
L
Site 37
S362
K
C
T
S
K
S
P
S
T
H
K
D
L
M
E
Site 38
S378
C
I
P
N
N
Q
L
S
K
P
D
A
L
V
R
Site 39
S409
Q
V
E
Q
E
L
R
S
Q
I
S
S
L
S
S
Site 40
S412
Q
E
L
R
S
Q
I
S
S
L
S
S
T
E
R
Site 41
S413
E
L
R
S
Q
I
S
S
L
S
S
T
E
R
G
Site 42
S415
R
S
Q
I
S
S
L
S
S
T
E
R
G
I
R
Site 43
S416
S
Q
I
S
S
L
S
S
T
E
R
G
I
R
S
Site 44
T417
Q
I
S
S
L
S
S
T
E
R
G
I
R
S
E
Site 45
S454
Q
K
D
K
Q
N
I
S
Q
L
E
K
K
L
K
Site 46
S468
K
A
E
Q
E
A
R
S
F
V
E
K
Q
L
M
Site 47
T505
S
R
G
E
C
T
E
T
L
R
N
R
I
R
E
Site 48
T521
E
A
E
G
K
K
L
T
M
D
M
K
V
K
E
Site 49
Y544
K
V
Q
E
L
R
K
Y
K
E
N
E
K
D
T
Site 50
T551
Y
K
E
N
E
K
D
T
E
V
L
M
S
A
L
Site 51
S556
K
D
T
E
V
L
M
S
A
L
S
A
M
Q
D
Site 52
T565
L
S
A
M
Q
D
K
T
Q
H
L
E
N
S
L
Site 53
S573
Q
H
L
E
N
S
L
S
A
E
T
R
I
K
L
Site 54
S584
R
I
K
L
D
L
F
S
A
L
G
D
A
K
R
Site 55
S631
I
T
Y
S
A
A
T
S
P
L
S
P
V
S
P
Site 56
S634
S
A
A
T
S
P
L
S
P
V
S
P
H
Y
S
Site 57
S637
T
S
P
L
S
P
V
S
P
H
Y
S
S
K
F
Site 58
Y640
L
S
P
V
S
P
H
Y
S
S
K
F
V
E
T
Site 59
S641
S
P
V
S
P
H
Y
S
S
K
F
V
E
T
S
Site 60
S642
P
V
S
P
H
Y
S
S
K
F
V
E
T
S
P
Site 61
T647
Y
S
S
K
F
V
E
T
S
P
S
G
L
D
P
Site 62
S648
S
S
K
F
V
E
T
S
P
S
G
L
D
P
N
Site 63
S650
K
F
V
E
T
S
P
S
G
L
D
P
N
A
S
Site 64
S657
S
G
L
D
P
N
A
S
V
Y
Q
P
L
K
K
Site 65
Y659
L
D
P
N
A
S
V
Y
Q
P
L
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation