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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPND
Full Name:
MPN domain-containing protein
Alias:
Type:
Mass (Da):
50662
Number AA:
471
UniProt ID:
Q8N594
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
P
E
P
L
S
P
A
G
G
A
G
E
Site 2
S42
A
G
A
G
G
G
R
S
G
G
G
G
S
S
V
Site 3
S47
G
R
S
G
G
G
G
S
S
V
S
G
G
G
G
Site 4
S48
R
S
G
G
G
G
S
S
V
S
G
G
G
G
G
Site 5
S50
G
G
G
G
S
S
V
S
G
G
G
G
G
G
G
Site 6
T71
G
G
P
G
G
A
L
T
R
R
A
V
T
L
R
Site 7
S94
E
P
G
A
G
V
L
S
I
Y
Y
L
G
K
K
Site 8
S123
E
T
G
Q
T
F
N
S
P
S
A
W
A
T
H
Site 9
T129
N
S
P
S
A
W
A
T
H
C
K
K
L
V
N
Site 10
S141
L
V
N
P
A
K
K
S
G
C
G
W
A
S
V
Site 11
S147
K
S
G
C
G
W
A
S
V
K
Y
K
G
Q
K
Site 12
Y150
C
G
W
A
S
V
K
Y
K
G
Q
K
L
D
K
Site 13
Y158
K
G
Q
K
L
D
K
Y
K
A
T
W
L
R
L
Site 14
T170
L
R
L
H
Q
L
H
T
P
A
T
A
A
D
E
Site 15
T173
H
Q
L
H
T
P
A
T
A
A
D
E
S
P
A
Site 16
S178
P
A
T
A
A
D
E
S
P
A
S
E
G
E
E
Site 17
S181
A
A
D
E
S
P
A
S
E
G
E
E
E
E
L
Site 18
S202
E
D
V
L
A
G
V
S
A
E
D
K
S
R
R
Site 19
S207
G
V
S
A
E
D
K
S
R
R
P
L
G
K
S
Site 20
S214
S
R
R
P
L
G
K
S
P
S
E
P
A
H
P
Site 21
S216
R
P
L
G
K
S
P
S
E
P
A
H
P
E
A
Site 22
T225
P
A
H
P
E
A
T
T
P
G
K
R
V
D
S
Site 23
S232
T
P
G
K
R
V
D
S
K
I
R
V
P
V
R
Site 24
Y240
K
I
R
V
P
V
R
Y
C
M
L
G
S
R
D
Site 25
T254
D
L
A
R
N
P
H
T
L
V
E
V
T
S
F
Site 26
S291
F
H
S
H
L
T
R
S
E
V
V
G
Y
L
G
Site 27
Y296
T
R
S
E
V
V
G
Y
L
G
G
R
W
D
V
Site 28
S305
G
G
R
W
D
V
N
S
Q
M
L
T
V
L
R
Site 29
T325
S
R
L
G
D
A
E
T
A
A
A
I
E
E
E
Site 30
S336
I
E
E
E
I
Y
Q
S
L
F
L
R
G
L
S
Site 31
S350
S
L
V
G
W
Y
H
S
H
P
H
S
P
A
L
Site 32
S354
W
Y
H
S
H
P
H
S
P
A
L
P
S
L
Q
Site 33
S359
P
H
S
P
A
L
P
S
L
Q
D
I
D
A
Q
Site 34
Y369
D
I
D
A
Q
M
D
Y
Q
L
R
L
Q
G
S
Site 35
S376
Y
Q
L
R
L
Q
G
S
S
N
G
F
Q
P
C
Site 36
S377
Q
L
R
L
Q
G
S
S
N
G
F
Q
P
C
L
Site 37
Y392
A
L
L
C
S
P
Y
Y
S
G
N
P
G
P
E
Site 38
S393
L
L
C
S
P
Y
Y
S
G
N
P
G
P
E
S
Site 39
S400
S
G
N
P
G
P
E
S
K
I
S
P
F
W
V
Site 40
S403
P
G
P
E
S
K
I
S
P
F
W
V
M
P
P
Site 41
S422
L
V
E
F
Y
K
G
S
P
D
L
V
R
L
Q
Site 42
S433
V
R
L
Q
E
P
W
S
Q
E
H
T
Y
L
D
Site 43
T437
E
P
W
S
Q
E
H
T
Y
L
D
K
L
K
I
Site 44
Y438
P
W
S
Q
E
H
T
Y
L
D
K
L
K
I
S
Site 45
S445
Y
L
D
K
L
K
I
S
L
A
S
R
T
P
K
Site 46
T450
K
I
S
L
A
S
R
T
P
K
D
Q
S
L
C
Site 47
S455
S
R
T
P
K
D
Q
S
L
C
H
V
L
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation