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Updated November 2019
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Protein Info
Short Name:
MINK1
Full Name:
Misshapen-like kinase 1
Alias:
B55; EC 2.7.11.1; Kinase MINK; MAP4K6; MINK; Misshapen/NIK-related kinase; Misshapen/NIK-related kinase MinK-1; Misshapen/NIKs-related kinase MinK-1; Misshapen-like kinase 1; YSK2; ZC3
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE20 family; MSN subfamily
Mass (Da):
149810
Number AA:
1332
UniProt ID:
Q8N4C8
International Prot ID:
IPI00218497
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
D
P
A
P
A
R
S
L
D
D
I
D
L
S
Site 2
S16
S
L
D
D
I
D
L
S
A
L
R
D
P
A
G
Site 3
Y36
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
Site 4
Y40
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
Site 5
T59
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
Site 6
Y76
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
Site 7
Y85
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
Site 8
Y86
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
Site 9
S93
Y
G
A
F
I
K
K
S
P
P
G
N
D
D
Q
Site 10
T162
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
Site 11
S175
K
L
V
D
F
G
V
S
A
Q
L
D
R
T
V
Site 12
T181
V
S
A
Q
L
D
R
T
V
G
R
R
N
T
F
Site 13
T187
R
T
V
G
R
R
N
T
F
I
G
T
P
Y
W
Site 14
T191
R
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
Site 15
Y193
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
Site 16
Y210
D
E
N
P
D
A
T
Y
D
Y
R
S
D
I
W
Site 17
Y212
N
P
D
A
T
Y
D
Y
R
S
D
I
W
S
L
Site 18
S218
D
Y
R
S
D
I
W
S
L
G
I
T
A
I
E
Site 19
S255
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
Site 20
S259
R
L
K
S
K
K
W
S
K
K
F
I
D
F
I
Site 21
T273
I
D
T
C
L
I
K
T
Y
L
S
R
P
P
T
Site 22
Y274
D
T
C
L
I
K
T
Y
L
S
R
P
P
T
E
Site 23
S276
C
L
I
K
T
Y
L
S
R
P
P
T
E
Q
L
Site 24
T280
T
Y
L
S
R
P
P
T
E
Q
L
L
K
F
P
Site 25
T294
P
F
I
R
D
Q
P
T
E
R
Q
V
R
I
Q
Site 26
T319
K
R
G
E
K
E
E
T
E
Y
E
Y
S
G
S
Site 27
Y321
G
E
K
E
E
T
E
Y
E
Y
S
G
S
E
E
Site 28
Y323
K
E
E
T
E
Y
E
Y
S
G
S
E
E
E
D
Site 29
S324
E
E
T
E
Y
E
Y
S
G
S
E
E
E
D
D
Site 30
S326
T
E
Y
E
Y
S
G
S
E
E
E
D
D
S
H
Site 31
S332
G
S
E
E
E
D
D
S
H
G
E
E
G
E
P
Site 32
S340
H
G
E
E
G
E
P
S
S
I
M
N
V
P
G
Site 33
S341
G
E
E
G
E
P
S
S
I
M
N
V
P
G
E
Site 34
S349
I
M
N
V
P
G
E
S
T
L
R
R
E
F
L
Site 35
T350
M
N
V
P
G
E
S
T
L
R
R
E
F
L
R
Site 36
S364
R
L
Q
Q
E
N
K
S
N
S
E
A
L
K
Q
Site 37
S366
Q
Q
E
N
K
S
N
S
E
A
L
K
Q
Q
Q
Site 38
Y451
Q
A
E
R
E
Q
E
Y
K
R
K
Q
L
E
E
Site 39
S462
Q
L
E
E
Q
R
Q
S
E
R
L
Q
R
Q
L
Site 40
S478
Q
E
H
A
Y
L
K
S
L
Q
Q
Q
Q
Q
Q
Site 41
Y505
P
G
D
R
K
P
L
Y
H
Y
G
R
G
M
N
Site 42
Y507
D
R
K
P
L
Y
H
Y
G
R
G
M
N
P
A
Site 43
S535
R
M
N
K
Q
Q
N
S
P
L
A
K
S
K
P
Site 44
S540
Q
N
S
P
L
A
K
S
K
P
G
S
T
G
P
Site 45
S544
L
A
K
S
K
P
G
S
T
G
P
E
P
P
I
Site 46
S555
E
P
P
I
P
Q
A
S
P
G
P
P
G
P
L
Site 47
S563
P
G
P
P
G
P
L
S
Q
T
P
P
M
Q
R
Site 48
T565
P
P
G
P
L
S
Q
T
P
P
M
Q
R
P
V
Site 49
S581
P
Q
E
G
P
H
K
S
L
V
A
H
R
V
P
Site 50
Y592
H
R
V
P
L
K
P
Y
A
A
P
V
P
R
S
Site 51
S599
Y
A
A
P
V
P
R
S
Q
S
L
Q
D
Q
P
Site 52
S601
A
P
V
P
R
S
Q
S
L
Q
D
Q
P
T
R
Site 53
S616
N
L
A
A
F
P
A
S
H
D
P
D
P
A
I
Site 54
T627
D
P
A
I
P
A
P
T
A
T
P
S
A
R
G
Site 55
S631
P
A
P
T
A
T
P
S
A
R
G
A
V
I
R
Site 56
S641
G
A
V
I
R
Q
N
S
D
P
T
S
E
G
P
Site 57
T644
I
R
Q
N
S
D
P
T
S
E
G
P
G
P
S
Site 58
S645
R
Q
N
S
D
P
T
S
E
G
P
G
P
S
P
Site 59
S651
T
S
E
G
P
G
P
S
P
N
P
P
A
W
V
Site 60
S673
P
K
V
P
Q
R
T
S
S
I
A
T
A
L
N
Site 61
S674
K
V
P
Q
R
T
S
S
I
A
T
A
L
N
T
Site 62
T677
Q
R
T
S
S
I
A
T
A
L
N
T
S
G
A
Site 63
S699
A
V
R
A
R
P
R
S
N
S
A
W
Q
I
Y
Site 64
S701
R
A
R
P
R
S
N
S
A
W
Q
I
Y
L
Q
Site 65
Y706
S
N
S
A
W
Q
I
Y
L
Q
R
R
A
E
R
Site 66
T715
Q
R
R
A
E
R
G
T
P
K
P
P
G
P
P
Site 67
S732
P
P
G
P
P
N
A
S
S
N
P
D
L
R
R
Site 68
S733
P
G
P
P
N
A
S
S
N
P
D
L
R
R
S
Site 69
S740
S
N
P
D
L
R
R
S
D
P
G
W
E
R
S
Site 70
S747
S
D
P
G
W
E
R
S
D
S
V
L
P
A
S
Site 71
S749
P
G
W
E
R
S
D
S
V
L
P
A
S
H
G
Site 72
S754
S
D
S
V
L
P
A
S
H
G
H
L
P
Q
A
Site 73
S763
G
H
L
P
Q
A
G
S
L
E
R
N
R
V
G
Site 74
S772
E
R
N
R
V
G
A
S
S
K
L
D
S
S
P
Site 75
S773
R
N
R
V
G
A
S
S
K
L
D
S
S
P
V
Site 76
S777
G
A
S
S
K
L
D
S
S
P
V
L
S
P
G
Site 77
S778
A
S
S
K
L
D
S
S
P
V
L
S
P
G
N
Site 78
S782
L
D
S
S
P
V
L
S
P
G
N
K
A
K
P
Site 79
S794
A
K
P
D
D
H
R
S
R
P
G
R
P
A
D
Site 80
T809
F
V
L
L
K
E
R
T
L
D
E
A
P
R
P
Site 81
Y823
P
P
K
K
A
M
D
Y
S
S
S
S
E
E
V
Site 82
S824
P
K
K
A
M
D
Y
S
S
S
S
E
E
V
E
Site 83
S825
K
K
A
M
D
Y
S
S
S
S
E
E
V
E
S
Site 84
S826
K
A
M
D
Y
S
S
S
S
E
E
V
E
S
S
Site 85
S827
A
M
D
Y
S
S
S
S
E
E
V
E
S
S
E
Site 86
S832
S
S
S
E
E
V
E
S
S
E
D
D
E
E
E
Site 87
S833
S
S
E
E
V
E
S
S
E
D
D
E
E
E
G
Site 88
S848
E
G
G
P
A
E
G
S
R
D
T
P
G
G
R
Site 89
T851
P
A
E
G
S
R
D
T
P
G
G
R
S
D
G
Site 90
S856
R
D
T
P
G
G
R
S
D
G
D
T
D
S
V
Site 91
T860
G
G
R
S
D
G
D
T
D
S
V
S
T
M
V
Site 92
S862
R
S
D
G
D
T
D
S
V
S
T
M
V
V
H
Site 93
S864
D
G
D
T
D
S
V
S
T
M
V
V
H
D
V
Site 94
T877
D
V
E
E
I
T
G
T
Q
P
P
Y
G
G
G
Site 95
T891
G
T
M
V
V
Q
R
T
P
E
E
E
R
N
L
Site 96
S903
R
N
L
L
H
A
D
S
N
G
Y
T
N
L
P
Site 97
Y906
L
H
A
D
S
N
G
Y
T
N
L
P
D
V
V
Site 98
T907
H
A
D
S
N
G
Y
T
N
L
P
D
V
V
Q
Site 99
S916
L
P
D
V
V
Q
P
S
H
S
P
T
E
N
S
Site 100
S918
D
V
V
Q
P
S
H
S
P
T
E
N
S
K
G
Site 101
T920
V
Q
P
S
H
S
P
T
E
N
S
K
G
Q
S
Site 102
S923
S
H
S
P
T
E
N
S
K
G
Q
S
P
P
S
Site 103
S927
T
E
N
S
K
G
Q
S
P
P
S
K
D
G
S
Site 104
S930
S
K
G
Q
S
P
P
S
K
D
G
S
G
D
Y
Site 105
S934
S
P
P
S
K
D
G
S
G
D
Y
Q
S
R
G
Site 106
Y937
S
K
D
G
S
G
D
Y
Q
S
R
G
L
V
K
Site 107
S939
D
G
S
G
D
Y
Q
S
R
G
L
V
K
A
P
Site 108
Y960
M
F
V
D
L
G
I
Y
Q
P
G
G
S
G
D
Site 109
Y987
T
R
L
D
Q
L
Q
Y
D
V
R
K
G
S
V
Site 110
S993
Q
Y
D
V
R
K
G
S
V
V
N
V
N
P
T
Site 111
T1000
S
V
V
N
V
N
P
T
N
T
R
A
H
S
E
Site 112
S1006
P
T
N
T
R
A
H
S
E
T
P
E
I
R
K
Site 113
T1008
N
T
R
A
H
S
E
T
P
E
I
R
K
Y
K
Site 114
Y1014
E
T
P
E
I
R
K
Y
K
K
R
F
N
S
E
Site 115
S1020
K
Y
K
K
R
F
N
S
E
I
L
C
A
A
L
Site 116
S1046
G
L
M
L
L
D
R
S
G
Q
G
K
V
Y
G
Site 117
Y1052
R
S
G
Q
G
K
V
Y
G
L
I
G
R
R
R
Site 118
T1074
E
G
L
N
L
L
I
T
I
S
G
K
R
N
K
Site 119
S1076
L
N
L
L
I
T
I
S
G
K
R
N
K
L
R
Site 120
Y1085
K
R
N
K
L
R
V
Y
Y
L
S
W
L
R
N
Site 121
Y1086
R
N
K
L
R
V
Y
Y
L
S
W
L
R
N
K
Site 122
S1088
K
L
R
V
Y
Y
L
S
W
L
R
N
K
I
L
Site 123
T1109
E
K
K
Q
G
W
T
T
V
G
D
M
E
G
C
Site 124
Y1119
D
M
E
G
C
G
H
Y
R
V
V
K
Y
E
R
Site 125
Y1124
G
H
Y
R
V
V
K
Y
E
R
I
K
F
L
V
Site 126
Y1141
L
K
S
S
V
E
V
Y
A
W
A
P
K
P
Y
Site 127
S1156
H
K
F
M
A
F
K
S
F
A
D
L
P
H
R
Site 128
T1170
R
P
L
L
V
D
L
T
V
E
E
G
Q
R
L
Site 129
Y1181
G
Q
R
L
K
V
I
Y
G
S
S
A
G
F
H
Site 130
Y1198
D
V
D
S
G
N
S
Y
D
I
Y
I
P
V
H
Site 131
Y1201
S
G
N
S
Y
D
I
Y
I
P
V
H
I
Q
S
Site 132
Y1236
C
Y
E
D
E
G
V
Y
V
N
T
Y
G
R
I
Site 133
Y1240
E
G
V
Y
V
N
T
Y
G
R
I
I
K
D
V
Site 134
S1278
E
K
A
I
E
I
R
S
V
E
T
G
H
L
D
Site 135
S1310
N
D
K
V
F
F
A
S
V
R
S
G
G
S
S
Site 136
S1317
S
V
R
S
G
G
S
S
Q
V
Y
F
M
T
L
Site 137
Y1320
S
G
G
S
S
Q
V
Y
F
M
T
L
N
R
N
Site 138
T1323
S
S
Q
V
Y
F
M
T
L
N
R
N
C
I
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation