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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NIN
Full Name:
Ninein
Alias:
Glycogen synthase kinase 3 beta-interacting; Glycogen synthase kinase 3 beta-interacting protein; GSK3B interacting protein; GSK3B-interacting; HNinein; Ninein (GSK3B interacting protein)
Type:
Cytoskeletal protein
Mass (Da):
243290
Number AA:
2090
UniProt ID:
Q8N4C6
International Prot ID:
IPI00441952
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051642
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
R
L
K
E
L
F
D
S
F
D
T
T
G
T
G
Site 2
T22
E
L
F
D
S
F
D
T
T
G
T
G
S
L
G
Site 3
T23
L
F
D
S
F
D
T
T
G
T
G
S
L
G
Q
Site 4
T34
S
L
G
Q
E
E
L
T
D
L
C
H
M
L
S
Site 5
S80
L
I
L
S
R
T
L
S
N
E
E
H
F
Q
E
Site 6
S91
H
F
Q
E
P
D
C
S
L
E
A
Q
P
K
Y
Site 7
Y98
S
L
E
A
Q
P
K
Y
V
R
G
G
K
R
Y
Site 8
Y105
Y
V
R
G
G
K
R
Y
G
R
R
S
L
P
E
Site 9
S109
G
K
R
Y
G
R
R
S
L
P
E
F
Q
E
S
Site 10
S116
S
L
P
E
F
Q
E
S
V
E
E
F
P
E
V
Site 11
S136
L
D
E
E
A
R
P
S
H
I
P
A
G
D
C
Site 12
T149
D
C
S
E
H
W
K
T
Q
R
S
E
E
Y
E
Site 13
S152
E
H
W
K
T
Q
R
S
E
E
Y
E
A
E
G
Site 14
Y155
K
T
Q
R
S
E
E
Y
E
A
E
G
Q
L
R
Site 15
S172
N
P
D
D
L
N
A
S
Q
S
G
S
S
P
P
Site 16
S174
D
D
L
N
A
S
Q
S
G
S
S
P
P
Q
D
Site 17
S176
L
N
A
S
Q
S
G
S
S
P
P
Q
D
W
I
Site 18
S177
N
A
S
Q
S
G
S
S
P
P
Q
D
W
I
E
Site 19
S209
L
N
R
K
K
L
V
S
I
C
E
Q
Y
G
L
Site 20
T236
H
N
L
D
P
D
G
T
M
S
V
E
D
F
F
Site 21
S238
L
D
P
D
G
T
M
S
V
E
D
F
F
Y
G
Site 22
Y244
M
S
V
E
D
F
F
Y
G
L
F
K
N
G
K
Site 23
S252
G
L
F
K
N
G
K
S
L
T
P
S
A
S
T
Site 24
T254
F
K
N
G
K
S
L
T
P
S
A
S
T
P
Y
Site 25
S256
N
G
K
S
L
T
P
S
A
S
T
P
Y
R
Q
Site 26
S258
K
S
L
T
P
S
A
S
T
P
Y
R
Q
L
K
Site 27
T259
S
L
T
P
S
A
S
T
P
Y
R
Q
L
K
R
Site 28
S269
R
Q
L
K
R
H
L
S
M
Q
S
F
D
E
S
Site 29
S272
K
R
H
L
S
M
Q
S
F
D
E
S
G
R
R
Site 30
S276
S
M
Q
S
F
D
E
S
G
R
R
T
T
T
S
Site 31
T280
F
D
E
S
G
R
R
T
T
T
S
S
A
M
T
Site 32
T281
D
E
S
G
R
R
T
T
T
S
S
A
M
T
S
Site 33
T282
E
S
G
R
R
T
T
T
S
S
A
M
T
S
T
Site 34
S283
S
G
R
R
T
T
T
S
S
A
M
T
S
T
I
Site 35
S284
G
R
R
T
T
T
S
S
A
M
T
S
T
I
G
Site 36
S306
D
D
G
M
G
H
A
S
V
E
R
I
L
D
T
Site 37
T313
S
V
E
R
I
L
D
T
W
Q
E
E
G
I
E
Site 38
S322
Q
E
E
G
I
E
N
S
Q
E
I
L
K
A
L
Site 39
T353
L
E
N
E
L
L
V
T
K
N
S
I
H
Q
A
Site 40
S364
I
H
Q
A
A
L
A
S
F
K
A
E
I
R
H
Site 41
S388
R
E
K
E
K
L
R
S
D
L
D
K
A
E
K
Site 42
S398
D
K
A
E
K
L
K
S
L
M
A
S
E
V
D
Site 43
S402
K
L
K
S
L
M
A
S
E
V
D
D
H
H
A
Site 44
Y417
A
I
E
R
R
N
E
Y
N
L
R
K
L
D
E
Site 45
Y426
L
R
K
L
D
E
E
Y
K
E
R
I
A
A
L
Site 46
T464
Q
E
I
E
K
A
K
T
E
E
N
Y
I
R
D
Site 47
Y468
K
A
K
T
E
E
N
Y
I
R
D
R
L
A
L
Site 48
S476
I
R
D
R
L
A
L
S
L
K
E
N
S
R
L
Site 49
S522
K
F
G
D
L
D
P
S
S
A
E
F
F
L
Q
Site 50
S523
F
G
D
L
D
P
S
S
A
E
F
F
L
Q
E
Site 51
T534
F
L
Q
E
E
R
L
T
Q
M
R
N
E
Y
E
Site 52
Y540
L
T
Q
M
R
N
E
Y
E
R
Q
C
R
V
L
Site 53
Y561
L
Q
S
E
L
E
E
Y
R
A
Q
G
R
V
L
Site 54
S575
L
R
L
P
L
K
N
S
P
S
E
E
V
E
A
Site 55
S577
L
P
L
K
N
S
P
S
E
E
V
E
A
N
S
Site 56
Y636
L
E
D
K
V
R
H
Y
E
K
Q
L
D
E
T
Site 57
T643
Y
E
K
Q
L
D
E
T
V
V
S
C
K
K
A
Site 58
S646
Q
L
D
E
T
V
V
S
C
K
K
A
Q
E
N
Site 59
S670
H
T
L
E
K
Q
I
S
D
L
K
N
E
I
A
Site 60
T713
V
K
L
E
E
E
K
T
H
L
Q
E
K
L
R
Site 61
T732
M
E
L
K
A
R
L
T
Q
A
Q
A
S
F
E
Site 62
S737
R
L
T
Q
A
Q
A
S
F
E
R
E
R
E
G
Site 63
S747
R
E
R
E
G
L
Q
S
S
A
W
T
E
E
K
Site 64
T751
G
L
Q
S
S
A
W
T
E
E
K
V
R
G
L
Site 65
T759
E
E
K
V
R
G
L
T
Q
E
L
E
Q
F
H
Site 66
S772
F
H
Q
E
Q
L
T
S
L
V
E
K
H
T
L
Site 67
T805
E
G
R
E
K
M
E
T
E
C
N
R
R
T
S
Site 68
T811
E
T
E
C
N
R
R
T
S
Q
I
E
A
Q
F
Site 69
S812
T
E
C
N
R
R
T
S
Q
I
E
A
Q
F
Q
Site 70
S820
Q
I
E
A
Q
F
Q
S
D
C
Q
K
V
T
E
Site 71
T826
Q
S
D
C
Q
K
V
T
E
R
C
E
S
A
L
Site 72
S831
K
V
T
E
R
C
E
S
A
L
Q
S
L
E
G
Site 73
S835
R
C
E
S
A
L
Q
S
L
E
G
R
Y
R
Q
Site 74
S856
E
Q
Q
R
E
E
K
S
Q
W
E
F
E
K
D
Site 75
T866
E
F
E
K
D
E
L
T
Q
E
C
A
E
A
Q
Site 76
T885
E
T
L
K
R
E
K
T
T
S
L
V
L
T
Q
Site 77
T886
T
L
K
R
E
K
T
T
S
L
V
L
T
Q
E
Site 78
S887
L
K
R
E
K
T
T
S
L
V
L
T
Q
E
R
Site 79
T891
K
T
T
S
L
V
L
T
Q
E
R
E
M
L
E
Site 80
T900
E
R
E
M
L
E
K
T
Y
K
E
H
L
N
S
Site 81
S907
T
Y
K
E
H
L
N
S
M
V
V
E
R
Q
Q
Site 82
S926
L
E
D
L
R
N
V
S
E
T
Q
Q
S
L
L
Site 83
T928
D
L
R
N
V
S
E
T
Q
Q
S
L
L
S
D
Site 84
S931
N
V
S
E
T
Q
Q
S
L
L
S
D
Q
I
L
Site 85
S934
E
T
Q
Q
S
L
L
S
D
Q
I
L
E
L
K
Site 86
S943
Q
I
L
E
L
K
S
S
H
K
R
E
L
R
E
Site 87
S966
G
A
S
E
Q
L
A
S
Q
R
L
E
R
L
E
Site 88
S985
Q
E
R
Q
E
M
M
S
K
L
L
A
M
E
N
Site 89
S1009
D
R
E
R
A
E
M
S
T
E
I
S
R
L
Q
Site 90
T1010
R
E
R
A
E
M
S
T
E
I
S
R
L
Q
S
Site 91
S1013
A
E
M
S
T
E
I
S
R
L
Q
S
K
I
K
Site 92
S1017
T
E
I
S
R
L
Q
S
K
I
K
E
M
Q
Q
Site 93
S1027
K
E
M
Q
Q
A
T
S
P
L
S
M
L
Q
S
Site 94
S1030
Q
Q
A
T
S
P
L
S
M
L
Q
S
G
C
Q
Site 95
S1051
V
E
G
D
G
A
L
S
L
L
Q
Q
G
E
Q
Site 96
S1069
E
N
G
D
V
L
L
S
L
Q
R
A
H
E
Q
Site 97
S1106
E
P
G
L
V
M
S
S
C
L
D
E
P
A
T
Site 98
T1113
S
C
L
D
E
P
A
T
E
F
F
G
N
T
A
Site 99
S1145
V
T
R
R
H
V
L
S
D
L
E
D
D
E
V
Site 100
S1157
D
E
V
R
D
L
G
S
T
G
T
S
S
V
Q
Site 101
T1158
E
V
R
D
L
G
S
T
G
T
S
S
V
Q
R
Site 102
S1161
D
L
G
S
T
G
T
S
S
V
Q
R
Q
E
V
Site 103
S1162
L
G
S
T
G
T
S
S
V
Q
R
Q
E
V
K
Site 104
S1173
Q
E
V
K
I
E
E
S
E
A
S
V
E
G
F
Site 105
S1176
K
I
E
E
S
E
A
S
V
E
G
F
S
E
L
Site 106
S1186
G
F
S
E
L
E
N
S
E
E
T
R
T
E
S
Site 107
T1191
E
N
S
E
E
T
R
T
E
S
W
E
L
K
N
Site 108
S1193
S
E
E
T
R
T
E
S
W
E
L
K
N
Q
I
Site 109
S1201
W
E
L
K
N
Q
I
S
Q
L
Q
E
Q
L
M
Site 110
S1218
C
A
D
C
D
R
A
S
E
K
K
Q
D
L
L
Site 111
S1229
Q
D
L
L
F
D
V
S
V
L
K
K
K
L
K
Site 112
S1245
L
E
R
I
P
E
A
S
P
K
Y
K
L
L
Y
Site 113
Y1252
S
P
K
Y
K
L
L
Y
E
D
V
S
R
E
N
Site 114
S1256
K
L
L
Y
E
D
V
S
R
E
N
D
C
L
Q
Site 115
Y1273
L
R
M
M
E
T
R
Y
D
E
A
L
E
N
N
Site 116
T1303
K
M
E
E
V
T
E
T
F
L
S
L
E
K
S
Site 117
S1306
E
V
T
E
T
F
L
S
L
E
K
S
Y
D
E
Site 118
S1310
T
F
L
S
L
E
K
S
Y
D
E
V
K
I
E
Site 119
S1338
K
I
E
K
L
Q
E
S
V
V
Q
R
C
D
C
Site 120
T1369
N
I
L
Q
L
N
Q
T
L
E
E
C
V
P
R
Site 121
S1379
E
C
V
P
R
V
R
S
V
H
H
V
I
E
E
Site 122
Y1393
E
C
K
Q
E
N
Q
Y
L
E
G
N
T
Q
L
Site 123
T1436
V
I
L
E
E
N
T
T
L
L
G
F
Q
D
K
Site 124
T1459
A
E
L
E
L
E
K
T
K
L
Q
E
L
T
R
Site 125
T1465
K
T
K
L
Q
E
L
T
R
K
L
K
E
R
V
Site 126
T1473
R
K
L
K
E
R
V
T
I
L
V
K
Q
K
D
Site 127
S1483
V
K
Q
K
D
V
L
S
H
G
E
K
E
E
E
Site 128
Y1514
Q
K
V
E
L
L
R
Y
E
S
E
K
L
Q
Q
Site 129
S1516
V
E
L
L
R
Y
E
S
E
K
L
Q
Q
E
N
Site 130
S1524
E
K
L
Q
Q
E
N
S
I
L
R
N
E
I
T
Site 131
T1532
I
L
R
N
E
I
T
T
L
N
E
E
D
S
I
Site 132
S1538
T
T
L
N
E
E
D
S
I
S
N
L
K
L
G
Site 133
S1540
L
N
E
E
D
S
I
S
N
L
K
L
G
T
L
Site 134
T1546
I
S
N
L
K
L
G
T
L
N
G
S
Q
E
E
Site 135
S1550
K
L
G
T
L
N
G
S
Q
E
E
M
W
Q
K
Site 136
T1560
E
M
W
Q
K
T
E
T
V
K
Q
E
N
A
A
Site 137
S1580
E
N
L
K
K
Q
I
S
E
L
K
I
K
N
Q
Site 138
S1597
D
L
E
N
T
E
L
S
Q
K
N
S
Q
N
Q
Site 139
S1601
T
E
L
S
Q
K
N
S
Q
N
Q
E
K
L
Q
Site 140
T1615
Q
E
L
N
Q
R
L
T
E
M
L
C
Q
K
E
Site 141
S1628
K
E
K
E
P
G
N
S
A
L
E
E
R
E
Q
Site 142
S1651
L
E
R
C
K
V
Q
S
S
T
L
V
S
S
L
Site 143
S1652
E
R
C
K
V
Q
S
S
T
L
V
S
S
L
E
Site 144
T1653
R
C
K
V
Q
S
S
T
L
V
S
S
L
E
A
Site 145
S1657
Q
S
S
T
L
V
S
S
L
E
A
E
L
S
E
Site 146
S1663
S
S
L
E
A
E
L
S
E
V
K
I
Q
T
H
Site 147
S1696
L
H
R
C
P
D
L
S
D
F
Q
Q
K
I
S
Site 148
S1703
S
D
F
Q
Q
K
I
S
S
V
L
S
Y
N
E
Site 149
S1704
D
F
Q
Q
K
I
S
S
V
L
S
Y
N
E
K
Site 150
S1707
Q
K
I
S
S
V
L
S
Y
N
E
K
L
L
K
Site 151
Y1708
K
I
S
S
V
L
S
Y
N
E
K
L
L
K
E
Site 152
S1720
L
K
E
K
E
A
L
S
E
E
L
N
S
C
V
Site 153
S1725
A
L
S
E
E
L
N
S
C
V
D
K
L
A
K
Site 154
S1733
C
V
D
K
L
A
K
S
S
L
L
E
H
R
I
Site 155
T1742
L
L
E
H
R
I
A
T
M
K
Q
E
Q
K
S
Site 156
S1749
T
M
K
Q
E
Q
K
S
W
E
H
Q
S
A
S
Site 157
S1754
Q
K
S
W
E
H
Q
S
A
S
L
K
S
Q
L
Site 158
S1756
S
W
E
H
Q
S
A
S
L
K
S
Q
L
V
A
Site 159
S1759
H
Q
S
A
S
L
K
S
Q
L
V
A
S
Q
E
Site 160
S1764
L
K
S
Q
L
V
A
S
Q
E
K
V
Q
N
L
Site 161
T1774
K
V
Q
N
L
E
D
T
V
Q
N
V
N
L
Q
Site 162
S1783
Q
N
V
N
L
Q
M
S
R
M
K
S
D
L
R
Site 163
S1787
L
Q
M
S
R
M
K
S
D
L
R
V
T
Q
Q
Site 164
T1792
M
K
S
D
L
R
V
T
Q
Q
E
K
E
A
L
Site 165
S1805
A
L
K
Q
E
V
M
S
L
H
K
Q
L
Q
N
Site 166
S1817
L
Q
N
A
G
G
K
S
W
A
P
E
I
A
T
Site 167
T1824
S
W
A
P
E
I
A
T
H
P
S
G
L
H
N
Site 168
S1837
H
N
Q
Q
K
R
L
S
W
D
K
L
D
H
L
Site 169
T1861
Q
E
N
E
R
L
Q
T
M
V
Q
N
T
K
A
Site 170
T1871
Q
N
T
K
A
E
L
T
H
S
R
E
K
V
R
Site 171
S1873
T
K
A
E
L
T
H
S
R
E
K
V
R
Q
L
Site 172
S1882
E
K
V
R
Q
L
E
S
N
L
L
P
K
H
Q
Site 173
T1897
K
H
L
N
P
S
G
T
M
N
P
T
E
Q
E
Site 174
T1901
P
S
G
T
M
N
P
T
E
Q
E
K
L
S
L
Site 175
S1907
P
T
E
Q
E
K
L
S
L
K
R
E
C
D
Q
Site 176
S1920
D
Q
F
Q
K
E
Q
S
P
A
N
R
K
V
S
Site 177
S1927
S
P
A
N
R
K
V
S
Q
M
N
S
L
E
Q
Site 178
S1931
R
K
V
S
Q
M
N
S
L
E
Q
E
L
E
T
Site 179
T1966
E
M
Q
H
L
R
S
T
A
T
P
S
P
S
P
Site 180
T1968
Q
H
L
R
S
T
A
T
P
S
P
S
P
H
A
Site 181
S1970
L
R
S
T
A
T
P
S
P
S
P
H
A
W
D
Site 182
S1972
S
T
A
T
P
S
P
S
P
H
A
W
D
L
Q
Site 183
S2020
E
E
L
E
N
R
T
S
E
T
N
T
P
Q
G
Site 184
T2022
L
E
N
R
T
S
E
T
N
T
P
Q
G
N
Q
Site 185
T2024
N
R
T
S
E
T
N
T
P
Q
G
N
Q
E
Q
Site 186
T2034
G
N
Q
E
Q
L
V
T
V
M
E
E
R
M
I
Site 187
S2066
N
Q
L
K
E
Q
V
S
L
P
G
H
L
C
S
Site 188
S2073
S
L
P
G
H
L
C
S
P
T
S
H
S
S
F
Site 189
T2075
P
G
H
L
C
S
P
T
S
H
S
S
F
N
S
Site 190
S2076
G
H
L
C
S
P
T
S
H
S
S
F
N
S
S
Site 191
S2078
L
C
S
P
T
S
H
S
S
F
N
S
S
F
T
Site 192
S2079
C
S
P
T
S
H
S
S
F
N
S
S
F
T
S
Site 193
S2082
T
S
H
S
S
F
N
S
S
F
T
S
L
Y
C
Site 194
S2083
S
H
S
S
F
N
S
S
F
T
S
L
Y
C
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation